JP2014015483A5 - - Google Patents
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- Publication number
- JP2014015483A5 JP2014015483A5 JP2013219880A JP2013219880A JP2014015483A5 JP 2014015483 A5 JP2014015483 A5 JP 2014015483A5 JP 2013219880 A JP2013219880 A JP 2013219880A JP 2013219880 A JP2013219880 A JP 2013219880A JP 2014015483 A5 JP2014015483 A5 JP 2014015483A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- compound according
- complex
- triethylenediamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical group C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 claims 8
- RXYPXQSKLGGKOL-UHFFFAOYSA-N 1,4-dimethylpiperazine Chemical compound CN1CCN(C)CC1 RXYPXQSKLGGKOL-UHFFFAOYSA-N 0.000 claims 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- SCZNXLWKYFICFV-UHFFFAOYSA-N 1,2,3,4,5,7,8,9-octahydropyrido[1,2-b]diazepine Chemical compound C1CCCNN2CCCC=C21 SCZNXLWKYFICFV-UHFFFAOYSA-N 0.000 claims 2
- HVCNXQOWACZAFN-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound CCN1CCOCC1 HVCNXQOWACZAFN-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229910014033 C-OH Inorganic materials 0.000 claims 1
- 229930008564 C01BA04 - Sparteine Natural products 0.000 claims 1
- 229910014570 C—OH Inorganic materials 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- SLRCCWJSBJZJBV-UHFFFAOYSA-N alpha-isosparteine Natural products C1N2CCCCC2C2CN3CCCCC3C1C2 SLRCCWJSBJZJBV-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- WRJWRGBVPUUDLA-UHFFFAOYSA-N chlorosulfonyl isocyanate Chemical compound ClS(=O)(=O)N=C=O WRJWRGBVPUUDLA-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical group C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 claims 1
- 229960001945 sparteine Drugs 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96300807P | 2007-08-02 | 2007-08-02 | |
| US60/963,008 | 2007-08-02 | ||
| US6237808P | 2008-01-25 | 2008-01-25 | |
| US61/062,378 | 2008-01-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519947A Division JP5479336B2 (ja) | 2007-08-02 | 2008-08-01 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014215250A Division JP2015025009A (ja) | 2007-08-02 | 2014-10-22 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014015483A JP2014015483A (ja) | 2014-01-30 |
| JP2014015483A5 true JP2014015483A5 (cg-RX-API-DMAC7.html) | 2014-12-04 |
| JP6148594B2 JP6148594B2 (ja) | 2017-06-14 |
Family
ID=40225413
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519947A Expired - Fee Related JP5479336B2 (ja) | 2007-08-02 | 2008-08-01 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
| JP2013219880A Expired - Fee Related JP6148594B2 (ja) | 2007-08-02 | 2013-10-23 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
| JP2014215250A Pending JP2015025009A (ja) | 2007-08-02 | 2014-10-22 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519947A Expired - Fee Related JP5479336B2 (ja) | 2007-08-02 | 2008-08-01 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014215250A Pending JP2015025009A (ja) | 2007-08-02 | 2014-10-22 | Ｅ１活性化酵素阻害剤の合成のためのプロセス |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8933225B2 (cg-RX-API-DMAC7.html) |
| EP (4) | EP2540726B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5479336B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101925902B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN106243111B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008305767B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2949336C (cg-RX-API-DMAC7.html) |
| ES (4) | ES2655028T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL203590A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010001126A (cg-RX-API-DMAC7.html) |
| RU (2) | RU2553476C2 (cg-RX-API-DMAC7.html) |
| TW (2) | TWI426077B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009042013A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201000482B (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2949336C (en) | 2007-08-02 | 2018-11-06 | Lei Zhu | Process for the synthesis of e1 activating enzyme inhibitors |
| UA108986C2 (uk) | 2009-05-14 | 2015-07-10 | Мілленніум Фармасьютікалз, Інк. | Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти) |
| US20120115892A1 (en) * | 2010-11-05 | 2012-05-10 | Millennium Pharmaceuticals, Inc. | Administration of nedd8-activating enzyme inhibitor |
| MX352963B (es) | 2012-02-17 | 2017-12-15 | Millennium Pharm Inc | Inhibidores de pirazolopirimidinilo en enzima activadora de ubiquitina. |
| CN104072381B (zh) * | 2013-03-26 | 2017-04-12 | 安徽贝克联合制药有限公司 | 光学纯氨基醇盐酸盐的制备方法 |
| WO2014186388A2 (en) | 2013-05-14 | 2014-11-20 | Millennium Pharmaceutcals, Inc. | Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents |
| CN106999479B (zh) | 2014-07-01 | 2021-07-16 | 米伦纽姆医药公司 | 可用作sumo活化酶抑制剂的杂芳基化合物 |
| US10335411B2 (en) | 2014-10-29 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and radiation |
| CN104974051A (zh) * | 2015-06-30 | 2015-10-14 | 苏州开元民生科技股份有限公司 | (1S,4R)-cis-4-氨基-2-环戊烯-1-甲醇盐酸盐的合成方法 |
| CN106854208B (zh) * | 2016-11-25 | 2019-04-09 | 成都柏睿泰生物科技有限公司 | 肿瘤抑制剂mln4924的合成方法 |
| EP3684363A4 (en) | 2017-09-21 | 2021-05-12 | Millennium Pharmaceuticals, Inc. | CO-CRYSTALLINE FORMS OF ((1S, 2S, 4R) -4- {4 - [(1S) -2,3-DIHYDRO-1H-INDÉN-1-YLAMINO] -7H-PYRROLO [2,3-D] PYRIMIDIN -7-YL} -2-HYDROXYCYCLOPENTYL) METHYLSULFAMATE, THEIR FORMULATIONS AND USES |
| KR102018341B1 (ko) * | 2018-06-21 | 2019-09-04 | 성균관대학교산학협력단 | RNF170 및 pUL50을 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 |
| EP3947388A4 (en) | 2019-04-02 | 2022-12-21 | Aligos Therapeutics, Inc. | PRMT5 TARGETING COMPOUNDS |
| DE112021002937T5 (de) * | 2020-05-26 | 2023-03-30 | Sony Semiconductor Solutions Corporation | Entfernungsmessvorrichtung |
| WO2022112951A1 (en) | 2020-11-25 | 2022-06-02 | Takeda Pharmaceutical Company Limited | Solid state forms of hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
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| US4138433A (en) * | 1975-06-26 | 1979-02-06 | Hoechst Aktiengesellschaft | Process for preparing 1,2-oxa-phospholanes |
| US4081455A (en) * | 1976-06-02 | 1978-03-28 | Pfizer Inc. | 6-Amino-2,2-dimethyl-3-cyanopenams |
| US4803272A (en) * | 1987-02-24 | 1989-02-07 | E. I. Du Pont De Nemours And Company | S-modified adenosyl-1,8-diamino-3-thiooctane derivatives |
| US4927830A (en) | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
| GB9204015D0 (en) * | 1992-02-25 | 1992-04-08 | Wellcome Found | Therapeutic nucleosides |
| GB9205071D0 (en) | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| AU3692895A (en) | 1994-09-09 | 1996-03-27 | Regents Of The University Of Michigan, The | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
| US5912356A (en) | 1995-09-11 | 1999-06-15 | Glaxo Wellcome Inc. | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
| CN1282316A (zh) | 1997-12-17 | 2001-01-31 | 生物晶体药品股份有限公司 | 用作神经氨酸酶抑制剂的取代环戊烷和环戊烯化合物 |
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| JP2000290201A (ja) * | 1998-07-06 | 2000-10-17 | Toray Ind Inc | 光学異性体の分割方法 |
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| JP2003516408A (ja) | 1999-12-10 | 2003-05-13 | グラクソ グループ リミテッド | 抗ウィルス薬としての（１Ｒ，シス）−４−［４−アミノ−７Ｈ−ピロロ（２，３−ｄ）ピリミジン−７−イル］−２−シクロペンテン−１−メタノール類縁物 |
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| SI1848718T1 (sl) * | 2005-02-04 | 2012-12-31 | Millennium Pharmaceuticals, Inc. | Inhibitorji E1 aktivacijskih enzimov |
| ES2593433T3 (es) * | 2006-02-02 | 2016-12-09 | Millennium Pharmaceuticals, Inc. | Inhibidores de las enzimas activadoras E1 |
| DE602007009998D1 (de) * | 2006-08-08 | 2010-12-02 | Millennium Pharm Inc | Heteroarylverbindungen als hemmer der e1-aktivierenden enzyme |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| CA2949336C (en) | 2007-08-02 | 2018-11-06 | Lei Zhu | Process for the synthesis of e1 activating enzyme inhibitors |
| UA108986C2 (uk) | 2009-05-14 | 2015-07-10 | Мілленніум Фармасьютікалз, Інк. | Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти) |
-
2008
- 2008-08-01 CA CA2949336A patent/CA2949336C/en not_active Expired - Fee Related
- 2008-08-01 TW TW097129447A patent/TWI426077B/zh not_active IP Right Cessation
- 2008-08-01 EP EP12172364.7A patent/EP2540726B1/en active Active
- 2008-08-01 RU RU2010107471/04A patent/RU2553476C2/ru active
- 2008-08-01 EP EP12172365.4A patent/EP2540727B1/en active Active
- 2008-08-01 US US12/221,399 patent/US8933225B2/en not_active Expired - Fee Related
- 2008-08-01 EP EP12172363.9A patent/EP2546256B1/en active Active
- 2008-08-01 KR KR1020157014228A patent/KR101925902B1/ko not_active Expired - Fee Related
- 2008-08-01 AU AU2008305767A patent/AU2008305767B2/en not_active Ceased
- 2008-08-01 ES ES08832973.5T patent/ES2655028T3/es active Active
- 2008-08-01 MX MX2010001126A patent/MX2010001126A/es active IP Right Grant
- 2008-08-01 TW TW102143875A patent/TW201434851A/zh unknown
- 2008-08-01 CA CA2695193A patent/CA2695193C/en not_active Expired - Fee Related
- 2008-08-01 ES ES12172363T patent/ES2757928T3/es active Active
- 2008-08-01 KR KR1020107004735A patent/KR20100066475A/ko not_active Ceased
- 2008-08-01 WO PCT/US2008/009338 patent/WO2009042013A1/en not_active Ceased
- 2008-08-01 ES ES12172365.4T patent/ES2684309T3/es active Active
- 2008-08-01 CN CN201610622354.9A patent/CN106243111B/zh not_active Expired - Fee Related
- 2008-08-01 CN CN201310356726.4A patent/CN103483342B/zh not_active Expired - Fee Related
- 2008-08-01 RU RU2015108944/04A patent/RU2015108944A/ru not_active Application Discontinuation
- 2008-08-01 ES ES12172364T patent/ES2758027T3/es active Active
- 2008-08-01 EP EP08832973.5A patent/EP2178880B1/en active Active
- 2008-08-01 CN CN2008801015257A patent/CN101868461B/zh not_active Expired - Fee Related
- 2008-08-01 JP JP2010519947A patent/JP5479336B2/ja not_active Expired - Fee Related
-
2010
- 2010-01-21 ZA ZA2010/00482A patent/ZA201000482B/en unknown
- 2010-01-28 IL IL203590A patent/IL203590A/en active IP Right Grant
-
2013
- 2013-10-23 JP JP2013219880A patent/JP6148594B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-22 JP JP2014215250A patent/JP2015025009A/ja active Pending
- 2014-11-25 US US14/552,883 patent/US9802938B2/en not_active Expired - Fee Related
-
2017
- 2017-03-23 IL IL251372A patent/IL251372B/en active IP Right Grant
- 2017-09-22 US US15/713,293 patent/US10745404B2/en not_active Expired - Fee Related
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