JP2014058559A - 局所コエンザイムq10製剤、及び疼痛、疲労、並びに創傷の治療 - Google Patents
局所コエンザイムq10製剤、及び疼痛、疲労、並びに創傷の治療 Download PDFInfo
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Abstract
【解決手段】コエンザイムQ10(CoQ10)、リポソーム、及び薬学的に許容される担体を含む、疼痛、疲労、及び創傷治癒の治療用の局所組成物。
【効果】CoQ10は、線維芽細胞及びケラチン生成細胞の促進効果を有し、ATP産生を増大させ、疼痛を軽減する。製剤は、急性創傷治癒、疲労並びに急性及び慢性疼痛の治療の促進に有用である。
【選択図】図1
Description
本発明は、CoQ10及びリン脂質リポソームを含む組成物を提供する。本発明は、疼痛、疲労、創傷治癒、及び低下したATP産生を治療する方法にも関する。
本発明に従い、かつ、本明細書で使用するように、下記の用語は、明示的に指示がない限り、下記の意味に定義する。
多くの異なる種からの対象を本発明の組成物で治療することができる。そのような動物の限定的な例示リストとしては、マウス、ラット、ウサギ、ヤギ、ヒツジ、ブタ、ウマ、ウシ、イヌ、ネコなどの哺乳類、サル、類人猿、及びヒトなどの霊長類が挙げられる。筋肉疲労、疼痛、創傷を患うことが知られているこれらの動物対象を本発明で使用するのが好ましい。特に、損傷、手術、関節炎、筋肉疲労などを患っているヒト患者は、本発明に使用する適切な動物対象である。本明細書に教示されている方法を医薬又は獣医学で知られているその他の方法に適用することで(例:対象動物の重量に従って投与物質の用量を調整すること)、本発明で利用する組成物をその他の動物への使用に容易に最適化することができる。
好適な実施形態では、本発明は、創傷、疼痛、疲労などの治療用のCoQ10組成物を提供する。2,3−ジメトキシ−5−メチル−6−デカプレニル−l,4−ベンゾキノン(コエンザイムQ‐10)の経皮、経口、及び静脈内投与製剤は、特に、助剤、有効量の肺表面活性剤、及び/又は、リポソームとの組み合わせを含む。
上述の組成物は、有効量で対象に投与するのが好ましい。有効量とは、処理動物又は細胞に望ましい結果を得ることができる量のことである。当該医学及び獣医学分野で周知のように、任意の動物に対する投与量は、特定の動物の大きさ、体表面積、年齢、投与する特定の組成物、投与回数及び経路、健康状態、及び同時に投与するその他の薬剤を含む多くの要因に依存している。本発明の組成物の局所投与に適切な投与量は、体重1kg当たり約0.1〜2.50mgの範囲のCoQ10(例、110〜300lbsの範囲の対象に対して10〜500mg)であると考えられる。培養中の細胞に使用する有効量は変わるが、経験的(例えば、細胞に異なる濃度を加え、最良の所望の結果を生む濃度を選択することにより)に容易に決めることができる。適切な濃度は約1〜250μMの範囲であると考えられる。
好適な実施形態では、有効成分として、すなわち、コエンザイムQ10を含む本発明の組成物は、筋肉及び骨格筋疲労を治癒し、創傷治癒を促進させ、創傷治癒、関節痛、全身疲労などの疼痛を改善する。理論と結びつけようとしなくとも、組成物は細胞内でATPを増やすと考えられる。
好適な実施形態では、本発明は、創傷、疼痛、疲労などの治療用のCoQ10組成物を含むキットを提供する。2,3−ジメトキシ−5−メチル−6−デカプレニル−1,4−ベンゾキノン(コエンザイムQ−10)の経皮、経口、及び静脈内投与製剤は、特に、助剤、有効量の肺表面活性剤を含み、及び/又は、リポソームと組み合わせる。
(実施例1)
有効成分Q10の平滑筋細胞増殖及びATP産生への影響を試験するためのin vitro研究
深部中間層の創傷治癒における組成物の効果の調査
本研究の目的は、ブタモデルの深部中間層の創傷治癒におけるCoQ10組成物の効果を調査することであった。
コエンザイムQ10は線維芽細胞及びケラチン生成細胞の増殖及び移動を亢進する:創傷治癒に対する影響
CoQ10組成物−臨床試験
詳細な説明と併せて本発明を説明してきたが、前述の説明は、本発明の範囲を限定することなく説明するものであることを理解されたい。その他の態様、利点、及び修正も以下の請求項の範囲内である。
Claims (23)
- CoQ10、リポソーム、及び薬学的に許容される担体を含む、疼痛、疲労、及び創傷治癒の治療用の局所組成物。
- 前記組成物が、約0.001%〜約60%(w/w)の間のコエンザイムQ10を含む請求項1に記載の局所組成物。
- 前記組成物が、ゲル剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、軟膏剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、クリーム剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、塗擦剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、ローション剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、噴霧剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、エアロゾル剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、ムース剤の形態である請求項1に記載の局所組成物。
- 前記組成物が、泡剤の形態である請求項1に記載の局所組成物。
- 必要とする患者の疼痛領域に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を局所投与することを含む、癌に伴う疼痛を治療する方法。
- 必要とする患者の疼痛領域に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を局所投与することを含む、筋肉痛に伴う疼痛を治療する方法。
- 必要とする患者の疼痛領域に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を局所投与することを含む、関節痛に伴う疼痛を治療する方法。
- 必要とする患者の疼痛領域に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を局所投与することを含む、疼痛を治療する方法。
- 必要とする患者の筋肉に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を局所投与することを含む、筋肉疲労を治療する方法。
- 必要とする患者の細胞又は組織に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を投与することを含む、細胞又は組織におけるATP産生を増加させる方法。
- 必要とする患者の創傷に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を投与することを含む、創傷治癒を促進させる方法。
- 必要とする患者の創傷に、治療に有効な量の請求項1に記載の組成物を含む局所組成物を投与することを含む、火傷を治療する方法。
- CoQ10、リポソーム、及び薬学的に許容される担体を含む、疼痛、疲労、及び創傷治癒の治療用の組成物。
- 前記組成物が約0.001%〜約60%(w/w)の間のコエンザイムQ10を含む請求項20に記載の組成物。
- 前記組成物がサイトカイン、成長因子、分化因子、ホルモン、鎮痛剤、及び疼痛止めをさらに含む請求項20に記載の組成物。
- 前記サイトカインが成長因子、遊走因子、モノカイン、リンホカインである請求項22に記載の組成物。
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JP2004531468A (ja) * | 2000-11-29 | 2004-10-14 | マグラル・リミテッド | スタチン副作用の処置 |
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Also Published As
Publication number | Publication date |
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MX352315B (es) | 2017-11-17 |
EP3173068B1 (en) | 2020-09-09 |
MX2008013855A (es) | 2009-01-29 |
WO2007131047A2 (en) | 2007-11-15 |
CA2894933C (en) | 2017-10-03 |
US10583098B2 (en) | 2020-03-10 |
EP3173068A1 (en) | 2017-05-31 |
JP5968865B2 (ja) | 2016-08-10 |
CA2650825C (en) | 2015-07-14 |
CA2977089A1 (en) | 2007-11-15 |
US20210000761A1 (en) | 2021-01-07 |
ES2836184T3 (es) | 2021-06-24 |
EP2073819A2 (en) | 2009-07-01 |
EP2073819A4 (en) | 2013-02-20 |
EP2073819B1 (en) | 2016-12-28 |
CA2650825A1 (en) | 2007-11-15 |
JP2009536215A (ja) | 2009-10-08 |
ES2620389T3 (es) | 2017-06-28 |
CA2894933A1 (en) | 2007-11-15 |
US20100062048A1 (en) | 2010-03-11 |
WO2007131047A3 (en) | 2008-07-24 |
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