JP2013545823A5 - - Google Patents

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JP2013545823A5
JP2013545823A5 JP2013544848A JP2013544848A JP2013545823A5 JP 2013545823 A5 JP2013545823 A5 JP 2013545823A5 JP 2013544848 A JP2013544848 A JP 2013544848A JP 2013544848 A JP2013544848 A JP 2013544848A JP 2013545823 A5 JP2013545823 A5 JP 2013545823A5
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optionally substituted
pharmaceutically acceptable
acceptable salt
compound according
alkyl
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JP2013544848A
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JP2013545823A (ja
JP5837091B2 (ja
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Priority claimed from PCT/US2011/065633 external-priority patent/WO2012083246A1/en
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JP2013544848A 2010-12-17 2011-12-16 ピルビン酸キナーゼｍ２（ｐｋｍ２）調節剤としての新規ｎ−（４−（アゼチジン−１−カルボニル）フェニル）−（ヘテロ−）アリールスルホンアミド誘導体 Expired - Fee Related JP5837091B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061424395P 2010-12-17 2010-12-17
US61/424,395 2010-12-17
PCT/US2011/065633 WO2012083246A1 (en) 2010-12-17 2011-12-16 Novel n- (4- (azetidine - 1 - carbonyl) phenyl) - (hetero - ) arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators

Publications (3)

Publication Number Publication Date
JP2013545823A JP2013545823A (ja) 2013-12-26
JP2013545823A5 true JP2013545823A5 (OSRAM) 2014-11-13
JP5837091B2 JP5837091B2 (ja) 2015-12-24

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JP2013544848A Expired - Fee Related JP5837091B2 (ja) 2010-12-17 2011-12-16 ピルビン酸キナーゼｍ２（ｐｋｍ２）調節剤としての新規ｎ−（４−（アゼチジン−１−カルボニル）フェニル）−（ヘテロ−）アリールスルホンアミド誘導体

Country Status (7)

Country Link
US (1) US9221792B2 (OSRAM)
EP (1) EP2651898B1 (OSRAM)
JP (1) JP5837091B2 (OSRAM)
CA (1) CA2821975A1 (OSRAM)
ES (1) ES2564952T3 (OSRAM)
MX (1) MX2013006900A (OSRAM)
WO (1) WO2012083246A1 (OSRAM)

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CA2944788C (en) 2009-06-29 2023-08-22 Agios Pharmaceuticals, Inc. Compounds, and compositions thereof, which modulate pyruvate kinase m2, and methods of making same
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WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
DK3448859T3 (da) 2017-03-20 2019-09-23 Forma Therapeutics Inc Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer
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WO2022170200A1 (en) 2021-02-08 2022-08-11 Global Blood Therapeutics, Inc. 1-(2-sulfonyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4h)-yl]-ethanone derivatives as pyruvate kinase (pkr) and pkm2 activators for the treatment of sickle cell disease
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JP2025500499A (ja) 2021-12-21 2025-01-09 サイノハブ ファーマシューティカル カンパニー リミテッド ビス（アザニリリデン）スルホニル構造を含む化合物および医薬におけるその使用
WO2024245143A1 (zh) 2023-05-26 2024-12-05 赛诺哈勃药业（成都）有限公司 含二氮杂亚基磺酰结构化合物的药物组合物在治疗贫血相关疾病中的用途

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