AR082707A1 - Sistema y metodo para detectar proteinas amiloides - Google Patents

Sistema y metodo para detectar proteinas amiloides

Info

Publication number
AR082707A1
AR082707A1 ARP110102977A ARP110102977A AR082707A1 AR 082707 A1 AR082707 A1 AR 082707A1 AR P110102977 A ARP110102977 A AR P110102977A AR P110102977 A ARP110102977 A AR P110102977A AR 082707 A1 AR082707 A1 AR 082707A1
Authority
AR
Argentina
Prior art keywords
amyloid
eye
binding compound
amyloid protein
fluorescence
Prior art date
Application number
ARP110102977A
Other languages
English (en)
Spanish (es)
Original Assignee
Neuroptix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuroptix Corp filed Critical Neuroptix Corp
Publication of AR082707A1 publication Critical patent/AR082707A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/1005—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring distances inside the eye, e.g. thickness of the cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/11—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils
    • A61B3/111—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils for measuring interpupillary distance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
    • A61B3/1173—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes for examining the eye lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6821—Eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/13—Ophthalmic microscopes
    • A61B3/135—Slit-lamp microscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Neurology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Developmental Disabilities (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ARP110102977A 2010-08-16 2011-08-16 Sistema y metodo para detectar proteinas amiloides AR082707A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37413110P 2010-08-16 2010-08-16
US201061425490P 2010-12-21 2010-12-21
EP11001148 2011-02-11

Publications (1)

Publication Number Publication Date
AR082707A1 true AR082707A1 (es) 2012-12-26

Family

ID=44168199

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110102977A AR082707A1 (es) 2010-08-16 2011-08-16 Sistema y metodo para detectar proteinas amiloides

Country Status (15)

Country Link
US (2) US9220403B2 (enExample)
EP (2) EP2605694B1 (enExample)
JP (2) JP5863797B2 (enExample)
KR (1) KR101905436B1 (enExample)
CN (1) CN103153168B (enExample)
AR (1) AR082707A1 (enExample)
AU (1) AU2011292233B2 (enExample)
BR (1) BR112013003754B1 (enExample)
CA (1) CA2807683C (enExample)
MX (1) MX357628B (enExample)
NZ (1) NZ607257A (enExample)
RU (1) RU2577810C2 (enExample)
SG (1) SG188227A1 (enExample)
TW (1) TWI476392B (enExample)
WO (1) WO2012024188A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2718938C (en) * 2008-03-27 2016-11-29 Neuroptix Corporation Ocular imaging
MX357628B (es) * 2010-08-16 2018-07-17 Cognoptix Inc Star Sistema y metodo para detectar proteinas amiloides.
EP2712425A2 (en) * 2011-04-27 2014-04-02 Adlyfe, Inc. Ocular detection of amyloid proteins
WO2013086516A1 (en) 2011-12-09 2013-06-13 Regents Of The University Of Minnesota Hyperspectral imaging for early detection of alzheimer's disease
US20130330711A1 (en) * 2012-06-06 2013-12-12 National Taiwan University Sensor for detection of a target of interest
JP6133053B2 (ja) * 2012-12-21 2017-05-24 浜松ホトニクス株式会社 アミロイドの凝集体の定量方法及びその定量装置
US20150042954A1 (en) * 2013-08-08 2015-02-12 University Of Rochester System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics
US20150065824A1 (en) * 2013-08-28 2015-03-05 Johnson & Johnson Vision Care, Inc. Methods and apparatus to form ophthalmic devices incorporating fluorescence detectors
TW201609183A (zh) * 2013-10-31 2016-03-16 康諾普堤克斯公司 眼用調配物之製備方法及其用途
CA2930112A1 (en) * 2013-11-12 2015-05-21 Cognoptix, Inc. Method for measuring fluorescence in ocular tissue
CN103709069B (zh) * 2014-01-07 2015-03-18 南方医科大学 一种6’-羟基萘基-2-氰基丙烯酸酯及其用途
JP2017512834A (ja) 2014-03-19 2017-05-25 アミディス・ダイアグノスティックス・インコーポレイテッド アミロイド標的剤及びその使用方法
JP2016014074A (ja) * 2014-06-19 2016-01-28 国立研究開発法人物質・材料研究機構 プログラム可能なナノロボットに添付されたセンサ、分子機械及びコントローラ
JP6550673B2 (ja) * 2015-04-03 2019-07-31 国立大学法人 東京大学 フォトルミネセンス寿命測定装置及び測定方法
US11402328B2 (en) 2015-09-29 2022-08-02 Hamamatsu Photonics K.K. Amyloid β oligomer detection method, amyloid β oligomer detection device, and amyloid β oligomer detection program
CN113520301B (zh) 2016-03-10 2024-11-26 明尼苏达大学董事会 空间-光谱成像方法和视网膜成像设备
CA3031528A1 (en) * 2016-08-01 2018-02-08 Cognoptix, Inc. System and method for detecting tau protein in ocular tissue
US10405785B2 (en) * 2016-08-04 2019-09-10 City University Of Hong Kong Determination of a concentration of an analyte in a subject
WO2018051209A1 (en) * 2016-09-16 2018-03-22 Novartis Ag Subtractive en face optical coherence tomography imaging
US10905897B2 (en) * 2016-10-20 2021-02-02 Neuro-Laser Foundation, Inc. Synergistic treatment methodologies using light therapy
US9950189B1 (en) * 2016-10-20 2018-04-24 Neuro-Laser Foundation Inc. Treatment methodologies using light therapy
KR101835815B1 (ko) * 2016-12-16 2018-03-07 (주) 인텍플러스 형광수명 측정장치 및 측정방법
WO2018132563A1 (en) * 2017-01-11 2018-07-19 Avedro, Inc. Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea
WO2018136910A1 (en) * 2017-01-23 2018-07-26 Rensselaer Polytechnic Institute Systems and methods for binding amyloid fibrils using fluorescent protein
JP7007132B2 (ja) * 2017-08-09 2022-01-24 浜松ホトニクス株式会社 アミロイド凝集体の検出方法、アミロイド凝集体検出装置、及びアミロイド凝集体検出プログラム
AU2018372578B2 (en) 2017-11-27 2024-11-07 Retispec Inc. Hyperspectral image-guided raman ocular imager for Alzheimer's Disease pathologies
CN108489941B (zh) * 2018-01-31 2021-07-27 吉林大学 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用
EP3803416A4 (en) * 2018-05-31 2022-05-18 Amydis, Inc. COMPOSITIONS AND METHODS FOR DETECTING BRAIN TRAUMA
US10746596B2 (en) * 2018-06-18 2020-08-18 Harry Owen Probe optic light shields
JP7380013B2 (ja) * 2019-09-26 2023-11-15 株式会社ニコン 眼科装置、眼科装置の制御方法及びプログラム
WO2021192910A1 (ja) * 2020-03-23 2021-09-30 コニカミノルタ株式会社 画像生成方法、画像生成装置及びプログラム
AU2021422913A1 (en) * 2021-01-26 2023-09-07 Edinburgh Biosciences Ltd Apparatus and systems for monitoring and treating cataracts
GB2603006B (en) * 2021-01-26 2024-07-03 Edinburgh Biosciences Ltd Apparatus and systems for monitoring and treating cataracts
JP7633102B2 (ja) 2021-06-22 2025-02-19 浜松ホトニクス株式会社 蛍光寿命計測のバックグラウンド除去方法及び標的物質の定量方法
KR102771665B1 (ko) * 2021-11-30 2025-02-24 세종대학교산학협력단 다채널 형광 시상수 신호를 이용한 알츠하이머 지수 판단 장치 및 방법
KR102784581B1 (ko) * 2022-11-15 2025-03-19 가톨릭대학교 산학협력단 비침습적 알츠하이머 위험 검사장치 및 검사방법
CN115855902B (zh) * 2022-11-30 2025-10-03 西南交通大学 水体中磷酸三甲苯酯浓度的检测方法和检测材料
EP4570166A1 (en) 2023-12-12 2025-06-18 Instytut Chemii Fizycznej Polskiej Akademii Nauk System for photomultiplier protection in eye imaging

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836969B2 (ja) 1978-01-23 1983-08-12 株式会社甲南カメラ研究所 眼球顕微鏡
US4529556A (en) 1983-08-19 1985-07-16 The Dow Chemical Company Bis((aryl)vinyl)benzenes
US4761071A (en) 1984-11-06 1988-08-02 Baron William S Apparatus and method for determining corneal and scleral topography
US4702576A (en) 1985-09-27 1987-10-27 Cambridge Instruments Inc. Ocular scattering analyzer
US5183044A (en) 1987-06-30 1993-02-02 Kabushiki Kaisha Topcon Noncontact type tonometer
US4806004A (en) 1987-07-10 1989-02-21 California Institute Of Technology Scanning microscopy
US4993827A (en) 1987-09-01 1991-02-19 Massachusetts Institute Of Technology Method for detecting cataractogenesis
US4957113A (en) 1987-09-01 1990-09-18 Massachusetts Institute Of Technology Method for detecting cataractogenesis using quasi-elastic light scattering
JPH0277228A (ja) 1988-09-14 1990-03-16 Kowa Co 眼科測定装置
JP2931325B2 (ja) 1989-06-29 1999-08-09 興和株式会社 眼科測定装置
US5048946A (en) 1990-05-15 1991-09-17 Phoenix Laser Systems, Inc. Spectral division of reflected light in complex optical diagnostic and therapeutic systems
US5279296A (en) 1991-01-04 1994-01-18 Oculon Corporation Method and apparatus for detecting cataractogenesis
US6198532B1 (en) 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US5303709A (en) 1991-12-16 1994-04-19 Dreher Andreas W Retinal eye disease diagnostic system
JPH05261068A (ja) 1992-03-19 1993-10-12 Topcon Corp 眼科装置
US5392776A (en) 1992-09-21 1995-02-28 Oculon Corporation Method and apparatus for detecting cataractogenesis
DE69414913T2 (de) 1993-06-10 1999-07-01 Konan Common Co., Ltd., Nishinomiya Verfahren und Vorrichtung zur Gewinnung von Bildern der Hornhaut
PT101290B (pt) 1993-06-18 2000-10-31 Fernandes Jose Guilherme Da Cu Fluorometro para medicao da concentracao de fluoroforos de localizacao ocular
US5427094A (en) 1993-11-08 1995-06-27 Oculon Corporation Method and apparatus for detecting cataractogenesis
US5427095A (en) 1993-11-09 1995-06-27 Massachusetts Institute of Technology Oculon Corporation Method and apparatus for detecting cataractogenesis
US6168776B1 (en) 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6417178B1 (en) 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
US5894340A (en) 1995-02-17 1999-04-13 The Regents Of The University Of California Method for quantifying optical properties of the human lens
US6096510A (en) 1995-10-04 2000-08-01 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical detection techniques
US5973779A (en) 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
JP3499093B2 (ja) 1996-07-25 2004-02-23 株式会社ニデック 前眼部断面解析装置
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
US5751395A (en) 1997-01-10 1998-05-12 Thall; Edmond H. Retinal diagnostic device
US6144754A (en) 1997-03-28 2000-11-07 Oki Electric Industry Co., Ltd. Method and apparatus for identifying individuals
US6302876B1 (en) 1997-05-27 2001-10-16 Visx Corporation Systems and methods for imaging corneal profiles
US6280386B1 (en) 1997-06-16 2001-08-28 The Research Foundation Of The City University Of New York Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same
US6299307B1 (en) 1997-10-10 2001-10-09 Visx, Incorporated Eye tracking device for laser eye surgery using corneal margin detection
US6179422B1 (en) 1998-04-27 2001-01-30 Ming Lai Optical tracking device
IL125614A (en) 1998-07-31 2003-01-12 Amiram Grinvald System and method for non-invasive imaging of retinal function
JP3848492B2 (ja) 1998-09-04 2006-11-22 株式会社ニデック 角膜手術装置
US7303281B2 (en) 1998-10-07 2007-12-04 Tracey Technologies, Llc Method and device for determining refractive components and visual function of the eye for vision correction
US6045503A (en) 1999-01-20 2000-04-04 Kamilllo Eisner-Stiftung Method of and apparatus for determining the topology of a cornea
JP3699853B2 (ja) 1999-02-18 2005-09-28 株式会社ニデック 眼科装置
US6088606A (en) * 1999-03-22 2000-07-11 Spectrx, Inc. Method and apparatus for determining a duration of a medical condition
US6275718B1 (en) 1999-03-23 2001-08-14 Philip Lempert Method and apparatus for imaging and analysis of ocular tissue
US7060793B2 (en) * 1999-05-21 2006-06-13 The Regents Of The University Of California Circularly permuted fluorescent protein indicators
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
AU2001259435A1 (en) * 2000-05-03 2001-11-12 Stephen T Flock Optical imaging of subsurface anatomical structures and biomolecules
US6878363B2 (en) * 2000-05-17 2005-04-12 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1913866A1 (en) 2000-08-21 2008-04-23 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7107092B2 (en) 2000-08-21 2006-09-12 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7297326B2 (en) 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
US7350522B2 (en) 2000-10-17 2008-04-01 Sony Corporation Scanning method for applying ultrasonic acoustic data to the human neural cortex
WO2002064031A2 (en) 2001-02-09 2002-08-22 Sensomotoric Instruments Gmbh Multidimensional eye tracking and position measurement system
US6600947B2 (en) * 2001-03-16 2003-07-29 Nymox Corporation Method of detecting amyloid-containing lesions by autofluorescence
DK1420830T3 (da) 2001-04-27 2011-05-09 Gen Hospital Corp Okular diagnose af Alzheimer-sygdom
WO2003032823A2 (en) 2001-10-17 2003-04-24 Carl Zeiss Meditec Ag Method and apparatus for measuring a corneal profile of an eye
DE10155464A1 (de) 2001-11-12 2003-05-22 Zeiss Carl Jena Gmbh Beleuchtungseinheit zur Erzeugung von optischen Schnittbildern in transparenten Medien, insbesondere im Auge
US6854847B2 (en) 2001-11-13 2005-02-15 Ming Lai Optical tracking device employing scanning beams on symmetric reference
JP3756127B2 (ja) 2002-04-19 2006-03-15 株式会社トプコン 眼科撮影装置
US7330305B2 (en) 2002-04-26 2008-02-12 Optiscan Pty Ltd Laser scanning confocal microscope with fibre bundle return
AU2003263811A1 (en) * 2002-07-25 2004-02-16 The Regents Of The University Of California Monitoring molecular interactions using photon arrival-time interval distribution analysis
EP1569547A1 (en) 2002-10-16 2005-09-07 Campbell Science Group, Inc. Cornea characteristics measuring device
WO2004036182A2 (en) 2002-10-17 2004-04-29 Control Delivery Systems, Inc. Methods for monitoring treatment of disease
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
US7575321B2 (en) 2003-10-30 2009-08-18 Welch Allyn, Inc. Apparatus and method of diagnosis of optically identifiable ophthalmic conditions
GB2409033B (en) 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
JP5085858B2 (ja) 2005-09-27 2012-11-28 株式会社ニデック 眼屈折力測定装置
US7445335B2 (en) 2006-01-20 2008-11-04 Clarity Medical Systems, Inc. Sequential wavefront sensor
CA2647147C (en) * 2006-04-11 2016-10-04 Neuroptix Corporation Ocular imaging
DE102006030382A1 (de) 2006-06-29 2008-01-03 Carl Zeiss Meditec Ag Verfahren und Vorrichtung zur optischen Detektion am Auge
WO2008076351A2 (en) * 2006-12-15 2008-06-26 The Regents Of The University Of California Dissolution of amyloid fibrils by flavonoids and other compounds
WO2008144065A1 (en) 2007-05-21 2008-11-27 Neuroptix Corporation Ophthalmic formulations of amyloid- contrast agents and methods of use thereof
DE102007061987A1 (de) * 2007-12-21 2009-06-25 Carl Zeiss Meditec Ag Vorrichtung und Verfahren zum Nachweisen von Molekülen im Auge
US8450466B2 (en) * 2008-03-21 2013-05-28 The General Hosptial Corporation Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders
CA2718938C (en) * 2008-03-27 2016-11-29 Neuroptix Corporation Ocular imaging
JP2009264787A (ja) * 2008-04-22 2009-11-12 Topcon Corp 光画像計測装置
GB0903274D0 (en) 2009-02-26 2009-04-08 Edinburgh Instr Fluoreence method and system
MX357628B (es) * 2010-08-16 2018-07-17 Cognoptix Inc Star Sistema y metodo para detectar proteinas amiloides.

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CN103153168A (zh) 2013-06-12
RU2577810C2 (ru) 2016-03-20
TWI476392B (zh) 2015-03-11
CN103153168B (zh) 2016-03-09
US9451909B2 (en) 2016-09-27
JP5863797B2 (ja) 2016-02-17
EP2605694B1 (en) 2021-10-27
AU2011292233A1 (en) 2013-03-07
CA2807683C (en) 2020-02-18
MX357628B (es) 2018-07-17
BR112013003754A2 (pt) 2016-05-31
EP2420179A3 (en) 2012-03-21
MX2013001537A (es) 2013-06-05
WO2012024188A1 (en) 2012-02-23
RU2013110796A (ru) 2014-09-27
CA2807683A1 (en) 2012-02-23
US20160183859A1 (en) 2016-06-30
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AU2011292233B2 (en) 2015-05-21
US20130135580A1 (en) 2013-05-30
SG188227A1 (en) 2013-04-30
US9220403B2 (en) 2015-12-29
EP2420179B1 (en) 2020-10-07
KR101905436B1 (ko) 2018-10-08
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KR20130138211A (ko) 2013-12-18
BR112013003754B1 (pt) 2021-11-09

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