CA2804210A1 - Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna - Google Patents
Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna Download PDFInfo
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- CA2804210A1 CA2804210A1 CA2804210A CA2804210A CA2804210A1 CA 2804210 A1 CA2804210 A1 CA 2804210A1 CA 2804210 A CA2804210 A CA 2804210A CA 2804210 A CA2804210 A CA 2804210A CA 2804210 A1 CA2804210 A1 CA 2804210A1
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| PCT/US2011/042810 WO2012006241A2 (en) | 2010-07-06 | 2011-07-01 | Methods and compositions for the specific inhibition of androgen receptor by double-stranded rna |
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| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| ES2836128T3 (es) | 2008-04-16 | 2021-06-24 | Univ Johns Hopkins | Método para determinar variantes del receptor de andrógenos en cáncer de próstata |
| AR092982A1 (es) * | 2012-10-11 | 2015-05-13 | Isis Pharmaceuticals Inc | Modulacion de la expresion de receptores androgenicos |
| CA2893824A1 (en) | 2012-12-14 | 2014-06-19 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of ckap5 by double-stranded rna |
| RU2015137617A (ru) | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| US9458457B2 (en) * | 2013-07-03 | 2016-10-04 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA |
| CN105636594A (zh) | 2013-08-12 | 2016-06-01 | 托凯药业股份有限公司 | 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物 |
| WO2015179404A1 (en) | 2014-05-19 | 2015-11-26 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| CA2959336A1 (en) * | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| EP3234134B1 (en) | 2014-12-17 | 2020-05-27 | ProQR Therapeutics II B.V. | Targeted rna editing |
| CA2989384A1 (en) | 2015-07-30 | 2017-02-02 | Bayer Cropscience Aktiengesellschaft | Methods and compositions for the control of rust fungi by inhibiting expression of the hxt1 gene |
| US20170306334A1 (en) * | 2016-04-01 | 2017-10-26 | Avidity Biosciences Llc | Androgen receptor nucleic acids and uses thereof |
| WO2017220751A1 (en) | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| CN110352244B (zh) | 2016-09-01 | 2023-03-21 | ProQR治疗上市公司Ⅱ | 化学修饰的编辑rna的单链寡核苷酸 |
| CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| KR102321426B1 (ko) * | 2017-02-21 | 2021-11-05 | 올릭스 주식회사 | 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA |
| WO2019165242A1 (en) * | 2018-02-23 | 2019-08-29 | Paraskevi Giannakakou | Assay for detection of androgen receptor variants |
| JP7478923B2 (ja) | 2018-03-27 | 2024-05-08 | ユニバーシティ オブ ロチェスター | シュードウリジン化のための核酸分子 |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| KR102473989B1 (ko) * | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| WO2025160224A1 (en) * | 2024-01-24 | 2025-07-31 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of androgen receptor (ar), compositions thereof, and methods of use |
| WO2025226946A1 (en) * | 2024-04-24 | 2025-10-30 | Cedric Francois | Methods and compositions for the treatment of androgenic alopecia |
| WO2025254047A1 (ja) * | 2024-06-06 | 2025-12-11 | 東亞合成株式会社 | アンドロゲン受容体 ｒｎａ配列に基づく新規二本鎖ｒｎａ及びその利用 |
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| US20050170371A1 (en) * | 2001-05-18 | 2005-08-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
| AU2003295600A1 (en) * | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US20060257851A1 (en) * | 2002-11-26 | 2006-11-16 | Itzhak Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
| US20050164970A1 (en) * | 2003-12-22 | 2005-07-28 | University Of Kansas Medical Center | Method for treating prostate cancer using siRNA duplex for androgen receptor |
| CA2559955C (en) | 2004-03-15 | 2016-02-16 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| JP4961549B2 (ja) * | 2006-02-16 | 2012-06-27 | 国立大学法人愛媛大学 | アンドロゲン受容体遺伝子に特異的なｓｉＲＮＡ |
| US20080014584A1 (en) * | 2006-06-01 | 2008-01-17 | Mayo Foundation For Medical Education And Research | Modulating androgen receptor activity |
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- 2011-07-01 EP EP11804228.2A patent/EP2591104A4/en not_active Withdrawn
- 2011-07-01 WO PCT/US2011/042810 patent/WO2012006241A2/en not_active Ceased
- 2011-07-01 CA CA2804210A patent/CA2804210A1/en not_active Abandoned
- 2011-07-01 JP JP2013518760A patent/JP2013534424A/ja active Pending
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| JP2013534424A (ja) | 2013-09-05 |
| EP2591104A4 (en) | 2014-09-03 |
| US9732347B2 (en) | 2017-08-15 |
| US20150197756A1 (en) | 2015-07-16 |
| WO2012006241A3 (en) | 2012-04-19 |
| US8927515B2 (en) | 2015-01-06 |
| EP2591104A2 (en) | 2013-05-15 |
| US20130131149A1 (en) | 2013-05-23 |
| WO2012006241A2 (en) | 2012-01-12 |
| AU2011276363A1 (en) | 2013-01-10 |
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