JP2013525337A - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP2013525337A
JP2013525337A JP2013505533A JP2013505533A JP2013525337A JP 2013525337 A JP2013525337 A JP 2013525337A JP 2013505533 A JP2013505533 A JP 2013505533A JP 2013505533 A JP2013505533 A JP 2013505533A JP 2013525337 A JP2013525337 A JP 2013525337A
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JP
Japan
Prior art keywords
sodium
particles
efavirenz
polymer
surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013505533A
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English (en)
Japanese (ja)
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JP2013525337A5 (enExample
Inventor
ルルラ アマル
マルホトラ ゲエナ
Original Assignee
シプラ・リミテッド
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Application filed by シプラ・リミテッド filed Critical シプラ・リミテッド
Publication of JP2013525337A publication Critical patent/JP2013525337A/ja
Publication of JP2013525337A5 publication Critical patent/JP2013525337A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013505533A 2010-04-20 2011-04-20 医薬組成物 Pending JP2013525337A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1296MU2010 2010-04-20
IN1296/MUM/2010 2010-04-20
PCT/GB2011/000620 WO2011131943A2 (en) 2010-04-20 2011-04-20 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
JP2013525337A true JP2013525337A (ja) 2013-06-20
JP2013525337A5 JP2013525337A5 (enExample) 2014-06-05

Family

ID=44625957

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013505533A Pending JP2013525337A (ja) 2010-04-20 2011-04-20 医薬組成物

Country Status (13)

Country Link
US (1) US20130302415A1 (enExample)
EP (1) EP2560617A2 (enExample)
JP (1) JP2013525337A (enExample)
KR (1) KR20130076818A (enExample)
CN (1) CN102985072A (enExample)
AU (1) AU2011244783B2 (enExample)
BR (1) BR112012026843A2 (enExample)
CA (1) CA2796494A1 (enExample)
GT (1) GT201200284A (enExample)
NZ (1) NZ602955A (enExample)
RU (1) RU2012149115A (enExample)
WO (1) WO2011131943A2 (enExample)
ZA (1) ZA201207670B (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018532769A (ja) * 2015-08-28 2018-11-08 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ウロリチン化合物を含む組成物
JP2018533618A (ja) * 2015-08-28 2018-11-15 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ウロリチン化合物を含む組成物
JP2023505128A (ja) * 2019-12-02 2023-02-08 アストラゼネカ・アクチエボラーグ ６－（２－クロロ－６－メチルピリジン－４－イル）－５－（４－フルオロフェニル）－１，２，４－トリアジン－３－アミンの固形製剤処方物
JP2024038209A (ja) * 2020-04-20 2024-03-19 ポビバ コーポレーション 抗ウイルス薬剤の向上した送達の為の組成物及び方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201115633D0 (en) 2011-09-09 2011-10-26 Univ Liverpool Compositions of efavirenz
US10646452B2 (en) * 2013-03-15 2020-05-12 New Jersey Institute Of Technology System and method for fabrication of uniform polymer films containing nano and micro particles via continuous drying process
WO2015059466A1 (en) 2013-10-25 2015-04-30 Cipla Limited Pharmaceutical compositions comprising efavirenz
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
IN2014MU00916A (enExample) * 2014-03-20 2015-09-25 Cipla Ltd
CN104224790A (zh) * 2014-09-28 2014-12-24 苏州普罗达生物科技有限公司 一种依法韦仑组合物及其制备方法
PE20180690A1 (es) 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
AU2017364077A1 (en) 2016-11-22 2019-06-20 Elektrofi, Inc. Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof
AU2018306303A1 (en) * 2017-07-25 2020-02-20 Elektrofi, Inc. Formation of particles including agents
US20230040901A1 (en) * 2018-01-04 2023-02-09 PlantTec Medical GmbH Pharmaceutical composition for inhibiting postoperative adhesions
ES2732498B2 (es) * 2018-05-21 2020-04-27 Consejo Superior Investigacion Uso de efavirenz para el tratamiento de enfermedades de almacenamiento lipidico.
US12115262B2 (en) 2018-05-24 2024-10-15 Elektrofi, Inc. Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof
CN112236141A (zh) * 2018-06-11 2021-01-15 大塚制药株式会社 包含德拉马尼的组合物
AU2020214626B2 (en) 2019-01-31 2025-10-16 Elektrofi, Inc. Particle formation and morphology
JP7781743B2 (ja) 2019-09-13 2025-12-08 エレクトロフィ，インコーポレイテッド 疾患の処置のための治療用生物学的作用剤の送達のための組成物及び方法
JP2023522627A (ja) 2020-04-17 2023-05-31 エレクトロフィ，インコーポレイテッド 連続的な液滴形成及び脱水によって粒子を形成する方法
CN112245400B (zh) * 2020-11-10 2023-01-20 蓝龙药业(北京)有限公司 一种依法韦仑微片剂、制备方法及其应用
CN114404377B (zh) * 2022-01-10 2023-07-25 安徽贝克生物制药有限公司 一种阿巴卡韦、拉米夫定、依非韦伦复方片及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126797A1 (ja) * 2007-04-06 2008-10-23 Activus Pharma Co., Ltd. 微粉砕化有機化合物粒子の製造方法
WO2009026257A2 (en) * 2007-08-17 2009-02-26 Teva Pharmaceutical Industries Ltd. Methods and compositions for controlling the bioavailability of poorly soluble drugs
JP2009046438A (ja) * 2007-08-21 2009-03-05 Api Co Ltd アントシアニン含有組成物及びその製造方法

Family Cites Families (9)

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UA72207C2 (uk) 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
EP1332757B1 (en) * 1998-05-27 2012-06-13 Merck Sharp & Dohme Corp. Efavirenz compressed tablet formulation
CO5070643A1 (es) 1998-05-27 2001-08-28 Merck & Co Inc Formulacion en tabletas comprimidas
WO2003045327A2 (en) * 2001-11-27 2003-06-05 Bristol-Myers Squibb Company Efavirenz tablet formulation having unique biopharmaceutical characteristics
WO2007002823A2 (en) * 2005-06-29 2007-01-04 Wyeth Formulations of conjugated estrogens and bazedoxifene
US20080026062A1 (en) * 2006-07-31 2008-01-31 Isaac Farr Pharmaceutical compositions including nano-sized active agent
US8846096B2 (en) * 2008-12-12 2014-09-30 Creighton University Nanoparticles and methods of use
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
GB201006038D0 (en) * 2010-04-12 2010-05-26 Unilever Plc Improvements relating to antiviral compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126797A1 (ja) * 2007-04-06 2008-10-23 Activus Pharma Co., Ltd. 微粉砕化有機化合物粒子の製造方法
WO2009026257A2 (en) * 2007-08-17 2009-02-26 Teva Pharmaceutical Industries Ltd. Methods and compositions for controlling the bioavailability of poorly soluble drugs
JP2009046438A (ja) * 2007-08-21 2009-03-05 Api Co Ltd アントシアニン含有組成物及びその製造方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018532769A (ja) * 2015-08-28 2018-11-08 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ウロリチン化合物を含む組成物
JP2018533618A (ja) * 2015-08-28 2018-11-15 アマゼンティス エスアーＡｍａｚｅｎｔｉｓ Ｓａ ウロリチン化合物を含む組成物
JP7161402B2 (ja) 2015-08-28 2022-10-26 アマゼンティス エスアー ウロリチン化合物を含む組成物
JP7227003B2 (ja) 2015-08-28 2023-02-21 アマゼンティス エスアー ウロリチン化合物を含む組成物
JP2025004129A (ja) * 2015-08-28 2025-01-14 アマゼンティス エスアー ウロリチン化合物を含む組成物
JP2023505128A (ja) * 2019-12-02 2023-02-08 アストラゼネカ・アクチエボラーグ ６－（２－クロロ－６－メチルピリジン－４－イル）－５－（４－フルオロフェニル）－１，２，４－トリアジン－３－アミンの固形製剤処方物
JP7731883B2 (ja) 2019-12-02 2025-09-01 アストラゼネカ・アクチエボラーグ ６－（２－クロロ－６－メチルピリジン－４－イル）－５－（４－フルオロフェニル）－１，２，４－トリアジン－３－アミンの固形製剤処方物
JP2024038209A (ja) * 2020-04-20 2024-03-19 ポビバ コーポレーション 抗ウイルス薬剤の向上した送達の為の組成物及び方法

Also Published As

Publication number Publication date
WO2011131943A2 (en) 2011-10-27
WO2011131943A8 (en) 2012-11-29
GT201200284A (es) 2014-08-26
CN102985072A (zh) 2013-03-20
EP2560617A2 (en) 2013-02-27
ZA201207670B (en) 2013-05-29
WO2011131943A3 (en) 2011-12-29
KR20130076818A (ko) 2013-07-08
NZ602955A (en) 2015-02-27
AU2011244783B2 (en) 2015-11-12
AU2011244783A1 (en) 2012-11-01
RU2012149115A (ru) 2014-05-27
US20130302415A1 (en) 2013-11-14
BR112012026843A2 (pt) 2016-07-12
CA2796494A1 (en) 2011-10-27

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