JP5755741B2 - プロリルヒドロキシラーゼインヒビタとしての４−アミノキナゾリン−２−イル−１−ピラゾール−４−カルボン酸化合物 - Google Patents
プロリルヒドロキシラーゼインヒビタとしての４−アミノキナゾリン−２−イル−１−ピラゾール−４−カルボン酸化合物 Download PDFInfo
- Publication number
- JP5755741B2 JP5755741B2 JP2013524250A JP2013524250A JP5755741B2 JP 5755741 B2 JP5755741 B2 JP 5755741B2 JP 2013524250 A JP2013524250 A JP 2013524250A JP 2013524250 A JP2013524250 A JP 2013524250A JP 5755741 B2 JP5755741 B2 JP 5755741B2
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- carboxylic acid
- quinazolin
- amino
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc1cccc(C)c1Oc(cc(c(*C1CCOCC1)nc(-[n]1ncc(C(O)=O)c1)n1)c1c1)c1F Chemical compound Cc1cccc(C)c1Oc(cc(c(*C1CCOCC1)nc(-[n]1ncc(C(O)=O)c1)n1)c1c1)c1F 0.000 description 4
- NMHVPOFQHNITRZ-UHFFFAOYSA-N CC(C)c(cc12)ccc1nc(-[n]1ncc(C(O)=O)c1)nc2N1CCOCC1 Chemical compound CC(C)c(cc12)ccc1nc(-[n]1ncc(C(O)=O)c1)nc2N1CCOCC1 NMHVPOFQHNITRZ-UHFFFAOYSA-N 0.000 description 1
- OPJYBGQSJDNVFS-UHFFFAOYSA-N CC1(C)C=CC=C(C)C1OC(C=C1C(N2CCN(C)CCC2)=NC([n]2ncc(C(O)=O)c2)=NC1(C)C1)=C1F Chemical compound CC1(C)C=CC=C(C)C1OC(C=C1C(N2CCN(C)CCC2)=NC([n]2ncc(C(O)=O)c2)=NC1(C)C1)=C1F OPJYBGQSJDNVFS-UHFFFAOYSA-N 0.000 description 1
- HOHBCSVNZKFZRG-UHFFFAOYSA-N CC1N(c2nc3ccc(C4CCCCC4)cc3c(NC#N)n2)N=CC1C(O)=O Chemical compound CC1N(c2nc3ccc(C4CCCCC4)cc3c(NC#N)n2)N=CC1C(O)=O HOHBCSVNZKFZRG-UHFFFAOYSA-N 0.000 description 1
- ZXFSYWQZTNKUDK-UHFFFAOYSA-N CCCN(CCC)c1c(ccc(Oc2ccccc2)c2)c2nc(-[n]2ncc(C(O)=O)c2)n1 Chemical compound CCCN(CCC)c1c(ccc(Oc2ccccc2)c2)c2nc(-[n]2ncc(C(O)=O)c2)n1 ZXFSYWQZTNKUDK-UHFFFAOYSA-N 0.000 description 1
- MWENPMVJXYMYRO-UHFFFAOYSA-N CCN(C)c(c1c2)nc(-[n]3ncc(C(O)=O)c3)nc1cc(F)c2N1CCCCC1 Chemical compound CCN(C)c(c1c2)nc(-[n]3ncc(C(O)=O)c3)nc1cc(F)c2N1CCCCC1 MWENPMVJXYMYRO-UHFFFAOYSA-N 0.000 description 1
- HLQKTXRLWGVIGD-UHFFFAOYSA-N CCN(C)c1c(cc(cc2)N3CCCCC3)c2nc(-[n]2ncc(C(O)=O)c2)n1 Chemical compound CCN(C)c1c(cc(cc2)N3CCCCC3)c2nc(-[n]2ncc(C(O)=O)c2)n1 HLQKTXRLWGVIGD-UHFFFAOYSA-N 0.000 description 1
- UCTKAPXSUBYROW-UHFFFAOYSA-N CCN(CC)C(c1cc(C(C)C)ccc1N1)=NC1(C)[n]1ncc(C(O)=O)c1 Chemical compound CCN(CC)C(c1cc(C(C)C)ccc1N1)=NC1(C)[n]1ncc(C(O)=O)c1 UCTKAPXSUBYROW-UHFFFAOYSA-N 0.000 description 1
- PSGGKAPQDCRHGR-UHFFFAOYSA-N Cc1cccc(C)c1CNC(C(C1)Cl)=CC(C(N(C)C)=C)=C1/N=C(\N)/[n]1ncc(C(O)=O)c1 Chemical compound Cc1cccc(C)c1CNC(C(C1)Cl)=CC(C(N(C)C)=C)=C1/N=C(\N)/[n]1ncc(C(O)=O)c1 PSGGKAPQDCRHGR-UHFFFAOYSA-N 0.000 description 1
- JHYAXUAKMDJAPJ-UHFFFAOYSA-N Cc1cccc(C)c1CNc1nc(-[n]2ncc(C(O)=O)c2)nc2ccc(C3CCCCC3)cc12 Chemical compound Cc1cccc(C)c1CNc1nc(-[n]2ncc(C(O)=O)c2)nc2ccc(C3CCCCC3)cc12 JHYAXUAKMDJAPJ-UHFFFAOYSA-N 0.000 description 1
- XFUJIDZIIMBAQL-UHFFFAOYSA-N Cc1cccc(C)c1Oc(cc1c(NCC2CC2)nc(-[n]2ncc(C(O)=O)c2)nc1c1)c1F Chemical compound Cc1cccc(C)c1Oc(cc1c(NCC2CC2)nc(-[n]2ncc(C(O)=O)c2)nc1c1)c1F XFUJIDZIIMBAQL-UHFFFAOYSA-N 0.000 description 1
- WUVOQDWOGJHBFN-UHFFFAOYSA-N OC(c1c[n](-c(nc(c2c3)N4CCCC4)nc2cc(Cl)c3OC2CCCCC2)nc1)=O Chemical compound OC(c1c[n](-c(nc(c2c3)N4CCCC4)nc2cc(Cl)c3OC2CCCCC2)nc1)=O WUVOQDWOGJHBFN-UHFFFAOYSA-N 0.000 description 1
- GOCVQBYXSLQHSK-UHFFFAOYSA-N OC(c1c[n](-c(nc(c2c3)N4CCCC4)nc2ccc3N2CCCCC2)nc1)=O Chemical compound OC(c1c[n](-c(nc(c2c3)N4CCCC4)nc2ccc3N2CCCCC2)nc1)=O GOCVQBYXSLQHSK-UHFFFAOYSA-N 0.000 description 1
- ZOLSNRMUAQZBLI-UHFFFAOYSA-N OC(c1c[n](-c(nc(c2c3)N4CCOCC4)nc2ccc3-c2ccccc2)nc1)=O Chemical compound OC(c1c[n](-c(nc(c2c3)N4CCOCC4)nc2ccc3-c2ccccc2)nc1)=O ZOLSNRMUAQZBLI-UHFFFAOYSA-N 0.000 description 1
- MSMJLYVXARAWEA-UHFFFAOYSA-N OC(c1c[n](-c(nc(c2c3)N4CCSCC4)nc2ccc3Oc(cc2)ccc2Cl)nc1)=O Chemical compound OC(c1c[n](-c(nc(c2c3)N4CCSCC4)nc2ccc3Oc(cc2)ccc2Cl)nc1)=O MSMJLYVXARAWEA-UHFFFAOYSA-N 0.000 description 1
- XUEHYMTZQBABBE-UHFFFAOYSA-N OC(c1c[n](-c2nc3cc(Oc4ccccc4)ccc3c(NCC3CC3)n2)nc1)=O Chemical compound OC(c1c[n](-c2nc3cc(Oc4ccccc4)ccc3c(NCC3CC3)n2)nc1)=O XUEHYMTZQBABBE-UHFFFAOYSA-N 0.000 description 1
- CQJFJHFTHGNCPU-UHFFFAOYSA-N OC(c1c[n](C(Nc2ccc(C3CCCCC3)cc22)N=C2NC(CCC=C2)=C2Cl)nc1)=O Chemical compound OC(c1c[n](C(Nc2ccc(C3CCCCC3)cc22)N=C2NC(CCC=C2)=C2Cl)nc1)=O CQJFJHFTHGNCPU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37366410P | 2010-08-13 | 2010-08-13 | |
| US61/373,664 | 2010-08-13 | ||
| PCT/US2011/047626 WO2012021830A1 (en) | 2010-08-13 | 2011-08-12 | 4 - aminoquinazolin- 2 - yl - 1 - pyrrazole - 4 - carboxylic acid compounds as prolyl hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536194A JP2013536194A (ja) | 2013-09-19 |
| JP2013536194A5 JP2013536194A5 (enExample) | 2014-09-25 |
| JP5755741B2 true JP5755741B2 (ja) | 2015-07-29 |
Family
ID=44533176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524250A Expired - Fee Related JP5755741B2 (ja) | 2010-08-13 | 2011-08-12 | プロリルヒドロキシラーゼインヒビタとしての４−アミノキナゾリン−２−イル−１−ピラゾール−４−カルボン酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8796263B2 (enExample) |
| EP (1) | EP2603502B1 (enExample) |
| JP (1) | JP5755741B2 (enExample) |
| CN (1) | CN103068821B (enExample) |
| AU (1) | AU2011289230B2 (enExample) |
| WO (1) | WO2012021830A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2484678B1 (en) | 2009-09-28 | 2015-01-21 | Qilu Pharmaceutical Co., Ltd | 4-(substituted anilino)quinazoline derivatives as tyrosine kinase inhibitors |
| EP2603502B1 (en) * | 2010-08-13 | 2014-07-30 | Janssen Pharmaceutica, N.V. | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors |
| ES2818977T3 (es) | 2011-10-25 | 2021-04-14 | Janssen Pharmaceutica Nv | Método para obtener cristales de sal de meglumina de ácido 1-(5,6-dicloro-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-carboxílico |
| CA2959688C (en) | 2014-09-02 | 2024-02-27 | Sunshine Lake Pharma Co., Ltd. | Quinolone compounds and their use to treat diseases related to hypoxia inducible factor and/or erythropoietin |
| EP3380469B1 (en) * | 2015-11-25 | 2022-03-16 | Convergene Llc | Bicyclic bet bromodomain inhibitors and uses thereof |
| CN115243687A (zh) * | 2019-10-25 | 2022-10-25 | 默沙东有限责任公司 | 作为lrrk2抑制剂的n-(杂芳基)喹唑啉-2-胺衍生物、药物组合物及其用途 |
| WO2021216530A1 (en) | 2020-04-20 | 2021-10-28 | Akebia Therapeutics, Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| KR20230017204A (ko) * | 2020-04-29 | 2023-02-03 | 바이오에이지 랩스, 인코포레이티드 | 노화-관련 질환 치료용 저산소증-유도 인자 프롤릴 히드록실라제 억제제 |
| WO2022033420A1 (zh) * | 2020-08-14 | 2022-02-17 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| CN114075175B (zh) * | 2020-08-14 | 2026-06-26 | 成都海博为药业有限公司 | 一种作为pak4激酶抑制剂的化合物及其制备方法和应用 |
| TWI896831B (zh) * | 2020-12-31 | 2025-09-11 | 大陸商成都海博為藥業有限公司 | 一種作為ｐａｋ４激酶抑制劑的化合物及其製備方法和應用 |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| EP4347022A1 (en) | 2021-05-27 | 2024-04-10 | Keryx Biopharmaceuticals, Inc. | Pediatric formulations of ferric citrate |
| US20240415878A1 (en) * | 2021-10-13 | 2024-12-19 | Board Of Regents, The University Of Texas System | Compositions and Methods for Modulating Mitochondrial Function |
| US20230183356A1 (en) * | 2021-12-14 | 2023-06-15 | Brown University | HIF-1a MODULATORS AND USES THEREOF |
| WO2026015819A1 (en) * | 2024-07-12 | 2026-01-15 | The General Hospital Corporation | Trdmt1 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| CN101849943A (zh) | 2005-06-06 | 2010-10-06 | 菲布罗根公司 | 使用HIFα稳定剂的改进的贫血治疗 |
| AU2006326662B2 (en) | 2005-12-09 | 2011-07-28 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
| PE20071020A1 (es) | 2006-03-07 | 2007-12-11 | Smithkline Beecham Corp | Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa |
| TWI394747B (zh) | 2006-06-23 | 2013-05-01 | Smithkline Beecham Corp | 脯胺醯基羥化酶抑制劑 |
| NZ623002A (en) | 2006-06-26 | 2015-08-28 | Akebia Therapeutics Inc | Prolyl hydroxylase inhibitors and methods of use |
| DE102006050513A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substitiuierte Dihydropyrazolone und ihre Verwendung |
| AU2009225869B2 (en) | 2008-03-18 | 2014-01-23 | Merck Sharp & Dohme Llc | Substituted 4-hydroxypyrimidine-5-carboxamides |
| DE112009001995A5 (de) * | 2008-08-22 | 2011-09-29 | Inventus Engineering Gmbh | Bewegung dämpfende Vorrichtung |
| JP5643233B2 (ja) * | 2009-02-10 | 2014-12-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | プロリルヒドロキシラーゼ阻害物質としてのキナゾリノン |
| EP2603502B1 (en) * | 2010-08-13 | 2014-07-30 | Janssen Pharmaceutica, N.V. | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors |
-
2011
- 2011-08-12 EP EP11749643.0A patent/EP2603502B1/en active Active
- 2011-08-12 WO PCT/US2011/047626 patent/WO2012021830A1/en not_active Ceased
- 2011-08-12 CN CN201180039665.8A patent/CN103068821B/zh active Active
- 2011-08-12 US US13/816,747 patent/US8796263B2/en active Active
- 2011-08-12 AU AU2011289230A patent/AU2011289230B2/en not_active Ceased
- 2011-08-12 JP JP2013524250A patent/JP5755741B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-24 US US14/313,892 patent/US9006251B2/en active Active - Reinstated
-
2015
- 2015-03-26 US US14/670,352 patent/US9573940B2/en active Active
-
2017
- 2017-02-17 US US15/436,596 patent/US10246442B2/en active Active - Reinstated
-
2019
- 2019-04-01 US US16/371,400 patent/US10975062B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10975062B2 (en) | 2021-04-13 |
| US20140309215A1 (en) | 2014-10-16 |
| AU2011289230A1 (en) | 2013-02-21 |
| US20170320859A1 (en) | 2017-11-09 |
| EP2603502B1 (en) | 2014-07-30 |
| HK1184451A1 (en) | 2014-01-24 |
| US8796263B2 (en) | 2014-08-05 |
| US9573940B2 (en) | 2017-02-21 |
| US20150197507A1 (en) | 2015-07-16 |
| CN103068821A (zh) | 2013-04-24 |
| AU2011289230B2 (en) | 2014-09-04 |
| US20180148435A9 (en) | 2018-05-31 |
| CN103068821B (zh) | 2015-02-25 |
| US20130143871A1 (en) | 2013-06-06 |
| US10246442B2 (en) | 2019-04-02 |
| EP2603502A1 (en) | 2013-06-19 |
| US9006251B2 (en) | 2015-04-14 |
| US20200095234A1 (en) | 2020-03-26 |
| WO2012021830A1 (en) | 2012-02-16 |
| JP2013536194A (ja) | 2013-09-19 |
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