JP5571947B2 - 癌およびその他の疾患の予防および治療 - Google Patents

癌およびその他の疾患の予防および治療 Download PDF

Info

Publication number
JP5571947B2
JP5571947B2 JP2009500483A JP2009500483A JP5571947B2 JP 5571947 B2 JP5571947 B2 JP 5571947B2 JP 2009500483 A JP2009500483 A JP 2009500483A JP 2009500483 A JP2009500483 A JP 2009500483A JP 5571947 B2 JP5571947 B2 JP 5571947B2
Authority
JP
Japan
Prior art keywords
nucleoside
valine ester
nucleoside analog
cancer
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009500483A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009530295A5 (enExample
JP2009530295A (ja
Inventor
ボンダレフ,イゴール,イー.
Original Assignee
アルト ソリューションズ インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/019488 external-priority patent/WO2006125166A2/en
Application filed by アルト ソリューションズ インコーポレーテッド filed Critical アルト ソリューションズ インコーポレーテッド
Publication of JP2009530295A publication Critical patent/JP2009530295A/ja
Publication of JP2009530295A5 publication Critical patent/JP2009530295A5/ja
Application granted granted Critical
Publication of JP5571947B2 publication Critical patent/JP5571947B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009500483A 2006-03-14 2007-03-14 癌およびその他の疾患の予防および治療 Expired - Fee Related JP5571947B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US78255906P 2006-03-14 2006-03-14
US60/782,559 2006-03-14
US80169306P 2006-05-18 2006-05-18
USPCT/US2006/019488 2006-05-18
PCT/US2006/019488 WO2006125166A2 (en) 2005-05-18 2006-05-18 Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer
US60/801,693 2006-05-18
US86051806P 2006-11-21 2006-11-21
US60/860,518 2006-11-21
PCT/US2007/006538 WO2007106561A2 (en) 2006-03-14 2007-03-14 Prevention and treatment of cancer and other diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014048595A Division JP2014144962A (ja) 2006-03-14 2014-03-12 癌およびその他の疾患の予防および治療

Publications (3)

Publication Number Publication Date
JP2009530295A JP2009530295A (ja) 2009-08-27
JP2009530295A5 JP2009530295A5 (enExample) 2010-04-30
JP5571947B2 true JP5571947B2 (ja) 2014-08-13

Family

ID=38510093

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009500483A Expired - Fee Related JP5571947B2 (ja) 2006-03-14 2007-03-14 癌およびその他の疾患の予防および治療
JP2014048595A Pending JP2014144962A (ja) 2006-03-14 2014-03-12 癌およびその他の疾患の予防および治療
JP2016081985A Pending JP2016175917A (ja) 2006-03-14 2016-04-15 癌およびその他の疾患の予防および治療

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014048595A Pending JP2014144962A (ja) 2006-03-14 2014-03-12 癌およびその他の疾患の予防および治療
JP2016081985A Pending JP2016175917A (ja) 2006-03-14 2016-04-15 癌およびその他の疾患の予防および治療

Country Status (5)

Country Link
US (1) US20090203636A1 (enExample)
EP (1) EP2001488A4 (enExample)
JP (3) JP5571947B2 (enExample)
CA (1) CA2644297A1 (enExample)
WO (1) WO2007106561A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014144962A (ja) * 2006-03-14 2014-08-14 Alt Solutions Inc 癌およびその他の疾患の予防および治療

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012061053A (ja) * 2010-09-14 2012-03-29 Yuuki Kitaoka 投薬装置、投薬装置の作動方法及び投薬方法
US10420761B2 (en) 2013-03-15 2019-09-24 University Of Florida Research Foundation, Inc. Allosteric inhibitors of thymidylate synthase
US10835524B2 (en) 2015-06-24 2020-11-17 University Of Florida Research Foundation, Incorporated Compositions for the treatment of pancreatic cancer and uses thereof
US20200217837A1 (en) * 2016-07-15 2020-07-09 Northwestern University Chromatin protective therapeutics and chromatin heterogeneity
WO2018143911A1 (en) * 2017-01-31 2018-08-09 Kimberly-Clark Worldwide, Inc. Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same
WO2019246376A1 (en) * 2018-06-20 2019-12-26 Chernova Olga B Prevention of primary and treatment-resistant cancer by inhibitors of endogenous reverse transcriptase
EP3940075A1 (en) * 2020-07-17 2022-01-19 Istituto Nazionale Di Genetica Molecolare-INGM Inhibitors of line1 and uses thereof
WO2023141534A1 (en) * 2022-01-19 2023-07-27 Northwestern University Agents that target telomerase reverse transcriptase (tert) for treating cancer and sensitizing cancer cells to genotoxic therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
DE3665260D1 (en) * 1985-05-07 1989-10-05 Teijin Ltd Antitumor agent
JPS61254526A (ja) * 1985-05-07 1986-11-12 Teijin Ltd 経口投与用抗腫瘍剤
EP0659209A1 (en) * 1991-07-26 1995-06-28 The University Of Rochester Cancer therapy utilizing malignant cells
JP4651942B2 (ja) * 2001-12-20 2011-03-16 フアーマセツト・インコーポレイテッド Ebv及びkhsv感染並びにそれに伴う異常細胞増殖の治療
US20050113324A1 (en) * 2003-01-15 2005-05-26 Bondarev Igor E. Modulation of line-1 reverse transcriptase
US20050026902A1 (en) * 2003-01-31 2005-02-03 Timothy Maziasz Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents
CN104997783A (zh) * 2005-03-25 2015-10-28 Alt解决方案公司 端粒酶阳性细胞中端粒长度的调节和癌症治疗
EP1885370A4 (en) * 2005-05-18 2012-07-25 Alt Solutions Inc PHARMACOLOGICAL MODULATION OF THE TELOMER LENGTH OF CANCER CELLS FOR THE PREVENTION AND TREATMENT OF CANCER
JP5571947B2 (ja) * 2006-03-14 2014-08-13 アルト ソリューションズ インコーポレーテッド 癌およびその他の疾患の予防および治療

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014144962A (ja) * 2006-03-14 2014-08-14 Alt Solutions Inc 癌およびその他の疾患の予防および治療

Also Published As

Publication number Publication date
WO2007106561A3 (en) 2008-08-14
EP2001488A2 (en) 2008-12-17
JP2009530295A (ja) 2009-08-27
EP2001488A4 (en) 2009-11-25
CA2644297A1 (en) 2007-09-20
JP2016175917A (ja) 2016-10-06
US20090203636A1 (en) 2009-08-13
WO2007106561A2 (en) 2007-09-20
JP2014144962A (ja) 2014-08-14

Similar Documents

Publication Publication Date Title
JP5571947B2 (ja) 癌およびその他の疾患の予防および治療
JP6660993B2 (ja) デオキシウリジントリホスファターゼ阻害剤
JP6836589B2 (ja) ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤
US20190292215A1 (en) Compounds, compositions, and methods for the treatment of disease
US8580753B2 (en) Modulation of telomere length in telomerase positive cells and cancer therapy
CN106061952B (zh) 含有杂原子的脱氧尿苷三磷酸酶抑制剂
JP2018035196A (ja) 骨髄増殖性疾患および骨髄増殖性腫瘍を処置するためのテロメラーゼ阻害剤の使用
US9078901B2 (en) Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer
KR102653041B1 (ko) 암 요법에 사용하기 위한 데옥시-시티딘 또는 우리딘 유도체
AU2019315406A1 (en) Methods of identifying patients likely to benefit from treatment with a telomerase inhibitor
US10697020B2 (en) MicroRNA-129 as a biomarker for colorectal cancer
CN101443021A (zh) 癌和其他疾病的预防和治疗
JPWO2010104035A1 (ja) 非小細胞肺癌に対する化学療法の治療効果予測方法
WO2024181391A1 (ja) Il-11アンチセンスオリゴヌクレオチド

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100312

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120807

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121102

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121109

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130207

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130312

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130606

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130613

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130912

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20131112

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140312

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20140508

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140603

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140627

R150 Certificate of patent or registration of utility model

Ref document number: 5571947

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees