JP2009530295A5 - - Google Patents
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- Publication number
- JP2009530295A5 JP2009530295A5 JP2009500483A JP2009500483A JP2009530295A5 JP 2009530295 A5 JP2009530295 A5 JP 2009530295A5 JP 2009500483 A JP2009500483 A JP 2009500483A JP 2009500483 A JP2009500483 A JP 2009500483A JP 2009530295 A5 JP2009530295 A5 JP 2009530295A5
- Authority
- JP
- Japan
- Prior art keywords
- cocktail
- administering
- therapy
- nucleoside analog
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 26
- 239000002777 nucleoside Substances 0.000 claims 17
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 13
- 238000002560 therapeutic procedure Methods 0.000 claims 12
- 239000000651 prodrug Substances 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000003937 drug carrier Substances 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 102100034343 Integrase Human genes 0.000 claims 5
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 5
- 230000001028 anti-proliverative effect Effects 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims 4
- -1 acyclic nucleoside Chemical class 0.000 claims 4
- 230000006907 apoptotic process Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 108010017842 Telomerase Proteins 0.000 claims 3
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 claims 3
- 230000001093 anti-cancer Effects 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 229960002656 didanosine Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- ATKOZYBRBNGECU-UHFFFAOYSA-N 1-(2-hydroxyethoxymethyl)-5-methylpyrimidine-2,4-dione Chemical compound CC1=CN(COCCO)C(=O)NC1=O ATKOZYBRBNGECU-UHFFFAOYSA-N 0.000 claims 1
- PEIRNIBZTBBIHT-UHFFFAOYSA-N 2-[(6-aminopurin-9-yl)methoxy]ethanol Chemical compound NC1=NC=NC2=C1N=CN2COCCO PEIRNIBZTBBIHT-UHFFFAOYSA-N 0.000 claims 1
- FCZOVUJWOBSMSS-UHFFFAOYSA-N 5-[(6-aminopurin-9-yl)methyl]-5-methyl-3-methylideneoxolan-2-one Chemical compound C1=NC2=C(N)N=CN=C2N1CC1(C)CC(=C)C(=O)O1 FCZOVUJWOBSMSS-UHFFFAOYSA-N 0.000 claims 1
- 230000005778 DNA damage Effects 0.000 claims 1
- 231100000277 DNA damage Toxicity 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000032823 cell division Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229940127073 nucleoside analogue Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 230000001235 sensitizing effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 108091035539 telomere Proteins 0.000 claims 1
- 102000055501 telomere Human genes 0.000 claims 1
- 210000003411 telomere Anatomy 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78255906P | 2006-03-14 | 2006-03-14 | |
| US60/782,559 | 2006-03-14 | ||
| US80169306P | 2006-05-18 | 2006-05-18 | |
| US60/801,693 | 2006-05-18 | ||
| USPCT/US2006/019488 | 2006-05-18 | ||
| PCT/US2006/019488 WO2006125166A2 (en) | 2005-05-18 | 2006-05-18 | Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer |
| US86051806P | 2006-11-21 | 2006-11-21 | |
| US60/860,518 | 2006-11-21 | ||
| PCT/US2007/006538 WO2007106561A2 (en) | 2006-03-14 | 2007-03-14 | Prevention and treatment of cancer and other diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048595A Division JP2014144962A (ja) | 2006-03-14 | 2014-03-12 | 癌およびその他の疾患の予防および治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009530295A JP2009530295A (ja) | 2009-08-27 |
| JP2009530295A5 true JP2009530295A5 (enExample) | 2010-04-30 |
| JP5571947B2 JP5571947B2 (ja) | 2014-08-13 |
Family
ID=38510093
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500483A Expired - Fee Related JP5571947B2 (ja) | 2006-03-14 | 2007-03-14 | 癌およびその他の疾患の予防および治療 |
| JP2014048595A Pending JP2014144962A (ja) | 2006-03-14 | 2014-03-12 | 癌およびその他の疾患の予防および治療 |
| JP2016081985A Pending JP2016175917A (ja) | 2006-03-14 | 2016-04-15 | 癌およびその他の疾患の予防および治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048595A Pending JP2014144962A (ja) | 2006-03-14 | 2014-03-12 | 癌およびその他の疾患の予防および治療 |
| JP2016081985A Pending JP2016175917A (ja) | 2006-03-14 | 2016-04-15 | 癌およびその他の疾患の予防および治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090203636A1 (enExample) |
| EP (1) | EP2001488A4 (enExample) |
| JP (3) | JP5571947B2 (enExample) |
| CA (1) | CA2644297A1 (enExample) |
| WO (1) | WO2007106561A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2001488A4 (en) * | 2006-03-14 | 2009-11-25 | Alt Solutions Inc | PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES |
| JP2012061053A (ja) * | 2010-09-14 | 2012-03-29 | Yuuki Kitaoka | 投薬装置、投薬装置の作動方法及び投薬方法 |
| WO2014145386A2 (en) * | 2013-03-15 | 2014-09-18 | University Of Florida Research Foundation Incorporated | Novel allosteric inhibitors of thymidylate synthase |
| WO2016209688A1 (en) | 2015-06-24 | 2016-12-29 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of cancer and uses thereof |
| WO2018013942A1 (en) * | 2016-07-15 | 2018-01-18 | Northwestern University | Chromatin protective therapeutics and chromatin heterogeneity |
| WO2018143911A1 (en) * | 2017-01-31 | 2018-08-09 | Kimberly-Clark Worldwide, Inc. | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same |
| WO2019246376A1 (en) * | 2018-06-20 | 2019-12-26 | Chernova Olga B | Prevention of primary and treatment-resistant cancer by inhibitors of endogenous reverse transcriptase |
| EP3940075A1 (en) * | 2020-07-17 | 2022-01-19 | Istituto Nazionale Di Genetica Molecolare-INGM | Inhibitors of line1 and uses thereof |
| WO2023141534A1 (en) | 2022-01-19 | 2023-07-27 | Northwestern University | Agents that target telomerase reverse transcriptase (tert) for treating cancer and sensitizing cancer cells to genotoxic therapy |
| WO2025260081A1 (en) * | 2024-06-14 | 2025-12-18 | Northwestern University | Targeted degraders of telomerase reverse transcriptase (tert) and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
| US4347360A (en) * | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
| JPS61254526A (ja) * | 1985-05-07 | 1986-11-12 | Teijin Ltd | 経口投与用抗腫瘍剤 |
| EP0202056B1 (en) * | 1985-05-07 | 1989-08-30 | Teijin Limited | Antitumor agent |
| JPH06509578A (ja) * | 1991-07-26 | 1994-10-27 | ユニバーシティ・オブ・ロチェスター | 悪性細胞利用による癌治療法 |
| WO2003053360A2 (en) * | 2001-12-20 | 2003-07-03 | Pharmassett Ltd. | Treatment of ebv and khsv infection and associated abnormal cellular proliferation |
| US20050113324A1 (en) * | 2003-01-15 | 2005-05-26 | Bondarev Igor E. | Modulation of line-1 reverse transcriptase |
| US20050026902A1 (en) * | 2003-01-31 | 2005-02-03 | Timothy Maziasz | Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents |
| CN101193643A (zh) * | 2005-03-25 | 2008-06-04 | Alt解决方案公司 | 端粒酶阳性细胞中端粒长度的调节和癌症治疗 |
| CN104906105A (zh) * | 2005-05-18 | 2015-09-16 | Alt解决方案公司 | 为预防和治疗癌症对癌细胞中端粒长度的药理学调节 |
| EP2001488A4 (en) * | 2006-03-14 | 2009-11-25 | Alt Solutions Inc | PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES |
-
2007
- 2007-03-14 EP EP07753185A patent/EP2001488A4/en not_active Withdrawn
- 2007-03-14 JP JP2009500483A patent/JP5571947B2/ja not_active Expired - Fee Related
- 2007-03-14 CA CA002644297A patent/CA2644297A1/en not_active Abandoned
- 2007-03-14 WO PCT/US2007/006538 patent/WO2007106561A2/en not_active Ceased
- 2007-03-14 US US12/225,199 patent/US20090203636A1/en not_active Abandoned
-
2014
- 2014-03-12 JP JP2014048595A patent/JP2014144962A/ja active Pending
-
2016
- 2016-04-15 JP JP2016081985A patent/JP2016175917A/ja active Pending
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