JP2017528505A5 - - Google Patents
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- JP2017528505A5 JP2017528505A5 JP2017516375A JP2017516375A JP2017528505A5 JP 2017528505 A5 JP2017528505 A5 JP 2017528505A5 JP 2017516375 A JP2017516375 A JP 2017516375A JP 2017516375 A JP2017516375 A JP 2017516375A JP 2017528505 A5 JP2017528505 A5 JP 2017528505A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alopecia
- subject
- item
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 38
- 201000004384 Alopecia Diseases 0.000 claims description 22
- 229960005345 trimebutine Drugs 0.000 claims description 15
- 231100000360 alopecia Toxicity 0.000 claims description 11
- LORDFXWUHHSAQU-UHFFFAOYSA-N 3,4,5-trimethoxybenzoic acid [2-(dimethylamino)-2-phenylbutyl] ester Chemical compound C=1C=CC=CC=1C(CC)(N(C)C)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 LORDFXWUHHSAQU-UHFFFAOYSA-N 0.000 claims description 9
- 230000003676 hair loss Effects 0.000 claims description 9
- 208000024963 hair loss Diseases 0.000 claims description 9
- 210000004209 hair Anatomy 0.000 claims description 7
- FSRLGULMGJGKGI-BTJKTKAUSA-N Trimebutine maleate Chemical group OC(=O)\C=C/C(O)=O.C=1C=CC=CC=1C(CC)(N(C)C)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 FSRLGULMGJGKGI-BTJKTKAUSA-N 0.000 claims description 6
- 206010040844 Skin exfoliation Diseases 0.000 claims description 5
- 230000003779 hair growth Effects 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 4
- ZFPDLGDYDUPYEZ-UHFFFAOYSA-N [2-(methylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate Chemical compound C=1C=CC=CC=1C(CC)(NC)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 ZFPDLGDYDUPYEZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000002207 metabolite Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 3
- 230000000284 resting effect Effects 0.000 claims description 3
- 238000011200 topical administration Methods 0.000 claims description 3
- 208000025865 Ulcer Diseases 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 claims description 2
- 208000004631 alopecia areata Diseases 0.000 claims description 2
- 230000003698 anagen phase Effects 0.000 claims description 2
- 201000002996 androgenic alopecia Diseases 0.000 claims description 2
- 231100000481 chemical toxicant Toxicity 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000037452 priming Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000037390 scarring Effects 0.000 claims description 2
- 210000003625 skull Anatomy 0.000 claims description 2
- 230000009469 supplementation Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 239000003440 toxic substance Substances 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 231100000397 ulcer Toxicity 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 239000011976 maleic acid Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 description 31
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 description 4
- 239000002677 5-alpha reductase inhibitor Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000003803 hair density Effects 0.000 description 3
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 2
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 229960000711 alprostadil Drugs 0.000 description 2
- 229960000997 bicalutamide Drugs 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 229960004199 dutasteride Drugs 0.000 description 2
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 description 2
- 229960004039 finasteride Drugs 0.000 description 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 2
- 229960002074 flutamide Drugs 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000003662 hair growth rate Effects 0.000 description 2
- 239000004036 potassium channel stimulating agent Substances 0.000 description 2
- 150000003126 pregnane derivatives Chemical class 0.000 description 2
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 description 1
- 229960001160 latanoprost Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 150000003145 progesterone derivatives Chemical class 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000003762 total hair loss Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055195P | 2014-09-25 | 2014-09-25 | |
| US62/055,195 | 2014-09-25 | ||
| PCT/CA2015/050966 WO2016044951A1 (en) | 2014-09-25 | 2015-09-25 | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528505A JP2017528505A (ja) | 2017-09-28 |
| JP2017528505A5 true JP2017528505A5 (https=) | 2018-11-08 |
Family
ID=55580010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516375A Pending JP2017528505A (ja) | 2014-09-25 | 2015-09-25 | 発毛増進、皮膚再生促進及び創傷治癒のための組成物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9962360B2 (https=) |
| EP (1) | EP3197443A4 (https=) |
| JP (1) | JP2017528505A (https=) |
| CA (1) | CA3000117A1 (https=) |
| WO (1) | WO2016044951A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016044951A1 (en) * | 2014-09-25 | 2016-03-31 | The Hospital For Sick Children | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
| HK1251593A1 (zh) | 2015-07-24 | 2019-02-01 | 豪夫迈‧罗氏有限公司 | Bace1抑制剂肽 |
| KR102112736B1 (ko) * | 2017-08-01 | 2020-05-20 | 주식회사 씨케이바이오텍 | 탈모 방지 또는 발모 촉진용 조성물 |
| US12285401B2 (en) | 2019-04-04 | 2025-04-29 | Daegu-Gyeongbuk Medical Innovation Foundation | Pharmaceutical composition comprising trimebutine or pharmaceutically acceptable salt thereof as an active ingredient for prevention or treatment of cancer |
| US20220362292A1 (en) * | 2019-07-26 | 2022-11-17 | Tufts Medical Center, Inc. | Adoptive transfer of plasmacytoid dendritic cells to prevent or treat hair loss |
| WO2022225427A1 (ru) * | 2021-04-22 | 2022-10-27 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые соли [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата и их применение |
| US11744788B2 (en) * | 2021-10-27 | 2023-09-05 | James D. Welch | Method of encouraging growth and regrowth of hair in human males technical area |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991001624A2 (en) * | 1989-07-31 | 1991-02-21 | Massachusetts Institute Of Technology | Use of calcium antagonists for treating scars |
| FR2793681B1 (fr) | 1999-05-18 | 2001-06-22 | Oreal | Utilisation d'au moins un inhibiteur d'au moins un canal calcique dans le traitement des rides |
| US20080318910A1 (en) * | 2005-10-04 | 2008-12-25 | Mistral Pharma, Inc. | Controlled-Release Oral Dosage Form |
| US20110144188A1 (en) * | 2006-06-06 | 2011-06-16 | Antibe Therapeutics Inc. | Salts of trimebutine and n-desmethyl trimebutine |
| US8748177B2 (en) * | 2008-09-30 | 2014-06-10 | The Hospital For Sick Children | Compositions for proliferation of cells and related methods |
| US9333209B2 (en) * | 2012-02-10 | 2016-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions for increasing hair growth |
| WO2016044951A1 (en) * | 2014-09-25 | 2016-03-31 | The Hospital For Sick Children | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
-
2015
- 2015-09-25 WO PCT/CA2015/050966 patent/WO2016044951A1/en not_active Ceased
- 2015-09-25 CA CA3000117A patent/CA3000117A1/en not_active Abandoned
- 2015-09-25 US US15/513,877 patent/US9962360B2/en active Active
- 2015-09-25 EP EP15845138.5A patent/EP3197443A4/en not_active Withdrawn
- 2015-09-25 JP JP2017516375A patent/JP2017528505A/ja active Pending
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