JP5857043B2 - Ｐｒｐｋ−ｔｐｒｋｂモジュレーター及びその使用 - Google Patents

Ｐｒｐｋ−ｔｐｒｋｂモジュレーター及びその使用 Download PDF

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Publication number
JP5857043B2
JP5857043B2 JP2013515555A JP2013515555A JP5857043B2 JP 5857043 B2 JP5857043 B2 JP 5857043B2 JP 2013515555 A JP2013515555 A JP 2013515555A JP 2013515555 A JP2013515555 A JP 2013515555A JP 5857043 B2 JP5857043 B2 JP 5857043B2
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JP
Japan
Prior art keywords
prpk
tprkb
complex
agent
lage3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013515555A
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English (en)
Japanese (ja)
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JP2013535009A5 (enExample
JP2013535009A (ja
Inventor
パーク，ウン，スン
ペリシュ，ヘンリー，イー．
クラーク，アストリッド，エス．
ウィリアムズ，グレイス，エル．
カスタルディ，マリア，パオラ
アルフォロ，アレキサンダー
リング，ジェニファー，イー．
シェア，マシュー，ディー．
キング，ランドル，ダブリュー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of JP2013535009A publication Critical patent/JP2013535009A/ja
Publication of JP2013535009A5 publication Critical patent/JP2013535009A5/ja
Application granted granted Critical
Publication of JP5857043B2 publication Critical patent/JP5857043B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013515555A 2010-06-18 2011-06-17 Ｐｒｐｋ−ｔｐｒｋｂモジュレーター及びその使用 Expired - Fee Related JP5857043B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35655410P 2010-06-18 2010-06-18
US61/356,554 2010-06-18
PCT/US2011/040918 WO2011160042A2 (en) 2010-06-18 2011-06-17 Prpk-tprkb modulators and uses thereof

Publications (3)

Publication Number Publication Date
JP2013535009A JP2013535009A (ja) 2013-09-09
JP2013535009A5 JP2013535009A5 (enExample) 2014-07-10
JP5857043B2 true JP5857043B2 (ja) 2016-02-10

Family

ID=45348903

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013515555A Expired - Fee Related JP5857043B2 (ja) 2010-06-18 2011-06-17 Ｐｒｐｋ−ｔｐｒｋｂモジュレーター及びその使用

Country Status (5)

Country Link
US (1) US9193989B2 (enExample)
EP (1) EP2582836B1 (enExample)
JP (1) JP5857043B2 (enExample)
ES (1) ES2664872T3 (enExample)
WO (1) WO2011160042A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013089278A1 (en) * 2011-12-14 2013-06-20 Taiho Pharmaceutical Co., Ltd. Recombinant prpk-tprkb and uses thereof
KR20150130284A (ko) 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 백신 및 이를 이용한 치료 방법
CN105440014B (zh) * 2014-08-29 2018-08-28 杭州和泽医药科技有限公司 一种来那度胺的制备方法
ES2812877T3 (es) 2014-10-30 2021-03-18 Kangpu Biopharmaceuticals Ltd Derivado de isoindolina, producto intermedio, método de preparación, composición farmacéutica y uso del mismo
US10302644B2 (en) * 2014-11-04 2019-05-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating multiple myeloma
WO2017176289A1 (en) * 2016-04-08 2017-10-12 Celgene Corporation Uses of lenalidomide and car t-cells
JP7143296B2 (ja) * 2016-11-24 2022-09-28 ティアンジン ヘメイ ファーマスーティカル サイ－テック カンパニー リミテッド ピペリジン－２，６－ジオン誘導体及び潰瘍性結腸炎の治療
US12233073B2 (en) 2017-06-09 2025-02-25 Regents Of The University Of Minnesota Skin care formulations and skin cancer treatment
TWI689501B (zh) * 2017-08-21 2020-04-01 諾瑞特國際藥業股份有限公司 泊馬度胺衍生物及其製備方法
WO2019036839A1 (zh) * 2017-08-21 2019-02-28 诺瑞特国际药业股份有限公司 泊马度胺衍生物及其制备方法
CA3119343C (en) 2018-11-13 2024-01-16 Biotheryx, Inc. Substituted isoindolinones
CN111434659A (zh) * 2019-01-11 2020-07-21 南京诺瑞特医药科技有限公司 泊马度胺前体药物的盐
CN111499610A (zh) * 2019-01-31 2020-08-07 南京诺瑞特医药科技有限公司 泊马度胺前体药物盐的多晶型物
US20240124459A9 (en) * 2020-06-29 2024-04-18 Dana-Farber Cancer Institute, Inc. Prpk inhibitors

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Also Published As

Publication number Publication date
EP2582836A2 (en) 2013-04-24
ES2664872T3 (es) 2018-04-23
EP2582836B1 (en) 2018-03-07
JP2013535009A (ja) 2013-09-09
US9193989B2 (en) 2015-11-24
US20110319277A1 (en) 2011-12-29
WO2011160042A3 (en) 2013-04-25
EP2582836A4 (en) 2014-03-19
WO2011160042A2 (en) 2011-12-22

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