JP2013536194A5 - - Google Patents
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- Publication number
- JP2013536194A5 JP2013536194A5 JP2013524250A JP2013524250A JP2013536194A5 JP 2013536194 A5 JP2013536194 A5 JP 2013536194A5 JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013536194 A5 JP2013536194 A5 JP 2013536194A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- carboxylic acid
- quinazolin
- amino
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *N[C@](C1=CC=N)NC([n]2ncc(C(O)=O)c2)=NC1=CC=C Chemical compound *N[C@](C1=CC=N)NC([n]2ncc(C(O)=O)c2)=NC1=CC=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37366410P | 2010-08-13 | 2010-08-13 | |
| US61/373,664 | 2010-08-13 | ||
| PCT/US2011/047626 WO2012021830A1 (en) | 2010-08-13 | 2011-08-12 | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536194A JP2013536194A (ja) | 2013-09-19 |
| JP2013536194A5 true JP2013536194A5 (enExample) | 2014-09-25 |
| JP5755741B2 JP5755741B2 (ja) | 2015-07-29 |
Family
ID=44533176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524250A Expired - Fee Related JP5755741B2 (ja) | 2010-08-13 | 2011-08-12 | プロリルヒドロキシラーゼインヒビタとしての４−アミノキナゾリン−２−イル−１−ピラゾール−４−カルボン酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8796263B2 (enExample) |
| EP (1) | EP2603502B1 (enExample) |
| JP (1) | JP5755741B2 (enExample) |
| CN (1) | CN103068821B (enExample) |
| AU (1) | AU2011289230B2 (enExample) |
| WO (1) | WO2012021830A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2775601C (en) | 2009-09-28 | 2017-10-03 | Qilu Pharmaceutical Co., Ltd | 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors |
| US8796263B2 (en) * | 2010-08-13 | 2014-08-05 | Janssen Pharmaceutica Nv | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors |
| ES2818977T3 (es) | 2011-10-25 | 2021-04-14 | Janssen Pharmaceutica Nv | Método para obtener cristales de sal de meglumina de ácido 1-(5,6-dicloro-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-carboxílico |
| WO2016034108A1 (zh) | 2014-09-02 | 2016-03-10 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其应用 |
| WO2017091661A1 (en) * | 2015-11-25 | 2017-06-01 | Strovel Jeffrey William | Bicyclic bet bromodomain inhibitors and uses thereof |
| AU2020371556A1 (en) * | 2019-10-25 | 2022-05-05 | Merck Sharp & Dohme Llc | N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof |
| WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| JP2023524035A (ja) * | 2020-04-29 | 2023-06-08 | バイオエイジ ラブス， インコーポレイテッド | 加齢性状態を処置するための低酸素誘導因子プロリルヒドロキシラーゼ阻害剤 |
| CN114075175A (zh) * | 2020-08-14 | 2022-02-22 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| CN115943144B (zh) * | 2020-08-14 | 2025-05-13 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| TWI896831B (zh) * | 2020-12-31 | 2025-09-11 | 大陸商成都海博為藥業有限公司 | 一種作為ｐａｋ４激酶抑制劑的化合物及其製備方法和應用 |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| WO2022251563A1 (en) | 2021-05-27 | 2022-12-01 | Keryx Biopharmaceuticals, Inc. | Pediatric formulations of ferric citrate |
| US20240415878A1 (en) * | 2021-10-13 | 2024-12-19 | Board Of Regents, The University Of Texas System | Compositions and Methods for Modulating Mitochondrial Function |
| US20230183356A1 (en) * | 2021-12-14 | 2023-06-15 | Brown University | HIF-1a MODULATORS AND USES THEREOF |
| WO2026015819A1 (en) * | 2024-07-12 | 2026-01-15 | The General Hospital Corporation | Trdmt1 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US20060276477A1 (en) | 2005-06-06 | 2006-12-07 | Fibrogen, Inc. | Treatment method for anemia |
| AU2006326662B2 (en) | 2005-12-09 | 2011-07-28 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
| AR059733A1 (es) | 2006-03-07 | 2008-04-23 | Smithkline Beecham Corp | Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| NZ601730A (en) * | 2006-06-26 | 2014-04-30 | Akebia Therapeutics Inc | Prolyl hydroxylase inhibitors and methods of use |
| DE102006050513A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substitiuierte Dihydropyrazolone und ihre Verwendung |
| JP5557832B2 (ja) | 2008-03-18 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 置換４−ヒドロキシピリジン−５−カルボキサミド |
| US8418819B2 (en) * | 2008-08-22 | 2013-04-16 | Inventus Engineering Gmbh | Movement damping apparatus |
| WO2010093727A1 (en) | 2009-02-10 | 2010-08-19 | Janssen Pharmaceutica Nv | Quinazolinones as prolyl hydroxylase inhibitors |
| US8796263B2 (en) * | 2010-08-13 | 2014-08-05 | Janssen Pharmaceutica Nv | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors |
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2011
- 2011-08-12 US US13/816,747 patent/US8796263B2/en active Active
- 2011-08-12 CN CN201180039665.8A patent/CN103068821B/zh active Active
- 2011-08-12 WO PCT/US2011/047626 patent/WO2012021830A1/en not_active Ceased
- 2011-08-12 EP EP11749643.0A patent/EP2603502B1/en active Active
- 2011-08-12 AU AU2011289230A patent/AU2011289230B2/en not_active Ceased
- 2011-08-12 JP JP2013524250A patent/JP5755741B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-24 US US14/313,892 patent/US9006251B2/en active Active - Reinstated
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2015
- 2015-03-26 US US14/670,352 patent/US9573940B2/en active Active
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2017
- 2017-02-17 US US15/436,596 patent/US10246442B2/en active Active - Reinstated
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2019
- 2019-04-01 US US16/371,400 patent/US10975062B2/en active Active