PT2190991T - Ácidos nucleicos que se ligam a sdf 1 e a sua utilização - Google Patents

Ácidos nucleicos que se ligam a sdf 1 e a sua utilização

Info

Publication number
PT2190991T
PT2190991T PT88015268T PT08801526T PT2190991T PT 2190991 T PT2190991 T PT 2190991T PT 88015268 T PT88015268 T PT 88015268T PT 08801526 T PT08801526 T PT 08801526T PT 2190991 T PT2190991 T PT 2190991T
Authority
PT
Portugal
Prior art keywords
sdf
nucleic acids
binding nucleic
binding
acids
Prior art date
Application number
PT88015268T
Other languages
English (en)
Inventor
Purschke Werner
Jarosch Florian
Eulberg Dirk
Klussmann Sven
Buchner Klaus
Maasch Christian
Dinse Nicole
Original Assignee
Noxxon Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag
Publication of PT2190991T publication Critical patent/PT2190991T/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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PT88015268T 2007-08-06 2008-08-06 Ácidos nucleicos que se ligam a sdf 1 e a sua utilização PT2190991T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07015379 2007-08-06
EP08008312 2008-04-30
EP08011024 2008-06-18

Publications (1)

Publication Number Publication Date
PT2190991T true PT2190991T (pt) 2019-12-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PT88015268T PT2190991T (pt) 2007-08-06 2008-08-06 Ácidos nucleicos que se ligam a sdf 1 e a sua utilização

Country Status (21)

Country Link
US (3) US8772257B2 (pt)
EP (1) EP2190991B1 (pt)
JP (1) JP5815945B2 (pt)
KR (1) KR101589442B1 (pt)
CN (1) CN101796188B (pt)
AU (1) AU2008285939B2 (pt)
BR (1) BRPI0815094B8 (pt)
CA (1) CA2695061C (pt)
DK (1) DK2190991T3 (pt)
ES (1) ES2768051T3 (pt)
HK (1) HK1144956A1 (pt)
HR (1) HRP20200117T1 (pt)
HU (1) HUE047459T2 (pt)
LT (1) LT2190991T (pt)
MX (1) MX2010001490A (pt)
PL (1) PL2190991T3 (pt)
PT (1) PT2190991T (pt)
RU (1) RU2612388C2 (pt)
SG (2) SG183682A1 (pt)
SI (1) SI2190991T1 (pt)
WO (1) WO2009019007A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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AU2007214668B2 (en) * 2006-02-14 2012-05-24 TME Pharma AG MCP-I binding nucleic acids
MX2009000656A (es) 2006-07-18 2009-03-25 Noxxon Pharma Ag Acidos nucleicos que se fijan a sdf-i.
DK2190991T3 (da) 2007-08-06 2020-02-10 Noxxon Pharma Ag SDF-1-Bindende nucleinsyrer og anvendelsen deraf
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
SG10201506725QA (en) * 2010-09-09 2015-10-29 Noxxon Pharma Ag Sdf-1 binding nucleic acids and the use thereof in cancer treatment
JP5843189B2 (ja) * 2011-03-15 2016-01-13 国立大学法人名古屋大学 Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物
WO2013155347A1 (en) * 2012-04-11 2013-10-17 Izumi Raquel Bruton's tyrosine kinase inhibitors for hematopoietic mobilization
JP2016536018A (ja) 2013-10-28 2016-11-24 ドッツ テクノロジー コーポレイションＤＯＴＳ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐ． アレルゲン検出
WO2016048105A1 (ko) 2014-09-26 2016-03-31 주식회사 바이로메드 간세포 성장인자 및 기질세포 유발인자1알파를 이용한 말초동맥질환의 예방 또는 치료용 조성물
US11213613B2 (en) * 2015-06-12 2022-01-04 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Three-dimensional tissue scaffold with stem cell attracting element and use thereof
GB201522223D0 (en) * 2015-12-16 2016-01-27 Ucl Business Plc Therapeutic T cells
US11371045B2 (en) * 2016-04-15 2022-06-28 Noxxon Pharma Ag Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors
EP3570670B1 (en) 2017-01-17 2024-03-06 Children's Medical Center Corporation Compositions and methods for treating lysosomal storage diseases and disorders
WO2018136434A1 (en) 2017-01-17 2018-07-26 Children's Medical Center Corporation Compositions and methods for diagnosing and treating peroxisomal diseases
KR20230031285A (ko) 2020-06-26 2023-03-07 라퀄리아 파마 인코포레이티드 레티노이드와 암 치료제의 병용 요법이 효과적인 암 환자를 선별하는 방법 및 레티노이드와 암 치료제의 병용 의약

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
JP4974408B2 (ja) * 1998-03-24 2012-07-11 中外製薬株式会社 血管形成抑制剤
IL145310A0 (en) * 1999-03-11 2003-01-12 Rmf Dictagene Sa Vascular adhesion molecules and modulation of their function
WO2000059941A1 (en) * 1999-04-08 2000-10-12 The General Hospital Corporation Purposeful movement of human migratory cells away from an agent source
US6949243B1 (en) * 1999-11-24 2005-09-27 Schering Corporation Methods of inhibiting metastasis
EP1133988A1 (en) * 2000-03-11 2001-09-19 Biognostik Gesellschaft für biomolekulare Diagnostik mbH Mixture comprising an inhibitor or suppressor of a gene and a molecule binding to an expression product of that gene
JP5414958B2 (ja) * 2000-06-05 2014-02-12 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク ヒト骨髄由来内皮前駆細胞の同定、及び虚血性傷害後の心筋細胞の機能を改善するためのヒト骨髄由来内皮前駆細胞の使用
US7468253B2 (en) * 2001-06-07 2008-12-23 Chemocentryx, Inc. Method for multiple chemokine receptor screening for antagonists using RAM assay
KR100635703B1 (ko) * 2001-06-07 2006-10-17 케모센트릭스, 인크. 세포 이동성 검사
GB0225833D0 (en) * 2002-11-06 2002-12-11 Univ Leeds Nucleic acid ligands and uses therefor
CA2623471C (en) * 2004-09-23 2018-02-13 Arc Pharmaceuticals, Inc. Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions or inflammatory disease using low sulphate fucans
SG157417A1 (en) * 2004-11-29 2009-12-29 Noxxon Pharma Ag Vasopressin-binding l-nucleic acids
AU2007293169A1 (en) * 2006-02-02 2008-03-13 Allergan, Inc. Compositions and methods for the treatment of ophthalmic disease
MX2009000656A (es) * 2006-07-18 2009-03-25 Noxxon Pharma Ag Acidos nucleicos que se fijan a sdf-i.
ES2625798T3 (es) * 2006-10-02 2017-07-20 E. R. Squibb & Sons, L.L.C. Anticuerpos humanos que se unen a CXCR4 y usos de los mismos
WO2008052774A2 (en) * 2006-10-31 2008-05-08 Noxxon Pharma Ag Methods for detection of a single- or double-stranded nucleic acid molecule
WO2008067559A2 (en) * 2006-11-30 2008-06-05 University Of Virginia Patent Foundation Methods for treating and diagnosing fibrotic and fibroproliferative diseases
DK2190991T3 (da) * 2007-08-06 2020-02-10 Noxxon Pharma Ag SDF-1-Bindende nucleinsyrer og anvendelsen deraf
US20090274687A1 (en) * 2008-05-02 2009-11-05 University Of Miami Attenuation of hypoxia induced cardiovascular disorders

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AU2008285939A1 (en) 2009-02-12
RU2010108222A (ru) 2011-09-20
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