WO2015027669A3 - 苯基取代化合物及其药物组合物和应用 - Google Patents

苯基取代化合物及其药物组合物和应用 Download PDF

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WO2015027669A3
WO2015027669A3 PCT/CN2014/000808 CN2014000808W WO2015027669A3 WO 2015027669 A3 WO2015027669 A3 WO 2015027669A3 CN 2014000808 W CN2014000808 W CN 2014000808W WO 2015027669 A3 WO2015027669 A3 WO 2015027669A3
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compound
antitumor
tumor cells
remarkably
phenyl
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PCT/CN2014/000808
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English (en)
French (fr)
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WO2015027669A2 (zh
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贺小琼
詹华强
黄清龙
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香港科技大学
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Publication of WO2015027669A2 publication Critical patent/WO2015027669A2/zh
Publication of WO2015027669A3 publication Critical patent/WO2015027669A3/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明公开了具有式（1）和式（2）结构的苯基取代化合物及其药用组合物和应用。该化合物在体内和体外均能显著性杀灭和/或抑制人类和动物的多种肿瘤细胞，能显著性促进癌细胞凋亡和坏死、调节癌细胞生长周期、抑制癌细胞增殖。在同等剂量下，该化合物对人体正常细胞的细胞毒性作用显著性低于对人类肿瘤细胞的细胞毒作用。该化合物与临床抗肿瘤药物联用具有显著性协同抗肿瘤作用。该化合物或其药学上可接受的盐可应用于制备抗肿瘤的药物、抗肿瘤药物组合物、联合抗肿瘤药物组合物或辅助抗肿瘤保健品。
PCT/CN2014/000808 2013-08-30 2014-08-29 苯基取代化合物及其药物组合物和应用 WO2015027669A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310390817.XA CN103483187B (zh) 2013-08-30 2013-08-30 4-乙氧基-2-羟基-6-甲基苯甲酸及其药用组合物和应用
CN201310390817.X 2013-08-30

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WO2015027669A2 WO2015027669A2 (zh) 2015-03-05
WO2015027669A3 true WO2015027669A3 (zh) 2015-04-23

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WO (1) WO2015027669A2 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103483187B (zh) * 2013-08-30 2016-08-24 香港科技大学 4-乙氧基-2-羟基-6-甲基苯甲酸及其药用组合物和应用
CN114948927A (zh) * 2021-02-20 2022-08-30 江苏九基生物科技有限公司 一种含亚苄基的3-苯并呋喃酮衍生物在制备抗肿瘤药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103102264A (zh) * 2013-01-07 2013-05-15 四川大学 一类水杨酸类化合物的制备方法
CN103483187A (zh) * 2013-08-30 2014-01-01 香港科技大学 4-乙氧基-2-羟基-6-甲基苯甲酸及其药用组合物和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6434913A (en) * 1987-07-31 1989-02-06 Mitsubishi Chem Ind Antitumor agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103102264A (zh) * 2013-01-07 2013-05-15 四川大学 一类水杨酸类化合物的制备方法
CN103483187A (zh) * 2013-08-30 2014-01-01 香港科技大学 4-乙氧基-2-羟基-6-甲基苯甲酸及其药用组合物和应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOHIL, V.M. ET AL.: "Nutrient-sensitized Screening for Drugs that Shift Energy Metabolism from Mitochondrial Respiration to Glycolysis''.", NATURE BIOTECHNOLOGY, vol. 28, no. 3, 14 February 2010 (2010-02-14) *
ROELL, D. ET AL.: "The Natural Compounds Atraric Acid and N-butylbenzene sulfonamide as Antagonists of the Human Androgen Receptor and Inhibitorsof Prostate Cancer", CELL GROWTH''., vol. 332, no. 1-2, 30 January 2011 (2011-01-30) *
SEEPHONKAI, P. ET AL.: "Ferruginenes A-C from Rhododendron ferrugineum and Their Cytotoxic Evaluation''.", JOURNAL OF NATURAL PRODUCTS, vol. 74, no. 4, 28 March 2011 (2011-03-28), pages 714 *
ZHANG, HONGXIA ET AL.: "Comparative Analyses on Chemical Composition of Sulcaria sulcata and Sulcaria sulcata f. Vulpinoides''.", JOURNAL OF SOUTHWEST FORESTRY UNIVERSITY, vol. 32, no. 2, 30 April 2012 (2012-04-30) *

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CN103483187B (zh) 2016-08-24
CN103483187A (zh) 2014-01-01

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