JP2012502914A5 - - Google Patents
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- Publication number
- JP2012502914A5 JP2012502914A5 JP2011527043A JP2011527043A JP2012502914A5 JP 2012502914 A5 JP2012502914 A5 JP 2012502914A5 JP 2011527043 A JP2011527043 A JP 2011527043A JP 2011527043 A JP2011527043 A JP 2011527043A JP 2012502914 A5 JP2012502914 A5 JP 2012502914A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- scyllo
- inositol
- uric acid
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 claims 20
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 20
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 19
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 18
- 229940116269 uric acid Drugs 0.000 claims 18
- 239000002552 dosage form Substances 0.000 claims 16
- 201000005569 Gout Diseases 0.000 claims 7
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 4
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 201000001320 Atherosclerosis Diseases 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 206010020772 Hypertension Diseases 0.000 claims 3
- 201000001431 Hyperuricemia Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000013265 extended release Methods 0.000 claims 3
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
- 208000017169 kidney disease Diseases 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 206010007027 Calculus urinary Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000034189 Sclerosis Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 210000002565 arteriole Anatomy 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000004575 stone Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000008281 urolithiasis Diseases 0.000 claims 2
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000019838 Blood disease Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 208000000913 Kidney Calculi Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010029148 Nephrolithiasis Diseases 0.000 claims 1
- 208000008601 Polycythemia Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9702308P | 2008-09-15 | 2008-09-15 | |
| US61/097,023 | 2008-09-15 | ||
| PCT/US2009/056985 WO2010031051A1 (en) | 2008-09-15 | 2009-09-15 | Methods of treatment of hyperuricemia and associated disease states |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502914A JP2012502914A (ja) | 2012-02-02 |
| JP2012502914A5 true JP2012502914A5 (https=) | 2012-11-08 |
| JP5685192B2 JP5685192B2 (ja) | 2015-03-18 |
Family
ID=41319433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527043A Active JP5685192B2 (ja) | 2008-09-15 | 2009-09-15 | 高尿酸血症と関連病態の治療の方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8748496B2 (https=) |
| EP (1) | EP2349280B1 (https=) |
| JP (1) | JP5685192B2 (https=) |
| AR (1) | AR073514A1 (https=) |
| AU (1) | AU2009290612B2 (https=) |
| CA (1) | CA2737163C (https=) |
| ES (1) | ES2521674T3 (https=) |
| TW (1) | TW201016208A (https=) |
| WO (2) | WO2010031051A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| SG161247A1 (en) | 2005-04-11 | 2010-05-27 | Savient Pharmaceuticals Inc | Variant forms of urate oxidase and use thereof |
| US9377454B2 (en) | 2009-06-25 | 2016-06-28 | Crealta Pharmaceuticals Llc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| CN102726721A (zh) * | 2011-12-21 | 2012-10-17 | 聂存良 | 一种平衡性的微量元素排铅口服液 |
| US20160303050A1 (en) * | 2015-04-20 | 2016-10-20 | Twi Biotechnology, Inc. | Formulations containing diacerein and methods of lowering blood levels of uric acid using the same |
| CN116637177A (zh) | 2016-11-11 | 2023-08-25 | 好利恩治疗美国公司 | 泼尼松和尿酸酶分子的组合疗法及其用途 |
| CN109666687B (zh) * | 2018-12-14 | 2020-08-04 | 艾美科健（中国）生物医药有限公司 | 一种生物转化生产鲨肌醇的大肠埃希氏菌工程菌株及其构建方法和应用 |
| WO2020160322A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Tolerization reduces intolerance to pegloticase and prolongs the urate lowering effect (triple) |
| WO2020160325A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| EP1824496A4 (en) | 2004-11-17 | 2008-07-16 | Joanne Mclaurin | COMPOSITIONS OF SCYLLO-INOSITOL DERIVATIVES AND METHOD FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS |
| WO2008082658A2 (en) * | 2006-12-29 | 2008-07-10 | Normoxys, Inc. | Cyclitols and their derivatives and their therapeutic applications |
-
2009
- 2009-09-15 ES ES09792556.4T patent/ES2521674T3/es active Active
- 2009-09-15 TW TW098131051A patent/TW201016208A/zh unknown
- 2009-09-15 US US12/560,113 patent/US8748496B2/en active Active
- 2009-09-15 JP JP2011527043A patent/JP5685192B2/ja active Active
- 2009-09-15 CA CA2737163A patent/CA2737163C/en active Active
- 2009-09-15 EP EP09792556.4A patent/EP2349280B1/en active Active
- 2009-09-15 WO PCT/US2009/056985 patent/WO2010031051A1/en not_active Ceased
- 2009-09-15 AR ARP090103535A patent/AR073514A1/es unknown
- 2009-09-15 AU AU2009290612A patent/AU2009290612B2/en active Active
- 2009-09-15 WO PCT/US2009/057003 patent/WO2010031061A1/en not_active Ceased
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