TWI476392B - 用於檢測類澱粉蛋白之系統及方法 - Google Patents
用於檢測類澱粉蛋白之系統及方法 Download PDFInfo
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- TWI476392B TWI476392B TW100129191A TW100129191A TWI476392B TW I476392 B TWI476392 B TW I476392B TW 100129191 A TW100129191 A TW 100129191A TW 100129191 A TW100129191 A TW 100129191A TW I476392 B TWI476392 B TW I476392B
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/13—Ophthalmic microscopes
- A61B3/135—Slit-lamp microscopes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
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- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Neurology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
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- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Neurosurgery (AREA)
- Physiology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Eye Examination Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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| US37413110P | 2010-08-16 | 2010-08-16 | |
| US201061425490P | 2010-12-21 | 2010-12-21 | |
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Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2718938C (en) * | 2008-03-27 | 2016-11-29 | Neuroptix Corporation | Ocular imaging |
| MX357628B (es) * | 2010-08-16 | 2018-07-17 | Cognoptix Inc Star | Sistema y metodo para detectar proteinas amiloides. |
| EP2712425A2 (en) * | 2011-04-27 | 2014-04-02 | Adlyfe, Inc. | Ocular detection of amyloid proteins |
| WO2013086516A1 (en) | 2011-12-09 | 2013-06-13 | Regents Of The University Of Minnesota | Hyperspectral imaging for early detection of alzheimer's disease |
| US20130330711A1 (en) * | 2012-06-06 | 2013-12-12 | National Taiwan University | Sensor for detection of a target of interest |
| JP6133053B2 (ja) * | 2012-12-21 | 2017-05-24 | 浜松ホトニクス株式会社 | アミロイドの凝集体の定量方法及びその定量装置 |
| US20150042954A1 (en) * | 2013-08-08 | 2015-02-12 | University Of Rochester | System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics |
| US20150065824A1 (en) * | 2013-08-28 | 2015-03-05 | Johnson & Johnson Vision Care, Inc. | Methods and apparatus to form ophthalmic devices incorporating fluorescence detectors |
| TW201609183A (zh) * | 2013-10-31 | 2016-03-16 | 康諾普堤克斯公司 | 眼用調配物之製備方法及其用途 |
| CA2930112A1 (en) * | 2013-11-12 | 2015-05-21 | Cognoptix, Inc. | Method for measuring fluorescence in ocular tissue |
| CN103709069B (zh) * | 2014-01-07 | 2015-03-18 | 南方医科大学 | 一种6’-羟基萘基-2-氰基丙烯酸酯及其用途 |
| JP2017512834A (ja) | 2014-03-19 | 2017-05-25 | アミディス・ダイアグノスティックス・インコーポレイテッド | アミロイド標的剤及びその使用方法 |
| JP2016014074A (ja) * | 2014-06-19 | 2016-01-28 | 国立研究開発法人物質・材料研究機構 | プログラム可能なナノロボットに添付されたセンサ、分子機械及びコントローラ |
| JP6550673B2 (ja) * | 2015-04-03 | 2019-07-31 | 国立大学法人 東京大学 | フォトルミネセンス寿命測定装置及び測定方法 |
| US11402328B2 (en) | 2015-09-29 | 2022-08-02 | Hamamatsu Photonics K.K. | Amyloid β oligomer detection method, amyloid β oligomer detection device, and amyloid β oligomer detection program |
| CN113520301B (zh) | 2016-03-10 | 2024-11-26 | 明尼苏达大学董事会 | 空间-光谱成像方法和视网膜成像设备 |
| CA3031528A1 (en) * | 2016-08-01 | 2018-02-08 | Cognoptix, Inc. | System and method for detecting tau protein in ocular tissue |
| US10405785B2 (en) * | 2016-08-04 | 2019-09-10 | City University Of Hong Kong | Determination of a concentration of an analyte in a subject |
| WO2018051209A1 (en) * | 2016-09-16 | 2018-03-22 | Novartis Ag | Subtractive en face optical coherence tomography imaging |
| US10905897B2 (en) * | 2016-10-20 | 2021-02-02 | Neuro-Laser Foundation, Inc. | Synergistic treatment methodologies using light therapy |
| US9950189B1 (en) * | 2016-10-20 | 2018-04-24 | Neuro-Laser Foundation Inc. | Treatment methodologies using light therapy |
| KR101835815B1 (ko) * | 2016-12-16 | 2018-03-07 | (주) 인텍플러스 | 형광수명 측정장치 및 측정방법 |
| WO2018132563A1 (en) * | 2017-01-11 | 2018-07-19 | Avedro, Inc. | Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea |
| WO2018136910A1 (en) * | 2017-01-23 | 2018-07-26 | Rensselaer Polytechnic Institute | Systems and methods for binding amyloid fibrils using fluorescent protein |
| JP7007132B2 (ja) * | 2017-08-09 | 2022-01-24 | 浜松ホトニクス株式会社 | アミロイド凝集体の検出方法、アミロイド凝集体検出装置、及びアミロイド凝集体検出プログラム |
| AU2018372578B2 (en) | 2017-11-27 | 2024-11-07 | Retispec Inc. | Hyperspectral image-guided raman ocular imager for Alzheimer's Disease pathologies |
| CN108489941B (zh) * | 2018-01-31 | 2021-07-27 | 吉林大学 | 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用 |
| EP3803416A4 (en) * | 2018-05-31 | 2022-05-18 | Amydis, Inc. | COMPOSITIONS AND METHODS FOR DETECTING BRAIN TRAUMA |
| US10746596B2 (en) * | 2018-06-18 | 2020-08-18 | Harry Owen | Probe optic light shields |
| JP7380013B2 (ja) * | 2019-09-26 | 2023-11-15 | 株式会社ニコン | 眼科装置、眼科装置の制御方法及びプログラム |
| WO2021192910A1 (ja) * | 2020-03-23 | 2021-09-30 | コニカミノルタ株式会社 | 画像生成方法、画像生成装置及びプログラム |
| AU2021422913A1 (en) * | 2021-01-26 | 2023-09-07 | Edinburgh Biosciences Ltd | Apparatus and systems for monitoring and treating cataracts |
| GB2603006B (en) * | 2021-01-26 | 2024-07-03 | Edinburgh Biosciences Ltd | Apparatus and systems for monitoring and treating cataracts |
| JP7633102B2 (ja) | 2021-06-22 | 2025-02-19 | 浜松ホトニクス株式会社 | 蛍光寿命計測のバックグラウンド除去方法及び標的物質の定量方法 |
| KR102771665B1 (ko) * | 2021-11-30 | 2025-02-24 | 세종대학교산학협력단 | 다채널 형광 시상수 신호를 이용한 알츠하이머 지수 판단 장치 및 방법 |
| KR102784581B1 (ko) * | 2022-11-15 | 2025-03-19 | 가톨릭대학교 산학협력단 | 비침습적 알츠하이머 위험 검사장치 및 검사방법 |
| CN115855902B (zh) * | 2022-11-30 | 2025-10-03 | 西南交通大学 | 水体中磷酸三甲苯酯浓度的检测方法和检测材料 |
| EP4570166A1 (en) | 2023-12-12 | 2025-06-18 | Instytut Chemii Fizycznej Polskiej Akademii Nauk | System for photomultiplier protection in eye imaging |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001082786A2 (en) * | 2000-05-03 | 2001-11-08 | Flock Stephen T | Optical imaging of subsurface anatomical structures and biomolecules |
| DE102007061987A1 (de) * | 2007-12-21 | 2009-06-25 | Carl Zeiss Meditec Ag | Vorrichtung und Verfahren zum Nachweisen von Molekülen im Auge |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5836969B2 (ja) | 1978-01-23 | 1983-08-12 | 株式会社甲南カメラ研究所 | 眼球顕微鏡 |
| US4529556A (en) | 1983-08-19 | 1985-07-16 | The Dow Chemical Company | Bis((aryl)vinyl)benzenes |
| US4761071A (en) | 1984-11-06 | 1988-08-02 | Baron William S | Apparatus and method for determining corneal and scleral topography |
| US4702576A (en) | 1985-09-27 | 1987-10-27 | Cambridge Instruments Inc. | Ocular scattering analyzer |
| US5183044A (en) | 1987-06-30 | 1993-02-02 | Kabushiki Kaisha Topcon | Noncontact type tonometer |
| US4806004A (en) | 1987-07-10 | 1989-02-21 | California Institute Of Technology | Scanning microscopy |
| US4993827A (en) | 1987-09-01 | 1991-02-19 | Massachusetts Institute Of Technology | Method for detecting cataractogenesis |
| US4957113A (en) | 1987-09-01 | 1990-09-18 | Massachusetts Institute Of Technology | Method for detecting cataractogenesis using quasi-elastic light scattering |
| JPH0277228A (ja) | 1988-09-14 | 1990-03-16 | Kowa Co | 眼科測定装置 |
| JP2931325B2 (ja) | 1989-06-29 | 1999-08-09 | 興和株式会社 | 眼科測定装置 |
| US5048946A (en) | 1990-05-15 | 1991-09-17 | Phoenix Laser Systems, Inc. | Spectral division of reflected light in complex optical diagnostic and therapeutic systems |
| US5279296A (en) | 1991-01-04 | 1994-01-18 | Oculon Corporation | Method and apparatus for detecting cataractogenesis |
| US6198532B1 (en) | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
| US5303709A (en) | 1991-12-16 | 1994-04-19 | Dreher Andreas W | Retinal eye disease diagnostic system |
| JPH05261068A (ja) | 1992-03-19 | 1993-10-12 | Topcon Corp | 眼科装置 |
| US5392776A (en) | 1992-09-21 | 1995-02-28 | Oculon Corporation | Method and apparatus for detecting cataractogenesis |
| DE69414913T2 (de) | 1993-06-10 | 1999-07-01 | Konan Common Co., Ltd., Nishinomiya | Verfahren und Vorrichtung zur Gewinnung von Bildern der Hornhaut |
| PT101290B (pt) | 1993-06-18 | 2000-10-31 | Fernandes Jose Guilherme Da Cu | Fluorometro para medicao da concentracao de fluoroforos de localizacao ocular |
| US5427094A (en) | 1993-11-08 | 1995-06-27 | Oculon Corporation | Method and apparatus for detecting cataractogenesis |
| US5427095A (en) | 1993-11-09 | 1995-06-27 | Massachusetts Institute of Technology Oculon Corporation | Method and apparatus for detecting cataractogenesis |
| US6168776B1 (en) | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US6417178B1 (en) | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
| US5894340A (en) | 1995-02-17 | 1999-04-13 | The Regents Of The University Of California | Method for quantifying optical properties of the human lens |
| US6096510A (en) | 1995-10-04 | 2000-08-01 | Cytoscan Sciences, Llc | Methods and systems for assessing biological materials using optical detection techniques |
| US5973779A (en) | 1996-03-29 | 1999-10-26 | Ansari; Rafat R. | Fiber-optic imaging probe |
| JP3499093B2 (ja) | 1996-07-25 | 2004-02-23 | 株式会社ニデック | 前眼部断面解析装置 |
| DE19649971A1 (de) | 1996-11-19 | 1998-05-28 | Diagnostikforschung Inst | Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung) |
| US5751395A (en) | 1997-01-10 | 1998-05-12 | Thall; Edmond H. | Retinal diagnostic device |
| US6144754A (en) | 1997-03-28 | 2000-11-07 | Oki Electric Industry Co., Ltd. | Method and apparatus for identifying individuals |
| US6302876B1 (en) | 1997-05-27 | 2001-10-16 | Visx Corporation | Systems and methods for imaging corneal profiles |
| US6280386B1 (en) | 1997-06-16 | 2001-08-28 | The Research Foundation Of The City University Of New York | Apparatus for enhancing the visibility of a luminous object inside tissue and methods for same |
| US6299307B1 (en) | 1997-10-10 | 2001-10-09 | Visx, Incorporated | Eye tracking device for laser eye surgery using corneal margin detection |
| US6179422B1 (en) | 1998-04-27 | 2001-01-30 | Ming Lai | Optical tracking device |
| IL125614A (en) | 1998-07-31 | 2003-01-12 | Amiram Grinvald | System and method for non-invasive imaging of retinal function |
| JP3848492B2 (ja) | 1998-09-04 | 2006-11-22 | 株式会社ニデック | 角膜手術装置 |
| US7303281B2 (en) | 1998-10-07 | 2007-12-04 | Tracey Technologies, Llc | Method and device for determining refractive components and visual function of the eye for vision correction |
| US6045503A (en) | 1999-01-20 | 2000-04-04 | Kamilllo Eisner-Stiftung | Method of and apparatus for determining the topology of a cornea |
| JP3699853B2 (ja) | 1999-02-18 | 2005-09-28 | 株式会社ニデック | 眼科装置 |
| US6088606A (en) * | 1999-03-22 | 2000-07-11 | Spectrx, Inc. | Method and apparatus for determining a duration of a medical condition |
| US6275718B1 (en) | 1999-03-23 | 2001-08-14 | Philip Lempert | Method and apparatus for imaging and analysis of ocular tissue |
| US7060793B2 (en) * | 1999-05-21 | 2006-06-13 | The Regents Of The University Of California | Circularly permuted fluorescent protein indicators |
| US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| US6878363B2 (en) * | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| EP1913866A1 (en) | 2000-08-21 | 2008-04-23 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
| US7107092B2 (en) | 2000-08-21 | 2006-09-12 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
| US7297326B2 (en) | 2000-08-21 | 2007-11-20 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
| US7350522B2 (en) | 2000-10-17 | 2008-04-01 | Sony Corporation | Scanning method for applying ultrasonic acoustic data to the human neural cortex |
| WO2002064031A2 (en) | 2001-02-09 | 2002-08-22 | Sensomotoric Instruments Gmbh | Multidimensional eye tracking and position measurement system |
| US6600947B2 (en) * | 2001-03-16 | 2003-07-29 | Nymox Corporation | Method of detecting amyloid-containing lesions by autofluorescence |
| DK1420830T3 (da) | 2001-04-27 | 2011-05-09 | Gen Hospital Corp | Okular diagnose af Alzheimer-sygdom |
| WO2003032823A2 (en) | 2001-10-17 | 2003-04-24 | Carl Zeiss Meditec Ag | Method and apparatus for measuring a corneal profile of an eye |
| DE10155464A1 (de) | 2001-11-12 | 2003-05-22 | Zeiss Carl Jena Gmbh | Beleuchtungseinheit zur Erzeugung von optischen Schnittbildern in transparenten Medien, insbesondere im Auge |
| US6854847B2 (en) | 2001-11-13 | 2005-02-15 | Ming Lai | Optical tracking device employing scanning beams on symmetric reference |
| JP3756127B2 (ja) | 2002-04-19 | 2006-03-15 | 株式会社トプコン | 眼科撮影装置 |
| US7330305B2 (en) | 2002-04-26 | 2008-02-12 | Optiscan Pty Ltd | Laser scanning confocal microscope with fibre bundle return |
| AU2003263811A1 (en) * | 2002-07-25 | 2004-02-16 | The Regents Of The University Of California | Monitoring molecular interactions using photon arrival-time interval distribution analysis |
| EP1569547A1 (en) | 2002-10-16 | 2005-09-07 | Campbell Science Group, Inc. | Cornea characteristics measuring device |
| WO2004036182A2 (en) | 2002-10-17 | 2004-04-29 | Control Delivery Systems, Inc. | Methods for monitoring treatment of disease |
| GB2407378B (en) | 2003-10-24 | 2006-09-06 | Lein Applied Diagnostics Ltd | Ocular property measuring apparatus and method therefor |
| US7575321B2 (en) | 2003-10-30 | 2009-08-18 | Welch Allyn, Inc. | Apparatus and method of diagnosis of optically identifiable ophthalmic conditions |
| GB2409033B (en) | 2003-12-12 | 2006-05-24 | Lein Applied Diagnostics Ltd | Extended focal region measuring apparatus and method |
| JP5085858B2 (ja) | 2005-09-27 | 2012-11-28 | 株式会社ニデック | 眼屈折力測定装置 |
| US7445335B2 (en) | 2006-01-20 | 2008-11-04 | Clarity Medical Systems, Inc. | Sequential wavefront sensor |
| CA2647147C (en) * | 2006-04-11 | 2016-10-04 | Neuroptix Corporation | Ocular imaging |
| DE102006030382A1 (de) | 2006-06-29 | 2008-01-03 | Carl Zeiss Meditec Ag | Verfahren und Vorrichtung zur optischen Detektion am Auge |
| WO2008076351A2 (en) * | 2006-12-15 | 2008-06-26 | The Regents Of The University Of California | Dissolution of amyloid fibrils by flavonoids and other compounds |
| WO2008144065A1 (en) | 2007-05-21 | 2008-11-27 | Neuroptix Corporation | Ophthalmic formulations of amyloid- contrast agents and methods of use thereof |
| US8450466B2 (en) * | 2008-03-21 | 2013-05-28 | The General Hosptial Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
| CA2718938C (en) * | 2008-03-27 | 2016-11-29 | Neuroptix Corporation | Ocular imaging |
| JP2009264787A (ja) * | 2008-04-22 | 2009-11-12 | Topcon Corp | 光画像計測装置 |
| GB0903274D0 (en) | 2009-02-26 | 2009-04-08 | Edinburgh Instr | Fluoreence method and system |
| MX357628B (es) * | 2010-08-16 | 2018-07-17 | Cognoptix Inc Star | Sistema y metodo para detectar proteinas amiloides. |
-
2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001082786A2 (en) * | 2000-05-03 | 2001-11-08 | Flock Stephen T | Optical imaging of subsurface anatomical structures and biomolecules |
| DE102007061987A1 (de) * | 2007-12-21 | 2009-06-25 | Carl Zeiss Meditec Ag | Vorrichtung und Verfahren zum Nachweisen von Molekülen im Auge |
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| CN103153168B (zh) | 2016-03-09 |
| US9451909B2 (en) | 2016-09-27 |
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| CA2807683A1 (en) | 2012-02-23 |
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| TW201215876A (en) | 2012-04-16 |
| EP2605694A1 (en) | 2013-06-26 |
| AR082707A1 (es) | 2012-12-26 |
| JP2015166749A (ja) | 2015-09-24 |
| NZ607257A (en) | 2015-02-27 |
| JP2013534171A (ja) | 2013-09-02 |
| AU2011292233B2 (en) | 2015-05-21 |
| US20130135580A1 (en) | 2013-05-30 |
| SG188227A1 (en) | 2013-04-30 |
| US9220403B2 (en) | 2015-12-29 |
| EP2420179B1 (en) | 2020-10-07 |
| KR101905436B1 (ko) | 2018-10-08 |
| EP2420179A2 (en) | 2012-02-22 |
| KR20130138211A (ko) | 2013-12-18 |
| BR112013003754B1 (pt) | 2021-11-09 |
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