JP2013535009A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013535009A5 JP2013535009A5 JP2013515555A JP2013515555A JP2013535009A5 JP 2013535009 A5 JP2013535009 A5 JP 2013535009A5 JP 2013515555 A JP2013515555 A JP 2013515555A JP 2013515555 A JP2013515555 A JP 2013515555A JP 2013535009 A5 JP2013535009 A5 JP 2013535009A5
- Authority
- JP
- Japan
- Prior art keywords
- prpk
- agent
- tprkb
- test agent
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100029493 EKC/KEOPS complex subunit TP53RK Human genes 0.000 claims 44
- 239000003795 chemical substances by application Substances 0.000 claims 35
- 101100245176 Homo sapiens TP53RK gene Proteins 0.000 claims 24
- 101001125560 Homo sapiens EKC/KEOPS complex subunit TP53RK Proteins 0.000 claims 20
- 101000830812 Homo sapiens EKC/KEOPS complex subunit TPRKB Proteins 0.000 claims 20
- 238000000034 method Methods 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 230000003993 interaction Effects 0.000 claims 7
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 102100020865 EKC/KEOPS complex subunit LAGE3 Human genes 0.000 claims 2
- 101001137983 Homo sapiens EKC/KEOPS complex subunit LAGE3 Proteins 0.000 claims 2
- 101000598806 Homo sapiens Probable tRNA N6-adenosine threonylcarbamoyltransferase Proteins 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 102100037775 Probable tRNA N6-adenosine threonylcarbamoyltransferase Human genes 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35655410P | 2010-06-18 | 2010-06-18 | |
| US61/356,554 | 2010-06-18 | ||
| PCT/US2011/040918 WO2011160042A2 (en) | 2010-06-18 | 2011-06-17 | Prpk-tprkb modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535009A JP2013535009A (ja) | 2013-09-09 |
| JP2013535009A5 true JP2013535009A5 (enExample) | 2014-07-10 |
| JP5857043B2 JP5857043B2 (ja) | 2016-02-10 |
Family
ID=45348903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515555A Expired - Fee Related JP5857043B2 (ja) | 2010-06-18 | 2011-06-17 | Ｐｒｐｋ−ｔｐｒｋｂモジュレーター及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9193989B2 (enExample) |
| EP (1) | EP2582836B1 (enExample) |
| JP (1) | JP5857043B2 (enExample) |
| ES (1) | ES2664872T3 (enExample) |
| WO (1) | WO2011160042A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013089278A1 (en) * | 2011-12-14 | 2013-06-20 | Taiho Pharmaceutical Co., Ltd. | Recombinant prpk-tprkb and uses thereof |
| KR20150130284A (ko) | 2013-03-15 | 2015-11-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 백신 및 이를 이용한 치료 방법 |
| CN105440014B (zh) * | 2014-08-29 | 2018-08-28 | 杭州和泽医药科技有限公司 | 一种来那度胺的制备方法 |
| ES2812877T3 (es) | 2014-10-30 | 2021-03-18 | Kangpu Biopharmaceuticals Ltd | Derivado de isoindolina, producto intermedio, método de preparación, composición farmacéutica y uso del mismo |
| US10302644B2 (en) * | 2014-11-04 | 2019-05-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating multiple myeloma |
| WO2017176289A1 (en) * | 2016-04-08 | 2017-10-12 | Celgene Corporation | Uses of lenalidomide and car t-cells |
| JP7143296B2 (ja) * | 2016-11-24 | 2022-09-28 | ティアンジン ヘメイ ファーマスーティカル サイ－テック カンパニー リミテッド | ピペリジン－２，６－ジオン誘導体及び潰瘍性結腸炎の治療 |
| US12233073B2 (en) | 2017-06-09 | 2025-02-25 | Regents Of The University Of Minnesota | Skin care formulations and skin cancer treatment |
| TWI689501B (zh) * | 2017-08-21 | 2020-04-01 | 諾瑞特國際藥業股份有限公司 | 泊馬度胺衍生物及其製備方法 |
| WO2019036839A1 (zh) * | 2017-08-21 | 2019-02-28 | 诺瑞特国际药业股份有限公司 | 泊马度胺衍生物及其制备方法 |
| CA3119343C (en) | 2018-11-13 | 2024-01-16 | Biotheryx, Inc. | Substituted isoindolinones |
| CN111434659A (zh) * | 2019-01-11 | 2020-07-21 | 南京诺瑞特医药科技有限公司 | 泊马度胺前体药物的盐 |
| CN111499610A (zh) * | 2019-01-31 | 2020-08-07 | 南京诺瑞特医药科技有限公司 | 泊马度胺前体药物盐的多晶型物 |
| US20240124459A9 (en) * | 2020-06-29 | 2024-04-18 | Dana-Farber Cancer Institute, Inc. | Prpk inhibitors |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US6045501A (en) | 1998-08-28 | 2000-04-04 | Celgene Corporation | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug |
| US6315720B1 (en) | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
| US20070134261A1 (en) * | 2001-12-03 | 2007-06-14 | Hancock Robert E | Effectors of innate immunity |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7973057B2 (en) | 2003-09-17 | 2011-07-05 | The United States Of America As Represented By The Department Of Health And Human Services | Thalidomide analogs |
| US20070208057A1 (en) * | 2003-11-06 | 2007-09-06 | Zeldis Jerome B | Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases |
-
2011
- 2011-06-17 EP EP11796526.9A patent/EP2582836B1/en not_active Not-in-force
- 2011-06-17 WO PCT/US2011/040918 patent/WO2011160042A2/en not_active Ceased
- 2011-06-17 JP JP2013515555A patent/JP5857043B2/ja not_active Expired - Fee Related
- 2011-06-17 ES ES11796526.9T patent/ES2664872T3/es active Active
- 2011-06-17 US US13/163,192 patent/US9193989B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013535009A5 (enExample) | ||
| JP2011137045A5 (enExample) | ||
| JP2015536446A5 (enExample) | ||
| JP2014508298A5 (enExample) | ||
| MX364410B (es) | Metodo para detectar nucleosomas que contienen nucleotidos. | |
| BR112014003380A2 (pt) | sistema e método para correção de aderência e deslizamento | |
| JP2013530964A5 (enExample) | ||
| EP2684062A4 (en) | FABRIC-BASED FUNCTION TEST ACCESS MECHANISM FOR SOC | |
| JP2011213717A5 (enExample) | ||
| JP2013514367A5 (enExample) | ||
| DK2718293T3 (da) | Substituerede pyridopyraziner som hidtil ukendte syk-inhibitorer | |
| AR082519A1 (es) | Fenilamidinas que tienen alta actividad fungicida, y su utilizacion | |
| PE20141046A1 (es) | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria | |
| WO2013072528A3 (en) | Substituted n-(tetrazol-5-yl)- and n-(triazol-5-yl)pyridin-3-yl-carboxamide compounds and their use as herbicides | |
| CY1116168T1 (el) | Συγκρυσταλλοι και αλατα αναστολεων toy ccr3 | |
| EP2464737A4 (en) | INDIVIDUAL AND MULTI-TEMPERATURE PROCESSES, KITS AND COMPOUNDS FOR NUCLEIC ACID RECOGNITION | |
| JP2013218558A5 (ja) | 情報処理装置、運動支援情報提供システム、運動支援情報提供方法及び運動支援情報提供プログラム | |
| JP2013533212A5 (enExample) | ||
| JP2017006122A5 (enExample) | ||
| BR112012026545A2 (pt) | composições e métodos para tratar exacerbação de copd | |
| JP2011245846A5 (enExample) | ||
| BR112013031048A2 (pt) | método de adaptação de um composto de assinatura de um fenótipo que é derivado a partir de medições da amostra; aparelho de imagem clínica para a adaptação de uma assinatura composta de um fenótipo que é derivado de medições de uma amostra; elemento do programa para a adaptação de uma assinatura composta de um fenótipo; meio de leitura por computador | |
| WO2006089185A3 (en) | Pharmacogenomic markers for prognosis of solid tumors | |
| JP2014532688A5 (enExample) | ||
| JP2017517480A5 (enExample) |