JP2013534424A5 - - Google Patents

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Publication number
JP2013534424A5
JP2013534424A5 JP2013518760A JP2013518760A JP2013534424A5 JP 2013534424 A5 JP2013534424 A5 JP 2013534424A5 JP 2013518760 A JP2013518760 A JP 2013518760A JP 2013518760 A JP2013518760 A JP 2013518760A JP 2013534424 A5 JP2013534424 A5 JP 2013534424A5
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JP
Japan
Prior art keywords
strand
nucleotides
dsrna
less
isolated
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Pending
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JP2013518760A
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English (en)
Japanese (ja)
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JP2013534424A (ja
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Priority claimed from PCT/US2011/042810 external-priority patent/WO2012006241A2/en
Publication of JP2013534424A publication Critical patent/JP2013534424A/ja
Publication of JP2013534424A5 publication Critical patent/JP2013534424A5/ja
Pending legal-status Critical Current

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JP2013518760A 2010-07-06 2011-07-01 二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物 Pending JP2013534424A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36175910P 2010-07-06 2010-07-06
US61/361,759 2010-07-06
PCT/US2011/042810 WO2012006241A2 (en) 2010-07-06 2011-07-01 Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna

Publications (2)

Publication Number Publication Date
JP2013534424A JP2013534424A (ja) 2013-09-05
JP2013534424A5 true JP2013534424A5 (https=) 2014-08-14

Family

ID=45441760

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013518760A Pending JP2013534424A (ja) 2010-07-06 2011-07-01 二本鎖ｒｎａによるアンドロゲン受容体の特異的阻害に対する方法と化合物

Country Status (6)

Country Link
US (2) US8927515B2 (https=)
EP (1) EP2591104A4 (https=)
JP (1) JP2013534424A (https=)
AU (1) AU2011276363A1 (https=)
CA (1) CA2804210A1 (https=)
WO (1) WO2012006241A2 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100048913A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
ES2836128T3 (es) 2008-04-16 2021-06-24 Univ Johns Hopkins Método para determinar variantes del receptor de andrógenos en cáncer de próstata
AR092982A1 (es) * 2012-10-11 2015-05-13 Isis Pharmaceuticals Inc Modulacion de la expresion de receptores androgenicos
CA2893824A1 (en) 2012-12-14 2014-06-19 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of ckap5 by double-stranded rna
RU2015137617A (ru) 2013-03-14 2017-04-18 Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер Агенты, подавляющие андрогенные рецепторы, и их применение
US9458457B2 (en) * 2013-07-03 2016-10-04 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA
CN105636594A (zh) 2013-08-12 2016-06-01 托凯药业股份有限公司 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物
WO2015179404A1 (en) 2014-05-19 2015-11-26 The Johns Hopkins University Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
CA2959336A1 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
EP3234134B1 (en) 2014-12-17 2020-05-27 ProQR Therapeutics II B.V. Targeted rna editing
CA2989384A1 (en) 2015-07-30 2017-02-02 Bayer Cropscience Aktiengesellschaft Methods and compositions for the control of rust fungi by inhibiting expression of the hxt1 gene
US20170306334A1 (en) * 2016-04-01 2017-10-26 Avidity Biosciences Llc Androgen receptor nucleic acids and uses thereof
WO2017220751A1 (en) 2016-06-22 2017-12-28 Proqr Therapeutics Ii B.V. Single-stranded rna-editing oligonucleotides
CN110352244B (zh) 2016-09-01 2023-03-21 ProQR治疗上市公司Ⅱ 化学修饰的编辑rna的单链寡核苷酸
CA3043768A1 (en) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes for delivery of therapeutic agents
EP3571300A1 (en) 2017-01-19 2019-11-27 ProQR Therapeutics II B.V. Oligonucleotide complexes for use in rna editing
KR102321426B1 (ko) * 2017-02-21 2021-11-05 올릭스 주식회사 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA
WO2019165242A1 (en) * 2018-02-23 2019-08-29 Paraskevi Giannakakou Assay for detection of androgen receptor variants
JP7478923B2 (ja) 2018-03-27 2024-05-08 ユニバーシティ オブ ロチェスター シュードウリジン化のための核酸分子
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
KR102473989B1 (ko) * 2018-11-28 2022-12-07 (주)바이오니아 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물
WO2025160224A1 (en) * 2024-01-24 2025-07-31 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of androgen receptor (ar), compositions thereof, and methods of use
WO2025226946A1 (en) * 2024-04-24 2025-10-30 Cedric Francois Methods and compositions for the treatment of androgenic alopecia
WO2025254047A1 (ja) * 2024-06-06 2025-12-11 東亞合成株式会社 アンドロゲン受容体 ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050170371A1 (en) * 2001-05-18 2005-08-04 Sirna Therapeutics, Inc. RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
AU2003295600A1 (en) * 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
US20060257851A1 (en) * 2002-11-26 2006-11-16 Itzhak Bentwich Bioinformatically detectable group of novel viral regulatory genes and uses thereof
US20050164970A1 (en) * 2003-12-22 2005-07-28 University Of Kansas Medical Center Method for treating prostate cancer using siRNA duplex for androgen receptor
CA2559955C (en) 2004-03-15 2016-02-16 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna
US20070265220A1 (en) 2004-03-15 2007-11-15 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
JP4961549B2 (ja) * 2006-02-16 2012-06-27 国立大学法人愛媛大学 アンドロゲン受容体遺伝子に特異的なｓｉＲＮＡ
US20080014584A1 (en) * 2006-06-01 2008-01-17 Mayo Foundation For Medical Education And Research Modulating androgen receptor activity

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