JP2013535494A5 - - Google Patents
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- Publication number
- JP2013535494A5 JP2013535494A5 JP2013523598A JP2013523598A JP2013535494A5 JP 2013535494 A5 JP2013535494 A5 JP 2013535494A5 JP 2013523598 A JP2013523598 A JP 2013523598A JP 2013523598 A JP2013523598 A JP 2013523598A JP 2013535494 A5 JP2013535494 A5 JP 2013535494A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous suspension
- suspension according
- amino acids
- polypeptide
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007900 aqueous suspension Substances 0.000 claims 27
- 235000001014 amino acid Nutrition 0.000 claims 15
- 150000001413 amino acids Chemical class 0.000 claims 15
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 239000007789 gas Substances 0.000 claims 8
- 239000002243 precursor Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000003904 phospholipids Chemical group 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical group O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 238000012285 ultrasound imaging Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10172318 | 2010-08-09 | ||
| EP10172318.7 | 2010-08-09 | ||
| PCT/EP2011/063720 WO2012020030A1 (en) | 2010-08-09 | 2011-08-09 | Targeted gas-filled microvesicles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535494A JP2013535494A (ja) | 2013-09-12 |
| JP2013535494A5 true JP2013535494A5 (cg-RX-API-DMAC7.html) | 2014-05-08 |
| JP5779646B2 JP5779646B2 (ja) | 2015-09-16 |
Family
ID=43216307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523598A Active JP5779646B2 (ja) | 2010-08-09 | 2011-08-09 | 標的気体封入マイクロベシクル |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9211348B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3338807B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5779646B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101893423B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103079599B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011288511B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013003393B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2806639C (cg-RX-API-DMAC7.html) |
| DK (2) | DK3338807T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2673277T3 (cg-RX-API-DMAC7.html) |
| HU (2) | HUE052894T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL224628A (cg-RX-API-DMAC7.html) |
| SI (2) | SI2603242T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012020030A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201300660B (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6594772B2 (ja) * | 2012-04-30 | 2019-10-23 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 発泡性組成物を容器に充填する方法 |
| CN110464709A (zh) * | 2012-08-10 | 2019-11-19 | 德克萨斯州大学系统董事会 | 用于治疗中风的神经保护性脂质体组合物和方法 |
| EP2934740B1 (en) * | 2012-12-21 | 2019-12-11 | Bracco Suisse SA | Gas-filled microvesicles |
| CN105228591B (zh) | 2013-03-15 | 2019-08-13 | 德克萨斯州大学系统董事会 | 富含稀有气体的液体及其制备和使用方法 |
| WO2015134671A1 (en) | 2014-03-04 | 2015-09-11 | Targeson, Inc. | Molecular imaging contrast agents and uses thereof |
| WO2016097130A1 (en) * | 2014-12-18 | 2016-06-23 | Bracco Suisse Sa | Targeted gas-filled microvesicles formulation |
| BR112017011881A2 (pt) * | 2014-12-22 | 2018-01-02 | Bracco Suisse Sa | microvesículas cheias com gás para uso como vacina |
| US11344498B2 (en) * | 2015-10-08 | 2022-05-31 | The Children's Medical Center Corporation | Compositions and methods for on-demand high-efficiency triggerable anesthesia |
| US11370826B2 (en) | 2016-02-09 | 2022-06-28 | Bracco Suisse Sa | Recombinant chimeric protein for selectins targeting |
| US20210190774A1 (en) * | 2017-12-18 | 2021-06-24 | The University Of Memphis Research Foundation | Compositions and methods for the detection and molecular profiling of membrane bound vesicles |
| US11988663B2 (en) | 2018-12-18 | 2024-05-21 | The University Of Memphis Research Foundation | Compositions and methods for the detection and molecular profiling of membrane bound vesicles |
| CA3120179A1 (en) | 2018-12-21 | 2020-06-25 | Bracco Suisse Sa | Gas-filled microvesicles with ligand |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| IN172208B (cg-RX-API-DMAC7.html) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
| DE69434119T3 (de) | 1993-07-30 | 2011-05-05 | Imcor Pharmaceutical Co., San Diego | Stabilisierte mikrogasbläschen-zusammensetzungen für echographie |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| EE9800248A (et) | 1996-02-19 | 1999-02-15 | Nycomed Imaging As | Külmkuivatatud, vesiikuleid sisaldav ultraheli kontrastaine, selle valmistamismeetod ning ladustamise ja transpordi meetod, ultraheli kontrastaine keskkond ja selle valmistamismeetod ning külmkuivatuse stabilisaatorite kasutamine |
| AU2001247929A1 (en) * | 2000-03-31 | 2001-10-15 | Genetics Institute, Llc | Inhibition of thrombosis by treatment with p-selectin antagonists |
| US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| KR101076053B1 (ko) * | 2003-02-04 | 2011-10-21 | 브라코 인터내셔날 비.브이. | 초음파 조영제 및 그것의 제조방법 |
| US20060241022A1 (en) | 2004-10-06 | 2006-10-26 | Bowen Benjamin P | Selectin targeting bioconjugates |
| CA2947346C (en) | 2005-12-09 | 2018-07-24 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| AU2008242757A1 (en) * | 2007-04-20 | 2008-10-30 | Oregon Health & Science University | Ultrasound imaging with targeted microbubbles |
| WO2009074569A1 (en) * | 2007-12-11 | 2009-06-18 | Bracco International Bv | Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds |
-
2011
- 2011-08-09 BR BR112013003393-2A patent/BR112013003393B1/pt active IP Right Grant
- 2011-08-09 DK DK18156131.7T patent/DK3338807T3/da active
- 2011-08-09 SI SI201131501T patent/SI2603242T1/sl unknown
- 2011-08-09 US US13/814,329 patent/US9211348B2/en active Active
- 2011-08-09 CA CA2806639A patent/CA2806639C/en active Active
- 2011-08-09 CN CN201180039277.XA patent/CN103079599B/zh active Active
- 2011-08-09 SI SI201131960T patent/SI3338807T1/sl unknown
- 2011-08-09 KR KR1020177027001A patent/KR101893423B1/ko active Active
- 2011-08-09 ES ES11743811.9T patent/ES2673277T3/es active Active
- 2011-08-09 EP EP18156131.7A patent/EP3338807B1/en active Active
- 2011-08-09 DK DK11743811.9T patent/DK2603242T3/en active
- 2011-08-09 WO PCT/EP2011/063720 patent/WO2012020030A1/en not_active Ceased
- 2011-08-09 KR KR1020137005859A patent/KR101783653B1/ko active Active
- 2011-08-09 ES ES18156131T patent/ES2848721T3/es active Active
- 2011-08-09 HU HUE18156131A patent/HUE052894T2/hu unknown
- 2011-08-09 HU HUE11743811A patent/HUE037768T2/hu unknown
- 2011-08-09 JP JP2013523598A patent/JP5779646B2/ja active Active
- 2011-08-09 EP EP11743811.9A patent/EP2603242B1/en active Active
- 2011-08-09 AU AU2011288511A patent/AU2011288511B2/en active Active
-
2013
- 2013-01-24 ZA ZA2013/00660A patent/ZA201300660B/en unknown
- 2013-02-07 IL IL224628A patent/IL224628A/en active IP Right Grant
-
2015
- 2015-10-30 US US14/927,865 patent/US9333273B2/en active Active
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