JP2013537203A - 三環式化合物、製造方法、およびそれらの使用 - Google Patents

三環式化合物、製造方法、およびそれらの使用 Download PDF

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JP2013537203A
JP2013537203A JP2013528497A JP2013528497A JP2013537203A JP 2013537203 A JP2013537203 A JP 2013537203A JP 2013528497 A JP2013528497 A JP 2013528497A JP 2013528497 A JP2013528497 A JP 2013528497A JP 2013537203 A JP2013537203 A JP 2013537203A
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trifluoromethyl
oxy
chloro
phenyl
dihydro
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JP2013537203A5 (https=
Inventor
ゼホン、ワン
ツァン、シャオミン
トン、ザオロン
ロン、カイ
サラ、イー.ダウデル
エリック、スティーブン、マナス
クリスタ、ビーバー、グッドマン
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013528497A 2010-09-20 2011-09-20 三環式化合物、製造方法、およびそれらの使用 Pending JP2013537203A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2010077154 2010-09-20
CNPCT/CN2010/077154 2010-09-20
PCT/CN2011/001597 WO2012037782A1 (en) 2010-09-20 2011-09-20 Tricyclic compounds, preparation methods, and their uses

Publications (2)

Publication Number Publication Date
JP2013537203A true JP2013537203A (ja) 2013-09-30
JP2013537203A5 JP2013537203A5 (https=) 2014-05-22

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JP2013528497A Pending JP2013537203A (ja) 2010-09-20 2011-09-20 三環式化合物、製造方法、およびそれらの使用

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US (2) US8871928B2 (https=)
EP (1) EP2619203A4 (https=)
JP (1) JP2013537203A (https=)
WO (1) WO2012037782A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017520613A (ja) * 2014-07-22 2017-07-27 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化合物
JP2018502105A (ja) * 2014-12-26 2018-01-25 中国科学院上海薬物研究所 Lp−PLA2阻害剤として用いられるピリミジノン系化合物およびその薬物組成物
KR20230028550A (ko) * 2020-07-10 2023-02-28 뉴스코 바이오테크 리미티드 트리사이클릭 피리미디논 화합물 및 그의 조성물의 제조 및 적용

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DK2731935T3 (en) * 2011-07-13 2016-06-06 Basf Agro Bv FUNGICIDE SUBSTITUTED 2- [2-HALOGENALKYL-4- (PHENOXY) -PHENYL] -1- [1,2,4] TRIAZOL-1-YLETHANOL COMPOUNDS
EP2731934A1 (en) 2011-07-15 2014-05-21 Basf Se Fungicidal alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds
EA201400137A1 (ru) 2011-07-15 2014-06-30 Басф Се Фунгицидные алкилзамещенные 2-[2-хлоро-4-(4-хлорофенокси)фенил]-1-[1,2,4]триазол-1-ил-этанольные соединения
EP2744791B1 (en) 2011-08-15 2015-10-28 Basf Se Fungicidal substituted 1-{2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-2-alkoxy-3-methyl-butyl}-1h-[1,2,4]triazole compounds
CN103717577B (zh) 2011-08-15 2016-06-15 巴斯夫欧洲公司 杀真菌的取代的1-{2-环基氧基-2-[2-卤代-4-(4-卤代苯氧基)苯基]乙基}-1h-[1,2,4]三唑化合物
AR087538A1 (es) 2011-08-15 2014-04-03 Basf Se Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-alcoxi-2-alquinil/alquenil-etil}-1h-[1,2,4]triazol sustituidos
SI2751094T1 (sl) 2011-09-01 2018-10-30 Glaxo Group Limited Nova kristalinična oblika
EA030875B1 (ru) 2012-12-20 2018-10-31 Басф Агро Б.В. Композиции, содержащие триазольное соединение
CA2895256C (en) 2013-01-09 2021-06-01 BASF Agro B.V. Process for the preparation of substituted oxiranes and triazoles
BR112015017397A2 (pt) * 2013-01-25 2017-07-11 Glaxosmithkline Ip Dev Ltd compostos pirimidona bicíclica como inibidores de lp-pla2
US9051325B2 (en) 2013-01-25 2015-06-09 Glaxo Group Limited Bicyclic [5,6] imidazo pyrimodone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2
UY35276A (es) * 2013-01-25 2014-08-29 Glaxosmithkline Ip Dev Ltd Nuevos compuestos que inhiben la actividad de Lp-PLA2
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
CN106028817A (zh) 2013-07-08 2016-10-12 巴斯夫农业公司 包含三唑化合物和生物农药的组合物
WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
EA201892682A1 (ru) 2014-06-25 2019-04-30 Басф Агро Б.В. Пестицидные композиции
UA120628C2 (uk) 2014-11-07 2020-01-10 Басф Се Пестицидні суміші
GB201506894D0 (en) 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
MX2018001885A (es) 2015-08-14 2018-08-16 Bayer Cropscience Ag Derivados de triazol, sus intermediarios y su utilizacion como fungicidas.
WO2017093120A1 (en) 2015-12-01 2017-06-08 Basf Se Pyridine compounds as fungicides
EP3383849B1 (en) 2015-12-01 2020-01-08 Basf Se Pyridine compounds as fungicides
ES3056157T3 (en) 2016-03-16 2026-02-18 Basf Se Use of a specific tetrazolinone for combating resistant phytopathogenic fungi on cereals
US11241012B2 (en) 2016-03-16 2022-02-08 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on soybean
CA3015456C (en) 2016-03-16 2024-09-17 Basf Se USE OF TETRAZOLINONES TO CONTROL RESISTANT PLANT PATHOGENIC FUNGI ON FRUIT
CN107011137B (zh) * 2017-04-10 2020-09-11 杭州科耀医药科技有限公司 一种匹莫范色林中间体的合成方法
CR20190580A (es) 2017-05-30 2020-02-10 Basf Se Compuestos de piridina y pirazina
CN110818653B (zh) * 2019-11-08 2021-12-28 暨南大学 苯并噻二嗪类化合物及其应用、ampar的正电子药物
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁(上海)医药科技有限公司 一种2-(三氟甲基)嘧啶-5-醇的合成方法
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
AU2024309346C1 (en) 2023-06-26 2026-03-12 Verona Pharma Plc Particulate composition comprising ensifentrine
TWI896037B (zh) 2023-07-17 2025-09-01 大陸商上海樞境生物科技有限公司 雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用
CN119241534B (zh) * 2024-09-18 2025-12-05 武汉九州钰民医药科技有限公司 一种恩塞芬汀的制备方法

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JP2001519798A (ja) * 1997-04-10 2001-10-23 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 抗痙攣作用を有するピリミド−イソキノリン化合物
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
JP2011088847A (ja) * 2009-10-21 2011-05-06 Takeda Chem Ind Ltd 三環性化合物およびその用途

Patent Citations (3)

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JP2001519798A (ja) * 1997-04-10 2001-10-23 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 抗痙攣作用を有するピリミド−イソキノリン化合物
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
JP2011088847A (ja) * 2009-10-21 2011-05-06 Takeda Chem Ind Ltd 三環性化合物およびその用途

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017520613A (ja) * 2014-07-22 2017-07-27 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化合物
JP2017521456A (ja) * 2014-07-22 2017-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化合物
JP2018502105A (ja) * 2014-12-26 2018-01-25 中国科学院上海薬物研究所 Lp−PLA2阻害剤として用いられるピリミジノン系化合物およびその薬物組成物
KR20230028550A (ko) * 2020-07-10 2023-02-28 뉴스코 바이오테크 리미티드 트리사이클릭 피리미디논 화합물 및 그의 조성물의 제조 및 적용
JP2023532698A (ja) * 2020-07-10 2023-07-31 上海紐思克生物科技有限公司 三環系ピリミジノン類化合物、その製造方法、その組成物及び使用
JP7548606B2 (ja) 2020-07-10 2024-09-10 上海紐思克生物科技有限公司 三環系ピリミジノン類化合物、その製造方法、その組成物及び使用
KR102926858B1 (ko) 2020-07-10 2026-02-13 뉴스코 바이오테크 리미티드 트리사이클릭 피리미디논 화합물 및 그의 조성물의 제조 및 적용

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Publication number Publication date
WO2012037782A1 (en) 2012-03-29
US20130178488A1 (en) 2013-07-11
US8871928B2 (en) 2014-10-28
EP2619203A1 (en) 2013-07-31
EP2619203A4 (en) 2014-04-16
US20140378487A1 (en) 2014-12-25

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