JP2013544779A5 - - Google Patents

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JP2013544779A5
JP2013544779A5 JP2013532947A JP2013532947A JP2013544779A5 JP 2013544779 A5 JP2013544779 A5 JP 2013544779A5 JP 2013532947 A JP2013532947 A JP 2013532947A JP 2013532947 A JP2013532947 A JP 2013532947A JP 2013544779 A5 JP2013544779 A5 JP 2013544779A5
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polypeptide
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seq
tables
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JP6039566B2 (ja
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JP2013532947A 2010-10-06 2011-10-06 治療用、診断用および抗体組成物に関連したトリプトファニルtRNA合成酵素のタンパク質フラグメントの革新的発見 Active JP6039566B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US39055310P 2010-10-06 2010-10-06
US39055410P 2010-10-06 2010-10-06
US39055510P 2010-10-06 2010-10-06
US61/390,555 2010-10-06
US61/390,553 2010-10-06
US61/390,554 2010-10-06
PCT/US2011/055130 WO2012048125A2 (en) 2010-10-06 2011-10-06 Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases

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JP2015186665A Division JP2016000052A (ja) 2010-10-06 2015-09-24 治療用、診断用および抗体組成物に関連したトリプトファニルtRNA合成酵素のタンパク質フラグメントの革新的発見

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JP2013544779A JP2013544779A (ja) 2013-12-19
JP2013544779A5 true JP2013544779A5 (OSRAM) 2014-05-22
JP6039566B2 JP6039566B2 (ja) 2016-12-07

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JP2013532947A Active JP6039566B2 (ja) 2010-10-06 2011-10-06 治療用、診断用および抗体組成物に関連したトリプトファニルtRNA合成酵素のタンパク質フラグメントの革新的発見
JP2015186665A Withdrawn JP2016000052A (ja) 2010-10-06 2015-09-24 治療用、診断用および抗体組成物に関連したトリプトファニルtRNA合成酵素のタンパク質フラグメントの革新的発見

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US (2) US9399770B2 (OSRAM)
EP (1) EP2624857B1 (OSRAM)
JP (2) JP6039566B2 (OSRAM)
CN (1) CN103118696B (OSRAM)
AU (1) AU2011311956C1 (OSRAM)
CA (1) CA2812795C (OSRAM)
ES (1) ES2645019T3 (OSRAM)
WO (1) WO2012048125A2 (OSRAM)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2552773T3 (es) 2009-02-27 2015-12-02 Atyr Pharma, Inc. Motivos estructurales de polipéptidos asociados con la actividad de señalización celular
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CN103096910A (zh) 2010-04-27 2013-05-08 Atyr医药公司 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ, インコーポレイテッド イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
CA2797799C (en) 2010-05-03 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
CA2797977C (en) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
AU2011248100B2 (en) 2010-05-04 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
CN103200953B (zh) 2010-05-14 2017-02-15 Atyr 医药公司 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
US20130202576A1 (en) 2010-07-12 2013-08-08 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103124561B (zh) 2010-07-12 2017-05-03 Atyr 医药公司 与天冬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2012048125A2 (en) 2010-10-06 2012-04-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
WO2012158945A2 (en) * 2011-05-19 2012-11-22 The Scripps Research Institute Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
WO2013086216A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Improved aspartyl-trna synthetases
US9822353B2 (en) 2011-12-06 2017-11-21 Atyr Pharma, Inc. PEGylated aspartyl-tRNA synthetase polypeptides
AU2012368189B2 (en) 2011-12-29 2017-08-31 Atyr Pharma, Inc. Aspartyl-tRNA synthetase-Fc conjugates
US9034442B2 (en) * 2012-11-30 2015-05-19 Corning Incorporated Strengthened borosilicate glass containers with improved damage tolerance
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
US10604585B2 (en) * 2014-09-09 2020-03-31 La Jolla Institute For Allergy & Immunology Modulation of PTPRA to treat arthritis
WO2016137280A1 (ko) * 2015-02-26 2016-09-01 재단법인 의약바이오컨버젼스연구단 트립토파닐 티알엔에이 합성효소를 유효성분으로 포함하는 감염성 염증 질환의 치료 또는 예방용 조성물 및 면역증강용 조성물
KR20170027258A (ko) 2015-09-01 2017-03-09 제이더블유바이오사이언스 주식회사 트립토파닐 티알엔에이 합성효소를 이용한 패혈증의 진단용 조성물과 진단 마커 검출 방법
KR101771697B1 (ko) * 2015-09-01 2017-08-25 제이더블유바이오사이언스 주식회사 트립토파닐 티알엔에이 합성효소를 이용한 감염 질환 또는 감염 합병증의 진단용 조성물과 진단 마커 검출 방법
US10254256B2 (en) * 2015-10-01 2019-04-09 Thermo Hypersil-Keystone Llc Method of packing chromatographic columns, packed chromatographic columns for use at high pressures and uses thereof
KR101729547B1 (ko) 2016-07-05 2017-04-25 충남대학교 산학협력단 트립토파닐-tRNA 합성효소 단백질을 함유하는 조성물의 백신 보조제로서의 활용
CN110536694A (zh) 2017-04-20 2019-12-03 Atyr 医药公司 用于治疗肺部炎症的组合物和方法
KR102489531B1 (ko) * 2019-07-18 2023-01-17 주식회사 큐어바이오테라퓨틱스 Wrs 단백질에 특이적으로 결합하는 항체 및 이의 용도
KR102478445B1 (ko) * 2019-07-18 2022-12-20 주식회사 큐어바이오테라퓨틱스 Wrs 단백질에 특이적으로 결합하는 항체 및 이의 용도
KR102726776B1 (ko) * 2021-07-09 2024-11-06 포항공과대학교 산학협력단 포밀 메티오닌 특이 항체 제조를 위한 신규한 항원 펩타이드

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9115660U1 (de) 1991-12-18 1992-07-30 Aventis Research & Technologies GmbH & Co KG, 65929 Frankfurt L-Phenylalanyl-tRNA-Synthetase mit erweiterter Substratselektivität aus Mikroorganismen
US5759833A (en) 1994-05-27 1998-06-02 Cubist Pharmaceuticals, Inc. Human isoleucyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same
US5756327A (en) 1994-09-13 1998-05-26 Cubist Pharmaceuticals, Inc. Recombinant mycobacterial isoleucyl-tRNA synthetase genes, tester strains and assays
US5798240A (en) 1994-09-13 1998-08-25 Cubist Pharmaceuticals, Inc. Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore
US5801013A (en) 1995-05-26 1998-09-01 Cubist Pharmaceuticals, Inc. Helicobacter aminoacyl-tRNA synthetase proteins, nucleic acids and strains comprising same
EP1876241A3 (en) 1996-01-11 2008-07-30 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
WO1997026354A1 (en) 1996-01-19 1997-07-24 Smithkline Beecham Plc HISTIDYL-tRNA SYNTHETASE OF STAPHYLOCOCCUS AUREUS
JPH11503618A (ja) 1996-01-19 1999-03-30 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー スタフィロコッカス・アウレウスのロイシル−tRNAシンセターゼ
US5795757A (en) 1997-01-17 1998-08-18 Smithkline Beecham, P.L.C. DNA encoding threonyl tRNA synthetase from staphylococcus aureus
GB9601067D0 (en) 1996-01-19 1996-03-20 Smithkline Beecham Plc Novel compounds
GB9607991D0 (en) 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
US5795758A (en) 1997-04-18 1998-08-18 Smithkline Beecham Corporation DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae
GB9607993D0 (en) 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
KR100203919B1 (ko) 1996-10-04 1999-06-15 신동권 수용성 단백질을 생산하는 새로운 발현 플라스미드
US5885815A (en) 1996-11-01 1999-03-23 Cubist Pharmaceuticals, Inc. Candida isoleucyl-tRNA synthetase proteins, nucleic acids and strains comprising same
US5776749A (en) 1997-01-17 1998-07-07 Smithkline Beecham P.L.C. DNA encoding cysteinyl tRNA synthetase from Staphylococcus aureus
EP0981625A2 (en) 1997-05-06 2000-03-01 Human Genome Sciences, Inc. $i(ENTEROCOCCUS FAECALIS) POLYNUCLEOTIDES AND POLYPEPTIDES
US5882892A (en) 1997-07-23 1999-03-16 Smithkline Beecham Corporation Asps
US5858720A (en) 1997-07-23 1999-01-12 Smithkline Beecham Corporation Hiss
US5939298A (en) 1997-07-23 1999-08-17 Smithkline Beecham Corporation DNA encoding phenylalanyl tRNA synthetase alpha sub-unit from chlamydi a trachomatis
US6428960B1 (en) 1998-03-04 2002-08-06 Onyx Pharmaceuticals, Inc. Selection method for producing recombinant baculovirus
JP2002505110A (ja) 1998-03-04 2002-02-19 オニックス ファーマシューティカルズ,インコーポレイティド 遺伝物質の高生産性発現のためのバキュロウイルス発現系及び方法
US6255090B1 (en) 1998-07-15 2001-07-03 E. I. Du Pont De Nemours & Company Plant aminoacyl-tRNA synthetase
US6271441B1 (en) 1998-07-21 2001-08-07 E. I. Du Pont De Nemours & Company Plant aminoacyl-tRNA synthetase
US6696619B1 (en) 1998-11-05 2004-02-24 Omolayo O. Famodu Plant aminoacyl-tRNA synthetases
CA2380317A1 (en) 1999-07-22 2001-02-01 Incyte Genomics, Inc. Human synthetases
WO2001019999A1 (en) 1999-09-14 2001-03-22 Shanghai Biorigin Gene Development Co. Ltd. A GENE ENCODING A NOVEL THREONYL-tRNA SYNTHETASE, ITS USES AND THE PREPARING METHODS
US6548060B1 (en) 1999-11-18 2003-04-15 Sunghoon Kim Anti-apoptotic use of human glutaminyl-tRNA synthetase with two consecutive pro-apoptotic mediators
CN1297999A (zh) * 1999-11-24 2001-06-06 上海博容基因开发有限公司 一种新的多肽——人谷氨酰转移核糖核酸合成酶58和编码这种多肽的多核苷酸
CN1311300A (zh) 2000-03-02 2001-09-05 上海博德基因开发有限公司 一种新的多肽-人苏氨酰-tRNA合成酶14和编码这种多肽的多核苷酸
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
US7144984B2 (en) 2000-03-31 2006-12-05 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
EP2258834B1 (en) * 2000-03-31 2015-09-23 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
US7273844B2 (en) 2000-03-31 2007-09-25 The Scripps Research Institute Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
US20040181830A1 (en) 2001-05-07 2004-09-16 Kovalic David K. Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
CN1322818A (zh) 2000-05-09 2001-11-21 上海博德基因开发有限公司 一种新的多肽——人II类氨酰基-tRNA合成酶10和编码这种多肽的多核苷酸
AU2001256780A1 (en) 2000-05-18 2001-11-26 Nihon University, School Juridical Person Method for examining ischemic conditions
CA2408315A1 (en) 2000-05-25 2001-11-29 Incyte Genomics, Inc. Aminoacyl trna synthetases
CN1341727A (zh) 2000-09-07 2002-03-27 上海博德基因开发有限公司 一种新的多肽——甲硫氨酰tRNA合成酶35.09和编码这种多肽的多核苷酸
CN1341725A (zh) 2000-09-07 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人苏氨酰-tRNA合成酶48.73和编码这种多肽的多核苷酸
CN1352242A (zh) 2000-11-02 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人谷氨酰tRNA合成酶12.65和编码这种多肽的多核苷酸
CN1352252A (zh) 2000-11-06 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人II类氨酰基-tRNA合成酶11.77和编码这种多肽的多核苷酸
AU2002223349A1 (en) 2000-11-28 2002-06-11 Mcgill University Incorporation and priming function of trnalys in hiv and related viruses
JP2004537270A (ja) 2000-12-15 2004-12-16 インサイト・ゲノミックス・インコーポレイテッド アミノアシルtRNA合成酵素
CN1361245A (zh) * 2000-12-26 2002-07-31 上海博德基因开发有限公司 一种新的多肽——组氨酰-tRNA合成酶13.09和编码这种多肽的多核苷酸
WO2002067970A1 (en) 2001-02-23 2002-09-06 The Scripps Research Institute TRYPTOPHANYL-tRNA SYNTHETASE DERIVED POLYPEPTIDES USEFUL FOR THE REGULATION OF ANGIOGENESIS
US6903189B2 (en) 2001-03-21 2005-06-07 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
IL158418A0 (en) 2001-04-19 2004-05-12 Scripps Research Inst In vivo incorporation of unnatural amino acids
US20030215827A1 (en) 2001-05-22 2003-11-20 Henry Yue Aminoacyl trna synthetases
KR100405919B1 (ko) 2001-06-05 2003-11-14 주식회사 이매진 p43의 N-말단 펩타이드를 유효성분으로 하는 면역증강용 약학조성물
US20040018505A1 (en) 2001-06-29 2004-01-29 Lee Ernestine A. Aminoacyl trna synthetases
WO2003009813A2 (en) 2001-07-26 2003-02-06 Novartis Ag Methods of treating neuropilin-mediated diseases
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US7785827B2 (en) 2001-09-20 2010-08-31 University Of Houston System Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules
US20040048290A1 (en) 2001-12-13 2004-03-11 Lee Ernestine A Aminoacyl trna synthetases
WO2003094862A2 (en) 2002-05-13 2003-11-20 Rigel Pharmaceuticals, Inc. tRNA SYNTHASE: MODULATORS OF ANGIOGENESIS
US20060248617A1 (en) 2002-08-30 2006-11-02 Japan Science And Technology Corporation Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same
US7842476B2 (en) 2002-09-06 2010-11-30 Isogenica Limited In vitro peptide expression library
KR100575251B1 (ko) 2003-03-03 2006-05-02 재단법인서울대학교산학협력재단 p38/JTV-1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법
WO2004087875A2 (en) 2003-03-25 2004-10-14 Incyte Corporation Nucleic acid-associated proteins
US20040224981A1 (en) 2003-05-01 2004-11-11 Nebojsa Janjic Antibacterial methods and compositions
EP1666604B1 (en) 2003-07-07 2008-02-13 The Scripps Research Institute Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
US7709604B2 (en) 2003-12-18 2010-05-04 The Scripps Research Institute Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
AU2005319099B2 (en) 2004-02-02 2010-09-16 Ambrx, Inc. Modified human growth hormone
KR100599454B1 (ko) 2004-04-27 2006-07-12 재단법인서울대학교산학협력재단 종양 억제자로 작용하는 aim3의 신규 용도
PT1765362E (pt) 2004-06-04 2012-06-04 Scripps Research Inst Composições e métodos para o tratamento de doenças neovasculares
US8282921B2 (en) * 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US20060024288A1 (en) 2004-08-02 2006-02-02 Pfizer Inc. tRNA synthetase fragments
US20060079673A1 (en) * 2004-08-02 2006-04-13 Paul Glidden Polynucleotides encoding tRNA synthetase fragments and uses thereof
US20060078553A1 (en) 2004-10-07 2006-04-13 Paul Glidden Diverse multi-unit complexes including a tRNA synthetase fragment
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
US8003780B2 (en) 2004-11-24 2011-08-23 Neomics Co., Ltd. AIMP2-DX2 gene and SiRNA targeting AIMP2-DX2
NZ555425A (en) 2004-12-22 2010-04-30 Ambrx Inc Compositions of aminoacyl-tRNA synthetase and uses thereof
US7608413B1 (en) * 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
CA2618878C (en) 2005-08-18 2016-06-28 Ambrx, Inc. Compositions of trna and uses thereof
US7514229B2 (en) 2005-09-29 2009-04-07 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosing and evaluating treatment of blood disorders
ES2528663T3 (es) 2005-12-02 2015-02-11 The Scripps Research Institute Composiciones de tirosil-ARNt sintetasa angiogénicas y procedimientos
EP1999259B1 (en) 2006-03-03 2014-06-25 California Institute of Technology Site-specific incorporation of amino acids into molecules
US9181543B2 (en) 2006-05-26 2015-11-10 Obodies Limited OB fold domains
US20100120627A1 (en) 2006-08-02 2010-05-13 Abdelmajid Belouchi Genemap of the human genes associated with psoriasis
JP5244103B2 (ja) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション 器官特異的蛋白質およびその使用方法
US20100093082A1 (en) * 2006-09-08 2010-04-15 Ambrx, Inc. Site Specific Incorporation of Non-Natural Amino Acids by Vertebrate Cells
RU2009122514A (ru) 2006-11-17 2010-12-27 Новартис АГ (CH) Молекулы, связывающие белок lingo, и их фармацевтическое применение
US20100138941A1 (en) 2007-04-27 2010-06-03 Imagene Co., Ltd. Method for screening immune modulator
JP2009017840A (ja) 2007-07-13 2009-01-29 Japan Agengy For Marine-Earth Science & Technology 外来遺伝子を細胞に安定に保持する方法
EP2220218A4 (en) 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
JP5585904B2 (ja) 2008-02-08 2014-09-10 独立行政法人理化学研究所 アミノアシルtRNA合成酵素活性を有するポリペプチド及びその利用
US20110104139A1 (en) 2008-03-11 2011-05-05 The University Of North Carolina At Chapel Hill ANGIOSTATIC COMPOSITIONS COMPRISING TRUNCATED TYROSYL-tRNA SYNTHETASE POLYPEPTIDES AND METHODS OF USING SAME
AU2009257538A1 (en) 2008-06-11 2009-12-17 Atyr Pharma, Inc. Thrombopoietic activity of tyrosyl-tRNA synthetase polypeptides
JP5756751B2 (ja) 2008-06-26 2015-07-29 エータイアー ファーマ, インコーポレイテッド 非正準的な生物学的活性を有するグリシル−tRNA合成酵素を含む組成物および方法
AU2009282480B2 (en) * 2008-08-11 2015-05-07 Children's Medical Center Corporation Halofuginone analogs for inhibition of tRNA synthetases and uses thereof
AU2008360729A1 (en) 2008-08-18 2010-02-25 Seoul National University Industry Foundation Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl tRNA synthetase
KR101067817B1 (ko) 2008-10-10 2011-09-27 서울대학교산학협력단 Aimp1 폴리펩티드에 대한 항체를 포함하는 관절염 진단용 조성물
US8901081B2 (en) 2008-10-10 2014-12-02 Snu R&Db Foundation Uses of GRS proteins or fragments thereof
KR101067815B1 (ko) 2009-02-05 2011-09-27 서울대학교산학협력단 제1형 당뇨병의 신규한 진단 마커
US20120058133A1 (en) 2009-02-19 2012-03-08 President And Fellows Of Harvard College Inhibition of trna synthetases and therapeutic applications thereof
ES2552773T3 (es) 2009-02-27 2015-12-02 Atyr Pharma, Inc. Motivos estructurales de polipéptidos asociados con la actividad de señalización celular
EP2408905B1 (en) 2009-03-16 2017-05-10 Pangu Biopharma Limited Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities
AU2010236913B2 (en) 2009-03-31 2016-03-24 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities
WO2011072266A2 (en) 2009-12-11 2011-06-16 Atyr Pharma, Inc. Aminoacyl trna synthetases for modulating hematopoiesis
WO2011072265A1 (en) 2009-12-11 2011-06-16 Atyr Pharma, Inc. Aminoacyl trna synthetases for modulating inflammation
US8828395B2 (en) 2009-12-11 2014-09-09 Atyr Pharma, Inc. Antibodies that bind tyrosyl-tRNA synthetases
US8828685B2 (en) 2010-02-04 2014-09-09 The Scripps Research Institute Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CN103096910A (zh) 2010-04-27 2013-05-08 Atyr医药公司 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ, インコーポレイテッド イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
CA2797977C (en) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
CA2797799C (en) 2010-05-03 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
AU2011248100B2 (en) 2010-05-04 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases
CN103200953B (zh) 2010-05-14 2017-02-15 Atyr 医药公司 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103124561B (zh) 2010-07-12 2017-05-03 Atyr 医药公司 与天冬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
US20130202576A1 (en) 2010-07-12 2013-08-08 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2012048125A2 (en) 2010-10-06 2012-04-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
WO2012158945A2 (en) 2011-05-19 2012-11-22 The Scripps Research Institute Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
WO2013086216A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Improved aspartyl-trna synthetases
US9822353B2 (en) 2011-12-06 2017-11-21 Atyr Pharma, Inc. PEGylated aspartyl-tRNA synthetase polypeptides
AU2012368189B2 (en) 2011-12-29 2017-08-31 Atyr Pharma, Inc. Aspartyl-tRNA synthetase-Fc conjugates
IN2014MN01642A (OSRAM) 2012-02-16 2015-07-03 Atyr Pharma Inc
US20140066321A1 (en) 2012-07-23 2014-03-06 Pangu Biopharma Limited Structures of human histidyl-trna synthetase and methods of use

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