JP2014074018A5 - - Google Patents

Info

Publication number

JP2014074018A5

JP2014074018A5 JP2013186829A JP2013186829A JP2014074018A5 JP 2014074018 A5 JP2014074018 A5 JP 2014074018A5 JP 2013186829 A JP2013186829 A JP 2013186829A JP 2013186829 A JP2013186829 A JP 2013186829A JP 2014074018 A5 JP2014074018 A5 JP 2014074018A5

Authority

JP

Japan

Prior art keywords

active ingredient

pharmaceutically acceptable

acceptable salt

tetramethylcyclohexyl

ethanone

Prior art date

2013-09-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• -1 troches Substances 0.000 claims 17
• 239000004480 active ingredient Substances 0.000 claims 16
• 150000003839 salts Chemical class 0.000 claims 15
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 8
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 8
• 201000004384 Alopecia Diseases 0.000 claims 8
• 231100000360 alopecia Toxicity 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 8
• 230000002265 prevention Effects 0.000 claims 8
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000004076 pyridyl group Chemical group 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 3
• NLWIAHYZKRCLBK-NRFANRHFSA-N 1-[(2s)-2-[5-[(3,4-dimethoxyphenoxy)methyl]-1,2-oxazol-3-yl]pyrrolidin-1-yl]-2,2-difluoro-2-(1-hydroxy-3,3,5,5-tetramethylcyclohexyl)ethanone Chemical compound C1=C(OC)C(OC)=CC=C1OCC1=CC([C@H]2N(CCC2)C(=O)C(F)(F)C2(O)CC(C)(C)CC(C)(C)C2)=NO1 NLWIAHYZKRCLBK-NRFANRHFSA-N 0.000 claims 2
• 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
• HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000002775 capsule Substances 0.000 claims 1
• 239000006071 cream Substances 0.000 claims 1
• 239000008298 dragée Substances 0.000 claims 1
• 239000006196 drop Substances 0.000 claims 1
• 239000007941 film coated tablet Substances 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 239000008187 granular material Substances 0.000 claims 1
• 238000010255 intramuscular injection Methods 0.000 claims 1
• 239000007927 intramuscular injection Substances 0.000 claims 1
• 239000007928 intraperitoneal injection Substances 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 239000003094 microcapsule Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 239000008188 pellet Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000006215 rectal suppository Substances 0.000 claims 1
• 229940100618 rectal suppository Drugs 0.000 claims 1
• 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
• 239000007901 soft capsule Substances 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 238000010254 subcutaneous injection Methods 0.000 claims 1
• 239000007929 subcutaneous injection Substances 0.000 claims 1
• 239000007940 sugar coated tablet Substances 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1
• 239000003826 tablet Substances 0.000 claims 1
• 239000006216 vaginal suppository Substances 0.000 claims 1
• 229940120293 vaginal suppository Drugs 0.000 claims 1