JP2013528402A - 体内管に、乾燥薬物送達ベシクルを送達するためのバルーン・カテーテル・システム - Google Patents
体内管に、乾燥薬物送達ベシクルを送達するためのバルーン・カテーテル・システム Download PDFInfo
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- JP2013528402A JP2013528402A JP2012547319A JP2012547319A JP2013528402A JP 2013528402 A JP2013528402 A JP 2013528402A JP 2012547319 A JP2012547319 A JP 2012547319A JP 2012547319 A JP2012547319 A JP 2012547319A JP 2013528402 A JP2013528402 A JP 2013528402A
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Abstract
【選択図】 図10
Description
Claims (25)
- 薬物または治療薬剤を血管に送達するためのシステムであって、
前記システムが、患者の血管系中に挿入するために適合された遠位端と、前記遠位端に設けられた多孔質バルーンと、流体源に連結されるように適合された近位端と、前記近位端から前記バルーンへと伸張しているルーメンとを有するカテーテル本体を備えたバルーンカテーテルと、
乾燥薬物送達ベシクルの貯蔵部を備えた貯蔵室と、
インフレータと、
インフレータと流体連結している懸濁室と、
前記貯蔵室を、前記懸濁室または前記カテーテルの前記ルーメンに選択的に連結するために操作可能なバルブとを有し、
前記インフレータは、前記乾燥薬物送達ベシクルを薬物送達ベシクルの流体懸濁液に水戻しするために、前記貯蔵室を流体で充填するため、および、前記バルブが前記貯蔵室を前記懸濁室へ連結する位置に位置づけられた際には、前記流体懸濁液を、前記懸濁室中に引き入れるために操作可能であり、
前記インフレータは、前記懸濁液を、前記懸濁室から前記カテーテルのルーメンおよび前記多孔質バルーンを通って前記血管へと押し入れるために操作可能であるシステム。 - 乾燥薬物送達ベシクルの前記貯蔵部は、ラパマイシンまたはラパマイシン類似体を積載したミセルを有する請求項1に記載のシステム。
- 乾燥薬物送達ベシクルの前記貯蔵部は、ABT−578、ゾタロリムス、エベロリムス、バイオリムスA9、デフォロリムス、テムシロリムス、タクロリムス、ピメクロリムス、窒素酸化物合成物、C3細胞外酵素、RhoA阻害剤、ツブルシン、A3作動薬、CB2作動薬、17−AAG、Hsp90拮抗薬、チルホスチン、カテプシンS阻害剤、パクリタキセル、デキサメタゾン、セラミド、ジメチル・スフィンゴシン、エーテル結合ジグリセリド、エーテル結合ホスファチジン酸、スフィンガニン、エストロゲン、タキソール、タキソール類似体、アクチノマイシンD、プロスタグランジン、ビタミンA、プロブコール、バチマスタット、スタチン、トラピジル、マイトマイシンCまたはサイトカラシンBを積載したミセルを有する請求項1に記載のシステム。
- 前記懸濁室は、2mm以下の径の管を有する請求項1に記載のシステム。
- 前記懸濁室は、1〜2mmの径で、全長が約300mmのコイル状管を有する請求項1に記載のシステム。
- 前記バルブは、三方バルブであって、前記貯蔵室と前記懸濁室との間に置かれて、前記貯蔵室と前記懸濁室とを流体連結させて並べてつなぐように操作可能であり、かつ、前記カテーテルと前記懸濁室との間にも設けられていて、前記カテーテルルーメンと懸濁室とを流体連結するように並べてつなぐように操作可能である請求項1に記載のシステム。
- 前記システムは、さらに、前記カテーテルの近位端に設けられたカテーテルハンドルを有し、前記貯蔵室および前記懸濁室は前記ハンドル内に設けられている請求項1に記載のシステム。
- 薬物または治療薬剤を、患者の体内の血管に送達する方法であって、前記方法は、
カテーテルシステムであって、
患者の血管系中に挿入するために適合された遠位端と、前記遠位端に設けられた多孔質バルーンと、流体源に連結されるように適合された近位端と、前記近位端から前記バルーンへと伸張しているルーメンとを有するカテーテル本体を備えたバルーンカテーテルと、
乾燥薬物送達ベシクルの貯蔵部を備えた貯蔵室と、
インフレータと、
インフレータと流体連結している懸濁室と、
前記貯蔵室を、前記懸濁室または前記カテーテルの前記ルーメンに選択的に連結するために操作可能なバルブとを有するカテーテルシステムを設ける工程と、
前記インフレータおよびコイル管状の懸濁室を、前記貯蔵室と並べてつなぐように、前記三方バルブを操作する工程と、
前記ミセル貯蔵室中のミセルを水戻しするために、および、薬物送達ベシクルの懸濁液を作るために、前記貯蔵室中に流体を押し入れる工程と
薬物送達ベシクルの懸濁液を前記懸濁室中に引き入れる工程と、
前記懸濁室と前記インフレータとを、前記カテーテルルーメンと並べてつなぐように、前記三方バルブを操作する工程と、
追加的な流体を、懸濁室からカテーテルへと押し入れ、これにより、薬物送達ベシクルの懸濁液を、前記バルーンの壁を通って、前記バルーンの周囲の体の組織中に押し入れるように、前記インフレータを操作する工程と、を含む方法。 - 前記薬物送達ベシクルは、ラパマイシンまたはラパマイシン類似体を積載したミセルを有する請求項8に記載の方法。
- 前記薬物送達ベシクルは、ABT−578、ゾタロリムス、エベロリムス、バイオリムスA9、デフォロリムス、テムシロリムス、タクロリムス、ピメクロリムス、窒素酸化物合成物、C3細胞外酵素、RhoA阻害剤、ツブルシン、A3作動薬、CB2作動薬、17−AAG、Hsp90拮抗薬、チルホスチン、カテプシンS阻害剤、パクリタキセル、デキサメタゾン、セラミド、ジメチル・スフィンゴシン、エーテル結合ジグリセリド、エーテル結合ホスファチジン酸、スフィンガニン、エストロゲン、タキソール、タキソール類似体、アクチノマイシンD、プロスタグランジン、ビタミンA、プロブコール、バチマスタット、スタチン、トラピジル、マイトマイシンCまたはサイトカラシンBを積載したミセルを有する請求項8に記載の方法。
- 遠位端部分と、近位端部分とで特徴付けられたカテーテル本体と、
前記カテーテル本体の遠位端に設けられた第1の外側バルーンと、
前記カテーテル中に設けられている凍結乾燥されたミセル貯蔵部であって、前記ミセル中にラパマイシンがカプセル化されている、ミセル貯蔵部と、
前記ミセル貯蔵部内のミセルを動かすのに適した水溶液の貯蔵部と、
前記カテーテル本体の近位端に設けられた第1の注入口と、
前記注入口から前記第1の外側バルーンへと連結している第1ルーメンと
を有するバルーン・カテーテル・システム。 - 前記第1の外側バルーン内で、前記カテーテル本体の遠位端に設けられた第2の内側バルーンであって、前記第1バルーンと前記第2バルーンとの間でバルーン間空間を規定している第2の内側バルーンと、
前記カテーテル本体の前記近位端に設けられた第2の注入口と、
前記注入口から前記第2の内側バルーンへと連結している第2ルーメンと
をさらに有し、
前記貯蔵部は、前記第1バルーンと前記第2バルーンとの間の前記バルーン間空間中に設けられている請求項11に記載のバルーン・カテーテル・システム。 - 前記貯蔵部は、前記第1バルーン内に設けられている請求項11に記載のバルーン・カテーテル・システム。
- 前記貯蔵部は、前記第1ルーメン内に設けられている請求項11に記載のバルーン・カテーテル・システム。
- 前記第2バルーンは、多孔質壁部分を有する請求項11に記載のバルーン・カテーテル・システム。
- 前記貯蔵部は、前記カテーテルの近位端に設けられている請求項11に記載のバルーン・カテーテル・システム。
- 前記貯蔵部は、前記カテーテル本体のある部分内に設けられている請求項11に記載のバルーン・カテーテル・システム。
- 患者の血管の病変部位を治療する方法であって、
バルーン・カテーテル・システムであって、
遠位端部分と、近位端部分とで特徴付けられたカテーテル本体と、
前記カテーテル本体の遠位端部分に設けられ、多孔質壁部分を有する第1の外側バルーンと、
前記カテーテル中に設けられている凍結乾燥されたミセル貯蔵部であって、前記ミセル中にラパマイシンがカプセル化されている、ミセル貯蔵部と、
前記ミセル貯蔵部内のミセルを動かすのに適した水溶液の貯蔵部と、
前記カテーテル本体の近位端に設けられた第1注入口と、
前記注入口から前記第1の外側バルーンへと連結している第1ルーメンと
を有するバルーン・カテーテル・システムを設ける工程と、
前記バルーンが前記病変部位付近に設けられるように、前記カテーテルの前記遠位端部分を、血管中に挿入する工程と、
前記ミセルを湿潤化させ、動かすために、前記バルーンを水溶液で充填させる工程と、
前記バルーンに加圧して、前記ミセルを、前記バルーンの前記多孔質壁部分から前記血管中へと押し入れる工程とを含む方法。 - バルーンであって、
前記第1の外側バルーン内で、前記カテーテル本体の遠位端部分に設けられた第2の内側バルーンであって、前記第1バルーンと前記第2バルーンとの間でバルーン間空間を規定している第2の内側バルーンと、
前記カテーテル本体の前記近位端に設けられた第2注入口と、
前記注入口から前記第2の内側バルーンへと連結している第2ルーメンと
をさらに有し、
前記貯蔵部が、前記第1バルーンと前記第2バルーンとの間の前記バルーン間空間中に設けられているバルーンを設ける工程と、
前記第1バルーンを充填させた後に、前記第1バルーンに加圧し、前記ミセルの一部分を押し込むために、前記第2バルーンを膨らませる工程とをさらに含む請求項18に記載の方法。 - さらに、前記血管内で血管形成術を行ために、前記第1バルーンを加圧する工程を含む請求項18に記載の方法。
- さらに、前記血管内で血管形成術を行うために、前記第1バルーンを加圧する工程を含む請求項19に記載の方法。
- さらに、前記血管内で血管形成術を行うために、前記第2バルーンを加圧する工程を含む請求項19に記載の方法。
- さらに、前記血管内で血管形成術を行うために、前記第1バルーンを加圧する工程と、
その後、前記第1バルーンに加圧し、これにより、ミセルを前記第1バルーンの前記多孔質壁部分を通過させるために前記第2バルーンを膨らませる工程とをさらに含む請求項19に記載の方法。 - 前記血管内で血管形成術を行うために、前記第2バルーンを加圧する工程と、
その後、前記第2バルーンを収縮させる工程と、
ミセルを湿潤化しおよび動かすために、前記第1バルーンを十分な水溶液で満たす工程と、
その後、前記第1バルーンに加圧し、それによりミセルが前記第1バルーンの前記多孔質壁を通って押し出すために、前記第2バルーンを膨らませる工程とを含む請求項19に記載の方法。 - 第2バルーンであって、
多孔質壁部分と、
前記第1バルーンと前記第2バルーンとの間で規定されたバルーン間空間中に設けられた凍結乾燥ミセル貯蔵部とを有する第2バルーンを設ける工程と、
前記水溶液の貯蔵部からの流体で前記第2バルーンを加圧する工程であって、
この工程が、前記血管内で前記血管形成術を行い、これにより、前記貯蔵部からの流れを、前記第2バルーンの多孔質壁部分を通って前記バルーン間空間中に押し入れ、前記バルーン間空間中に設けられたミセル貯蔵部を湿潤化し、前記ミセルを前記第1バルーンの前記多孔質壁部分を通って洗い流すために行われる工程とをさらに含む請求項19に記載の方法。
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JP2019510536A (ja) * | 2016-02-08 | 2019-04-18 | オーバスネイチ・メディカル・プライベート・リミテッド | 薬剤溶出性バルーン |
JP2021184843A (ja) * | 2016-02-08 | 2021-12-09 | オーバスネイチ・メディカル・プライベート・リミテッド | 薬剤溶出性バルーン |
JP7027319B2 (ja) | 2016-02-08 | 2022-03-01 | オーバスネイチ・メディカル・プライベート・リミテッド | 薬剤溶出性バルーン |
JP2020501723A (ja) * | 2016-12-16 | 2020-01-23 | シー・アール・バード・インコーポレーテッドC R Bard Incorporated | 医用バルーン、バルーンカテーテル、およびその方法 |
JP2022508608A (ja) * | 2018-10-04 | 2022-01-19 | カリバー セラピューティクス エルエルシー | 高圧でミセルを注入するためのバルーン・カテーテル・システム |
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