JP2013540725A5 - - Google Patents
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- Publication number
- JP2013540725A5 JP2013540725A5 JP2013527497A JP2013527497A JP2013540725A5 JP 2013540725 A5 JP2013540725 A5 JP 2013540725A5 JP 2013527497 A JP2013527497 A JP 2013527497A JP 2013527497 A JP2013527497 A JP 2013527497A JP 2013540725 A5 JP2013540725 A5 JP 2013540725A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cancer
- nucleic acid
- acid molecule
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 50
- 239000002773 nucleotide Substances 0.000 claims 44
- 125000003729 nucleotide group Chemical group 0.000 claims 44
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 30
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 30
- 102000039446 nucleic acids Human genes 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 238000011282 treatment Methods 0.000 claims 30
- 206010028980 Neoplasm Diseases 0.000 claims 28
- 201000010099 disease Diseases 0.000 claims 25
- 208000035475 disorder Diseases 0.000 claims 25
- 239000013543 active substance Substances 0.000 claims 20
- 201000011510 cancer Diseases 0.000 claims 18
- 238000000034 method Methods 0.000 claims 14
- 230000002265 prevention Effects 0.000 claims 14
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 10
- 201000005787 hematologic cancer Diseases 0.000 claims 10
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 10
- 238000002560 therapeutic procedure Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 5
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 5
- 208000026310 Breast neoplasm Diseases 0.000 claims 5
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 5
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 5
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 5
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 206010033128 Ovarian cancer Diseases 0.000 claims 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 5
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 5
- 206010060862 Prostate cancer Diseases 0.000 claims 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 5
- 206010038389 Renal cancer Diseases 0.000 claims 5
- 229930013930 alkaloid Natural products 0.000 claims 5
- 229940100198 alkylating agent Drugs 0.000 claims 5
- 239000002168 alkylating agent Substances 0.000 claims 5
- 230000000340 anti-metabolite Effects 0.000 claims 5
- 229940100197 antimetabolite Drugs 0.000 claims 5
- 239000002256 antimetabolite Substances 0.000 claims 5
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 5
- 229960001467 bortezomib Drugs 0.000 claims 5
- 238000002659 cell therapy Methods 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229960003957 dexamethasone Drugs 0.000 claims 5
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 5
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 5
- 229960002949 fluorouracil Drugs 0.000 claims 5
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 5
- 235000008191 folinic acid Nutrition 0.000 claims 5
- 239000011672 folinic acid Substances 0.000 claims 5
- 208000005017 glioblastoma Diseases 0.000 claims 5
- 201000010982 kidney cancer Diseases 0.000 claims 5
- 229960004942 lenalidomide Drugs 0.000 claims 5
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 5
- 229960001691 leucovorin Drugs 0.000 claims 5
- 208000032839 leukemia Diseases 0.000 claims 5
- 201000005202 lung cancer Diseases 0.000 claims 5
- 208000020816 lung neoplasm Diseases 0.000 claims 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
- 229960000485 methotrexate Drugs 0.000 claims 5
- 201000000050 myeloid neoplasm Diseases 0.000 claims 5
- 201000002528 pancreatic cancer Diseases 0.000 claims 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
- 229960004618 prednisone Drugs 0.000 claims 5
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 5
- 229960003787 sorafenib Drugs 0.000 claims 5
- 238000001356 surgical procedure Methods 0.000 claims 5
- 229960001603 tamoxifen Drugs 0.000 claims 5
- 150000003505 terpenes Chemical class 0.000 claims 5
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 5
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 4
- 229960004528 vincristine Drugs 0.000 claims 4
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 4
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 3
- 238000009098 adjuvant therapy Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 claims 2
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 102100022716 Atypical chemokine receptor 3 Human genes 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101000678890 Homo sapiens Atypical chemokine receptor 3 Proteins 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10009397.0 | 2010-09-09 | ||
| EP10009397 | 2010-09-09 | ||
| PCT/EP2011/004554 WO2012031773A1 (en) | 2010-09-09 | 2011-09-09 | Sdf-1 binding nucleic acids and the use thereof in cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540725A JP2013540725A (ja) | 2013-11-07 |
| JP2013540725A5 true JP2013540725A5 (OSRAM) | 2014-10-30 |
| JP6243736B2 JP6243736B2 (ja) | 2017-12-06 |
Family
ID=44653255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527497A Active JP6243736B2 (ja) | 2010-09-09 | 2011-09-09 | Ｓｄｆ−１結合核酸および癌治療におけるその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20130310442A1 (OSRAM) |
| EP (1) | EP2613789B1 (OSRAM) |
| JP (1) | JP6243736B2 (OSRAM) |
| KR (1) | KR101937939B1 (OSRAM) |
| CN (1) | CN103108641B (OSRAM) |
| AU (1) | AU2011300818B2 (OSRAM) |
| BR (1) | BR112013005664B8 (OSRAM) |
| CA (1) | CA2810950C (OSRAM) |
| DK (1) | DK2613789T3 (OSRAM) |
| ES (1) | ES2678497T3 (OSRAM) |
| MX (1) | MX357770B (OSRAM) |
| RU (1) | RU2679495C2 (OSRAM) |
| SG (2) | SG10201506725QA (OSRAM) |
| WO (1) | WO2012031773A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130310442A1 (en) * | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
| WO2017178119A1 (en) * | 2016-04-15 | 2017-10-19 | Noxxon Pharma Ag | Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors |
| US20230301950A1 (en) | 2020-06-26 | 2023-09-28 | Raqualia Pharma Inc. | Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| ATE333896T1 (de) | 1998-03-24 | 2006-08-15 | Chugai Pharmaceutical Co Ltd | Vaskularisierungsinhibitoren |
| NZ507161A (en) * | 1998-03-30 | 2003-12-19 | Northwest Biotherapeutics Inc | Theraupeutic and diagonistic applications based on the role of the CXCR-4 gene in tumorigenesis |
| US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| DE60110593T2 (de) * | 2000-06-26 | 2006-01-19 | Wellstat Biologics Corp. | Entfernung von zellen mit viren |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| US20060019917A1 (en) * | 2001-05-18 | 2006-01-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
| US7468253B2 (en) | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| EP1717583A3 (en) | 2001-06-07 | 2007-10-10 | ChemoCentryx Inc | Cell migration assay |
| US7629456B2 (en) | 2001-10-26 | 2009-12-08 | Noxxon Pharma Ag | Modified L-nucleic acid |
| EP1306382A1 (de) | 2001-10-26 | 2003-05-02 | Noxxon Pharma AG | Modifizierte L-Nukleinsäure |
| ATE441706T1 (de) | 2002-02-20 | 2009-09-15 | Gen Hospital Corp | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| JP2006524242A (ja) * | 2003-03-27 | 2006-10-26 | エモリー ユニバーシティー | Ｃｘｃｒ４アンタゴニストおよびそれらの使用方法 |
| KR20060015505A (ko) | 2003-04-13 | 2006-02-17 | 엔존 파마슈티컬즈, 인코포레이티드 | 올리고뉴클레오타이드 전구약물 |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| EP2087910B1 (en) | 2004-03-23 | 2022-05-04 | Ascendis Pharma GmbH | Polymeric prodrugs |
| CN101098703B (zh) | 2004-11-05 | 2011-08-03 | 费城儿童医院 | 用于分子治疗的生物降解连接剂 |
| EP1883651A1 (en) * | 2005-05-26 | 2008-02-06 | Rappaport Family Institute For Research in the Medical Sciences | Polypeptides and compositions comprising same and methods of using same for treating cxcr4 associated medical conditions |
| US20070043012A1 (en) * | 2005-08-19 | 2007-02-22 | Bridger Gary J | Methods to enhance chemotherapy |
| RU2590709C2 (ru) * | 2006-07-18 | 2016-07-10 | Ноксон Фарма Аг | Sdf-1-связывающие нуклеиновые кислоты |
| WO2008018641A1 (en) * | 2006-08-11 | 2008-02-14 | Ono Pharmaceutical Co., Ltd. | Monoclonal antibodies against stromal derived factor-1 (sdf-1) |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| WO2008077945A2 (en) * | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies |
| PT2190991T (pt) * | 2007-08-06 | 2019-12-16 | Noxxon Pharma Ag | Ácidos nucleicos que se ligam a sdf 1 e a sua utilização |
| US20130310442A1 (en) * | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
-
2011
- 2011-09-09 US US13/821,669 patent/US20130310442A1/en not_active Abandoned
- 2011-09-09 DK DK11757776.7T patent/DK2613789T3/en active
- 2011-09-09 AU AU2011300818A patent/AU2011300818B2/en active Active
- 2011-09-09 SG SG10201506725QA patent/SG10201506725QA/en unknown
- 2011-09-09 JP JP2013527497A patent/JP6243736B2/ja active Active
- 2011-09-09 SG SG2013011150A patent/SG188220A1/en unknown
- 2011-09-09 KR KR1020137006584A patent/KR101937939B1/ko active Active
- 2011-09-09 ES ES11757776.7T patent/ES2678497T3/es active Active
- 2011-09-09 RU RU2013115739A patent/RU2679495C2/ru active
- 2011-09-09 CN CN201180043233.4A patent/CN103108641B/zh active Active
- 2011-09-09 MX MX2013002722A patent/MX357770B/es active IP Right Grant
- 2011-09-09 BR BR112013005664A patent/BR112013005664B8/pt active IP Right Grant
- 2011-09-09 EP EP11757776.7A patent/EP2613789B1/en active Active
- 2011-09-09 WO PCT/EP2011/004554 patent/WO2012031773A1/en not_active Ceased
- 2011-09-09 CA CA2810950A patent/CA2810950C/en active Active
-
2015
- 2015-11-20 US US14/947,173 patent/US9387221B2/en active Active
-
2016
- 2016-07-03 US US15/201,477 patent/US10093934B2/en active Active
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