JP5795797B2 - ケモカイン受容体活性の調整薬としてのピペリジニル化合物 - Google Patents

ケモカイン受容体活性の調整薬としてのピペリジニル化合物 Download PDF

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Publication number
JP5795797B2
JP5795797B2 JP2013515497A JP2013515497A JP5795797B2 JP 5795797 B2 JP5795797 B2 JP 5795797B2 JP 2013515497 A JP2013515497 A JP 2013515497A JP 2013515497 A JP2013515497 A JP 2013515497A JP 5795797 B2 JP5795797 B2 JP 5795797B2
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disease
compound
compounds
chemokine
drugs
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JP2013528656A5 (enExample
JP2013528656A (ja
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ロバート・ジェイ・チャーニー
ジョン・ブイ・ダンシア
ダニエル・エス・ガードナー
ジョゼフ・ビー・サンテッラ
ワン・ジョンギュ
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
JP2013515497A 2010-06-16 2011-06-16 ケモカイン受容体活性の調整薬としてのピペリジニル化合物 Expired - Fee Related JP5795797B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35522510P 2010-06-16 2010-06-16
US61/355,225 2010-06-16
PCT/US2011/040605 WO2011159852A1 (en) 2010-06-16 2011-06-16 Piperidinyl compound as a modulator of chemokine receptor activity

Publications (3)

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JP2013528656A JP2013528656A (ja) 2013-07-11
JP2013528656A5 JP2013528656A5 (enExample) 2014-07-31
JP5795797B2 true JP5795797B2 (ja) 2015-10-14

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JP2013515497A Expired - Fee Related JP5795797B2 (ja) 2010-06-16 2011-06-16 ケモカイン受容体活性の調整薬としてのピペリジニル化合物

Country Status (20)

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US (1) US8642622B2 (enExample)
EP (1) EP2582670B1 (enExample)
JP (1) JP5795797B2 (enExample)
KR (1) KR20130032357A (enExample)
CN (1) CN103068800B (enExample)
AR (1) AR081943A1 (enExample)
AU (1) AU2011268373B2 (enExample)
BR (1) BR112012031768A2 (enExample)
CL (1) CL2012003521A1 (enExample)
CO (1) CO6650362A2 (enExample)
EA (1) EA022395B1 (enExample)
IL (1) IL223368A0 (enExample)
MA (1) MA34377B1 (enExample)
MX (1) MX2012014068A (enExample)
NZ (1) NZ605741A (enExample)
SG (1) SG186064A1 (enExample)
TN (1) TN2012000581A1 (enExample)
TW (1) TW201206435A (enExample)
WO (1) WO2011159852A1 (enExample)
ZA (1) ZA201300380B (enExample)

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US8642622B2 (en) 2014-02-04
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IL223368A0 (en) 2013-03-05
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