JP2013528656A5 - - Google Patents
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- Publication number
- JP2013528656A5 JP2013528656A5 JP2013515497A JP2013515497A JP2013528656A5 JP 2013528656 A5 JP2013528656 A5 JP 2013528656A5 JP 2013515497 A JP2013515497 A JP 2013515497A JP 2013515497 A JP2013515497 A JP 2013515497A JP 2013528656 A5 JP2013528656 A5 JP 2013528656A5
- Authority
- JP
- Japan
- Prior art keywords
- drugs
- disease
- chemokine
- receptor activity
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- 102000009410 Chemokine receptor Human genes 0.000 claims 5
- 108050000299 Chemokine receptor Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102000019034 Chemokines Human genes 0.000 claims 4
- 108010012236 Chemokines Proteins 0.000 claims 4
- 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 4
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
- 208000007353 Hip Osteoarthritis Diseases 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 206010065040 AIDS dementia complex Diseases 0.000 claims 2
- 206010001889 Alveolitis Diseases 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 2
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 claims 2
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 claims 2
- 102000004500 CCR1 Receptors Human genes 0.000 claims 2
- 108010017319 CCR1 Receptors Proteins 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims 2
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 206010023230 Joint stiffness Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000001088 anti-asthma Effects 0.000 claims 2
- 229940127003 anti-diabetic drug Drugs 0.000 claims 2
- 230000000340 anti-metabolite Effects 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 239000000924 antiasthmatic agent Substances 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 229940125715 antihistaminic agent Drugs 0.000 claims 2
- 239000000739 antihistaminic agent Substances 0.000 claims 2
- 229940100197 antimetabolite Drugs 0.000 claims 2
- 239000002256 antimetabolite Substances 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000006931 brain damage Effects 0.000 claims 2
- 231100000874 brain damage Toxicity 0.000 claims 2
- 208000029028 brain injury Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000000748 cardiovascular system Anatomy 0.000 claims 2
- 229940044683 chemotherapy drug Drugs 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 2
- 229960004963 mesalazine Drugs 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 230000003589 nefrotoxic effect Effects 0.000 claims 2
- 201000008383 nephritis Diseases 0.000 claims 2
- 231100000381 nephrotoxic Toxicity 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 201000002793 renal fibrosis Diseases 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 229940122444 Chemokine receptor antagonist Drugs 0.000 claims 1
- 229940123038 Integrin antagonist Drugs 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 239000002559 chemokine receptor antagonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35522510P | 2010-06-16 | 2010-06-16 | |
| US61/355,225 | 2010-06-16 | ||
| PCT/US2011/040605 WO2011159852A1 (en) | 2010-06-16 | 2011-06-16 | Piperidinyl compound as a modulator of chemokine receptor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528656A JP2013528656A (ja) | 2013-07-11 |
| JP2013528656A5 true JP2013528656A5 (enExample) | 2014-07-31 |
| JP5795797B2 JP5795797B2 (ja) | 2015-10-14 |
Family
ID=44278764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515497A Expired - Fee Related JP5795797B2 (ja) | 2010-06-16 | 2011-06-16 | ケモカイン受容体活性の調整薬としてのピペリジニル化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8642622B2 (enExample) |
| EP (1) | EP2582670B1 (enExample) |
| JP (1) | JP5795797B2 (enExample) |
| KR (1) | KR20130032357A (enExample) |
| CN (1) | CN103068800B (enExample) |
| AR (1) | AR081943A1 (enExample) |
| AU (1) | AU2011268373B2 (enExample) |
| BR (1) | BR112012031768A2 (enExample) |
| CL (1) | CL2012003521A1 (enExample) |
| CO (1) | CO6650362A2 (enExample) |
| EA (1) | EA022395B1 (enExample) |
| IL (1) | IL223368A0 (enExample) |
| MA (1) | MA34377B1 (enExample) |
| MX (1) | MX2012014068A (enExample) |
| NZ (1) | NZ605741A (enExample) |
| SG (1) | SG186064A1 (enExample) |
| TN (1) | TN2012000581A1 (enExample) |
| TW (1) | TW201206435A (enExample) |
| WO (1) | WO2011159852A1 (enExample) |
| ZA (1) | ZA201300380B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2486034A1 (en) * | 2009-10-07 | 2012-08-15 | Bristol-Myers Squibb Company | Spirocyclic compounds as modulators of chemokine receptor activity |
| JP5782438B2 (ja) | 2010-06-16 | 2015-09-24 | 武田薬品工業株式会社 | アミド化合物の結晶 |
| SI3297438T1 (sl) | 2015-05-21 | 2022-03-31 | Chemocentryx, Inc. | CCR2 modulatorji |
| CA3036862A1 (en) | 2016-09-16 | 2018-03-22 | Cortexyme, Inc. | Ketone inhibitors of lysine gingipain |
| EP3375778A1 (en) * | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidine derivatives |
| EP3687525B1 (en) | 2017-09-25 | 2025-10-29 | ChemoCentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
| KR102037494B1 (ko) | 2017-12-11 | 2019-10-28 | 씨제이헬스케어 주식회사 | 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법 |
| ES2991280T3 (es) | 2018-01-08 | 2024-12-03 | Chemocentryx Inc | Antagonistas de CCR2 para el tratamiento del linfoma cutáneo de linfocitos T |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| WO2024099908A1 (en) | 2022-11-09 | 2024-05-16 | Boehringer Ingelheim International Gmbh | Cyclic pyridine derivatives as cgas inhibitors |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9104656D0 (en) | 1991-03-05 | 1991-04-17 | Zambeletti Spa L | Pharmaceuticals |
| DE4243858A1 (de) | 1992-12-23 | 1994-06-30 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5459151A (en) | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
| US5492920A (en) | 1993-12-10 | 1996-02-20 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
| US5777112A (en) | 1994-06-13 | 1998-07-07 | Merck & Co., Inc | Piperazine compounds promote release of growth hormone |
| CA2226740A1 (en) | 1995-07-13 | 1997-01-30 | Mitsuyoshi Azuma | Piperazine derivative and its uses |
| CA2249601A1 (en) | 1996-04-03 | 1997-10-23 | Thorsten E. Fisher | Inhibitors of farnesyl-protein transferase |
| DK0927192T3 (da) | 1996-09-10 | 2004-09-13 | Boehringer Ingelheim Pharma | Modificerede aminosyrer, lægemidler indeholdende disse forbindelser og fremgangsmåder til deres fremstilling |
| WO1998017625A1 (en) | 1996-10-22 | 1998-04-30 | Daiichi Pharmaceutical Co., Ltd. | Novel remedies for infectious diseases |
| US5847148A (en) | 1997-04-10 | 1998-12-08 | Pharmacia & Upjohn Company | Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation |
| ZA987385B (en) | 1997-08-19 | 2000-04-18 | Lilly Co Eli | Growth hormone secretagogues. |
| ZA987383B (en) | 1997-08-19 | 2000-02-17 | Lilly Co Eli | Treatment of congestive heart failure with growth hormone secretagogues. |
| JP4949552B2 (ja) | 1998-04-16 | 2012-06-13 | エンサイシブ・フアーマシユーテイカルズ，インコーポレイテツド | インテグリンのそれの受容体への結合を阻害するｎ，ｎ−ジ置換アミド |
| US6391865B1 (en) | 1999-05-04 | 2002-05-21 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
| EP1187614A4 (en) | 1999-06-04 | 2005-06-22 | Merck & Co Inc | SUBSTITUTED PIPERIDINES THAN MELANOCORTIN-4 RECEPTOR AGONISTS |
| DE10041402A1 (de) | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| JP2001354657A (ja) | 2000-06-09 | 2001-12-25 | Sds Biotech:Kk | 置換ピペラジン誘導体及び農園芸用殺菌剤 |
| EP1296949A2 (en) | 2000-06-21 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
| JP2004523530A (ja) | 2001-01-23 | 2004-08-05 | イーライ・リリー・アンド・カンパニー | メラノコルチン受容体アゴニストとしてのピペラジンおよびピペリジン誘導体 |
| JP2005511475A (ja) | 2001-03-02 | 2005-04-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモジュレーターとして有用な化合物及びそれを含む製薬組成物 |
| DE10124041A1 (de) | 2001-05-16 | 2002-11-21 | Graffinity Pharm Design Gmbh | Protease Inhibitoren |
| US7115628B2 (en) | 2001-07-18 | 2006-10-03 | Merck & Co., Inc. | Bridged piperidine derivatives as melanocortin receptor agonists |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| AU2002326823B2 (en) | 2001-09-06 | 2005-12-15 | Merck Sharp & Dohme Corp. | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| AU2002366811B2 (en) | 2001-12-20 | 2009-01-15 | Osi Pharmaceuticals, Inc. | Pyrimidine A2B selective antagonist compounds, their synthesis and use |
| CN1816551A (zh) | 2001-12-20 | 2006-08-09 | Osi药物公司 | 吡咯并嘧啶A2b选择性拮抗剂化合物,它们的合成及用途 |
| US7041681B2 (en) | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
| US20050256130A1 (en) | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| GB0224917D0 (en) | 2002-10-25 | 2002-12-04 | Novartis Ag | Organic compounds |
| CA2503844A1 (en) | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity |
| CA2512886A1 (en) | 2003-02-28 | 2004-09-10 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
| US6846836B2 (en) | 2003-04-18 | 2005-01-25 | Bristol-Myers Squibb Company | N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase |
| MXPA05013474A (es) | 2003-06-13 | 2006-03-09 | Schering Ag | Derivados de quinolilamida como antagonistas de ccr-5. |
| GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| DE10358539A1 (de) | 2003-12-15 | 2005-07-07 | Merck Patent Gmbh | Carbonsäureamidderivate |
| WO2005084672A1 (de) | 2004-03-03 | 2005-09-15 | Boehringer Ingelheim International Gmbh | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB0412468D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| US7723360B2 (en) | 2004-08-06 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Alkyl-and piperidine-substituted benzimidazole derivatives |
| US7601844B2 (en) * | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| CN101600691A (zh) * | 2006-01-27 | 2009-12-09 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶基衍生物 |
| US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| EP2173713B1 (en) | 2007-07-24 | 2016-02-17 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| CN101808990B (zh) | 2007-07-24 | 2012-09-05 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶衍生物 |
| TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
-
2011
- 2011-06-15 US US13/160,944 patent/US8642622B2/en active Active
- 2011-06-16 MX MX2012014068A patent/MX2012014068A/es active IP Right Grant
- 2011-06-16 AU AU2011268373A patent/AU2011268373B2/en not_active Ceased
- 2011-06-16 JP JP2013515497A patent/JP5795797B2/ja not_active Expired - Fee Related
- 2011-06-16 MA MA35558A patent/MA34377B1/fr unknown
- 2011-06-16 WO PCT/US2011/040605 patent/WO2011159852A1/en not_active Ceased
- 2011-06-16 AR ARP110102087A patent/AR081943A1/es unknown
- 2011-06-16 TW TW100121094A patent/TW201206435A/zh unknown
- 2011-06-16 BR BR112012031768A patent/BR112012031768A2/pt not_active IP Right Cessation
- 2011-06-16 EA EA201270790A patent/EA022395B1/ru not_active IP Right Cessation
- 2011-06-16 KR KR1020137001026A patent/KR20130032357A/ko not_active Withdrawn
- 2011-06-16 NZ NZ605741A patent/NZ605741A/en not_active IP Right Cessation
- 2011-06-16 CN CN201180039590.3A patent/CN103068800B/zh not_active Expired - Fee Related
- 2011-06-16 EP EP11728134.5A patent/EP2582670B1/en not_active Not-in-force
- 2011-06-16 SG SG2012085353A patent/SG186064A1/en unknown
-
2012
- 2012-11-29 IL IL223368A patent/IL223368A0/en unknown
- 2012-12-07 TN TNP2012000581A patent/TN2012000581A1/en unknown
- 2012-12-12 CL CL2012003521A patent/CL2012003521A1/es unknown
-
2013
- 2013-01-04 CO CO13001893A patent/CO6650362A2/es active IP Right Grant
- 2013-01-15 ZA ZA2013/00380A patent/ZA201300380B/en unknown
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