JP2013540766A5 - - Google Patents

Info

Publication number

JP2013540766A5

JP2013540766A5 JP2013532316A JP2013532316A JP2013540766A5 JP 2013540766 A5 JP2013540766 A5 JP 2013540766A5 JP 2013532316 A JP2013532316 A JP 2013532316A JP 2013532316 A JP2013532316 A JP 2013532316A JP 2013540766 A5 JP2013540766 A5 JP 2013540766A5

Authority

JP

Japan

Prior art keywords

composition

copper oxide

inhibitor

skin

oxide

Prior art date

2011-10-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 26
• QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims 22
• 229960004643 cupric oxide Drugs 0.000 claims 20
• 239000005751 Copper oxide Substances 0.000 claims 18
• 229910000431 copper oxide Inorganic materials 0.000 claims 18
• 239000003112 inhibitor Substances 0.000 claims 10
• 239000003795 chemical substances by application Substances 0.000 claims 4
• -1 prostanoic acid prostaglandin Chemical class 0.000 claims 4
• 150000003431 steroids Chemical class 0.000 claims 4
• 239000002245 particle Substances 0.000 claims 3
• VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 2
• 101800004538 Bradykinin Proteins 0.000 claims 2
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
• 108010036949 Cyclosporine Proteins 0.000 claims 2
• 229940122069 Glycosidase inhibitor Drugs 0.000 claims 2
• QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 2
• 102100035792 Kininogen-1 Human genes 0.000 claims 2
• 239000000867 Lipoxygenase Inhibitor Substances 0.000 claims 2
• 229940122142 Lipoxygenase inhibitor Drugs 0.000 claims 2
• 229940118169 Prostaglandin receptor agonist Drugs 0.000 claims 2
• 229940122144 Prostaglandin receptor antagonist Drugs 0.000 claims 2
• 102000003923 Protein Kinase C Human genes 0.000 claims 2
• 108090000315 Protein Kinase C Proteins 0.000 claims 2
• 208000003251 Pruritus Diseases 0.000 claims 2
• 239000012190 activator Substances 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 239000000556 agonist Substances 0.000 claims 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 230000002280 anti-androgenic effect Effects 0.000 claims 2
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 2
• 239000000051 antiandrogen Substances 0.000 claims 2
• QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 2
• 229960001265 ciclosporin Drugs 0.000 claims 2
• BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 claims 2
• 239000006071 cream Substances 0.000 claims 2
• 229940112669 cuprous oxide Drugs 0.000 claims 2
• KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical group [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 claims 2
• 229930182912 cyclosporin Natural products 0.000 claims 2
• 230000007547 defect Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229960005309 estradiol Drugs 0.000 claims 2
• 229930182833 estradiol Natural products 0.000 claims 2
• 229940011871 estrogen Drugs 0.000 claims 2
• 239000000262 estrogen Substances 0.000 claims 2
• 239000006260 foam Substances 0.000 claims 2
• 239000000499 gel Substances 0.000 claims 2
• 239000003316 glycosidase inhibitor Substances 0.000 claims 2
• 230000007803 itching Effects 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000003921 oil Substances 0.000 claims 2
• 239000002674 ointment Substances 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000002089 prostaglandin antagonist Substances 0.000 claims 2
• 239000002522 prostaglandin receptor stimulating agent Substances 0.000 claims 2
• 150000003180 prostaglandins Chemical class 0.000 claims 2
• 229930002330 retinoic acid Natural products 0.000 claims 2
• 150000004492 retinoid derivatives Chemical class 0.000 claims 2
• 230000009759 skin aging Effects 0.000 claims 2
• 239000007921 spray Substances 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 229960001727 tretinoin Drugs 0.000 claims 2
• 229930003231 vitamin Natural products 0.000 claims 2
• 239000011782 vitamin Substances 0.000 claims 2
• 229940088594 vitamin Drugs 0.000 claims 2
• 235000013343 vitamin Nutrition 0.000 claims 2
• 150000003722 vitamin derivatives Chemical class 0.000 claims 2
• NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
• 229920002678 cellulose Polymers 0.000 claims 1
• 239000001913 cellulose Substances 0.000 claims 1