JP2014012688A5 - - Google Patents
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- JP2014012688A5 JP2014012688A5 JP2013168325A JP2013168325A JP2014012688A5 JP 2014012688 A5 JP2014012688 A5 JP 2014012688A5 JP 2013168325 A JP2013168325 A JP 2013168325A JP 2013168325 A JP2013168325 A JP 2013168325A JP 2014012688 A5 JP2014012688 A5 JP 2014012688A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- sequence
- recombinantly expressed
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66017705P | 2005-03-10 | 2005-03-10 | |
| US60/660,177 | 2005-03-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011290449A Division JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014012688A JP2014012688A (ja) | 2014-01-23 |
| JP2014012688A5 true JP2014012688A5 (enExample) | 2014-06-19 |
| JP5788443B2 JP5788443B2 (ja) | 2015-09-30 |
Family
ID=36992268
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500966A Expired - Lifetime JP4949373B2 (ja) | 2005-03-10 | 2006-03-09 | 抗メソテリン抗体 |
| JP2011290449A Expired - Lifetime JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
| JP2013168325A Expired - Lifetime JP5788443B2 (ja) | 2005-03-10 | 2013-08-13 | 抗メソテリン抗体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008500966A Expired - Lifetime JP4949373B2 (ja) | 2005-03-10 | 2006-03-09 | 抗メソテリン抗体 |
| JP2011290449A Expired - Lifetime JP5378497B2 (ja) | 2005-03-10 | 2011-12-29 | 抗メソテリン抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7592426B2 (enExample) |
| EP (2) | EP1861425B1 (enExample) |
| JP (3) | JP4949373B2 (enExample) |
| AU (2) | AU2006223301B2 (enExample) |
| CA (1) | CA2600505C (enExample) |
| ES (2) | ES2386367T3 (enExample) |
| WO (1) | WO2006099141A2 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007500508A (ja) * | 2003-07-29 | 2007-01-18 | モルフォテック、インク． | 抗体とエフェクター機能が増強された遺伝子組み換え抗体を作成する方法 |
| AU2005214331B2 (en) | 2004-02-12 | 2011-09-15 | Eisai, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| EP1861425B1 (en) | 2005-03-10 | 2012-05-16 | Morphotek, Inc. | Anti-mesothelin antibodies |
| AU2006241099B2 (en) * | 2005-04-22 | 2012-04-19 | Eisai, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| KR100694508B1 (ko) * | 2005-05-24 | 2007-03-13 | 울산대학교 산학협력단 | Ｈｂｂｋ４항체를 포함하는 암 질환 치료용 약학조성물및 이를 이용한 암의 면역치료 방법 |
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| US7795411B2 (en) | 2006-10-05 | 2010-09-14 | Fred Hutchinson Cancer Research Center | Vectors for expressing in vivo biotinylated recombinant proteins |
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| AU2010230063B2 (en) * | 2009-03-24 | 2015-06-25 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Anti-mesothelin antibodies |
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| US10233240B1 (en) * | 2011-04-18 | 2019-03-19 | The Regents Of The University Of California | Methods for treating cholestatic liver fibrosis |
| BR112013028537A2 (pt) | 2011-05-06 | 2017-01-17 | Us Gov Health & Human Serv | imunotoxina recombinante que visa a mesotelina |
| KR102084806B1 (ko) | 2012-02-17 | 2020-03-04 | 시애틀 지네틱스, 인크. | 인테그린 αvβ6에 대한 항체 및 암을 치료하기 위한 그의 용도 |
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| US9359447B2 (en) | 2012-03-23 | 2016-06-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| WO2014004549A2 (en) | 2012-06-27 | 2014-01-03 | Amgen Inc. | Anti-mesothelin binding proteins |
| EP2888282B1 (en) * | 2012-08-21 | 2018-03-14 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Mesothelin domain-specific monoclonal antibodies and use thereof |
| RS61010B1 (sr) | 2014-11-20 | 2020-11-30 | Hoffmann La Roche | Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije protiv folr1 i cd3 |
| BR112017010513A2 (pt) | 2014-11-20 | 2018-04-03 | F. Hoffmann-La Roche Ag | ?cadeias leves comuns e métodos de uso? |
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| US10793641B2 (en) * | 2015-08-21 | 2020-10-06 | Carsgen Therapeutics Co., Ltd. | Fully human anti-mesothelin antibodies and immune effector cells targeting mesothelin |
| KR101782487B1 (ko) | 2015-09-24 | 2017-09-27 | 재단법인 목암생명과학연구소 | 신규 항-메소텔린 항체 및 이를 포함하는 조성물 |
| US20170096485A1 (en) * | 2015-10-02 | 2017-04-06 | Hoffmann-La Roche Inc. | Bispecific t cell activating antigen binding molecules |
| BR112018006811A2 (en) | 2015-10-06 | 2018-10-16 | Regents Of The University Of Minnesota | therapeutic compounds and methods |
| CN109072195A (zh) | 2015-12-30 | 2018-12-21 | 诺华股份有限公司 | 具有增强功效的免疫效应细胞疗法 |
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| PL3433280T3 (pl) | 2016-03-22 | 2023-07-31 | F. Hoffmann-La Roche Ag | Dwuswoiste cząsteczki limfocytów T aktywowane przez proteazy |
| SG11201808085WA (en) * | 2016-03-22 | 2018-10-30 | Hoffmann La Roche | Protease-activated t cell bispecific molecules |
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| EP3448421B1 (en) * | 2016-04-29 | 2021-11-03 | The Board of Trustees of the Leland Stanford Junior University | Methods and compositions for the prevention and treatment of surgical adhesions |
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| CN110267677A (zh) | 2016-08-01 | 2019-09-20 | 诺华股份有限公司 | 使用与原m2巨噬细胞分子抑制剂组合的嵌合抗原受体治疗癌症 |
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| MX2019003899A (es) | 2016-10-07 | 2019-08-14 | Tcr2 Therapeutics Inc | Composiciones y metodos para reprogramacion de receptores de linfocitos t mediante el uso de proteinas de fusion. |
| EP3544996A2 (en) | 2016-11-22 | 2019-10-02 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| FI3548515T3 (fi) | 2016-12-01 | 2026-03-04 | Regeneron Pharma | Radioleimattuja anti-PD-L1-vasta-aineita immuno-PET-kuvantamiseen |
| EP3574005B1 (en) | 2017-01-26 | 2021-12-15 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| EP3638295A1 (en) | 2017-06-13 | 2020-04-22 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2018387741B2 (en) | 2017-12-19 | 2025-09-25 | Invox Pharma Limited | FC binding fragments comprising a PD-L1 antigen-binding site |
| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
| WO2019237035A1 (en) | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
| EP3806889A4 (en) * | 2018-06-18 | 2022-07-13 | Anwita Biosciences, Inc. | CYTOKI FUSION PROTEINS AND USES THEREOF |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
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| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
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| MX2021000399A (es) | 2018-07-12 | 2021-05-27 | F Star Therapeutics Ltd | Moleculas de anticuerpo que se unen a cd137 y ox40. |
| US12344672B2 (en) | 2018-07-12 | 2025-07-01 | Invox Pharma Limited | Antibody molecules that bind PD-L1 and CD137 |
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| TW202026006A (zh) | 2018-08-30 | 2020-07-16 | 美商Ｔｃｒ２療法股份有限公司 | 使用融合蛋白進行tcr再程式化之組成物及方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN120535653A (zh) | 2018-10-19 | 2025-08-26 | 明尼苏达大学董事会 | Nk接合子分子及其使用方法 |
| WO2020092631A1 (en) * | 2018-10-31 | 2020-05-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for detecting and treating cancers characterized by expression of mesothelin |
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| CN112321714B (zh) * | 2019-01-08 | 2022-06-28 | 上海霖科生物科技有限公司 | 与间皮素结合的单克隆抗体及其核酸分子 |
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| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
| WO2021260528A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| JP7819176B2 (ja) | 2020-08-03 | 2026-02-24 | ノバルティス アーゲー | ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| TW202321296A (zh) | 2021-10-06 | 2023-06-01 | 美商鏈接免疫療法公司 | 抗間皮素抗原結合分子及其用途 |
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-
2006
- 2006-03-09 EP EP06737748A patent/EP1861425B1/en not_active Expired - Lifetime
- 2006-03-09 EP EP10180413.6A patent/EP2322560B1/en not_active Expired - Lifetime
- 2006-03-09 JP JP2008500966A patent/JP4949373B2/ja not_active Expired - Lifetime
- 2006-03-09 ES ES06737748T patent/ES2386367T3/es not_active Expired - Lifetime
- 2006-03-09 AU AU2006223301A patent/AU2006223301B2/en not_active Expired
- 2006-03-09 WO PCT/US2006/008598 patent/WO2006099141A2/en not_active Ceased
- 2006-03-09 CA CA2600505A patent/CA2600505C/en not_active Expired - Lifetime
- 2006-03-09 ES ES10180413T patent/ES2429340T3/es not_active Expired - Lifetime
- 2006-03-09 US US11/373,546 patent/US7592426B2/en active Active
-
2009
- 2009-08-21 US US12/545,369 patent/US8206710B2/en active Active
-
2011
- 2011-01-24 AU AU2011200251A patent/AU2011200251B2/en not_active Expired
- 2011-12-29 JP JP2011290449A patent/JP5378497B2/ja not_active Expired - Lifetime
-
2012
- 2012-05-21 US US13/476,656 patent/US8481703B2/en not_active Expired - Lifetime
-
2013
- 2013-03-13 US US13/799,766 patent/US8658173B2/en not_active Expired - Lifetime
- 2013-08-13 JP JP2013168325A patent/JP5788443B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-06 US US14/148,011 patent/US9115197B2/en not_active Expired - Lifetime
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