BRPI0815094B8 - Uso de uma molécula de ácido l-nucleico ligada a sdf-1 - Google Patents

Uso de uma molécula de ácido l-nucleico ligada a sdf-1

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Publication number
BRPI0815094B8
BRPI0815094B8 BRPI0815094A BRPI0815094A BRPI0815094B8 BR PI0815094 B8 BRPI0815094 B8 BR PI0815094B8 BR PI0815094 A BRPI0815094 A BR PI0815094A BR PI0815094 A BRPI0815094 A BR PI0815094A BR PI0815094 B8 BRPI0815094 B8 BR PI0815094B8
Authority
BR
Brazil
Prior art keywords
sdf
nucleic acid
molecule
acid molecule
acid attached
Prior art date
Application number
BRPI0815094A
Other languages
English (en)
Inventor
Purschke Werner
Jarosch Florian
Eulberg Dirk
Buchner Klaus
Maasch Christian
Dinse Nicole
Klussmann Sven
Original Assignee
Noxxon Pharma Ag
TME Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noxxon Pharma Ag, TME Pharma AG filed Critical Noxxon Pharma Ag
Publication of BRPI0815094A2 publication Critical patent/BRPI0815094A2/pt
Publication of BRPI0815094B1 publication Critical patent/BRPI0815094B1/pt
Publication of BRPI0815094B8 publication Critical patent/BRPI0815094B8/pt

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    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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Abstract

LIGAÇÃO DE MOLÉCULA DE ÁCIDO NUCLEICO A SDF-1, USO DOS MESMOS, MÉTODO PARA OBTENÇÃO DE CÉLULAS PROGENITORAS E/OU CÉLULAS-TRONCO DE UM PRIMEIRO INDIVÍDUO, MÉTODO PARA DEPLEÇÃO DE CÉLULAS DE PLASMA DE LONGA VIDA, MOLÉCULA QUE INIBE A SINALIZAÇÃO ENTRE SDF-1 E O RECEPTOR DE SDF-1 E MOLÉCULA DE LIGAÇÃO DE SDF-1 QUE NÃO ATRAVESSA A BARREIRA HEMATOENCEFÁLICA. A presente invenção refere-se a uma molécula de ácido nucleico que se liga a SDF-1, em que a molécula de ácido nucleico influencia a migração de células.
BRPI0815094A 2007-08-06 2008-08-06 Uso de uma molécula de ácido l-nucleico ligada a sdf-1 BRPI0815094B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP07015379 2007-08-06
EP07015379.6 2007-08-06
EP08008312 2008-04-30
EP08008312.4 2008-04-30
EP08011024.0 2008-06-18
EP08011024 2008-06-18
PCT/EP2008/006473 WO2009019007A2 (en) 2007-08-06 2008-08-06 Sdf-1 binding nucleic acids and the use thereof

Publications (3)

Publication Number Publication Date
BRPI0815094A2 BRPI0815094A2 (pt) 2015-02-03
BRPI0815094B1 BRPI0815094B1 (pt) 2020-09-24
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2135949T3 (pl) * 2006-02-14 2013-03-29 Noxxon Pharma Ag Kwasy nukleinowe wiążące MCP-1
MX2009000656A (es) 2006-07-18 2009-03-25 Noxxon Pharma Ag Acidos nucleicos que se fijan a sdf-i.
AU2008285939B2 (en) * 2007-08-06 2014-09-18 TME Pharma AG SDF-1 binding nucleic acids and the use thereof
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
WO2012031773A1 (en) * 2010-09-09 2012-03-15 Noxxon Pharma Ag Sdf-1 binding nucleic acids and the use thereof in cancer treatment
JP5843189B2 (ja) * 2011-03-15 2016-01-13 国立大学法人名古屋大学 Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物
ES2681050T3 (es) * 2012-04-11 2018-09-11 Acerta Pharma B.V. Inhibidores de la tirosina quinasa de Bruton para la movilización hematopoyética
CA3120508A1 (en) 2013-10-28 2015-05-07 Dots Technology Corp. Allergen detection
WO2016048105A1 (ko) * 2014-09-26 2016-03-31 주식회사 바이로메드 간세포 성장인자 및 기질세포 유발인자1알파를 이용한 말초동맥질환의 예방 또는 치료용 조성물
WO2016197491A1 (en) * 2015-06-12 2016-12-15 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences A three-dimensional tissue scaffold with stem cell attracting element and use thereof
GB201522223D0 (en) * 2015-12-16 2016-01-27 Ucl Business Plc Therapeutic T cells
EP3443095A1 (en) * 2016-04-15 2019-02-20 Noxxon Pharma AG Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors
US11548936B2 (en) 2017-01-17 2023-01-10 Children's Medical Center Corporation Compositions and methods for treating lysosomal storage diseases and disorders
WO2018136434A1 (en) 2017-01-17 2018-07-26 Children's Medical Center Corporation Compositions and methods for diagnosing and treating peroxisomal diseases
CA3184767A1 (en) 2020-06-26 2021-12-30 Raqualia Pharma Inc. Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5567588A (en) * 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5840867A (en) * 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
EP1745797A3 (en) * 1998-03-24 2007-07-18 Chugai Seiyaku Kabushiki Kaisha Vascularization inhibitors
NZ514091A (en) * 1999-03-11 2004-01-30 Rmf Dictagene S Vascular adhesion molecules and modulation of their function
AU4230900A (en) * 1999-04-08 2000-10-23 General Hospital Corporation, The Purposeful movement of human migratory cells away from an agent source
US6949243B1 (en) * 1999-11-24 2005-09-27 Schering Corporation Methods of inhibiting metastasis
EP1133988A1 (en) * 2000-03-11 2001-09-19 Biognostik Gesellschaft für biomolekulare Diagnostik mbH Mixture comprising an inhibitor or suppressor of a gene and a molecule binding to an expression product of that gene
WO2001094420A1 (en) * 2000-06-05 2001-12-13 The Trustees Of Columbia University In The City Of New York Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury
JP4233092B2 (ja) * 2001-06-07 2009-03-04 ケモセントリックス， インコーポレイテッド 細胞移動アッセイ
US7468253B2 (en) * 2001-06-07 2008-12-23 Chemocentryx, Inc. Method for multiple chemokine receptor screening for antagonists using RAM assay
GB0225833D0 (en) * 2002-11-06 2002-12-11 Univ Leeds Nucleic acid ligands and uses therefor
DK1809303T3 (da) * 2004-09-23 2019-06-11 Arc Medical Devices Inc Farmaceutisk sammensætning og metoder i relation til hæmning af fibrøs adhæsion eller inflammatoriske lidelser ved brug af lavsulfat-fucan
CA2588980A1 (en) * 2004-11-29 2006-06-08 Noxxon Pharma Ag Vasopressin-binding l-nucleic acid
EP2407171A3 (en) * 2006-02-02 2012-04-11 Allergan, Inc. Compositions and methods for the treatment of ophthalmic disease
MX2009000656A (es) * 2006-07-18 2009-03-25 Noxxon Pharma Ag Acidos nucleicos que se fijan a sdf-i.
KR20150065959A (ko) * 2006-10-02 2015-06-15 메다렉스, 엘.엘.시. Ｃｘｃｒ4에 결합하는 인간 항체 및 이의 용도
US20100062436A1 (en) * 2006-10-31 2010-03-11 Noxxon Pharma Ag Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule
WO2008067559A2 (en) * 2006-11-30 2008-06-05 University Of Virginia Patent Foundation Methods for treating and diagnosing fibrotic and fibroproliferative diseases
AU2008285939B2 (en) * 2007-08-06 2014-09-18 TME Pharma AG SDF-1 binding nucleic acids and the use thereof
US20090274687A1 (en) * 2008-05-02 2009-11-05 University Of Miami Attenuation of hypoxia induced cardiovascular disorders

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CA2695061A1 (en) 2009-02-12
CN101796188B (zh) 2014-10-29
MX2010001490A (es) 2010-03-04
PT2190991T (pt) 2019-12-16
AU2008285939B2 (en) 2014-09-18
KR101589442B1 (ko) 2016-02-01
ES2768051T3 (es) 2020-06-19
BRPI0815094A2 (pt) 2015-02-03
LT2190991T (lt) 2020-02-10
US20140370034A1 (en) 2014-12-18
SG10201600632QA (en) 2016-03-30
RU2010108222A (ru) 2011-09-20
US9988636B2 (en) 2018-06-05
SI2190991T1 (sl) 2020-03-31
PL2190991T3 (pl) 2020-05-18
WO2009019007A3 (en) 2009-04-16
AU2008285939A1 (en) 2009-02-12
BRPI0815094B1 (pt) 2020-09-24
CA2695061C (en) 2021-10-19
KR20100050500A (ko) 2010-05-13
HUE047459T2 (hu) 2020-04-28
US20110223127A1 (en) 2011-09-15
EP2190991A2 (en) 2010-06-02
JP5815945B2 (ja) 2015-11-17
EP2190991B1 (en) 2019-11-06
US8772257B2 (en) 2014-07-08
JP2010535479A (ja) 2010-11-25
HK1144956A1 (en) 2011-03-18
WO2009019007A2 (en) 2009-02-12
RU2612388C2 (ru) 2017-03-09
HRP20200117T1 (hr) 2020-04-03
CN101796188A (zh) 2010-08-04
SG183682A1 (en) 2012-09-27
DK2190991T3 (da) 2020-02-10

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