JP2013534425A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013534425A5 JP2013534425A5 JP2013518762A JP2013518762A JP2013534425A5 JP 2013534425 A5 JP2013534425 A5 JP 2013534425A5 JP 2013518762 A JP2013518762 A JP 2013518762A JP 2013518762 A JP2013518762 A JP 2013518762A JP 2013534425 A5 JP2013534425 A5 JP 2013534425A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotides
- strand
- less
- dsrna
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36177610P | 2010-07-06 | 2010-07-06 | |
| US61/361,776 | 2010-07-06 | ||
| PCT/US2011/042820 WO2012006243A2 (en) | 2010-07-06 | 2011-07-01 | Methods and compositions for the specific inhibition of beta-catenin by double-stranded rna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534425A JP2013534425A (ja) | 2013-09-05 |
| JP2013534425A5 true JP2013534425A5 (https=) | 2014-08-14 |
| JP5976643B2 JP5976643B2 (ja) | 2016-08-24 |
Family
ID=45441761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518762A Expired - Fee Related JP5976643B2 (ja) | 2010-07-06 | 2011-07-01 | 二本鎖ｒｎａによるベータ−カテニンの特異的阻害に対する方法と組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8815825B2 (https=) |
| EP (4) | EP3037538B1 (https=) |
| JP (1) | JP5976643B2 (https=) |
| AU (1) | AU2011276365B2 (https=) |
| CA (2) | CA2804214C (https=) |
| DK (3) | DK3037538T3 (https=) |
| ES (3) | ES2635388T3 (https=) |
| PT (1) | PT3587579T (https=) |
| WO (1) | WO2012006243A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2802658A2 (en) * | 2012-01-09 | 2014-11-19 | Novartis AG | Rnai agents to treat beta-catenin related diseases |
| US10753938B2 (en) * | 2015-03-04 | 2020-08-25 | The University Of Chicago | Beta-catenin inhibitors in cancer immunotherapy |
| US10821112B2 (en) | 2016-03-16 | 2020-11-03 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of a beta-catenin-associated disease or disorder |
| WO2017173297A1 (en) * | 2016-04-01 | 2017-10-05 | Avidity Biosciences Llc | Beta-catenin nucleic acids and uses thereof |
| CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| US10407681B2 (en) * | 2017-03-28 | 2019-09-10 | The United States Of America, As Represented By The Secretary Of Agriculture | Plant-mediated silencing of a fatty acid and retinoid binding protein in Pratylenchus penetrans |
| CA3057679A1 (en) * | 2017-03-28 | 2018-10-04 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin expression to potentiate immunotherapy |
| WO2019079472A1 (en) * | 2017-10-18 | 2019-04-25 | Dicerna Pharmaceuticals, Inc. | BETA-CATENIN NUCLEIC ACID INHIBITOR MOLECULE |
| WO2019100039A1 (en) * | 2017-11-20 | 2019-05-23 | Alnylam Pharmaceuticals, Inc. | Serum amyloid p component (apcs) irna compositions and methods of use thereof |
| US11813280B2 (en) | 2018-01-05 | 2023-11-14 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| EP3740248A4 (en) * | 2018-03-02 | 2022-01-26 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for treating bile duct paucity-associated conditions |
| US10961534B2 (en) | 2018-07-13 | 2021-03-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating porphyria |
| AU2022316139A1 (en) * | 2021-07-23 | 2024-01-18 | Alnylam Pharmaceuticals, Inc. | Beta-catenin (ctnnb1) irna compositions and methods of use thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| ES2061416T3 (es) | 1990-10-12 | 1997-03-01 | Max Planck Gesellschaft | Ribozimas modificadas. |
| US5652094A (en) | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
| US6326487B1 (en) | 1995-06-05 | 2001-12-04 | Aventis Pharma Deutschland Gmbh | 3 modified oligonucleotide derivatives |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| US6248878B1 (en) | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
| US7829693B2 (en) * | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
| US20030064384A1 (en) * | 2001-04-02 | 2003-04-03 | Mien-Chie Hung | Beta-catenin is a strong and independent prognostic factor for cancer |
| US20060019917A1 (en) * | 2001-05-18 | 2006-01-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
| CA2521464C (en) | 2003-04-09 | 2013-02-05 | Alnylam Pharmaceuticals, Inc. | Irna conjugates |
| JP4912873B2 (ja) * | 2003-04-09 | 2012-04-11 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | ｉＲＮＡ複合体 |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| WO2005116204A1 (ja) * | 2004-05-11 | 2005-12-08 | Rnai Co., Ltd. | Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法 |
| US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
| US20090012018A1 (en) * | 2004-09-13 | 2009-01-08 | Matthias Hebrok | Inhibition of pancretic cancer cell growth |
| US20090176725A1 (en) * | 2005-08-17 | 2009-07-09 | Sirna Therapeutics Inc. | Chemically modified short interfering nucleic acid molecules that mediate rna interference |
| WO2007030167A1 (en) | 2005-09-02 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Modification of double-stranded ribonucleic acid molecules |
| WO2007031091A2 (en) * | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| WO2008109369A2 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting tnf gene expression and uses thereof |
| DK2152879T3 (da) * | 2007-05-01 | 2013-02-18 | Santaris Pharma As | RNA antagonistforbindelser til modulering af beta-catenin |
| US20100239546A1 (en) * | 2007-06-15 | 2010-09-23 | Beth Israel Deaconess Medical Center | Bacterial mediated tnf alpha gene silencing |
| TWI455944B (zh) * | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| JP2012005734A (ja) | 2010-06-28 | 2012-01-12 | Panasonic Corp | 電気掃除機用吸込具及びそれを備えた電気掃除機 |
| EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
-
2011
- 2011-07-01 AU AU2011276365A patent/AU2011276365B2/en not_active Ceased
- 2011-07-01 EP EP16155285.6A patent/EP3037538B1/en active Active
- 2011-07-01 ES ES11804230.8T patent/ES2635388T3/es active Active
- 2011-07-01 CA CA2804214A patent/CA2804214C/en active Active
- 2011-07-01 DK DK16155285.6T patent/DK3037538T3/da active
- 2011-07-01 PT PT191716893T patent/PT3587579T/pt unknown
- 2011-07-01 CA CA3146952A patent/CA3146952A1/en active Pending
- 2011-07-01 ES ES16155285T patent/ES2734743T3/es active Active
- 2011-07-01 EP EP11804230.8A patent/EP2591105B1/en active Active
- 2011-07-01 JP JP2013518762A patent/JP5976643B2/ja not_active Expired - Fee Related
- 2011-07-01 WO PCT/US2011/042820 patent/WO2012006243A2/en not_active Ceased
- 2011-07-01 DK DK11804230.8T patent/DK2591105T3/en active
- 2011-07-01 DK DK19171689.3T patent/DK3587579T3/da active
- 2011-07-01 ES ES19171689T patent/ES2873893T3/es active Active
- 2011-07-01 EP EP21154097.6A patent/EP3854874A1/en not_active Withdrawn
- 2011-07-01 EP EP19171689.3A patent/EP3587579B1/en active Active
-
2012
- 2012-12-18 US US13/718,525 patent/US8815825B2/en active Active
-
2014
- 2014-06-10 US US14/300,754 patent/US9243244B2/en active Active
-
2015
- 2015-10-28 US US14/925,952 patent/US9428752B2/en not_active Expired - Fee Related
-
2016
- 2016-03-08 US US15/064,376 patent/US10072263B2/en active Active
-
2018
- 2018-07-09 US US16/030,253 patent/US10612023B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013534424A5 (https=) | ||
| JP2013534425A5 (https=) | ||
| JP7307137B2 (ja) | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 | |
| JP7109416B2 (ja) | 二本鎖ｒｎａによるグリコール酸オキシダーゼ（ｈａｏ１）の特異的阻害に関する方法および組成物 | |
| KR101166214B1 (ko) | 아이지에프비피-2 및 아이지에프비피-5를 억제하는 양특이성 안티센스 올리고뉴클레오티드 및 그 사용방법 | |
| JP2022159552A (ja) | ｉＮＯＳ阻害組成物および乳がん治療薬としてのその使用 | |
| JP2007529224A5 (https=) | ||
| RU2013148024A (ru) | Композиции и способы ингибирования экспрессии гена tmprss6 | |
| SG170780A1 (en) | Compositions and methods for inhibiting expression of eg5 gene | |
| CN107177598A (zh) | 用于抑制BIRC5靶基因mRNA表达的寡核酸分子及其成套组合物 | |
| CN102719432B (zh) | 特异性抑制肿瘤凋亡抑制基因Bcl2的双链不对称小核酸干扰分子asiRNA及其应用 | |
| JP2022031642A (ja) | アンチセンスオリゴヌクレオチド | |
| US8193333B2 (en) | Cancer therapy using Bcl-Xl-specific siNA | |
| JP2007530431A5 (https=) | ||
| EP2064328B1 (en) | Sensitization of cancer cells to therapy using sina targeting genes from the 1p and 19q chromosomal regions | |
| WO2017191021A1 (en) | The incrna meg3 for therapy and diagnosis of cardiac remodelling | |
| KR101993377B1 (ko) | Bcl2 유전자 및 bi-1 유전자의 발현을 동시에 억제하는 핵산 | |
| CA3227144A1 (en) | Modified small interfering rna molecules with reduced off-target effects | |
| EP3680334A1 (en) | Double-stranded rna molecule targeting ckip-1 and use thereof | |
| CN101173275B (zh) | 抑制sars冠状病毒m蛋白基因表达的小干扰rna及其编码基因与应用 | |
| US20250179497A1 (en) | Use of dinucleotide repeat rnas to treat cancer | |
| JP6751185B2 (ja) | ＧＳＴ−π遺伝子を調節するためのＲＮＡ干渉剤 | |
| WO2025016342A1 (zh) | 靶向血管紧张素原的寡核苷酸及其用途 | |
| Li et al. | Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification | |
| CN120519453A (zh) | 一种靶向FASN基因的siRNA、载体复合物及其应用 |