JP2013536865A5 - - Google Patents
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- Publication number
- JP2013536865A5 JP2013536865A5 JP2013527294A JP2013527294A JP2013536865A5 JP 2013536865 A5 JP2013536865 A5 JP 2013536865A5 JP 2013527294 A JP2013527294 A JP 2013527294A JP 2013527294 A JP2013527294 A JP 2013527294A JP 2013536865 A5 JP2013536865 A5 JP 2013536865A5
- Authority
- JP
- Japan
- Prior art keywords
- propyl
- methyl
- hexadecyloxy
- degrees
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37874310P | 2010-08-31 | 2010-08-31 | |
| US61/378,743 | 2010-08-31 | ||
| PCT/US2011/050099 WO2012031045A2 (en) | 2010-08-31 | 2011-08-31 | Phosphonate ester derivatives and methods of synthesis thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015196930A Division JP2016094388A (ja) | 2010-08-31 | 2015-10-02 | ホスホン酸エステル誘導体およびその合成方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536865A JP2013536865A (ja) | 2013-09-26 |
| JP2013536865A5 true JP2013536865A5 (https=) | 2015-08-06 |
Family
ID=45771142
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527294A Pending JP2013536865A (ja) | 2010-08-31 | 2011-08-31 | ホスホン酸エステル誘導体およびその合成方法 |
| JP2015196930A Pending JP2016094388A (ja) | 2010-08-31 | 2015-10-02 | ホスホン酸エステル誘導体およびその合成方法 |
| JP2017110073A Pending JP2017214378A (ja) | 2010-08-31 | 2017-06-02 | ホスホン酸エステル誘導体およびその合成方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015196930A Pending JP2016094388A (ja) | 2010-08-31 | 2015-10-02 | ホスホン酸エステル誘導体およびその合成方法 |
| JP2017110073A Pending JP2017214378A (ja) | 2010-08-31 | 2017-06-02 | ホスホン酸エステル誘導体およびその合成方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8569321B2 (https=) |
| EP (2) | EP3020720B1 (https=) |
| JP (3) | JP2013536865A (https=) |
| CN (3) | CN105998039A (https=) |
| AU (1) | AU2011295937B2 (https=) |
| BR (1) | BR112013004925B1 (https=) |
| CA (1) | CA2809679C (https=) |
| ES (2) | ES2700117T3 (https=) |
| IL (4) | IL224955A (https=) |
| RU (2) | RU2581045C2 (https=) |
| WO (1) | WO2012031045A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012031045A2 (en) * | 2010-08-31 | 2012-03-08 | Chimerix, Inc. | Phosphonate ester derivatives and methods of synthesis thereof |
| SG10201800188SA (en) | 2013-03-15 | 2018-02-27 | Univ California | Acyclic nucleoside phosphonate diesters |
| US8962829B1 (en) * | 2013-11-15 | 2015-02-24 | Chimerix, Inc. | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof |
| EP3077403A4 (en) * | 2013-12-05 | 2017-08-02 | Chimerix, Inc. | Branched chain acyclic nucleoside phosphonate esters and methods of synthesis and uses thereof |
| CN103951703A (zh) * | 2014-04-28 | 2014-07-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 制备膦酯衍生物的方法 |
| CN111808136B (zh) | 2014-09-15 | 2024-06-11 | 加利福尼亚大学董事会 | 核苷酸类似物 |
| US10160778B2 (en) | 2014-10-27 | 2018-12-25 | Concert Pharmaceuticals, Inc. | Pyrimidine phosphonic acid esters |
| EP3350191B9 (en) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nucleotide analogs |
| AU2017290703B2 (en) | 2016-06-28 | 2023-03-30 | Emergent Biodefense Operations Lansing Llc | Formulations of brincidofovir |
| WO2020006050A1 (en) | 2018-06-26 | 2020-01-02 | Tsrl, Inc. | Metabolically stable prodrugs |
| CN109021011A (zh) * | 2018-08-14 | 2018-12-18 | 山东沾化永浩医药科技有限公司 | 一种合成对甲苯磺酰氧甲基膦酸二乙酯的方法 |
| KR20250052378A (ko) | 2022-07-21 | 2025-04-18 | 안티바 바이오사이언시즈, 인크. | Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| JP3116079B2 (ja) * | 1990-08-10 | 2000-12-11 | インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック | ヌクレオチドの新規な製法 |
| JP2002528461A (ja) * | 1998-10-23 | 2002-09-03 | ダーウィン・ディスカバリー・リミテッド | 公知ペプチドメタロプロテイナーゼインヒビターの単一形態型 |
| CA2747954C (en) | 1999-12-03 | 2014-02-25 | The Regents Of The University Of California | Phosphonate compounds |
| NZ543864A (en) * | 2003-06-16 | 2009-10-30 | Leuven K U Res & Dev | Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs |
| JP2005045073A (ja) | 2003-07-23 | 2005-02-17 | Hamamatsu Photonics Kk | 裏面入射型光検出素子 |
| WO2005090370A1 (en) * | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| WO2005087788A2 (en) * | 2004-03-04 | 2005-09-22 | The Regents Of The University Of California | Methods for preparation of nucleoside phosphonate esters |
| ES2401285T3 (es) * | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
| US8642577B2 (en) * | 2005-04-08 | 2014-02-04 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| EP2842559A3 (en) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| WO2007130783A2 (en) * | 2006-05-03 | 2007-11-15 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
| AU2008246195B2 (en) * | 2007-04-27 | 2014-06-05 | Emergent Biodefence Operations Lansing Llc | Methods of Reducing Nephrotoxicity in Subjects Administered with Nucleoside Phosphonates |
| WO2011011519A1 (en) | 2009-07-21 | 2011-01-27 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| CA2770282A1 (en) | 2009-08-03 | 2011-02-10 | Chimerix, Inc. | Composition and methods of treating viral infections and viral induced tumors |
| CA2779473C (en) | 2009-10-30 | 2016-08-16 | Chimerix, Inc. | Methods of treating viral associated diseases |
| US20110263536A1 (en) | 2010-04-22 | 2011-10-27 | Chimerix, Inc. | Methods of Treating Orthopox Virus Infections and Associated Diseases |
| WO2012031045A2 (en) * | 2010-08-31 | 2012-03-08 | Chimerix, Inc. | Phosphonate ester derivatives and methods of synthesis thereof |
| US20140303092A1 (en) * | 2011-10-26 | 2014-10-09 | Chimerix, Inc | Hexadecyloxypropyl cidofovir for the treatment of double-stranded dna virus infection |
| WO2013163509A1 (en) * | 2012-04-27 | 2013-10-31 | Chimerix, Inc. | A method of mitigating virus associated end-organ damage |
| US8962829B1 (en) * | 2013-11-15 | 2015-02-24 | Chimerix, Inc. | Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof |
-
2011
- 2011-08-31 WO PCT/US2011/050099 patent/WO2012031045A2/en not_active Ceased
- 2011-08-31 AU AU2011295937A patent/AU2011295937B2/en active Active
- 2011-08-31 EP EP15193479.1A patent/EP3020720B1/en active Active
- 2011-08-31 BR BR112013004925-1A patent/BR112013004925B1/pt active IP Right Grant
- 2011-08-31 EP EP11822622.4A patent/EP2611818B1/en active Active
- 2011-08-31 CN CN201610571915.7A patent/CN105998039A/zh active Pending
- 2011-08-31 RU RU2013114370/04A patent/RU2581045C2/ru active
- 2011-08-31 US US13/223,249 patent/US8569321B2/en active Active
- 2011-08-31 CN CN201180051834.XA patent/CN103209985B/zh active Active
- 2011-08-31 ES ES15193479T patent/ES2700117T3/es active Active
- 2011-08-31 RU RU2015141024A patent/RU2015141024A/ru unknown
- 2011-08-31 CA CA2809679A patent/CA2809679C/en active Active
- 2011-08-31 JP JP2013527294A patent/JP2013536865A/ja active Pending
- 2011-08-31 CN CN201510533631.4A patent/CN105218580A/zh active Pending
- 2011-08-31 ES ES11822622.4T patent/ES2604137T3/es active Active
-
2013
- 2013-02-27 IL IL224955A patent/IL224955A/en active IP Right Grant
- 2013-10-18 US US14/057,391 patent/US20140046085A1/en not_active Abandoned
-
2015
- 2015-04-12 IL IL238217A patent/IL238217A/en active IP Right Grant
- 2015-07-24 US US14/808,388 patent/US9303051B2/en active Active - Reinstated
- 2015-08-13 IL IL240574A patent/IL240574A0/en unknown
- 2015-10-02 JP JP2015196930A patent/JP2016094388A/ja active Pending
-
2016
- 2016-02-11 IL IL244076A patent/IL244076A0/en unknown
-
2017
- 2017-06-02 JP JP2017110073A patent/JP2017214378A/ja active Pending
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