JP5843853B2 - 局所用パルミトイルグルタチオン製剤 - Google Patents
局所用パルミトイルグルタチオン製剤 Download PDFInfo
- Publication number
- JP5843853B2 JP5843853B2 JP2013515592A JP2013515592A JP5843853B2 JP 5843853 B2 JP5843853 B2 JP 5843853B2 JP 2013515592 A JP2013515592 A JP 2013515592A JP 2013515592 A JP2013515592 A JP 2013515592A JP 5843853 B2 JP5843853 B2 JP 5843853B2
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- JP
- Japan
- Prior art keywords
- glutathione
- composition
- tocotrienol
- derivatives
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 230000000699 topical effect Effects 0.000 title claims description 24
- OPZUFCSODCAIIR-SFTDATJTSA-N (2s)-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-(hexadecanoylamino)-5-oxopentanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O OPZUFCSODCAIIR-SFTDATJTSA-N 0.000 title 1
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Description
本発明は、皮膚老化を予防および治療するための、S−アシルグルタチオンを含む局所用組成物に関する。より具体的には、本発明は、皮膚の皺および小皺、乾燥、くすみもしくは輝きの欠乏の外観を改善するのに有用な、または皮膚の過剰な(exaggerated)線(lines)および皺、たるみ、変色、もしくは発赤および染み(blotchiness)の外観、閉経前後の、閉経期の、もしくは閉経後の皮膚の全ての目に見える状態を予防もしくは治療するための、グルタチオンのS−パルミトイル誘導体を含む製剤に関する。
還元型グルタチオンは、最も一般的にはグルタチオンまたはGSHと呼ばれており、動物および植物に見られる比較的小さな分子であり、下記の式を有する。
本発明は、式(I)
[式中、R1は不飽和または飽和C16基からなり、かつ、R2は水素、脂肪族または芳香族アシル基である]のS−アシルグルタチオン誘導体の有効量、および皮膚科学的に許容される担体を含む、老化皮膚に適用するための局所用組成物を含む。
皮膚細胞の老化は、しばしば皮膚の細胞内のタンパク質の糖化と関連するが、これは皮膚の弾力性の減少およびコラーゲンの分解の原因となる。糖化タンパク質は、炎症、皺、および褐色の染みまたはリポフスチンなどの状態を示す。
Claims (14)
- S−パルミトイルグルタチオンが0.01重量%〜20重量%存在する、請求項1に記載の組成物。
- S−パルミトイルグルタチオンが0.1重量%〜5重量%存在する、請求項2に記載の組成物。
- S−パルミトイルグルタチオンが1.0重量%〜3.0重量%存在する、請求項3に記載の組成物。
- 組成物がステアリン酸の脂肪酸誘導体を含む、請求項1、2、3、または4に記載の組成物。
- アスコルビン酸およびアスコルビン酸誘導体、リポ酸、α−ヒドロキシ酸、トコトリエノール、トコトリエノール誘導体、ならびにトコトリエノールまたはトコトリエノール誘導体で強化されたビタミンE組成物、ならびにその混合物からなる群から選択される1つ以上の付加的成分をさらに含む、請求項1、2、3、4、または5に記載の組成物。
- 組成物がクリーム剤を含む、請求項1、2、3、4、または5に記載の組成物。
- 0.01重量%〜20重量%のS−パルミトイルグルタチオン;
0.01重量%〜15重量%の少なくとも1つの乳化剤;
アスパラギン酸マグネシウム、グルコン酸亜鉛およびグルコン酸銅の混合物;
水中油型エマルション;ならびに
水
を含む、老化皮膚に適用するための局所用組成物。 - S−パルミトイルグルタチオンが0.1重量%〜5重量%存在する、請求項8に記載の組成物。
- S−パルミトイルグルタチオンが1.0重量%〜3.0重量%存在する、請求項9に記載の組成物。
- 乳化剤がステアリン酸の脂肪酸誘導体を含む、請求項8、9、または10に記載の組成物。
- アスコルビン酸およびアスコルビン酸誘導体;リポ酸;α−ヒドロキシ酸;ならびにトコトリエノールおよびトコトリエノール誘導体、ならびにトコトリエノールまたはトコトリエノール誘導体で強化されたビタミンE組成物からなる群から選択される1つ以上の付加的成分をさらに含む、請求項8、9、または10に記載の組成物。
- 組成物がクリーム剤を含む、請求項8、9、または10に記載の組成物。
- パルミチン酸イソプロピルをさらに含む、請求項8、9、または10に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/072,277 US8609618B2 (en) | 2011-03-25 | 2011-03-25 | Topical palmitoyl glutathione formulations |
US13/072,277 | 2011-03-25 | ||
PCT/US2012/028234 WO2012134758A2 (en) | 2011-03-25 | 2012-03-08 | Topical palmitoyl glutathione formulations |
Publications (2)
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JP2013528662A JP2013528662A (ja) | 2013-07-11 |
JP5843853B2 true JP5843853B2 (ja) | 2016-01-13 |
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JP2013515592A Expired - Fee Related JP5843853B2 (ja) | 2011-03-25 | 2012-03-08 | 局所用パルミトイルグルタチオン製剤 |
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US (2) | US8609618B2 (ja) |
EP (1) | EP2547316A2 (ja) |
JP (1) | JP5843853B2 (ja) |
KR (1) | KR101445182B1 (ja) |
CN (1) | CN103327958A (ja) |
AU (1) | AU2012238087B2 (ja) |
CA (1) | CA2795557C (ja) |
WO (1) | WO2012134758A2 (ja) |
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US8580742B2 (en) * | 2010-03-05 | 2013-11-12 | N.V. Perricone Llc | Topical glutathione formulations for menopausal skin |
US8609604B2 (en) * | 2009-12-28 | 2013-12-17 | N.V. Perricone Llc | Methods of improving the appearance of aging skin |
JP6360437B2 (ja) * | 2011-12-20 | 2018-07-18 | ユニリーバー・ナームローゼ・ベンノートシヤープ | アミノペプチド混合物を含む保湿組成物 |
WO2017103936A1 (en) * | 2015-12-16 | 2017-06-22 | Avshalomov Mattityahu | Skin care preparations for babies |
US11185492B2 (en) | 2018-12-14 | 2021-11-30 | Mary Kay Inc. | Cosmetic compositions |
US20200405609A1 (en) * | 2019-06-26 | 2020-12-31 | Johnson & Johnson Consumer Inc. | Topical compositions containing n-acyl dipeptide derivatives and glycolic acid |
IT202000013393A1 (it) | 2020-06-05 | 2021-12-05 | Francesco Sestito | Composizioni fitoterapiche per uso topico |
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US20120245098A1 (en) | 2012-09-27 |
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US8609618B2 (en) | 2013-12-17 |
US9023801B2 (en) | 2015-05-05 |
KR20120130300A (ko) | 2012-11-30 |
EP2547316A2 (en) | 2013-01-23 |
JP2013528662A (ja) | 2013-07-11 |
AU2012238087A1 (en) | 2012-11-08 |
US20140045767A1 (en) | 2014-02-13 |
AU2012238087B2 (en) | 2014-07-31 |
CA2795557A1 (en) | 2012-10-04 |
WO2012134758A3 (en) | 2013-01-17 |
CA2795557C (en) | 2016-06-21 |
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