JP2013529647A5 - - Google Patents
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- JP2013529647A5 JP2013529647A5 JP2013516840A JP2013516840A JP2013529647A5 JP 2013529647 A5 JP2013529647 A5 JP 2013529647A5 JP 2013516840 A JP2013516840 A JP 2013516840A JP 2013516840 A JP2013516840 A JP 2013516840A JP 2013529647 A5 JP2013529647 A5 JP 2013529647A5
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- nephritis
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 19
- 201000010099 disease Diseases 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 201000008383 nephritis Diseases 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 208000010247 contact dermatitis Diseases 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 claims 1
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000004852 Lung Injury Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 208000010718 Multiple Organ Failure Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 1
- 206010069363 Traumatic lung injury Diseases 0.000 claims 1
- 206010052568 Urticaria chronic Diseases 0.000 claims 1
- 206010053648 Vascular occlusion Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000024376 chronic urticaria Diseases 0.000 claims 1
- 208000002528 coronary thrombosis Diseases 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 231100000515 lung injury Toxicity 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000021331 vascular occlusion disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/823,039 | 2010-06-24 | ||
| US12/823,039 US20100311753A1 (en) | 2008-12-22 | 2010-06-24 | C5aR ANTAGONISTS |
| US13/072,616 US20110275639A1 (en) | 2008-12-22 | 2011-03-25 | C5aR ANTAGONISTS |
| US13/072,616 | 2011-03-25 | ||
| PCT/US2011/041910 WO2011163640A1 (en) | 2010-06-24 | 2011-06-24 | C5ar antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053725A Division JP6189989B2 (ja) | 2010-06-24 | 2016-03-17 | Ｃ５ａＲアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013529647A JP2013529647A (ja) | 2013-07-22 |
| JP2013529647A5 true JP2013529647A5 (https=) | 2014-08-14 |
Family
ID=47996916
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516840A Withdrawn JP2013529647A (ja) | 2010-06-24 | 2011-06-24 | Ｃ５ａＲアンタゴニスト |
| JP2016053725A Active JP6189989B2 (ja) | 2010-06-24 | 2016-03-17 | Ｃ５ａＲアンタゴニスト |
| JP2017150928A Active JP6438086B2 (ja) | 2010-06-24 | 2017-08-03 | Ｃ５ａＲアンタゴニスト |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053725A Active JP6189989B2 (ja) | 2010-06-24 | 2016-03-17 | Ｃ５ａＲアンタゴニスト |
| JP2017150928A Active JP6438086B2 (ja) | 2010-06-24 | 2017-08-03 | Ｃ５ａＲアンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US9126939B2 (https=) |
| EP (1) | EP2585064B1 (https=) |
| JP (3) | JP2013529647A (https=) |
| CN (1) | CN103068385B (https=) |
| BR (1) | BR112012033075B1 (https=) |
| DK (1) | DK2585064T3 (https=) |
| ES (1) | ES2632975T3 (https=) |
| HR (1) | HRP20171176T1 (https=) |
| HU (1) | HUE033644T2 (https=) |
| PL (1) | PL2585064T3 (https=) |
| PT (1) | PT2585064T (https=) |
| RS (1) | RS56332B1 (https=) |
| SI (1) | SI2585064T1 (https=) |
| WO (1) | WO2011163640A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS54998B1 (sr) | 2008-12-22 | 2016-11-30 | Chemocentryx Inc | Antagonisti c5ar |
| US20110275639A1 (en) * | 2008-12-22 | 2011-11-10 | Chemocentryx, Inc. | C5aR ANTAGONISTS |
| RS56332B1 (sr) * | 2010-06-24 | 2017-12-29 | Chemocentryx Inc | Antagonisti c5ar |
| LT3466955T (lt) | 2014-01-13 | 2021-02-25 | Aurigene Discovery Technologies Limited | Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas |
| AU2015275730A1 (en) * | 2014-06-20 | 2016-12-15 | Aurigene Discovery Technologies Limited | Substituted indazole compounds as IRAK4 inhibitors |
| DK3200791T3 (da) * | 2014-09-29 | 2020-05-25 | Chemocentryx Inc | Fremgangsmåder og mellemprodukter i fremstilling af C5AR- antagonister |
| JP7339733B2 (ja) * | 2016-01-14 | 2023-09-06 | ケモセントリックス，インコーポレイティド | Ｃ３腎症を処置する方法 |
| EP3439658B1 (en) * | 2016-04-04 | 2021-11-24 | ChemoCentryx, Inc. | Soluble c5ar antagonists |
| EP3600270B1 (en) | 2017-03-31 | 2023-06-14 | Aurigene Oncology Limited | Compounds and compositions for treating hematological disorders |
| TWI826364B (zh) | 2017-04-03 | 2023-12-21 | 德商因夫萊亞斯有限公司 | 活性抑制劑於發炎性疾病之治療 |
| US10562896B2 (en) | 2017-05-31 | 2020-02-18 | Chemocentryx, Inc. | 6-5 fused rings as C5a inhibitors |
| WO2018222601A1 (en) | 2017-05-31 | 2018-12-06 | Chemocentryx, Inc. | 5-5 FUSED RINGS AS C5a INHIBITORS |
| TWI786132B (zh) * | 2017-06-23 | 2022-12-11 | 德商因夫萊亞斯有限公司 | 活性抑制劑於發炎性疾病之治療 |
| CA3077395A1 (en) * | 2017-10-30 | 2019-05-09 | Chemocentryx, Inc. | Deuterated compounds as immunomodulators |
| CA3078732A1 (en) | 2017-10-31 | 2019-05-09 | Chemocentryx, Inc. | C5ar inhibitor reduction of urinary scd163 |
| HUE067356T2 (hu) | 2017-10-31 | 2024-10-28 | Curis Inc | IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra |
| MX2020006460A (es) | 2017-12-22 | 2020-11-06 | Chemocentryx Inc | Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar. |
| WO2019126424A1 (en) | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
| WO2019137927A1 (en) * | 2018-01-10 | 2019-07-18 | Idorsia Pharmaceuticals Ltd | 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases |
| EP3740477A1 (en) * | 2018-01-19 | 2020-11-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
| BR112020019822A2 (pt) | 2018-04-02 | 2021-03-16 | Chemocentryx, Inc. | Profármacos de antagonistas bicíclicos fundidos de c5ar |
| CN108440514A (zh) * | 2018-05-16 | 2018-08-24 | 张玉叶 | 一种甲酰胺类衍生物、制备方法及其在抗肿瘤药物中的应用 |
| CN108440513A (zh) * | 2018-05-16 | 2018-08-24 | 张玉叶 | 一种甲酰胺类衍生物及其在抗肿瘤药物中的应用 |
| CN108558844A (zh) * | 2018-05-16 | 2018-09-21 | 张玉叶 | 一种甲酰胺类衍生物及其在抗肿瘤药物中的应用 |
| CN108727354A (zh) * | 2018-05-16 | 2018-11-02 | 张玉叶 | 一种甲酰胺类衍生物及其在抗肿瘤药物中的应用 |
| CN108727355A (zh) * | 2018-05-16 | 2018-11-02 | 张玉叶 | 一种甲酰胺类衍生物、制备方法及其在抗肿瘤药物中的应用 |
| US11191756B2 (en) | 2018-06-07 | 2021-12-07 | Chemocentryx, Inc. | Dosing and effect of C5a antagonist with ANCA-associated vasculitis |
| WO2020112961A1 (en) * | 2018-11-30 | 2020-06-04 | Chemocentryx, Inc. | Capsule formulations |
| BR112021025888A2 (pt) | 2019-07-10 | 2022-04-26 | Chemocentryx Inc | Indanos como inibidores de pd-l1 |
| ES3064674T3 (en) | 2019-10-16 | 2026-04-28 | Chemocentryx Inc | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases |
| JP7736678B2 (ja) | 2019-10-16 | 2025-09-09 | ケモセントリックス，インコーポレイティド | Ｐｄ－ｌ１疾患の処置のためのヘテロアリール－ビフェニルアミド |
| CN114867473A (zh) * | 2019-11-08 | 2022-08-05 | 凯莫森特里克斯股份有限公司 | 补体成分c5a受体的盐形式 |
| JP2022554019A (ja) * | 2019-11-08 | 2022-12-27 | ケモセントリックス，インコーポレイティド | 補体成分Ｃ５ａ受容体の遊離塩基結晶形態 |
| US11603356B2 (en) * | 2019-11-08 | 2023-03-14 | Chemocentryx, Inc. | Amorphous form of a complement component C5a receptor |
| PH12022552556A1 (en) | 2020-03-27 | 2024-04-22 | Inflarx Gmbh | Inhibitors of c5a for the treatment of corona virus infection |
| TW202208427A (zh) | 2020-05-06 | 2022-03-01 | 德商因夫萊亞斯有限公司 | 人源化抗ｃ５ａ抗體 |
| KR20230050364A (ko) * | 2020-08-07 | 2023-04-14 | 키라 파마슈티칼스 (수조우) 엘티디. | C5ar 억제제로서의 화합물 |
| WO2022078269A1 (zh) * | 2020-10-16 | 2022-04-21 | 苏州科睿思制药有限公司 | Avacopan的晶型及其制备方法和用途 |
| JP7839157B2 (ja) | 2020-10-28 | 2026-04-01 | ケモセントリックス， インコーポレイテッド | 化膿性汗腺炎を処置する方法 |
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| CN117402104A (zh) * | 2021-12-06 | 2024-01-16 | 重庆医科大学 | 阿伐可泮手性中间体的制备方法 |
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| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
| AU2024324780A1 (en) * | 2023-08-16 | 2026-02-05 | Inflarx Gmbh | Fused piperidinyl bicyclic and related compounds for use in the treatment of diseases |
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| US20260027049A1 (en) | 2024-07-23 | 2026-01-29 | Amgen Inc. | Avacopan formulations |
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| JP7339733B2 (ja) | 2016-01-14 | 2023-09-06 | ケモセントリックス，インコーポレイティド | Ｃ３腎症を処置する方法 |
-
2011
- 2011-06-24 RS RS20170761A patent/RS56332B1/sr unknown
- 2011-06-24 PL PL11799027T patent/PL2585064T3/pl unknown
- 2011-06-24 US US13/806,339 patent/US9126939B2/en active Active
- 2011-06-24 EP EP11799027.5A patent/EP2585064B1/en active Active
- 2011-06-24 DK DK11799027.5T patent/DK2585064T3/en active
- 2011-06-24 BR BR112012033075-6A patent/BR112012033075B1/pt active IP Right Grant
- 2011-06-24 SI SI201131229T patent/SI2585064T1/sl unknown
- 2011-06-24 PT PT117990275T patent/PT2585064T/pt unknown
- 2011-06-24 HR HRP20171176TT patent/HRP20171176T1/hr unknown
- 2011-06-24 JP JP2013516840A patent/JP2013529647A/ja not_active Withdrawn
- 2011-06-24 ES ES11799027.5T patent/ES2632975T3/es active Active
- 2011-06-24 HU HUE11799027A patent/HUE033644T2/en unknown
- 2011-06-24 CN CN201180039245.XA patent/CN103068385B/zh active Active
- 2011-06-24 WO PCT/US2011/041910 patent/WO2011163640A1/en not_active Ceased
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2015
- 2015-09-04 US US14/846,487 patent/US9573897B2/en active Active
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2016
- 2016-03-17 JP JP2016053725A patent/JP6189989B2/ja active Active
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2017
- 2017-01-06 US US15/400,820 patent/US20170114017A1/en not_active Abandoned
- 2017-08-03 JP JP2017150928A patent/JP6438086B2/ja active Active
- 2017-10-02 US US15/722,819 patent/US10035768B2/en active Active
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2018
- 2018-06-27 US US16/020,139 patent/US20190062275A1/en not_active Abandoned
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2020
- 2020-10-20 US US17/075,131 patent/US20210269398A1/en not_active Abandoned
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2022
- 2022-09-26 US US17/935,434 patent/US20230102258A1/en not_active Abandoned