JP2013537203A - 三環式化合物、製造方法、およびそれらの使用 - Google Patents

三環式化合物、製造方法、およびそれらの使用 Download PDF

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JP2013537203A
JP2013537203A JP2013528497A JP2013528497A JP2013537203A JP 2013537203 A JP2013537203 A JP 2013537203A JP 2013528497 A JP2013528497 A JP 2013528497A JP 2013528497 A JP2013528497 A JP 2013528497A JP 2013537203 A JP2013537203 A JP 2013537203A
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trifluoromethyl
oxy
chloro
phenyl
dihydro
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JP2013537203A5 (enExample
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ゼホン、ワン
ツァン、シャオミン
トン、ザオロン
ロン、カイ
サラ、イー．ダウデル
エリック、スティーブン、マナス
クリスタ、ビーバー、グッドマン
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013528497A 2010-09-20 2011-09-20 三環式化合物、製造方法、およびそれらの使用 Pending JP2013537203A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2010/077154 2010-09-20
CN2010077154 2010-09-20
PCT/CN2011/001597 WO2012037782A1 (en) 2010-09-20 2011-09-20 Tricyclic compounds, preparation methods, and their uses

Publications (2)

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JP2013537203A true JP2013537203A (ja) 2013-09-30
JP2013537203A5 JP2013537203A5 (enExample) 2014-05-22

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JP2013528497A Pending JP2013537203A (ja) 2010-09-20 2011-09-20 三環式化合物、製造方法、およびそれらの使用

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US (2) US8871928B2 (enExample)
EP (1) EP2619203A4 (enExample)
JP (1) JP2013537203A (enExample)
WO (1) WO2012037782A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017520613A (ja) * 2014-07-22 2017-07-27 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 化合物
JP2018502105A (ja) * 2014-12-26 2018-01-25 中国科学院上海薬物研究所 Ｌｐ−ＰＬＡ２阻害剤として用いられるピリミジノン系化合物およびその薬物組成物
JP2023532698A (ja) * 2020-07-10 2023-07-31 上海紐思克生物科技有限公司 三環系ピリミジノン類化合物、その製造方法、その組成物及び使用

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DK2731935T3 (en) 2011-07-13 2016-06-06 Basf Agro Bv FUNGICIDE SUBSTITUTED 2- [2-HALOGENALKYL-4- (PHENOXY) -PHENYL] -1- [1,2,4] TRIAZOL-1-YLETHANOL COMPOUNDS
EP2731934A1 (en) 2011-07-15 2014-05-21 Basf Se Fungicidal alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds
MX2014000039A (es) 2011-07-15 2014-02-17 Basf Se Compuestos fungicidas 2 - [2 - cloro - 4 - (4 -cloro - fenoxi) - fenil] -1 - [1,2,4]triazol - 1 - il - etanol alquilo sustituidos.
BR112014003412A2 (pt) 2011-08-15 2017-03-14 Basf Se compostos de fórmula i, processo, compostos de fórmula xii, viii e xi, composições agroquímicas, utilização e semente revestida
WO2013024077A1 (en) 2011-08-15 2013-02-21 Basf Se Fungicidal substituted 1-{2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-2-alkoxy-3-methyl-butyl}-1h-[1,2,4]triazole compounds
BR112014003216A2 (pt) 2011-08-15 2017-04-25 Basf Se compostos, processos para preparação de compostos de fórmula i, composições agroquímicas, uso de compostos de fórmula i ou viii e uso de pelo menos um composto de fórmula i ou viii
SG2014011886A (en) 2011-09-01 2014-05-29 Glaxo Group Ltd Novel crystal form
BR112015014753B8 (pt) 2012-12-20 2020-03-03 Basf Agro Bv composições, uso de uma composição, método para o combate de fungos fitopatogênicos e uso dos componentes
WO2014108286A1 (en) 2013-01-09 2014-07-17 Basf Se Process for the preparation of substituted oxiranes and triazoles
KR20150108897A (ko) * 2013-01-25 2015-09-30 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 2,3-디히드로이미다졸[1,2-c]피리미딘-5(1h)-온계의 지단백질-연관 포스포리파제 a2 (lp-pla2) 억제제
US9051325B2 (en) 2013-01-25 2015-06-09 Glaxo Group Limited Bicyclic [5,6] imidazo pyrimodone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2
AU2014210260B2 (en) * 2013-01-25 2016-08-04 Glaxosmithkline Intellectual Property Development Limited Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
US10512267B2 (en) 2013-07-08 2019-12-24 BASF Agro, B.V. Compositions comprising a triazole compound and a biopesticide
WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
CA2951177C (en) 2014-06-25 2023-07-04 BASF Agro B.V. Pesticidal compositions
PL3214937T3 (pl) 2014-11-07 2024-10-14 Basf Se Mieszaniny szkodnikobójcze
GB201506894D0 (en) 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2017029179A1 (en) 2015-08-14 2017-02-23 Bayer Cropscience Aktiengesellschaft Triazole derivatives, intermediates thereof and their use as fungicides
US10696634B2 (en) 2015-12-01 2020-06-30 Basf Se Pyridine compounds as fungicides
US20180368403A1 (en) 2015-12-01 2018-12-27 Basf Se Pyridine compounds as fungicides
RU2754614C2 (ru) 2016-03-16 2021-09-03 Басф Се Применение тетразолинонов для борьбы с устойчивыми фитопатогенными грибами на злаковых культурах
US11241012B2 (en) 2016-03-16 2022-02-08 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on soybean
CA3015456C (en) 2016-03-16 2024-09-17 Basf Se USE OF TETRAZOLINONES TO CONTROL RESISTANT PLANT PATHOGENIC FUNGI ON FRUIT
CN107011137B (zh) * 2017-04-10 2020-09-11 杭州科耀医药科技有限公司 一种匹莫范色林中间体的合成方法
WO2018219725A1 (en) 2017-05-30 2018-12-06 Basf Se Pyridine and pyrazine compounds
CN110818653B (zh) * 2019-11-08 2021-12-28 暨南大学 苯并噻二嗪类化合物及其应用、ampar的正电子药物
CN111533699B (zh) * 2020-05-27 2023-12-01 龙曦宁（上海）医药科技有限公司 一种2-（三氟甲基）嘧啶-5-醇的合成方法
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
TW202506117A (zh) 2023-06-26 2025-02-16 英商維羅納製藥Ｐｌｃ公司 顆粒組成物
CN119241534B (zh) * 2024-09-18 2025-12-05 武汉九州钰民医药科技有限公司 一种恩塞芬汀的制备方法

Citations (3)

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JP2001519798A (ja) * 1997-04-10 2001-10-23 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 抗痙攣作用を有するピリミド−イソキノリン化合物
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
JP2011088847A (ja) * 2009-10-21 2011-05-06 Takeda Chem Ind Ltd 三環性化合物およびその用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519798A (ja) * 1997-04-10 2001-10-23 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 抗痙攣作用を有するピリミド−イソキノリン化合物
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
JP2011088847A (ja) * 2009-10-21 2011-05-06 Takeda Chem Ind Ltd 三環性化合物およびその用途

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017520613A (ja) * 2014-07-22 2017-07-27 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 化合物
JP2017521456A (ja) * 2014-07-22 2017-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 化合物
JP2018502105A (ja) * 2014-12-26 2018-01-25 中国科学院上海薬物研究所 Ｌｐ−ＰＬＡ２阻害剤として用いられるピリミジノン系化合物およびその薬物組成物
JP2023532698A (ja) * 2020-07-10 2023-07-31 上海紐思克生物科技有限公司 三環系ピリミジノン類化合物、その製造方法、その組成物及び使用
JP7548606B2 (ja) 2020-07-10 2024-09-10 上海紐思克生物科技有限公司 三環系ピリミジノン類化合物、その製造方法、その組成物及び使用

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Publication number Publication date
US20130178488A1 (en) 2013-07-11
EP2619203A4 (en) 2014-04-16
US8871928B2 (en) 2014-10-28
EP2619203A1 (en) 2013-07-31
US20140378487A1 (en) 2014-12-25
WO2012037782A1 (en) 2012-03-29

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