JP2013532662A5 - - Google Patents
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- JP2013532662A5 JP2013532662A5 JP2013520880A JP2013520880A JP2013532662A5 JP 2013532662 A5 JP2013532662 A5 JP 2013532662A5 JP 2013520880 A JP2013520880 A JP 2013520880A JP 2013520880 A JP2013520880 A JP 2013520880A JP 2013532662 A5 JP2013532662 A5 JP 2013532662A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- disease
- amyloidosis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36717310P | 2010-07-23 | 2010-07-23 | |
| US61/367,173 | 2010-07-23 | ||
| PCT/US2011/044999 WO2012012712A2 (en) | 2010-07-23 | 2011-07-22 | Tricyclic proteasome activity enhancing compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532662A JP2013532662A (ja) | 2013-08-19 |
| JP2013532662A5 true JP2013532662A5 (enExample) | 2014-08-28 |
| JP6042331B2 JP6042331B2 (ja) | 2016-12-14 |
Family
ID=45497483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520880A Expired - Fee Related JP6042331B2 (ja) | 2010-07-23 | 2011-07-22 | プロテアソーム活性を向上させる三環系化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8933087B2 (enExample) |
| EP (1) | EP2595993B1 (enExample) |
| JP (1) | JP6042331B2 (enExample) |
| CN (1) | CN103119047B (enExample) |
| AU (1) | AU2011281015B2 (enExample) |
| CA (1) | CA2808432C (enExample) |
| WO (1) | WO2012012712A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102844313B (zh) * | 2010-01-28 | 2016-10-05 | 哈佛大学校长及研究员协会 | 提高蛋白酶体活性的组合物和方法 |
| WO2012012712A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| EP2663312B1 (en) | 2011-01-10 | 2017-10-11 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| US9556166B2 (en) | 2011-05-12 | 2017-01-31 | Proteostasis Therapeutics, Inc. | Proteostasis regulators |
| CN104582705A (zh) | 2012-01-10 | 2015-04-29 | 林伯士艾瑞斯公司 | 白介素-1受体相关激酶(irak)抑制剂和其用途 |
| WO2013112651A2 (en) | 2012-01-25 | 2013-08-01 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
| CN104902959A (zh) | 2012-07-11 | 2015-09-09 | 林伯士艾瑞斯公司 | Irak抑制剂和其用途 |
| EP2872144A4 (en) * | 2012-07-11 | 2015-12-02 | Nimbus Iris Inc | IRAQ INHIBITOR AND USES THEREOF |
| JP2016504365A (ja) | 2012-12-28 | 2016-02-12 | アメリカ合衆国 | Ｕｓｐ１／ｕａｆ１デユビキチナーゼ複合体阻害剤及びその使用 |
| AU2014205577A1 (en) | 2013-01-10 | 2015-05-28 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| WO2014116228A1 (en) | 2013-01-25 | 2014-07-31 | President And Fellows Of Harvard College | Usp14 inhibitors for treating or preventing viral infections |
| WO2014145576A2 (en) | 2013-03-15 | 2014-09-18 | Northwestern University | Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer |
| EP3049086A4 (en) | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577420A (en) * | 1968-01-05 | 1971-05-04 | Pfizer | Certain 4-aminofuro(2,3-d)pyrimidines |
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| DD245666A1 (de) | 1985-09-20 | 1987-05-13 | Univ Halle Wittenberg | Verfahren zur herstellung von 4-aminosubstituierten thieno 2,3-d-pyrimidin-2-ylessigsaeureestern |
| JPH01313480A (ja) | 1988-06-14 | 1989-12-18 | Nippon Soda Co Ltd | ピリミジン誘導体、その製造方法及び農園芸用殺菌剤 |
| AU7890598A (en) * | 1996-12-27 | 1998-07-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused pyrimidine compounds and medicinal use thereof |
| KR20010105399A (ko) | 1999-03-30 | 2001-11-28 | 쓰끼하시 다미까따 | 티에노피리미딘 화합물 및 그의 염, 및 그들의 제조 방법 |
| EP1175421A1 (en) | 1999-04-30 | 2002-01-30 | Neurogen Corporation | 9H-PYRIMIDO[4,5-b]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS |
| JP2002105082A (ja) | 2000-09-29 | 2002-04-10 | Nippon Soda Co Ltd | 縮合チエノピリミジン化合物、その塩及び製造法 |
| DE10064994A1 (de) | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
| JP2004517940A (ja) | 2001-01-31 | 2004-06-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ピラゾロ［４，３−ｄ］ピリミジンおよびニトレートまたはチエノピリミジンおよびニトレートを含む医薬製剤 |
| EP1401840A4 (en) | 2001-04-30 | 2007-05-16 | Bayer Corp | NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D | PYRIMIDINE |
| DE10148883A1 (de) | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| WO2003037898A1 (en) * | 2001-10-31 | 2003-05-08 | Bayer Healthcare Ag | Pyrimido [4,5-b] indole derivatives |
| JP2003137886A (ja) * | 2001-10-31 | 2003-05-14 | Bayer Ag | ピリミド［４，５−ｂ］インドール |
| US7199119B2 (en) | 2002-10-31 | 2007-04-03 | Amgen Inc. | Antiinflammation agents |
| ES2217956B1 (es) | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| JP4677518B2 (ja) * | 2003-03-31 | 2011-04-27 | エピックス デラウェア， インコーポレイテッド | 新規ピペリジニルアミノ−チエノ［２，３−ｄ］ピリミジン化合物 |
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| JP5249772B2 (ja) * | 2005-11-22 | 2013-07-31 | メルク・シャープ・アンド・ドーム・コーポレーション | キナーゼの阻害剤として有用な三環式化合物 |
| US7960400B2 (en) | 2007-08-27 | 2011-06-14 | Duquesne University Of The Holy Ghost | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof |
| US7982035B2 (en) | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
| WO2009033581A1 (en) | 2007-09-14 | 2009-03-19 | Bayer Schering Pharma Aktiengesellschaft | Substituted tricyclic compounds and methods of use thereof |
| US20100227853A1 (en) | 2008-04-18 | 2010-09-09 | Trustees Of Boston College | Inhibitors of cyclic amp phosphodiesterases |
| US8507502B2 (en) | 2008-11-10 | 2013-08-13 | National Health Research Institutes | Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors |
| KR20110136819A (ko) | 2009-02-27 | 2011-12-21 | 시가 테크놀로지스, 인크. | 뎅기 바이러스 감염의 치료 및 예방을 위한 티에노피리딘 유도체 |
| CN102844313B (zh) | 2010-01-28 | 2016-10-05 | 哈佛大学校长及研究员协会 | 提高蛋白酶体活性的组合物和方法 |
| WO2012012712A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| TW201219401A (en) | 2010-09-14 | 2012-05-16 | Lexicon Pharmaceuticals Inc | Bicyclic inhibitors of Notum Pectinacetylesterase and methods of their use |
| CN103261205B (zh) | 2010-11-12 | 2015-08-19 | 姚雪彪 | 动点马达蛋白cenp-e小分子抑制剂syntelin及其应用 |
| EP2663312B1 (en) | 2011-01-10 | 2017-10-11 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN104582705A (zh) | 2012-01-10 | 2015-04-29 | 林伯士艾瑞斯公司 | 白介素-1受体相关激酶(irak)抑制剂和其用途 |
-
2011
- 2011-07-22 WO PCT/US2011/044999 patent/WO2012012712A2/en not_active Ceased
- 2011-07-22 CN CN201180045618.4A patent/CN103119047B/zh not_active Expired - Fee Related
- 2011-07-22 AU AU2011281015A patent/AU2011281015B2/en not_active Ceased
- 2011-07-22 EP EP11810459.5A patent/EP2595993B1/en not_active Not-in-force
- 2011-07-22 CA CA2808432A patent/CA2808432C/en not_active Expired - Fee Related
- 2011-07-22 US US13/811,129 patent/US8933087B2/en active Active
- 2011-07-22 JP JP2013520880A patent/JP6042331B2/ja not_active Expired - Fee Related
-
2014
- 2014-12-17 US US14/572,927 patent/US9981981B2/en active Active
-
2018
- 2018-05-21 US US15/984,937 patent/US20180265519A1/en not_active Abandoned
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