JP2014042533A5 - - Google Patents
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- Publication number
- JP2014042533A5 JP2014042533A5 JP2013250586A JP2013250586A JP2014042533A5 JP 2014042533 A5 JP2014042533 A5 JP 2014042533A5 JP 2013250586 A JP2013250586 A JP 2013250586A JP 2013250586 A JP2013250586 A JP 2013250586A JP 2014042533 A5 JP2014042533 A5 JP 2014042533A5
- Authority
- JP
- Japan
- Prior art keywords
- pseudomonas aeruginosa
- host cell
- recombinant
- protein
- coli
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 14
- 241000588724 Escherichia coli Species 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 3
- 101710116435 Outer membrane protein Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000589875 Campylobacter jejuni Species 0.000 claims 2
- 241000205834 Escherichia coli O16 Species 0.000 claims 2
- 108010079246 OMPA outer membrane proteins Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 241000205838 Escherichia coli O9 Species 0.000 claims 1
- 235000019687 Lamb Nutrition 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 108700028353 OmpC Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 238000005457 optimization Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05010276 | 2005-05-11 | ||
| EP05010276.3 | 2005-05-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012001342A Division JP5687637B2 (ja) | 2005-05-11 | 2012-01-06 | 原核細胞由来の組み換えｎ−グリコシル化タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014042533A JP2014042533A (ja) | 2014-03-13 |
| JP2014042533A5 true JP2014042533A5 (https=) | 2014-05-08 |
| JP5827303B2 JP5827303B2 (ja) | 2015-12-02 |
Family
ID=37396912
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510495A Active JP5356807B2 (ja) | 2005-05-11 | 2006-05-10 | 原核細胞由来の組み換えｎ−グリコシル化タンパク質 |
| JP2012001342A Active JP5687637B2 (ja) | 2005-05-11 | 2012-01-06 | 原核細胞由来の組み換えｎ−グリコシル化タンパク質 |
| JP2013250586A Active JP5827303B2 (ja) | 2005-05-11 | 2013-12-03 | 原核細胞由来の組み換えｎ−グリコシル化タンパク質 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510495A Active JP5356807B2 (ja) | 2005-05-11 | 2006-05-10 | 原核細胞由来の組み換えｎ−グリコシル化タンパク質 |
| JP2012001342A Active JP5687637B2 (ja) | 2005-05-11 | 2012-01-06 | 原核細胞由来の組み換えｎ−グリコシル化タンパク質 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8753864B2 (https=) |
| EP (3) | EP2311972B1 (https=) |
| JP (3) | JP5356807B2 (https=) |
| KR (2) | KR101408653B1 (https=) |
| CN (2) | CN101360831B (https=) |
| AT (1) | ATE483027T1 (https=) |
| AU (1) | AU2006245969B8 (https=) |
| CA (1) | CA2607595C (https=) |
| CY (1) | CY1116285T1 (https=) |
| DE (1) | DE602006017207D1 (https=) |
| DK (2) | DK2311972T3 (https=) |
| ES (3) | ES2353814T3 (https=) |
| HK (1) | HK1205193A1 (https=) |
| HR (1) | HRP20150312T1 (https=) |
| IL (2) | IL187293A (https=) |
| PL (1) | PL2311972T3 (https=) |
| PT (2) | PT1888761E (https=) |
| SI (1) | SI2311972T1 (https=) |
| WO (1) | WO2006119987A2 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| IL163806A0 (en) | 2002-03-07 | 2005-12-18 | Eidgenoess Tech Hochschule | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| NZ548123A (en) | 2004-01-08 | 2010-05-28 | Novo Nordisk As | O-linked glycosylation of peptides |
| JP2007527431A (ja) | 2004-03-03 | 2007-09-27 | ルバンス セラピュティックス | 局所的診断及び治療用の輸送のための組成物及び方法 |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| ZA200707352B (en) | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP2049144B8 (en) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylation of peptides via o-linked glycosylation sequences |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
| HRP20130382T1 (hr) | 2007-04-03 | 2013-05-31 | Biogenerix Ag | Postupci lijeäśenja pomoä†u glikopegiliranog g-csf |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| CN107119095B (zh) | 2008-01-03 | 2022-07-05 | 康乃尔研究基金会有限公司 | 原核生物中的糖基化蛋白表达 |
| CA2711503A1 (en) * | 2008-01-08 | 2009-07-16 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
| CN101983070B (zh) * | 2008-02-20 | 2016-03-30 | 格林考瓦因有限公司 | 由来源于原核细胞的重组n-糖基化蛋白制备生物共轭物 |
| PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| PL2411503T3 (pl) * | 2009-03-27 | 2018-01-31 | Eidgenoessische Technische Hochschule Zuerich | Salmonella enterica prezentująca n-glikan z c. jejuni lub jego pochodne |
| NO2501406T3 (https=) * | 2009-11-19 | 2018-05-19 | ||
| PT2545081E (pt) | 2010-02-11 | 2015-05-18 | Univ Alberta | Compostos de glicano ligados por n |
| EP3281639B1 (en) * | 2010-05-06 | 2020-11-11 | GlaxoSmithKline Biologicals S.A. | Capsular gram-positive bacteria bioconjugate vaccines |
| US20130266604A1 (en) * | 2010-09-03 | 2013-10-10 | The Governors of the University of Alberta a non-profit educational institution | Peptide containing multiple n-linked glycosylation sequons |
| US20140336366A1 (en) * | 2011-09-06 | 2014-11-13 | Glycovaxyn Ag | Bioconjugate vaccines made in prokaryotic cells |
| EP3508579B1 (en) | 2012-11-07 | 2021-06-30 | GlaxoSmithKline Biologicals SA | Production of recombinant vaccine in e. coli by enzymatic conjugation |
| PL2945651T3 (pl) | 2013-01-17 | 2018-08-31 | Arsanis Biosciences Gmbh | Przeciwciało swoiste wobec E.coli MDR |
| CA2923957C (en) | 2013-01-18 | 2021-08-31 | London School Of Hygiene And Tropical Medicine | Glycosylation method |
| GB201301085D0 (en) | 2013-01-22 | 2013-03-06 | London School Hygiene & Tropical Medicine | Glycoconjugate Vaccine |
| CN105228984B (zh) * | 2013-03-15 | 2018-03-23 | 爱西里斯药物技术有限公司 | 硝羟喹啉碱加成盐及其用途 |
| RU2671473C2 (ru) | 2013-04-05 | 2018-10-31 | Де Гавенерс Оф Де Юниверсити Оф Альберта | Вакцина против кампилобактериоза |
| MX371513B (es) * | 2013-10-11 | 2020-01-31 | Glaxosmithkline Biologicals Sa | Metodos de modificacion de celulas huespedes. |
| WO2015124769A1 (en) | 2014-02-24 | 2015-08-27 | Glycovaxyn Ag | Novel polysaccharide and uses thereof |
| CA2945542C (en) * | 2014-04-17 | 2024-03-05 | Glycovaxyn Ag | Modified host cells and uses thereof |
| WO2016020499A2 (en) | 2014-08-08 | 2016-02-11 | Glycovaxyn Ag | Modified host cells for use in bioconjugate production |
| CN107614679B (zh) * | 2014-12-30 | 2026-04-07 | 葛兰素史密丝克莱恩生物有限公司 | 用于蛋白糖基化的组合物和方法 |
| TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| GB201518668D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
| WO2017117539A1 (en) | 2015-12-30 | 2017-07-06 | Northwestern University | Cell-free glycoprotein synthesis (cfgps) in prokaryotic cell lysates enriched with components for glycosylation |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| US10829795B2 (en) | 2016-07-14 | 2020-11-10 | Northwestern University | Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates |
| AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| BR112019015425A2 (pt) * | 2017-01-27 | 2020-05-26 | University Of Florida Research Foundation, Incorporated | Uma vacina de segurança alimentar para controlar salmonella enterica e reduzir campylobacter em aves domésticas |
| GB201711635D0 (en) | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
| WO2019035916A1 (en) | 2017-08-15 | 2019-02-21 | Northwestern University | DESIGN OF PROTEIN GLYCOSYLATION SITES BY RAPID EXPRESSION AND CHARACTERIZATION OF N-GLYCOSYLTRANSFERASES |
| GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
| GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
| WO2019175147A1 (en) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccines against intra-abdominal infections |
| US11530432B2 (en) | 2018-03-19 | 2022-12-20 | Northwestern University | Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates |
| WO2019204346A1 (en) | 2018-04-16 | 2019-10-24 | Northwestern University | METHODS FOR CO-ACTIVATING IN VITRO NON-STANDARD AMINO ACID (nsAA) INCORPORATION AND GLYCOSYLATION IN CRUDE CELLLYSATES |
| US12098433B2 (en) | 2018-08-03 | 2024-09-24 | Northwestern University | On demand, portable, cell-free molecular sensing platform |
| CN113227125A (zh) | 2018-12-12 | 2021-08-06 | 葛兰素史密丝克莱恩生物有限公司 | 用于o-连接的糖基化的修饰的载体蛋白 |
| CN113646438A (zh) | 2019-01-11 | 2021-11-12 | 西北大学 | 在原核生物细胞裂解物中合成生物缀合物疫苗 |
| US12325884B2 (en) | 2019-03-04 | 2025-06-10 | Northwestern University | Riboswitch-based fluoride sensing in cell-free extract |
| CA3134216A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
| IL286467B2 (en) | 2019-03-18 | 2026-02-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of polysaccharides E. coli o-antigen, preparations thereof and methods for using them |
| EP3757217A1 (en) | 2019-06-27 | 2020-12-30 | GlaxoSmithKline Biologicals S.A. | Methods for protein purification |
| EP3770269A1 (en) | 2019-07-23 | 2021-01-27 | GlaxoSmithKline Biologicals S.A. | Quantification of bioconjugate glycosylation |
| EP3777884A1 (en) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| US12226410B2 (en) | 2019-10-18 | 2025-02-18 | Northwestern University | Methods for enhancing cellular clearance of pathological molecules via activation of the cellular protein ykt6 |
| CN115135771A (zh) | 2019-10-25 | 2022-09-30 | 西北大学 | 用于富集膜泡和增加糖蛋白产量的无细胞提取物制备方案 |
| EP4461744A3 (en) | 2020-01-16 | 2025-01-08 | Janssen Pharmaceuticals, Inc. | Fimh mutant, compositions therewith and use thereof |
| WO2021255684A1 (en) | 2020-06-18 | 2021-12-23 | Glaxosmithkline Biologicals Sa | Shigella-tetravalent (shigella4v) bioconjugate |
| WO2021259743A2 (en) | 2020-06-25 | 2021-12-30 | Glaxosmithkline Biologicals Sa | Vaccine |
| AU2021342797B2 (en) | 2020-09-17 | 2024-02-08 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
| KR20250007029A (ko) | 2021-01-12 | 2025-01-13 | 얀센 파마슈티칼즈, 인코포레이티드 | FimH 돌연변이체, 이를 포함하는 조성물 및 이의 용도 |
| IL307247A (en) | 2021-04-01 | 2023-11-01 | Janssen Pharmaceuticals Inc | Production of E. Coli O18 bioconjugates |
| WO2023118033A1 (en) | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccine |
| GB202302579D0 (en) | 2023-02-23 | 2023-04-12 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| CN121646639A (zh) * | 2023-08-09 | 2026-03-10 | 葛兰素史克生物有限公司 | 经修饰的蛋白质 |
| WO2025032534A2 (en) | 2023-08-09 | 2025-02-13 | Glaxosmithkline Biologicals Sa | Modified proteins |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE67786T1 (de) | 1984-08-01 | 1991-10-15 | Boehringer Ingelheim Int | Neue genetische sequenzen, die durch sie codierten interferon-peptide vom typ i und diese sie produzierende organismen. |
| US5643758A (en) | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| JPH09501044A (ja) | 1993-05-14 | 1997-02-04 | ジ・アップジョン・カンパニー | ＵＤＰ−ＧＡＬＮＡｃ：ポリペプチド、Ｎ−アセチルガラクトサミニルトランスフェラーゼをコードするクローン化されたＤＮＡ |
| US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
| EP1399538A4 (en) | 1999-03-02 | 2004-03-24 | Human Genome Sciences Inc | TECHOLOGICAL MANIPULATION OF INTRACELLULAR SIALIZATION PATHS |
| US20020127219A1 (en) * | 1999-12-30 | 2002-09-12 | Okkels Jens Sigurd | Lysosomal enzymes and lysosomal enzyme activators |
| JP2004528001A (ja) | 2000-05-12 | 2004-09-16 | ネオーズ テクノロジーズ， インコーポレイテッド | インビトロにおけるフコシル化組換えグリコペプチド |
| EP1294910B1 (en) | 2000-06-30 | 2008-11-19 | VIB vzw | Protein glycosylation modification in pichia pastoris |
| DE10113573A1 (de) * | 2001-03-20 | 2002-02-28 | Messer Griesheim Gmbh | Verfahren zum Regenerieren von Schwefelsäure aus schwefelhaltigen Reststoffen |
| KR101495616B1 (ko) | 2002-03-07 | 2015-02-26 | 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 | 원핵 숙주에서의 재조합 글리코실화 단백질 생산 방법 및 생산계 |
| IL163806A0 (en) | 2002-03-07 | 2005-12-18 | Eidgenoess Tech Hochschule | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
| WO2004013151A2 (en) | 2002-08-01 | 2004-02-12 | National Research Council Of Canada | Campylobacter glycans and glycopeptides |
-
2006
- 2006-05-10 ES ES06753552T patent/ES2353814T3/es active Active
- 2006-05-10 ES ES10179208.3T patent/ES2535084T3/es active Active
- 2006-05-10 CN CN200680020861XA patent/CN101360831B/zh active Active
- 2006-05-10 PT PT06753552T patent/PT1888761E/pt unknown
- 2006-05-10 ES ES14199949T patent/ES2703061T3/es active Active
- 2006-05-10 AU AU2006245969A patent/AU2006245969B8/en active Active
- 2006-05-10 WO PCT/EP2006/004397 patent/WO2006119987A2/en not_active Ceased
- 2006-05-10 CA CA2607595A patent/CA2607595C/en active Active
- 2006-05-10 DK DK10179208T patent/DK2311972T3/en active
- 2006-05-10 KR KR1020077028970A patent/KR101408653B1/ko active Active
- 2006-05-10 EP EP10179208.3A patent/EP2311972B1/en active Active
- 2006-05-10 SI SI200631910T patent/SI2311972T1/sl unknown
- 2006-05-10 CN CN201310241471.7A patent/CN103396478B/zh active Active
- 2006-05-10 PL PL10179208T patent/PL2311972T3/pl unknown
- 2006-05-10 PT PT101792083T patent/PT2311972E/pt unknown
- 2006-05-10 KR KR1020147001671A patent/KR101524636B1/ko active Active
- 2006-05-10 US US11/920,175 patent/US8753864B2/en active Active
- 2006-05-10 DE DE602006017207T patent/DE602006017207D1/de active Active
- 2006-05-10 JP JP2008510495A patent/JP5356807B2/ja active Active
- 2006-05-10 EP EP06753552A patent/EP1888761B1/en active Active
- 2006-05-10 EP EP14199949.0A patent/EP2853600B1/en active Active
- 2006-05-10 DK DK06753552.6T patent/DK1888761T3/da active
- 2006-05-10 AT AT06753552T patent/ATE483027T1/de active
-
2007
- 2007-11-11 IL IL187293A patent/IL187293A/en active IP Right Grant
-
2012
- 2012-01-06 JP JP2012001342A patent/JP5687637B2/ja active Active
-
2013
- 2013-06-10 IL IL226857A patent/IL226857A/en not_active IP Right Cessation
- 2013-12-03 JP JP2013250586A patent/JP5827303B2/ja active Active
-
2014
- 2014-02-06 US US14/174,742 patent/US9551019B2/en active Active
-
2015
- 2015-03-18 HR HRP20150312TT patent/HRP20150312T1/hr unknown
- 2015-04-15 CY CY20151100351T patent/CY1116285T1/el unknown
- 2015-06-09 HK HK15105466.7A patent/HK1205193A1/en unknown
-
2016
- 2016-05-19 US US15/159,535 patent/US20160326563A1/en not_active Abandoned
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