JP2013539747A5 - - Google Patents
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- Publication number
- JP2013539747A5 JP2013539747A5 JP2013528294A JP2013528294A JP2013539747A5 JP 2013539747 A5 JP2013539747 A5 JP 2013539747A5 JP 2013528294 A JP2013528294 A JP 2013528294A JP 2013528294 A JP2013528294 A JP 2013528294A JP 2013539747 A5 JP2013539747 A5 JP 2013539747A5
- Authority
- JP
- Japan
- Prior art keywords
- cyano
- phenyl
- xanthine oxidoreductase
- oxidoreductase inhibitor
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 74
- 229940122272 Oxidoreductase inhibitor Drugs 0.000 claims 43
- 108010091383 Xanthine dehydrogenase Proteins 0.000 claims 43
- 102000005773 Xanthine dehydrogenase Human genes 0.000 claims 43
- 108010093894 Xanthine oxidase Proteins 0.000 claims 43
- 239000002457 oxidoreductase inhibitor Substances 0.000 claims 43
- 229960000278 theophylline Drugs 0.000 claims 37
- 201000010099 disease Diseases 0.000 claims 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 33
- 201000005569 Gout Diseases 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 12
- FFDDWBJYRJGZQH-UHFFFAOYSA-N 2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound S1C(C(O)=O)=C(C)N=C1C1=CC=C(OCC(C)(C)O)C(C#N)=C1 FFDDWBJYRJGZQH-UHFFFAOYSA-N 0.000 claims 8
- FPODSLPQWIIKKI-UHFFFAOYSA-N 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound C1=C(C#N)C(OCC(CO)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 FPODSLPQWIIKKI-UHFFFAOYSA-N 0.000 claims 8
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical group C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 8
- 201000001431 Hyperuricemia Diseases 0.000 claims 7
- 206010020772 Hypertension Diseases 0.000 claims 6
- 206010029148 Nephrolithiasis Diseases 0.000 claims 6
- 208000017169 kidney disease Diseases 0.000 claims 6
- 206010006458 Bronchitis chronic Diseases 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 5
- 206010014561 Emphysema Diseases 0.000 claims 5
- 208000001647 Renal Insufficiency Diseases 0.000 claims 5
- 208000007718 Stable Angina Diseases 0.000 claims 5
- 206010046337 Urate nephropathy Diseases 0.000 claims 5
- 230000001154 acute effect Effects 0.000 claims 5
- 208000008784 apnea Diseases 0.000 claims 5
- 206010003246 arthritis Diseases 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 5
- 230000036471 bradycardia Effects 0.000 claims 5
- 208000006218 bradycardia Diseases 0.000 claims 5
- 206010006451 bronchitis Diseases 0.000 claims 5
- 208000007451 chronic bronchitis Diseases 0.000 claims 5
- 230000001684 chronic effect Effects 0.000 claims 5
- 201000006370 kidney failure Diseases 0.000 claims 5
- 230000000750 progressive effect Effects 0.000 claims 5
- ZJDGVDDELZNDRA-UHFFFAOYSA-N 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound S1C(C(O)=O)=C(C)N=C1C1=CC=C(O)C(C#N)=C1 ZJDGVDDELZNDRA-UHFFFAOYSA-N 0.000 claims 4
- -1 3- (2-methyl-4-pyridyl) -5-cyano-4-isobutoxyphenyl Chemical group 0.000 claims 4
- CCUJKCXSZIJMAO-UHFFFAOYSA-N C(#N)C=1C=C(C=CC1OCC(C)(C)C)N1N=CC(=C1)C(=O)O.C(=O)(O)C(COC1=C(C=C(C=C1)C=1SC(=C(N1)C)C(=O)O)C#N)C Chemical compound C(#N)C=1C=C(C=CC1OCC(C)(C)C)N1N=CC(=C1)C(=O)O.C(=O)(O)C(COC1=C(C=C(C=C1)C=1SC(=C(N1)C)C(=O)O)C#N)C CCUJKCXSZIJMAO-UHFFFAOYSA-N 0.000 claims 4
- 201000001509 acute urate nephropathy Diseases 0.000 claims 4
- 238000011260 co-administration Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 208000026101 uric acid urolithiasis Diseases 0.000 claims 4
- 230000000977 initiatory effect Effects 0.000 claims 2
- 206010007027 Calculus urinary Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000007094 prostatitis Diseases 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 208000008281 urolithiasis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38148210P | 2010-09-10 | 2010-09-10 | |
| US61/381,482 | 2010-09-10 | ||
| PCT/US2011/050870 WO2012033941A1 (en) | 2010-09-10 | 2011-09-08 | Methods for concomitant treatment of theophylline and febuxostat |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539747A JP2013539747A (ja) | 2013-10-28 |
| JP2013539747A5 true JP2013539747A5 (https=) | 2014-10-23 |
| JP5978216B2 JP5978216B2 (ja) | 2016-08-24 |
Family
ID=44653592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013528294A Active JP5978216B2 (ja) | 2010-09-10 | 2011-09-08 | テオフィリンとフェブキソスタットの併用療法のための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9107912B2 (https=) |
| EP (1) | EP2613780B1 (https=) |
| JP (1) | JP5978216B2 (https=) |
| KR (1) | KR101797936B1 (https=) |
| CN (1) | CN103298466B (https=) |
| AU (1) | AU2011299153B2 (https=) |
| BR (1) | BR112013005792A8 (https=) |
| CA (1) | CA2812034C (https=) |
| ES (1) | ES2532210T3 (https=) |
| RU (1) | RU2013109380A (https=) |
| WO (1) | WO2012033941A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1883405A4 (en) * | 2005-05-09 | 2010-01-27 | Takeda Pharmaceuticals North A | METHODS OF TREATING NEPHROLITHIASIS |
| JP5242393B2 (ja) * | 2005-08-03 | 2013-07-24 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | 高血圧症の治療方法 |
| US20090124623A1 (en) * | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
| KR20150024919A (ko) * | 2006-11-13 | 2015-03-09 | 다케다 파마슈티칼스 유에스에이, 인코포레이티드 | 크산틴 옥시도리덕타아제 억제제를 사용하여 신장 기능을 보존하는 방법 |
| AU2008206231A1 (en) * | 2007-01-19 | 2008-07-24 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents |
| US20100311756A1 (en) * | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
| CA2812034C (en) | 2010-09-10 | 2018-10-23 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for concomitant treatment of theophylline and febuxostat |
| CN103862983B (zh) * | 2012-12-12 | 2016-12-21 | 石狮市冠鑫反光材料有限公司 | 3d立体画制作工艺 |
| ES2552706B1 (es) * | 2014-05-29 | 2016-09-13 | Universitat De Les Illes Balears | La teobromina y sus derivados para el tratamiento o prevenciónde la litiasis renal |
| KR102133290B1 (ko) * | 2018-10-23 | 2020-07-13 | 연세대학교 산학협력단 | 결핵의 예방 또는 치료용 조성물 |
| CN120271528B (zh) * | 2025-04-08 | 2025-08-22 | 中国食品药品检定研究院 | 一种非布司他与苦豆碱共无定型物及其制备方法和应用 |
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| JP5242393B2 (ja) * | 2005-08-03 | 2013-07-24 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | 高血圧症の治療方法 |
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| US20090124623A1 (en) | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
| KR20150024919A (ko) | 2006-11-13 | 2015-03-09 | 다케다 파마슈티칼스 유에스에이, 인코포레이티드 | 크산틴 옥시도리덕타아제 억제제를 사용하여 신장 기능을 보존하는 방법 |
| AU2008206231A1 (en) * | 2007-01-19 | 2008-07-24 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents |
| MX2007011927A (es) | 2007-09-26 | 2009-03-26 | World Trade Imp Export Wtie Ag | Composiciones farmaceuticas que comprenden la combinacion de un agente antiinflamatorio no esteroideo y un agente inhibidor de la xantino oxidasa utiles para el control y tratamiento de la gota, artritis gotosa y enfermedades relacionadas. |
| US20100311756A1 (en) | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
| AR082022A1 (es) | 2010-06-25 | 2012-11-07 | Teijin Pharma Ltd | Agente terapeutico de liberacion sostenida para la hipertension y la disfuncion renal |
| NZ605562A (en) | 2010-07-09 | 2013-11-29 | Teijin Pharma Ltd | Deuterated benzylbenzene derivatives and methods of use |
| CA2812034C (en) | 2010-09-10 | 2018-10-23 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for concomitant treatment of theophylline and febuxostat |
-
2011
- 2011-09-08 CA CA2812034A patent/CA2812034C/en not_active Expired - Fee Related
- 2011-09-08 WO PCT/US2011/050870 patent/WO2012033941A1/en not_active Ceased
- 2011-09-08 KR KR1020137009027A patent/KR101797936B1/ko not_active Expired - Fee Related
- 2011-09-08 JP JP2013528294A patent/JP5978216B2/ja active Active
- 2011-09-08 AU AU2011299153A patent/AU2011299153B2/en not_active Ceased
- 2011-09-08 CN CN201180054390.5A patent/CN103298466B/zh not_active Expired - Fee Related
- 2011-09-08 BR BR112013005792A patent/BR112013005792A8/pt not_active Application Discontinuation
- 2011-09-08 US US13/227,828 patent/US9107912B2/en active Active
- 2011-09-08 RU RU2013109380/15A patent/RU2013109380A/ru unknown
- 2011-09-08 ES ES11758053.0T patent/ES2532210T3/es active Active
- 2011-09-08 EP EP20110758053 patent/EP2613780B1/en not_active Revoked
- 2011-10-27 US US13/282,659 patent/US20120065207A1/en not_active Abandoned
- 2011-11-14 US US13/295,696 patent/US8372872B2/en active Active
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