JP2013533229A5 - - Google Patents
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- Publication number
- JP2013533229A5 JP2013533229A5 JP2013513747A JP2013513747A JP2013533229A5 JP 2013533229 A5 JP2013533229 A5 JP 2013533229A5 JP 2013513747 A JP2013513747 A JP 2013513747A JP 2013513747 A JP2013513747 A JP 2013513747A JP 2013533229 A5 JP2013533229 A5 JP 2013533229A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- phenyl
- propan
- dihydroxy
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 glycine ester compound Chemical class 0.000 claims 61
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 23
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000004452 carbocyclyl group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 15
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 6
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 6
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 101710113864 Heat shock protein 90 Proteins 0.000 claims 3
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- IPBVNPXQWQGGJP-UHFFFAOYSA-N phenyl acetate Chemical compound CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical class NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000262 haloalkenyl group Chemical group 0.000 claims 2
- 125000005291 haloalkenyloxy group Chemical group 0.000 claims 2
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 102000013392 Carboxylesterase Human genes 0.000 claims 1
- 108010051152 Carboxylesterase Proteins 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- VLFKQONGLOBNAU-JOCHJYFZSA-N cyclopentyl (2r)-2-[[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]amino]-4-methylpentanoate Chemical compound N([C@H](CC(C)C)C(=O)OC1CCCC1)C(CC1)CCN1C(=O)C1=CC(C(C)C)=C(O)C=C1O VLFKQONGLOBNAU-JOCHJYFZSA-N 0.000 claims 1
- FEURQRRBHVNYIR-HSZRJFAPSA-N cyclopentyl (2r)-2-[[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]methylamino]-4-methylpentanoate Chemical compound N([C@H](CC(C)C)C(=O)OC1CCCC1)CC(CC1)CCN1C(=O)C1=CC(C(C)C)=C(O)C=C1O FEURQRRBHVNYIR-HSZRJFAPSA-N 0.000 claims 1
- UZRMMHXDKLGRRR-FBLFFUNLSA-N cyclopentyl (2r)-2-[[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)pyrrolidin-3-yl]amino]-4-methylpentanoate Chemical compound N([C@H](CC(C)C)C(=O)OC1CCCC1)C(C1)CCN1C(=O)C1=CC(C(C)C)=C(O)C=C1O UZRMMHXDKLGRRR-FBLFFUNLSA-N 0.000 claims 1
- VQWYPLSTMDVOBB-MHZLTWQESA-N cyclopentyl (2s)-2-[2-[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]ethylamino]-3-phenylpropanoate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N2CCC(CCN[C@@H](CC=3C=CC=CC=3)C(=O)OC3CCCC3)CC2)=C1O VQWYPLSTMDVOBB-MHZLTWQESA-N 0.000 claims 1
- RKQMPLBYHMNMGC-UHFFFAOYSA-N cyclopentyl 1-[2-[2-(2,4-dihydroxy-5-propan-2-ylbenzoyl)-1,3-dihydroisoindol-5-yl]ethylamino]cyclopentane-1-carboxylate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N2CC3=CC(CCNC4(CCCC4)C(=O)OC4CCCC4)=CC=C3C2)=C1O RKQMPLBYHMNMGC-UHFFFAOYSA-N 0.000 claims 1
- KQWITRAWKIXZQZ-UHFFFAOYSA-N cyclopentyl 2-[2-[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]ethylamino]-2-methylpropanoate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N2CCC(CCNC(C)(C)C(=O)OC3CCCC3)CC2)=C1O KQWITRAWKIXZQZ-UHFFFAOYSA-N 0.000 claims 1
- NHACHHHEAFEWQO-UHFFFAOYSA-N cyclopentyl 2-[2-[4-[[(2,4-dihydroxy-5-propan-2-ylbenzoyl)-methylamino]methyl]phenyl]ethylamino]-2-methylpropanoate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N(C)CC=2C=CC(CCNC(C)(C)C(=O)OC3CCCC3)=CC=2)=C1O NHACHHHEAFEWQO-UHFFFAOYSA-N 0.000 claims 1
- CUACTRXXHHMKQW-UHFFFAOYSA-N cyclopentyl 2-[[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]amino]-2-methylpropanoate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N2CCC(CC2)NC(C)(C)C(=O)OC2CCCC2)=C1O CUACTRXXHHMKQW-UHFFFAOYSA-N 0.000 claims 1
- VEMBMPVDPWRGSX-UHFFFAOYSA-N cyclopentyl 2-[[3-[[(2,4-dihydroxy-5-propan-2-ylbenzoyl)-methylamino]methyl]phenyl]methylamino]-2-methylpropanoate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N(C)CC=2C=C(CNC(C)(C)C(=O)OC3CCCC3)C=CC=2)=C1O VEMBMPVDPWRGSX-UHFFFAOYSA-N 0.000 claims 1
- RWVINNQSFLRKPE-UHFFFAOYSA-N cyclopentyl 2-[[4-[[(2,4-dihydroxy-5-propan-2-ylbenzoyl)-methylamino]methyl]phenyl]methylamino]-2-methylpropanoate Chemical compound C1=C(O)C(C(C)C)=CC(C(=O)N(C)CC=2C=CC(CNC(C)(C)C(=O)OC3CCCC3)=CC=2)=C1O RWVINNQSFLRKPE-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 150000002333 glycines Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- UTUVLRLIFUZZPI-HXUWFJFHSA-N tert-butyl (2r)-2-[[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]amino]-4-methylpentanoate Chemical compound C1CC(N[C@H](CC(C)C)C(=O)OC(C)(C)C)CCN1C(=O)C1=CC(C(C)C)=C(O)C=C1O UTUVLRLIFUZZPI-HXUWFJFHSA-N 0.000 claims 1
- MNZODNUXSRQICM-OAQYLSRUSA-N tert-butyl (2r)-2-[[1-(2,4-dihydroxy-5-propan-2-ylbenzoyl)piperidin-4-yl]methylamino]-4-methylpentanoate Chemical compound C1CC(CN[C@H](CC(C)C)C(=O)OC(C)(C)C)CCN1C(=O)C1=CC(C(C)C)=C(O)C=C1O MNZODNUXSRQICM-OAQYLSRUSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1009853.1A GB201009853D0 (en) | 2010-06-11 | 2010-06-11 | HSP90 inhibitors |
| GB1009853.1 | 2010-06-11 | ||
| PCT/GB2011/000879 WO2011154708A1 (en) | 2010-06-11 | 2011-06-10 | Benzamide derivatives and their use as hsp90 inhibtors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533229A JP2013533229A (ja) | 2013-08-22 |
| JP2013533229A5 true JP2013533229A5 (enExample) | 2014-07-31 |
| JP5955317B2 JP5955317B2 (ja) | 2016-07-20 |
Family
ID=42471553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513747A Expired - Fee Related JP5955317B2 (ja) | 2010-06-11 | 2011-06-10 | Ｈｓｐ９０阻害剤としてのベンズアミド誘導体およびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9321718B2 (enExample) |
| EP (1) | EP2580193B1 (enExample) |
| JP (1) | JP5955317B2 (enExample) |
| KR (1) | KR20130112026A (enExample) |
| CN (1) | CN103068799B (enExample) |
| AU (1) | AU2011263543B2 (enExample) |
| BR (1) | BR112012031634A2 (enExample) |
| CA (1) | CA2802279A1 (enExample) |
| DK (1) | DK2580193T3 (enExample) |
| EA (1) | EA021237B1 (enExample) |
| ES (1) | ES2587256T3 (enExample) |
| GB (1) | GB201009853D0 (enExample) |
| IL (1) | IL223514A (enExample) |
| MX (1) | MX341341B (enExample) |
| NZ (1) | NZ605558A (enExample) |
| SG (1) | SG186232A1 (enExample) |
| WO (1) | WO2011154708A1 (enExample) |
| ZA (1) | ZA201300036B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| SI2909175T1 (sl) | 2012-10-17 | 2017-08-31 | Macrophage Pharma Limited | Terc-butil-n-(2-(4-(6-amino-5-(2,4-difluorobenzoil)-2-oksopiridin-1 (2h)-il)-3,5-difluorofenil)etil)-l-alaninat ali njegova sol, hidrat ali solvat |
| CN102924318B (zh) * | 2012-11-26 | 2014-06-04 | 武汉大学 | 阻断h5n1禽流感病毒进入的l-亮氨酸衍生物及其制备方法 |
| WO2017131500A1 (ko) * | 2016-01-29 | 2017-08-03 | 계명대학교 산학협력단 | Hsp90 억제 활성을 갖는 신규 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도 |
| WO2019027203A1 (ko) * | 2017-08-02 | 2019-02-07 | 계명대학교 산학협력단 | Ｈｓｐ９０ 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도 |
| GB201713975D0 (en) | 2017-08-31 | 2017-10-18 | Macrophage Pharma Ltd | Medical use |
| AU2019417833B2 (en) * | 2018-12-31 | 2024-11-07 | Biomea Fusion, Inc. | Irreversible inhibitors of menin-MLL interaction |
| US11174263B2 (en) | 2018-12-31 | 2021-11-16 | Biomea Fusion, Inc. | Inhibitors of menin-MLL interaction |
| CA3228627A1 (en) | 2021-08-11 | 2023-02-16 | Thomas Butler | Covalent inhibitors of menin-mll interaction for diabetes mellitus |
| EP4387972A1 (en) | 2021-08-20 | 2024-06-26 | Biomea Fusion, Inc. | Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer |
| WO2024155710A1 (en) | 2023-01-18 | 2024-07-25 | Biomea Fusion, Inc. | Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2-pyridinecarboxamide as a covalent inhibitor of menin-mll interaction |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DK1769679T3 (da) | 2004-07-16 | 2011-04-26 | Ishihara Sangyo Kaisha | Baktericid sammensætning til landbrugsmæssig eller havebrugsmæssig anvendelse samt fremgangsmåde til bekæmpelse af plantesygdom |
| JP2008525243A (ja) * | 2004-12-29 | 2008-07-17 | ハネウェル・インターナショナル・インコーポレーテッド | 耐湿性ｐｂｏ繊維およびその物品ならびにその製造方法 |
| BRPI0607739A2 (pt) | 2005-02-25 | 2009-09-29 | Serenex Inc | derivados de tetraidroindolona e tetraidroindazolona, composição compreendendo os mesmos e uso relacionado |
| CA2604042C (en) * | 2005-04-13 | 2016-06-21 | Astex Therapeutics Limited | Pharmaceutical compounds |
| CA2605985A1 (en) * | 2005-05-03 | 2006-11-09 | Pfizer Inc. | Amide resorcinol compounds |
| US20090215800A1 (en) | 2005-05-05 | 2009-08-27 | Chroma Therapeutics Ltd | Enzyme and Receptor Modulation |
| GB0509223D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| US20080076800A1 (en) | 2006-08-24 | 2008-03-27 | Huang Kenneth H | Benzene, Pyridine, and Pyridazine Derivatives |
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| US8916552B2 (en) * | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008053319A1 (en) * | 2006-10-30 | 2008-05-08 | Pfizer Products Inc. | Amide resorcinol compounds |
| GB0803747D0 (en) | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
| GB0806527D0 (en) * | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
-
2010
- 2010-06-11 GB GBGB1009853.1A patent/GB201009853D0/en not_active Ceased
-
2011
- 2011-06-10 SG SG2012090304A patent/SG186232A1/en unknown
- 2011-06-10 ES ES11726470.5T patent/ES2587256T3/es active Active
- 2011-06-10 NZ NZ605558A patent/NZ605558A/en not_active IP Right Cessation
- 2011-06-10 MX MX2012014506A patent/MX341341B/es active IP Right Grant
- 2011-06-10 KR KR1020137000721A patent/KR20130112026A/ko not_active Ceased
- 2011-06-10 DK DK11726470.5T patent/DK2580193T3/en active
- 2011-06-10 US US13/703,387 patent/US9321718B2/en not_active Expired - Fee Related
- 2011-06-10 WO PCT/GB2011/000879 patent/WO2011154708A1/en not_active Ceased
- 2011-06-10 EP EP11726470.5A patent/EP2580193B1/en not_active Not-in-force
- 2011-06-10 BR BR112012031634A patent/BR112012031634A2/pt not_active IP Right Cessation
- 2011-06-10 CA CA2802279A patent/CA2802279A1/en not_active Abandoned
- 2011-06-10 CN CN201180038937.2A patent/CN103068799B/zh not_active Expired - Fee Related
- 2011-06-10 JP JP2013513747A patent/JP5955317B2/ja not_active Expired - Fee Related
- 2011-06-10 EA EA201270816A patent/EA021237B1/ru not_active IP Right Cessation
- 2011-06-10 AU AU2011263543A patent/AU2011263543B2/en not_active Ceased
-
2012
- 2012-12-09 IL IL223514A patent/IL223514A/en active IP Right Grant
-
2013
- 2013-01-02 ZA ZA2013/00036A patent/ZA201300036B/en unknown
-
2016
- 2016-03-17 US US15/073,352 patent/US20160193200A1/en not_active Abandoned
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