JP2017511368A5 - - Google Patents

Info

Publication number

JP2017511368A5

JP2017511368A5 JP2016562898A JP2016562898A JP2017511368A5 JP 2017511368 A5 JP2017511368 A5 JP 2017511368A5 JP 2016562898 A JP2016562898 A JP 2016562898A JP 2016562898 A JP2016562898 A JP 2016562898A JP 2017511368 A5 JP2017511368 A5 JP 2017511368A5

Authority

JP

Japan

Prior art keywords

pharmaceutically acceptable

acceptable salt

grams

stereoisomer

formula

Prior art date

2015-04-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000003839 salts Chemical class 0.000 claims 64
• 150000001875 compounds Chemical class 0.000 claims 32
• WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 claims 31
• WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 31
• 229960003644 aztreonam Drugs 0.000 claims 31
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 10
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
• 150000002148 esters Chemical class 0.000 claims 6
• QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 4
• 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims 2
• -1 5-((S) -pyrrolidin-2-yl)-[1,3,4] -oxadiazol-2-yl Chemical group 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• UKXQKDPNYXVESI-RKDXNWHRSA-N N1CC(C1)CC1=NN=C(O1)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O Chemical compound N1CC(C1)CC1=NN=C(O1)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O UKXQKDPNYXVESI-RKDXNWHRSA-N 0.000 claims 2
• IIGJRSBRPZGZLI-RRKCRQDMSA-N [(2R,5R)-2-[5-[(1S)-1-aminoethyl]-1,3,4-oxadiazol-2-yl]-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound N[C@@H](C)C1=NN=C(O1)[C@@H]1N2C(N([C@H](CC1)C2)OS(O)(=O)=O)=O IIGJRSBRPZGZLI-RRKCRQDMSA-N 0.000 claims 2
• JQDYTHSKUVKCRO-PHDIDXHHSA-N [(2R,5R)-2-cyano-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound C1N2[C@@H](C#N)CC[C@@]1([H])N(OS(O)(=O)=O)C2=O JQDYTHSKUVKCRO-PHDIDXHHSA-N 0.000 claims 2
• DQAAOYQVZVPGLQ-AXFHLTTASA-N [(2s,5r)-7-oxo-2-[[(2s)-piperidin-2-yl]methoxycarbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound O=C([C@H]1N2C[C@@H](CC1)N(C2=O)OS(=O)(=O)O)NOC[C@@H]1CCCCN1 DQAAOYQVZVPGLQ-AXFHLTTASA-N 0.000 claims 2
• ZUNVUNFTDRACHR-AEJSXWLSSA-N [(2s,5r)-7-oxo-2-[[(2s)-pyrrolidin-2-yl]methoxycarbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate Chemical compound O=C([C@H]1N2C[C@@](CC1)(N(C2=O)OS(O)(=O)=O)[H])NOC[C@@H]1CCCN1 ZUNVUNFTDRACHR-AEJSXWLSSA-N 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000003085 diluting agent Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1