JP2013544256A5 - - Google Patents
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- Publication number
- JP2013544256A5 JP2013544256A5 JP2013540089A JP2013540089A JP2013544256A5 JP 2013544256 A5 JP2013544256 A5 JP 2013544256A5 JP 2013540089 A JP2013540089 A JP 2013540089A JP 2013540089 A JP2013540089 A JP 2013540089A JP 2013544256 A5 JP2013544256 A5 JP 2013544256A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- thiazol
- amino
- methyl
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41568510P | 2010-11-19 | 2010-11-19 | |
| US61/415,685 | 2010-11-19 | ||
| PCT/US2011/061532 WO2012068546A1 (en) | 2010-11-19 | 2011-11-18 | Heterocycle amines and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016171817A Division JP6316888B2 (ja) | 2010-11-19 | 2016-09-02 | 複素環式アミンおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013544256A JP2013544256A (ja) | 2013-12-12 |
| JP2013544256A5 true JP2013544256A5 (US07981874-20110719-C00313.png) | 2016-03-24 |
| JP6005050B2 JP6005050B2 (ja) | 2016-10-12 |
Family
ID=45094285
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540089A Active JP6005050B2 (ja) | 2010-11-19 | 2011-11-18 | 複素環式アミンおよびその使用 |
| JP2016171817A Active JP6316888B2 (ja) | 2010-11-19 | 2016-09-02 | 複素環式アミンおよびその使用 |
| JP2018059583A Active JP6726226B2 (ja) | 2010-11-19 | 2018-03-27 | 複素環式アミンおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016171817A Active JP6316888B2 (ja) | 2010-11-19 | 2016-09-02 | 複素環式アミンおよびその使用 |
| JP2018059583A Active JP6726226B2 (ja) | 2010-11-19 | 2018-03-27 | 複素環式アミンおよびその使用 |
Country Status (14)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102971311B (zh) * | 2010-05-06 | 2015-07-08 | 百时美施贵宝公司 | 作为gpr119调节剂的二环杂芳基化合物 |
| EP2847215A1 (en) * | 2012-05-07 | 2015-03-18 | Synthes GmbH | Methods and devices for treating intervertebral disc disease |
| JP6215338B2 (ja) * | 2012-11-08 | 2017-10-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | キナーゼモジュレーターとして有用な二環式ヘテロ環置換ピリジル化合物 |
| CA2925211A1 (en) * | 2013-09-27 | 2015-04-02 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| MX2016008688A (es) * | 2013-12-30 | 2017-01-12 | Lifesci Pharmaceuticals Inc | Compuestos terapéuticos inhibidores. |
| SI3094329T1 (sl) * | 2014-01-13 | 2019-02-28 | Aurigene Discovery Technologies Limited | Biciklični heterociklilni derivati kot inhibitorji IRAK4 |
| SG10201912656SA (en) | 2015-04-22 | 2020-02-27 | Rigel Pharmaceuticals Inc | Pyrazole compounds and method for making and using the compounds |
| US20180208605A1 (en) * | 2015-07-15 | 2018-07-26 | Aurigene Discovery Technologies Limited | Substituted Aza Compounds as IRAK-4 Inhibitors |
| KR102670695B1 (ko) * | 2015-09-18 | 2024-06-05 | 메르크 파텐트 게엠베하 | Irak 억제제로서의 헤테로아릴 화합물 및 이의 용도 |
| WO2017102091A1 (en) | 2015-12-18 | 2017-06-22 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
| WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| CN110691589A (zh) | 2017-03-31 | 2020-01-14 | 奥列基因发现技术有限公司 | 用于治疗血液病的化合物和组合物 |
| JP2020524663A (ja) * | 2017-06-21 | 2020-08-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｉｒａｋ４調節因子としてのイソインドリノン誘導体 |
| IL295603B2 (en) | 2017-09-22 | 2024-03-01 | Kymera Therapeutics Inc | Protein compounds and their uses |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2019089580A1 (en) | 2017-10-31 | 2019-05-09 | Curis, Inc. | Compounds and compositions for treating hematological disorders |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL275649B2 (en) | 2017-12-26 | 2023-12-01 | Kymera Therapeutics Inc | IRAK joints and used in them |
| EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND THEIR USES |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| EP3817748A4 (en) | 2018-07-06 | 2022-08-24 | Kymera Therapeutics, Inc. | TRICYCLIC CRBN LIGANDS AND USES THEREOF |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CN113423427A (zh) | 2018-11-30 | 2021-09-21 | 凯麦拉医疗公司 | Irak降解剂和其用途 |
| PE20220970A1 (es) | 2019-08-30 | 2022-06-10 | Rigel Pharmaceuticals Inc | Compuestos de pirazol, formulaciones de los mismos y un metodo para usar los compuestos y/o formulaciones |
| WO2021066573A1 (ko) * | 2019-10-04 | 2021-04-08 | 파렌키마바이오텍 주식회사 | 신규 화합물 및 이의 자가면역질환 치료 용도 |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| IL293917A (en) | 2019-12-17 | 2022-08-01 | Kymera Therapeutics Inc | Iraq joints and their uses |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| AU2020470423B2 (en) | 2020-09-30 | 2024-01-18 | Asahi Kasei Pharma Corporation | Macrocycle compound |
| EP4223750A4 (en) | 2020-09-30 | 2024-06-19 | Asahi Kasei Pharma Corporation | NITROGEN-CONTAINING BICYCLIC COMPOUND WITH PYRIMIDINE |
| TW202334139A (zh) | 2021-11-09 | 2023-09-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳氧基苯并咪唑及氮雜苯并咪唑 |
| TW202345806A (zh) | 2022-03-31 | 2023-12-01 | 美商艾伯維有限公司 | 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5542990B2 (US07981874-20110719-C00313.png) * | 1972-01-27 | 1980-11-04 | ||
| CN1102593C (zh) | 1996-06-27 | 2003-03-05 | 詹森药业有限公司 | N－[4－(杂芳基甲基)苯基]－杂芳基胺类化合物 |
| KR20010031912A (ko) | 1997-11-10 | 2001-04-16 | 스티븐 비. 데이비스 | 벤조티아졸 단백질 티로신 키나제 억제제 |
| JP2000086641A (ja) * | 1998-09-11 | 2000-03-28 | Kyorin Pharmaceut Co Ltd | ２−置換ベンゾチアゾール誘導体及びその製造法 |
| MXPA04009541A (es) * | 2002-03-29 | 2005-01-25 | Chiron Corp | Benzazoles sustituidos y uso de los mismos como inhibidores de cinasa raf. |
| US20040023978A1 (en) * | 2002-07-24 | 2004-02-05 | Yu Ren | Active salt forms with tyrosine kinase activity |
| US7531553B2 (en) * | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
| US20070066577A1 (en) * | 2003-04-03 | 2007-03-22 | Hea Young Park Choo | Benzoxazole derivative or analogue thereof for inhibiting 5-lipoxygenase and pharmaceutical composition containing same |
| WO2005033105A2 (en) | 2003-09-30 | 2005-04-14 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| CN1882345A (zh) * | 2003-10-16 | 2006-12-20 | 希龙公司 | 作为raf激酶抑制剂以治疗癌症的2,6－二取代的喹唑啉、喹喔啉、喹啉和异喹啉 |
| JP4842829B2 (ja) | 2003-10-31 | 2011-12-21 | 武田薬品工業株式会社 | 含窒素縮合複素環化合物 |
| GB0401334D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| EP1674466A1 (en) | 2004-12-27 | 2006-06-28 | 4Sc Ag | 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors |
| US7473784B2 (en) * | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| KR20070052207A (ko) * | 2005-11-16 | 2007-05-21 | 주식회사 엘지생명과학 | 신규한 ｋｄｒ 억제제 |
| CN101360707A (zh) * | 2005-11-23 | 2009-02-04 | 利亘制药公司 | 血小板生成素活性调节化合物和方法 |
| EP1981343B8 (en) * | 2006-01-17 | 2015-06-24 | Stiefel Laboratories, Inc. | Treatment of inflammatory disorders with triazole compounds |
| ATE539748T1 (de) * | 2006-01-27 | 2012-01-15 | Array Biopharma Inc | Glucokinaseaktivatoren |
| US20080293785A1 (en) * | 2006-04-11 | 2008-11-27 | Connolly Peter J | Substituted benzothiazole kinase inhibitors |
| CN101558059B (zh) * | 2006-08-11 | 2014-12-03 | 百时美施贵宝公司 | 丙型肝炎病毒抑制剂 |
| AU2007292929A1 (en) * | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Indazole derivatives as modulators of interleukin- 1 receptor-associated kinase |
| EP2063962A2 (en) * | 2006-09-07 | 2009-06-03 | Biogen Idec MA Inc. | Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder |
| JP2008255024A (ja) * | 2007-04-02 | 2008-10-23 | Banyu Pharmaceut Co Ltd | ビアリールアミン誘導体 |
| WO2009126635A1 (en) | 2008-04-09 | 2009-10-15 | Abbott Laboratories | 2-amino-benzothiazole derivates useful as inhibitors of rock kinases |
| EP2277881A4 (en) * | 2008-04-18 | 2011-09-07 | Shionogi & Co | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| JP5177076B2 (ja) | 2008-07-28 | 2013-04-03 | 日産自動車株式会社 | 車両運転支援装置及び車両運転支援方法 |
| TWI396689B (zh) * | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶１０抑制劑之吡衍生物 |
| US9067947B2 (en) * | 2009-01-16 | 2015-06-30 | Universal Display Corporation | Organic electroluminescent materials and devices |
| EP2401273A1 (en) * | 2009-02-27 | 2012-01-04 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| JP2012520845A (ja) * | 2009-03-17 | 2012-09-10 | グラクソ グループ リミテッド | Ｉｔｋ阻害剤として使用されるピリミジン誘導体 |
| CN102480966B (zh) * | 2009-06-12 | 2015-09-16 | 达娜-法勃肿瘤研究所公司 | 融合的杂环化合物及其用途 |
| WO2011110575A1 (en) * | 2010-03-11 | 2011-09-15 | Glaxo Group Limited | Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases |
| WO2012035055A1 (en) * | 2010-09-17 | 2012-03-22 | Glaxo Group Limited | Novel compounds |
| EP3126330B1 (en) | 2014-04-04 | 2019-02-27 | Pfizer Inc | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
-
2011
- 2011-11-18 JP JP2013540089A patent/JP6005050B2/ja active Active
- 2011-11-18 WO PCT/US2011/061532 patent/WO2012068546A1/en active Application Filing
- 2011-11-18 MX MX2016016899A patent/MX366318B/es unknown
- 2011-11-18 PL PL14153493T patent/PL2730564T3/pl unknown
- 2011-11-18 KR KR1020137015153A patent/KR101903204B1/ko active IP Right Grant
- 2011-11-18 RU RU2017135541A patent/RU2017135541A/ru unknown
- 2011-11-18 HU HUE14153493A patent/HUE037860T2/hu unknown
- 2011-11-18 PT PT141534933T patent/PT2730564T/pt unknown
- 2011-11-18 EP EP11791162.8A patent/EP2640708A1/en not_active Withdrawn
- 2011-11-18 ES ES14153493.3T patent/ES2672203T3/es active Active
- 2011-11-18 CN CN201810959036.0A patent/CN108864151A/zh active Pending
- 2011-11-18 EP EP18161665.7A patent/EP3357915A1/en not_active Withdrawn
- 2011-11-18 MX MX2013005549A patent/MX344521B/es active IP Right Grant
- 2011-11-18 KR KR1020187024789A patent/KR20180099933A/ko not_active Application Discontinuation
- 2011-11-18 RU RU2013124101A patent/RU2632900C2/ru active
- 2011-11-18 RS RS20180735A patent/RS57375B1/sr unknown
- 2011-11-18 EP EP14153493.3A patent/EP2730564B1/en active Active
- 2011-11-18 CN CN2011800643922A patent/CN103298792A/zh active Pending
-
2013
- 2013-05-16 MX MX2019008122A patent/MX2019008122A/es unknown
- 2013-12-20 US US14/137,318 patent/US9266874B2/en active Active
-
2016
- 2016-01-26 US US15/006,940 patent/US10030034B2/en active Active
- 2016-09-02 JP JP2016171817A patent/JP6316888B2/ja active Active
-
2018
- 2018-03-27 JP JP2018059583A patent/JP6726226B2/ja active Active
- 2018-06-22 US US16/015,925 patent/US10604533B2/en active Active
- 2018-09-07 HK HK18111558.1A patent/HK1252165A1/zh unknown
-
2020
- 2020-01-07 US US16/735,988 patent/US11186593B2/en active Active
-
2021
- 2021-10-28 US US17/513,093 patent/US11773110B2/en active Active
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