BR112017025051A2 - ensaio celular para detecção de homodímeros anti-cd3 - Google Patents
ensaio celular para detecção de homodímeros anti-cd3Info
- Publication number
- BR112017025051A2 BR112017025051A2 BR112017025051-9A BR112017025051A BR112017025051A2 BR 112017025051 A2 BR112017025051 A2 BR 112017025051A2 BR 112017025051 A BR112017025051 A BR 112017025051A BR 112017025051 A2 BR112017025051 A2 BR 112017025051A2
- Authority
- BR
- Brazil
- Prior art keywords
- homodimers
- detection
- cell
- cellular assay
- tdb
- Prior art date
Links
- 238000000423 cell based assay Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 230000006044 T cell activation Effects 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Eye Examination Apparatus (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção refere-se a um ensaio baseado em células para identificar e/ou quantificar homodímeros anti-cd3 em uma composição compreendendo um anticorpo biespecífico dependente de células t (tdb). em alguns aspectos, as células t da invenção compreendendo um repórter que responde à ativação de células t são contatadas com o tdb para detectar a presença de homodímeros anti-cd3. composições de células t repórter e kits também são contemplados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562167761P | 2015-05-28 | 2015-05-28 | |
US62/167,761 | 2015-05-28 | ||
PCT/US2016/034868 WO2016191750A1 (en) | 2015-05-28 | 2016-05-27 | Cell-based assay for detecting anti-cd3 homodimers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017025051A2 true BR112017025051A2 (pt) | 2018-08-07 |
Family
ID=56236065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017025051-9A BR112017025051A2 (pt) | 2015-05-28 | 2016-05-27 | ensaio celular para detecção de homodímeros anti-cd3 |
Country Status (16)
Country | Link |
---|---|
US (2) | US10690678B2 (pt) |
EP (2) | EP3303400B1 (pt) |
JP (1) | JP6810058B2 (pt) |
KR (1) | KR102583058B1 (pt) |
CN (1) | CN107646038B (pt) |
AU (1) | AU2016267691B2 (pt) |
BR (1) | BR112017025051A2 (pt) |
CA (1) | CA2987403A1 (pt) |
ES (1) | ES2823033T3 (pt) |
HK (1) | HK1250045A1 (pt) |
HR (1) | HRP20201779T1 (pt) |
IL (1) | IL255696B (pt) |
MX (1) | MX2017015011A (pt) |
SG (1) | SG10201911335TA (pt) |
SI (1) | SI3303400T1 (pt) |
WO (1) | WO2016191750A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110156893B (zh) | 2013-12-17 | 2023-03-03 | 基因泰克公司 | 抗cd3抗体及使用方法 |
EP3191520B1 (en) | 2014-09-12 | 2020-01-01 | Genentech, Inc. | Anti-cll-1 antibodies and immunoconjugates |
CN107646038B (zh) | 2015-05-28 | 2021-08-20 | 基因泰克公司 | 用于检测抗cd3同二聚体的基于细胞的测定 |
AR105026A1 (es) | 2015-06-16 | 2017-08-30 | Genentech Inc | ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO |
TW201718647A (zh) | 2015-06-16 | 2017-06-01 | 建南德克公司 | 抗-cll-1抗體及使用方法 |
CN109073635A (zh) | 2016-01-25 | 2018-12-21 | 豪夫迈·罗氏有限公司 | 用于测定t细胞依赖性双特异性抗体的方法 |
TWI791471B (zh) | 2016-11-15 | 2023-02-11 | 美商建南德克公司 | 用於用抗cd20/抗cd3雙特異性抗體進行治療之給藥 |
WO2018108759A1 (en) * | 2016-12-13 | 2018-06-21 | F. Hoffmann-La Roche Ag | Method to determine the presence of a target antigen in a tumor sample |
AR115360A1 (es) | 2018-02-08 | 2021-01-13 | Genentech Inc | Moléculas de unión al antígeno y métodos de uso |
CN108918892B (zh) * | 2018-08-01 | 2021-04-27 | 百奥泰生物制药股份有限公司 | 一种测定抗vegf抗体活性的方法及其应用 |
TW202028244A (zh) * | 2018-10-09 | 2020-08-01 | 美商建南德克公司 | 用於確定突觸形成之方法及系統 |
KR20220113790A (ko) | 2019-12-13 | 2022-08-16 | 제넨테크, 인크. | 항-ly6g6d 항체 및 사용 방법 |
CN111077311B (zh) * | 2019-12-30 | 2023-05-09 | 北京立康生命科技有限公司 | 一种酶联免疫斑点检测试剂盒及其检测方法 |
CN112433055A (zh) * | 2020-11-04 | 2021-03-02 | 上海药明生物技术有限公司 | 一种基于报告基因方法检测pvrig抗体的生物学活性的方法 |
CN112458149B (zh) * | 2020-12-03 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种以cd3为靶点的抗体药物对t细胞激活程度的检测方法 |
CN112921004B (zh) * | 2021-02-05 | 2023-08-08 | 上海精翰生物科技有限公司 | 用于cd3受体激动剂检测的细胞株及其构建方法及cd3受体激动剂检测方法 |
CN114395047B (zh) * | 2021-12-07 | 2023-11-07 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
WO2023250485A1 (en) | 2022-06-23 | 2023-12-28 | LAVA Therapeutics N.V. | Assay for t cell dependent multispecific compounds |
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2016
- 2016-05-27 CN CN201680030308.8A patent/CN107646038B/zh active Active
- 2016-05-27 AU AU2016267691A patent/AU2016267691B2/en active Active
- 2016-05-27 MX MX2017015011A patent/MX2017015011A/es unknown
- 2016-05-27 WO PCT/US2016/034868 patent/WO2016191750A1/en active Application Filing
- 2016-05-27 BR BR112017025051-9A patent/BR112017025051A2/pt active Search and Examination
- 2016-05-27 EP EP16732377.3A patent/EP3303400B1/en active Active
- 2016-05-27 CA CA2987403A patent/CA2987403A1/en active Pending
- 2016-05-27 JP JP2017561777A patent/JP6810058B2/ja active Active
- 2016-05-27 SG SG10201911335TA patent/SG10201911335TA/en unknown
- 2016-05-27 EP EP20190490.1A patent/EP3795679A1/en not_active Withdrawn
- 2016-05-27 KR KR1020177036974A patent/KR102583058B1/ko active IP Right Grant
- 2016-05-27 ES ES16732377T patent/ES2823033T3/es active Active
- 2016-05-27 SI SI201631004T patent/SI3303400T1/sl unknown
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2017
- 2017-11-15 IL IL255696A patent/IL255696B/en unknown
- 2017-11-28 US US15/824,992 patent/US10690678B2/en active Active
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2018
- 2018-07-23 HK HK18109493.3A patent/HK1250045A1/zh unknown
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2020
- 2020-05-14 US US16/874,550 patent/US12007398B2/en active Active
- 2020-11-04 HR HRP20201779TT patent/HRP20201779T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
US20200378987A1 (en) | 2020-12-03 |
CA2987403A1 (en) | 2016-12-01 |
KR102583058B1 (ko) | 2023-09-25 |
IL255696A (en) | 2018-01-31 |
AU2016267691B2 (en) | 2022-06-16 |
AU2016267691A1 (en) | 2017-12-21 |
US10690678B2 (en) | 2020-06-23 |
SG10201911335TA (en) | 2020-01-30 |
EP3303400B1 (en) | 2020-09-09 |
EP3795679A1 (en) | 2021-03-24 |
HRP20201779T1 (hr) | 2021-01-22 |
US12007398B2 (en) | 2024-06-11 |
MX2017015011A (es) | 2018-03-23 |
CN107646038A (zh) | 2018-01-30 |
JP2018521635A (ja) | 2018-08-09 |
WO2016191750A1 (en) | 2016-12-01 |
CN107646038B (zh) | 2021-08-20 |
ES2823033T3 (es) | 2021-05-05 |
IL255696B (en) | 2022-04-01 |
SI3303400T1 (sl) | 2021-01-29 |
HK1250045A1 (zh) | 2018-11-23 |
EP3303400A1 (en) | 2018-04-11 |
JP6810058B2 (ja) | 2021-01-06 |
KR20180013986A (ko) | 2018-02-07 |
US20180267055A1 (en) | 2018-09-20 |
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