WO2013043011A3 - 갈화 추출물을 유효성분으로 함유하는 자궁내막증의 예방 및 치료용 약학적 조성물 - Google Patents

갈화 추출물을 유효성분으로 함유하는 자궁내막증의 예방 및 치료용 약학적 조성물 Download PDF

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Publication number
WO2013043011A3
WO2013043011A3 PCT/KR2012/007653 KR2012007653W WO2013043011A3 WO 2013043011 A3 WO2013043011 A3 WO 2013043011A3 KR 2012007653 W KR2012007653 W KR 2012007653W WO 2013043011 A3 WO2013043011 A3 WO 2013043011A3
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WO
WIPO (PCT)
Prior art keywords
preventing
pharmaceutical composition
active ingredients
treating endometriosis
composition containing
Prior art date
Application number
PCT/KR2012/007653
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English (en)
French (fr)
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WO2013043011A2 (ko
Inventor
최정혜
김지현
Original Assignee
경희대학교 산학협력단
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Application filed by 경희대학교 산학협력단 filed Critical 경희대학교 산학협력단
Priority to EP12833704.5A priority Critical patent/EP2762147B1/en
Priority to US14/346,667 priority patent/US9504724B2/en
Publication of WO2013043011A2 publication Critical patent/WO2013043011A2/ko
Publication of WO2013043011A3 publication Critical patent/WO2013043011A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

본 발명은 갈화(Puerariae Flos) 추출물을 유효성분으로 함유하는 자궁내막증 및 이의 합병증의 예방 또는 치료용 약학적 조성물에 관한 것으로, 더욱 구체적으로는 갈화(Puerariae Flos) 추출물은 자궁내막증 세포의 이동 및 부착을 억제하고, 이동 및 부착 관련 인자인 MMP-2 및 MMP-9의 발현을 억제하고, 통증 관련 인자인 COX-2의 발현을 억제하고, 염증 관련 사이토카인인 MCP-1 및 RANTES의 발현을 억제하는 활성을 가짐으로써 자궁내막증 및 이의 합병증의 예방 또는 치료용 약학적 조성물, 및 건강식품의 유효성분으로 유용하게 사용될 수 있다.
PCT/KR2012/007653 2011-09-23 2012-09-24 갈화 추출물을 유효성분으로 함유하는 자궁내막증의 예방 및 치료용 약학적 조성물 WO2013043011A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12833704.5A EP2762147B1 (en) 2011-09-23 2012-09-24 Pharmaceutical composition containing puerariae flos extracts as active ingredients for preventing and treating endometriosis
US14/346,667 US9504724B2 (en) 2011-09-23 2012-09-24 Pharmaceutical composition comprising extract of Puerariae flos for prevention and treatment of endometriosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0096323 2011-09-23
KR1020110096323A KR101357119B1 (ko) 2011-09-23 2011-09-23 갈화 추출물을 유효성분으로 함유하는 자궁내막증의 예방 및 치료용 약학적 조성물

Publications (2)

Publication Number Publication Date
WO2013043011A2 WO2013043011A2 (ko) 2013-03-28
WO2013043011A3 true WO2013043011A3 (ko) 2013-05-23

Family

ID=47915042

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/007653 WO2013043011A2 (ko) 2011-09-23 2012-09-24 갈화 추출물을 유효성분으로 함유하는 자궁내막증의 예방 및 치료용 약학적 조성물

Country Status (4)

Country Link
US (1) US9504724B2 (ko)
EP (1) EP2762147B1 (ko)
KR (1) KR101357119B1 (ko)
WO (1) WO2013043011A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101693573B1 (ko) * 2015-05-08 2017-01-06 경희대학교 산학협력단 갱년기 증상의 예방 또는 치료 효과가 있는 약제학적 조성물 및 그 제조방법
KR102233990B1 (ko) 2019-01-24 2021-03-30 건양대학교 산학협력단 유레아플라즈마 유레아리티쿰 감염을 통한 자궁내막증 동물 모델 개발

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050038853A (ko) * 2003-10-23 2005-04-29 학교법인 상지학원 항염증 활성을 갖는 해동피, 갈화, 옻나무 추출물을함유하는 조성물
KR100540788B1 (ko) * 2005-05-24 2006-01-10 롯데제과주식회사 갈화 추출물을 함유하는 건강식품
KR100547560B1 (ko) * 2005-08-29 2006-01-31 학교법인 상지학원 항염증 활성을 갖는 해동피, 갈화, 옻나무 추출물을함유하는 약학조성물
KR100552995B1 (ko) * 2003-04-17 2006-02-16 롯데제과주식회사 뇌기능 개선 효과가 있는 갈화 추출물 및 이의 제조방법
WO2007110241A1 (en) * 2006-03-29 2007-10-04 G.I.M.-Gesellschaft Für Innovative Medizin G.M.B.H. Nfg Ohg Plant extracts, plant components and the uses thereof
WO2009033103A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of pueraria lobata willd, ohwi of the leguminosae family and uses thereof
KR100950564B1 (ko) * 2008-03-03 2010-04-01 동아대학교 산학협력단 한약재 추출물을 유효성분으로 함유하는 항암용 조성물

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Publication number Priority date Publication date Assignee Title
CN1057936C (zh) * 1995-04-20 2000-11-01 裴玉环 治子宫内膜异位症的中药“内异散”及制作工艺
JP2008214191A (ja) * 2005-04-27 2008-09-18 Toyo Shinyaku:Kk 肝中脂質蓄積抑制剤
ITMI20051049A1 (it) * 2005-06-07 2006-12-08 Marfarma Holding S P A "composizioni a base di estratti fitroestrogenici per il trattamento dela sindrome menopausale e pre-mestruale e dell'ipertrofia prostatica benigna"
JP2009126853A (ja) * 2007-11-27 2009-06-11 Tsujido Kagaku Kk 治療剤
CN101670064A (zh) * 2008-09-11 2010-03-17 北京天科仁祥医药科技有限公司 一种用于治疗子宫内膜异位症的复方中药
CN101966301A (zh) * 2010-07-13 2011-02-09 泰一和浦（北京）中医药研究院有限公司 一种治疗盆腔炎的中药组合物及其制备方法

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KR100552995B1 (ko) * 2003-04-17 2006-02-16 롯데제과주식회사 뇌기능 개선 효과가 있는 갈화 추출물 및 이의 제조방법
KR20050038853A (ko) * 2003-10-23 2005-04-29 학교법인 상지학원 항염증 활성을 갖는 해동피, 갈화, 옻나무 추출물을함유하는 조성물
KR100540788B1 (ko) * 2005-05-24 2006-01-10 롯데제과주식회사 갈화 추출물을 함유하는 건강식품
KR100547560B1 (ko) * 2005-08-29 2006-01-31 학교법인 상지학원 항염증 활성을 갖는 해동피, 갈화, 옻나무 추출물을함유하는 약학조성물
WO2007110241A1 (en) * 2006-03-29 2007-10-04 G.I.M.-Gesellschaft Für Innovative Medizin G.M.B.H. Nfg Ohg Plant extracts, plant components and the uses thereof
WO2009033103A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of pueraria lobata willd, ohwi of the leguminosae family and uses thereof
KR100950564B1 (ko) * 2008-03-03 2010-04-01 동아대학교 산학협력단 한약재 추출물을 유효성분으로 함유하는 항암용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP2762147A4 *
SO-JUNG, KIM ET AL.: "A Study on the Estrogenicity of Korean Arrowroot (Pueraria thunbergiana)", JOURNAL OF THE KOREAN SOCIETY OF FOOD SCIENCE AND NUTRITION, vol. 33, no. 1, 2004, pages 16 - 21, XP053026043 *

Also Published As

Publication number Publication date
WO2013043011A2 (ko) 2013-03-28
EP2762147A4 (en) 2014-08-06
US20140234451A1 (en) 2014-08-21
EP2762147A2 (en) 2014-08-06
US9504724B2 (en) 2016-11-29
KR101357119B1 (ko) 2014-02-05
EP2762147B1 (en) 2015-11-18
KR20130032612A (ko) 2013-04-02

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