JP2013534424A5 - - Google Patents
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- Publication number
- JP2013534424A5 JP2013534424A5 JP2013518760A JP2013518760A JP2013534424A5 JP 2013534424 A5 JP2013534424 A5 JP 2013534424A5 JP 2013518760 A JP2013518760 A JP 2013518760A JP 2013518760 A JP2013518760 A JP 2013518760A JP 2013534424 A5 JP2013534424 A5 JP 2013534424A5
- Authority
- JP
- Japan
- Prior art keywords
- strand
- nucleotides
- dsrna
- less
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36175910P | 2010-07-06 | 2010-07-06 | |
| US61/361,759 | 2010-07-06 | ||
| PCT/US2011/042810 WO2012006241A2 (en) | 2010-07-06 | 2011-07-01 | Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013534424A JP2013534424A (ja) | 2013-09-05 |
| JP2013534424A5 true JP2013534424A5 (https=) | 2014-08-14 |
Family
ID=45441760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518760A Pending JP2013534424A (ja) | 2010-07-06 | 2011-07-01 | 二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8927515B2 (https=) |
| EP (1) | EP2591104A4 (https=) |
| JP (1) | JP2013534424A (https=) |
| AU (1) | AU2011276363A1 (https=) |
| CA (1) | CA2804210A1 (https=) |
| WO (1) | WO2012006241A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US9146238B2 (en) | 2008-04-16 | 2015-09-29 | The Johns Hopkins University | Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants |
| US9175291B2 (en) * | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| CN105189541A (zh) | 2012-12-14 | 2015-12-23 | 戴瑟纳制药公司 | 用于通过双链rna特异性抑制ckap5的方法和组合物 |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| DK3444350T3 (da) * | 2013-07-03 | 2022-02-07 | Dicerna Pharmaceuticals Inc | Fremgangsmåder og sammensætninger til specifik hæmning af alpha-1 antitrypsin ved dobbeltstrenget rna |
| CA2920317A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| US10774387B2 (en) | 2014-05-19 | 2020-09-15 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| WO2016033114A1 (en) * | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| US10676737B2 (en) | 2014-12-17 | 2020-06-09 | Proqr Therapeutics Ii B.V. | Targeted RNA editing |
| EP3328878A1 (en) * | 2015-07-30 | 2018-06-06 | Bayer CropScience Aktiengesellschaft | Methods and compositions for the control of rust fungi by inhibiting expression of the hxt1 gene |
| MA45340A (fr) * | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Acides nucléiques du récepteur des androgènes et leurs utilisations |
| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| US10941402B2 (en) | 2016-09-01 | 2021-03-09 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded RNA-editing oligonucleotides |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| US11274300B2 (en) | 2017-01-19 | 2022-03-15 | Proqr Therapeutics Ii B.V. | Oligonucleotide complexes for use in RNA editing |
| KR102321426B1 (ko) * | 2017-02-21 | 2021-11-05 | 올릭스 주식회사 | 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA |
| WO2019165242A1 (en) * | 2018-02-23 | 2019-08-29 | Paraskevi Giannakakou | Assay for detection of androgen receptor variants |
| US11866702B2 (en) | 2018-03-27 | 2024-01-09 | University Of Rochester | Nucleic acid molecules for pseudouridylation |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| KR102473989B1 (ko) * | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| WO2025160224A1 (en) * | 2024-01-24 | 2025-07-31 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of androgen receptor (ar), compositions thereof, and methods of use |
| WO2025226946A1 (en) * | 2024-04-24 | 2025-10-30 | Cedric Francois | Methods and compositions for the treatment of androgenic alopecia |
| WO2025254047A1 (ja) * | 2024-06-06 | 2025-12-11 | 東亞合成株式会社 | アンドロゲン受容体 ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050170371A1 (en) * | 2001-05-18 | 2005-08-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
| EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| US20060257851A1 (en) * | 2002-11-26 | 2006-11-16 | Itzhak Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
| US20050164970A1 (en) * | 2003-12-22 | 2005-07-28 | University Of Kansas Medical Center | Method for treating prostate cancer using siRNA duplex for androgen receptor |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| AU2005222965B8 (en) | 2004-03-15 | 2010-07-01 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| JP4961549B2 (ja) * | 2006-02-16 | 2012-06-27 | 国立大学法人愛媛大学 | アンドロゲン受容体遺伝子に特異的なｓｉＲＮＡ |
| US20080014584A1 (en) * | 2006-06-01 | 2008-01-17 | Mayo Foundation For Medical Education And Research | Modulating androgen receptor activity |
-
2011
- 2011-07-01 WO PCT/US2011/042810 patent/WO2012006241A2/en not_active Ceased
- 2011-07-01 CA CA2804210A patent/CA2804210A1/en not_active Abandoned
- 2011-07-01 JP JP2013518760A patent/JP2013534424A/ja active Pending
- 2011-07-01 AU AU2011276363A patent/AU2011276363A1/en not_active Abandoned
- 2011-07-01 EP EP11804228.2A patent/EP2591104A4/en not_active Withdrawn
-
2012
- 2012-12-21 US US13/723,623 patent/US8927515B2/en active Active
-
2014
- 2014-11-17 US US14/543,257 patent/US9732347B2/en not_active Expired - Fee Related
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