JP2013534171A5 - - Google Patents
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- JP2013534171A5 JP2013534171A5 JP2013524895A JP2013524895A JP2013534171A5 JP 2013534171 A5 JP2013534171 A5 JP 2013534171A5 JP 2013524895 A JP2013524895 A JP 2013524895A JP 2013524895 A JP2013524895 A JP 2013524895A JP 2013534171 A5 JP2013534171 A5 JP 2013534171A5
- Authority
- JP
- Japan
- Prior art keywords
- amyloid
- eye
- fluorescence
- binding compound
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 167
- 102000009091 Amyloidogenic Proteins Human genes 0.000 claims description 144
- 108010048112 Amyloidogenic Proteins Proteins 0.000 claims description 144
- 230000003287 optical effect Effects 0.000 claims description 50
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 230000003942 amyloidogenic effect Effects 0.000 claims description 32
- 230000001678 irradiating effect Effects 0.000 claims description 29
- 210000003484 anatomy Anatomy 0.000 claims description 24
- 238000005070 sampling Methods 0.000 claims description 24
- 238000009826 distribution Methods 0.000 claims description 20
- 238000000695 excitation spectrum Methods 0.000 claims description 20
- 210000001519 tissue Anatomy 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 238000000295 emission spectrum Methods 0.000 claims description 14
- 238000005286 illumination Methods 0.000 claims description 12
- 230000001747 exhibiting effect Effects 0.000 claims description 11
- 238000002189 fluorescence spectrum Methods 0.000 claims description 10
- 230000010287 polarization Effects 0.000 claims description 10
- XFFSCOOTVXBLCK-QAVVBOBSSA-N OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)-c1ccc(cc1)\N=N\c1ccc(O)c(c1)C(O)=O Chemical compound OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)-c1ccc(cc1)\N=N\c1ccc(O)c(c1)C(O)=O XFFSCOOTVXBLCK-QAVVBOBSSA-N 0.000 claims description 8
- AZOPGDOIOXKJRA-UHFFFAOYSA-L chembl1817788 Chemical compound [Na+].[Na+].C1=C(C([O-])=O)C(O)=CC=C1N=NC1=CC=C(C=2C=CC(=CC=2)N=NC=2C=C(C(O)=CC=2)C([O-])=O)C=C1 AZOPGDOIOXKJRA-UHFFFAOYSA-L 0.000 claims description 8
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- NRZNTGUFHSJBTD-HKOYGPOVSA-N 2-[2-(2-methoxyethoxy)ethoxy]ethyl (e)-2-cyano-3-(6-piperidin-1-ylnaphthalen-2-yl)prop-2-enoate Chemical compound C1=CC2=CC(/C=C(C(=O)OCCOCCOCCOC)\C#N)=CC=C2C=C1N1CCCCC1 NRZNTGUFHSJBTD-HKOYGPOVSA-N 0.000 claims description 6
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 6
- 210000001742 aqueous humor Anatomy 0.000 claims description 6
- 230000005284 excitation Effects 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- JADVWWSKYZXRGX-UHFFFAOYSA-M thioflavine T Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C1=[N+](C)C2=CC=C(C)C=C2S1 JADVWWSKYZXRGX-UHFFFAOYSA-M 0.000 claims description 6
- 238000001161 time-correlated single photon counting Methods 0.000 claims description 6
- 210000004087 cornea Anatomy 0.000 claims description 5
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 4
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 230000002123 temporal effect Effects 0.000 claims description 4
- 230000003941 amyloidogenesis Effects 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 102400000269 Amyloid protein A Human genes 0.000 claims 2
- 101710144835 Amyloid protein A Proteins 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 68
- 230000023077 detection of light stimulus Effects 0.000 description 2
- 208000012201 sexual and gender identity disease Diseases 0.000 description 2
- 208000015891 sexual disease Diseases 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37413110P | 2010-08-16 | 2010-08-16 | |
| US61/374,131 | 2010-08-16 | ||
| US201061425490P | 2010-12-21 | 2010-12-21 | |
| US61/425,490 | 2010-12-21 | ||
| EP11001148 | 2011-02-11 | ||
| EP11001148.3 | 2011-02-11 | ||
| PCT/US2011/047628 WO2012024188A1 (en) | 2010-08-16 | 2011-08-12 | System and method for detecting amyloid proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015130669A Division JP2015166749A (ja) | 2010-08-16 | 2015-06-30 | アミロイドタンパク質を検出するためのシステムおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534171A JP2013534171A (ja) | 2013-09-02 |
| JP2013534171A5 true JP2013534171A5 (enExample) | 2014-08-07 |
| JP5863797B2 JP5863797B2 (ja) | 2016-02-17 |
Family
ID=44168199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524895A Expired - Fee Related JP5863797B2 (ja) | 2010-08-16 | 2011-08-12 | アミロイドタンパク質を検出するためのデバイス |
| JP2015130669A Withdrawn JP2015166749A (ja) | 2010-08-16 | 2015-06-30 | アミロイドタンパク質を検出するためのシステムおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015130669A Withdrawn JP2015166749A (ja) | 2010-08-16 | 2015-06-30 | アミロイドタンパク質を検出するためのシステムおよび方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9220403B2 (enExample) |
| EP (2) | EP2605694B1 (enExample) |
| JP (2) | JP5863797B2 (enExample) |
| KR (1) | KR101905436B1 (enExample) |
| CN (1) | CN103153168B (enExample) |
| AR (1) | AR082707A1 (enExample) |
| AU (1) | AU2011292233B2 (enExample) |
| BR (1) | BR112013003754B1 (enExample) |
| CA (1) | CA2807683C (enExample) |
| MX (1) | MX357628B (enExample) |
| NZ (1) | NZ607257A (enExample) |
| RU (1) | RU2577810C2 (enExample) |
| SG (1) | SG188227A1 (enExample) |
| TW (1) | TWI476392B (enExample) |
| WO (1) | WO2012024188A1 (enExample) |
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| CA2718938C (en) * | 2008-03-27 | 2016-11-29 | Neuroptix Corporation | Ocular imaging |
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| EP2712425A2 (en) * | 2011-04-27 | 2014-04-02 | Adlyfe, Inc. | Ocular detection of amyloid proteins |
| WO2013086516A1 (en) | 2011-12-09 | 2013-06-13 | Regents Of The University Of Minnesota | Hyperspectral imaging for early detection of alzheimer's disease |
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| JP6133053B2 (ja) * | 2012-12-21 | 2017-05-24 | 浜松ホトニクス株式会社 | アミロイドの凝集体の定量方法及びその定量装置 |
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| US20150065824A1 (en) * | 2013-08-28 | 2015-03-05 | Johnson & Johnson Vision Care, Inc. | Methods and apparatus to form ophthalmic devices incorporating fluorescence detectors |
| TW201609183A (zh) * | 2013-10-31 | 2016-03-16 | 康諾普堤克斯公司 | 眼用調配物之製備方法及其用途 |
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| JP2017512834A (ja) | 2014-03-19 | 2017-05-25 | アミディス・ダイアグノスティックス・インコーポレイテッド | アミロイド標的剤及びその使用方法 |
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| CN113520301B (zh) | 2016-03-10 | 2024-11-26 | 明尼苏达大学董事会 | 空间-光谱成像方法和视网膜成像设备 |
| CA3031528A1 (en) * | 2016-08-01 | 2018-02-08 | Cognoptix, Inc. | System and method for detecting tau protein in ocular tissue |
| US10405785B2 (en) * | 2016-08-04 | 2019-09-10 | City University Of Hong Kong | Determination of a concentration of an analyte in a subject |
| WO2018051209A1 (en) * | 2016-09-16 | 2018-03-22 | Novartis Ag | Subtractive en face optical coherence tomography imaging |
| US10905897B2 (en) * | 2016-10-20 | 2021-02-02 | Neuro-Laser Foundation, Inc. | Synergistic treatment methodologies using light therapy |
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| KR101835815B1 (ko) * | 2016-12-16 | 2018-03-07 | (주) 인텍플러스 | 형광수명 측정장치 및 측정방법 |
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| JP7007132B2 (ja) * | 2017-08-09 | 2022-01-24 | 浜松ホトニクス株式会社 | アミロイド凝集体の検出方法、アミロイド凝集体検出装置、及びアミロイド凝集体検出プログラム |
| AU2018372578B2 (en) | 2017-11-27 | 2024-11-07 | Retispec Inc. | Hyperspectral image-guided raman ocular imager for Alzheimer's Disease pathologies |
| CN108489941B (zh) * | 2018-01-31 | 2021-07-27 | 吉林大学 | 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用 |
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| US10746596B2 (en) * | 2018-06-18 | 2020-08-18 | Harry Owen | Probe optic light shields |
| JP7380013B2 (ja) * | 2019-09-26 | 2023-11-15 | 株式会社ニコン | 眼科装置、眼科装置の制御方法及びプログラム |
| WO2021192910A1 (ja) * | 2020-03-23 | 2021-09-30 | コニカミノルタ株式会社 | 画像生成方法、画像生成装置及びプログラム |
| AU2021422913A1 (en) * | 2021-01-26 | 2023-09-07 | Edinburgh Biosciences Ltd | Apparatus and systems for monitoring and treating cataracts |
| GB2603006B (en) * | 2021-01-26 | 2024-07-03 | Edinburgh Biosciences Ltd | Apparatus and systems for monitoring and treating cataracts |
| JP7633102B2 (ja) | 2021-06-22 | 2025-02-19 | 浜松ホトニクス株式会社 | 蛍光寿命計測のバックグラウンド除去方法及び標的物質の定量方法 |
| KR102771665B1 (ko) * | 2021-11-30 | 2025-02-24 | 세종대학교산학협력단 | 다채널 형광 시상수 신호를 이용한 알츠하이머 지수 판단 장치 및 방법 |
| KR102784581B1 (ko) * | 2022-11-15 | 2025-03-19 | 가톨릭대학교 산학협력단 | 비침습적 알츠하이머 위험 검사장치 및 검사방법 |
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| US8450466B2 (en) * | 2008-03-21 | 2013-05-28 | The General Hosptial Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
| CA2718938C (en) * | 2008-03-27 | 2016-11-29 | Neuroptix Corporation | Ocular imaging |
| JP2009264787A (ja) * | 2008-04-22 | 2009-11-12 | Topcon Corp | 光画像計測装置 |
| GB0903274D0 (en) | 2009-02-26 | 2009-04-08 | Edinburgh Instr | Fluoreence method and system |
| MX357628B (es) * | 2010-08-16 | 2018-07-17 | Cognoptix Inc Star | Sistema y metodo para detectar proteinas amiloides. |
-
2011
- 2011-08-12 MX MX2013001537A patent/MX357628B/es active IP Right Grant
- 2011-08-12 JP JP2013524895A patent/JP5863797B2/ja not_active Expired - Fee Related
- 2011-08-12 RU RU2013110796/14A patent/RU2577810C2/ru not_active IP Right Cessation
- 2011-08-12 CN CN201180045350.4A patent/CN103153168B/zh not_active Expired - Fee Related
- 2011-08-12 KR KR1020137006889A patent/KR101905436B1/ko not_active Expired - Fee Related
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- 2011-08-12 WO PCT/US2011/047628 patent/WO2012024188A1/en not_active Ceased
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- 2011-08-12 SG SG2013011531A patent/SG188227A1/en unknown
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