JP2013528176A - 局所用アシルグルタチオン製剤 - Google Patents
局所用アシルグルタチオン製剤 Download PDFInfo
- Publication number
- JP2013528176A JP2013528176A JP2013512073A JP2013512073A JP2013528176A JP 2013528176 A JP2013528176 A JP 2013528176A JP 2013512073 A JP2013512073 A JP 2013512073A JP 2013512073 A JP2013512073 A JP 2013512073A JP 2013528176 A JP2013528176 A JP 2013528176A
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- glutathione
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- RWSXRVCMGQZWBV-WDSKDSINSA-N N[C@@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)C(O)=O Chemical compound N[C@@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)C(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明は、老化皮膚の外観を改善し、かつ、老化皮膚の状態を予防および治療するための、グルタチオンのアシル誘導体を含む製剤の使用に関する。より具体的には、本発明は、皮膚の皺および小皺、乾燥、くすみまたは輝きの欠乏の外観を改善するための、または皮膚の過剰な(exaggerated)線(lines)および皺、たるみ、変色、もしくは発赤および染み(blotchiness)、閉経前後の、閉経期の、もしくは閉経後の皮膚の全ての目に見える状態の外観を予防もしくは治療するための、S−パルミトイルグルタチオンを含む局所用組成物の使用に関する。
還元型グルタチオンは、最も一般的にはグルタチオンまたはGSHと呼ばれており、動物および植物に見られる比較的小さな分子であり、下記の式を有する。
本発明は、式(I)
[式中、R1は不飽和または飽和C16基からなり、かつ、R2は水素、脂肪族または芳香族アシル基である]のS−アシルグルタチオン誘導体、および皮膚科学的に許容される担体を含有する組成物の安全かつ有効な量を皮膚組織に適用することを含む、老化皮膚の外観を改善する方法を提供する。
[式中、R1は不飽和または飽和C16基からなり、かつ、R2は水素、脂肪族または芳香族アシル基である]のS−アシルグルタチオン誘導体、および皮膚科学的に許容される担体を含有する組成物の安全かつ有効な量を適用することを含む方法を提供する。
皮膚細胞の老化は、しばしば皮膚の細胞内のタンパク質の糖化と関連するが、これは皮膚の弾力性の減少およびコラーゲンの分解の原因となる。糖化タンパク質は、炎症、皺、および褐色の染みまたはリポフスチンなどの状態を示す。
Claims (10)
- 1.0重量%〜3重量%のS−パルミトイルグルタチオンおよび皮膚科学的に許容される担体を含む組成物の安全かつ有効な量を皮膚組織に適用することを含む、閉経前後の、閉経期の、または閉経後の皮膚における老化皮膚の外観を予防または治療する化粧方法。
- R1がパルミトイル基である、請求項1または2に記載の方法。
- 組成物が約0.01重量%〜約20重量%のS−パルミトイルグルタチオン誘導体を含む、請求項1または2に記載の方法。
- 組成物が約0.1重量%〜約5重量%のS−パルミトイルグルタチオン誘導体を含む、請求項5に記載の方法。
- 組成物が約1.0重量%〜約3重量%のS−パルミトイルグルタチオンを含む、請求項6に記載の方法。
- 担体がステアリン酸の脂肪酸誘導体を含む、請求項1、2、または3に記載の方法。
- 組成物がアスコルビン酸およびアスコルビン酸誘導体、リポ酸、神経ペプチド、α−ヒドロキシ酸、マグネシウム、亜鉛および銅の塩、ならびにトコトリエノールおよびトコトリエノール誘導体、ならびにトコトリエノールまたはトコトリエノール誘導体で強化されたビタミンE組成物からなる群から選択される1つ以上の付加的成分をさらに含む、請求項1、2、または3に記載の方法。
- 老化皮膚の外観が乾燥、皺および線(lines)、マリオネットライン(marionette lines)、イレブンライン(eleven lines)、水平な額の線(horizontal forehead lines)、たるみ、変色、発赤もしくは染み(blotchiness)、くすみ、または輝きの欠乏の1つ以上を含む、請求項1、2、または3に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/070,945 US8609604B2 (en) | 2009-12-28 | 2011-03-24 | Methods of improving the appearance of aging skin |
US13/070,945 | 2011-03-24 | ||
PCT/US2012/028404 WO2012128971A2 (en) | 2011-03-24 | 2012-03-09 | Topical acyl glutathione formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013528176A true JP2013528176A (ja) | 2013-07-08 |
JP5695188B2 JP5695188B2 (ja) | 2015-04-01 |
Family
ID=45894666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013512073A Active JP5695188B2 (ja) | 2011-03-24 | 2012-03-09 | 局所用アシルグルタチオン製剤 |
Country Status (8)
Country | Link |
---|---|
US (2) | US8609604B2 (ja) |
EP (1) | EP2547317B1 (ja) |
JP (1) | JP5695188B2 (ja) |
KR (1) | KR101530307B1 (ja) |
CN (2) | CN103167864A (ja) |
AU (1) | AU2012227308B2 (ja) |
CA (1) | CA2794421C (ja) |
WO (1) | WO2012128971A2 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013528662A (ja) * | 2011-03-25 | 2013-07-11 | エヌ・ブイ・ペリコーン・リミテッド・ライアビリティ・カンパニー | 局所用パルミトイルグルタチオン製剤 |
JP2021535208A (ja) * | 2018-08-23 | 2021-12-16 | エルジー ハウスホールド アンド ヘルスケア リミテッド | ヒト脂肪幹細胞の分化または増殖促進用組成物 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8580742B2 (en) * | 2010-03-05 | 2013-11-12 | N.V. Perricone Llc | Topical glutathione formulations for menopausal skin |
US8609604B2 (en) * | 2009-12-28 | 2013-12-17 | N.V. Perricone Llc | Methods of improving the appearance of aging skin |
ITPO20110021A1 (it) * | 2011-11-08 | 2013-05-09 | Enrichetta Fedeli | Composizione farmaceutica per la protezione dei tessuti dall'invecchiamento cellulare specialmente provocato dalle radiazioni ionizzanti |
CN105744835A (zh) | 2013-07-22 | 2016-07-06 | 俄亥俄州国家创新基金会 | 用于减少热潮红发生的方法 |
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2011
- 2011-03-24 US US13/070,945 patent/US8609604B2/en active Active
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2012
- 2012-03-09 WO PCT/US2012/028404 patent/WO2012128971A2/en active Application Filing
- 2012-03-09 AU AU2012227308A patent/AU2012227308B2/en active Active
- 2012-03-09 EP EP12711066.6A patent/EP2547317B1/en active Active
- 2012-03-09 CA CA2794421A patent/CA2794421C/en active Active
- 2012-03-09 JP JP2013512073A patent/JP5695188B2/ja active Active
- 2012-03-09 CN CN2012800010055A patent/CN103167864A/zh active Pending
- 2012-03-09 KR KR1020127024283A patent/KR101530307B1/ko active IP Right Grant
- 2012-03-09 CN CN201510111812.8A patent/CN104814882A/zh active Pending
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2013
- 2013-12-09 US US14/100,820 patent/US9029317B2/en active Active
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JPS4719775B1 (ja) * | 1969-02-08 | 1972-06-06 | ||
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013528662A (ja) * | 2011-03-25 | 2013-07-11 | エヌ・ブイ・ペリコーン・リミテッド・ライアビリティ・カンパニー | 局所用パルミトイルグルタチオン製剤 |
JP2021535208A (ja) * | 2018-08-23 | 2021-12-16 | エルジー ハウスホールド アンド ヘルスケア リミテッド | ヒト脂肪幹細胞の分化または増殖促進用組成物 |
Also Published As
Publication number | Publication date |
---|---|
KR20120138771A (ko) | 2012-12-26 |
EP2547317B1 (en) | 2018-05-09 |
EP2547317A2 (en) | 2013-01-23 |
US20140100171A1 (en) | 2014-04-10 |
CA2794421A1 (en) | 2012-09-27 |
JP5695188B2 (ja) | 2015-04-01 |
WO2012128971A2 (en) | 2012-09-27 |
US8609604B2 (en) | 2013-12-17 |
CN104814882A (zh) | 2015-08-05 |
CN103167864A (zh) | 2013-06-19 |
KR101530307B1 (ko) | 2015-06-19 |
WO2012128971A3 (en) | 2013-03-21 |
CA2794421C (en) | 2016-06-21 |
US9029317B2 (en) | 2015-05-12 |
US20110293743A1 (en) | 2011-12-01 |
AU2012227308A1 (en) | 2012-10-18 |
AU2012227308B2 (en) | 2014-07-24 |
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