JP2013525262A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013525262A5 JP2013525262A5 JP2012547392A JP2012547392A JP2013525262A5 JP 2013525262 A5 JP2013525262 A5 JP 2013525262A5 JP 2012547392 A JP2012547392 A JP 2012547392A JP 2012547392 A JP2012547392 A JP 2012547392A JP 2013525262 A5 JP2013525262 A5 JP 2013525262A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- salt
- optionally substituted
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000002249 Diabetes Complications Diseases 0.000 claims 2
- 206010012655 Diabetic complications Diseases 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical group C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 208000001076 sarcopenia Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical compound C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- AFSPJJIONSZSCB-AWEZNQCLSA-N n-[(2s)-1-[1-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C1=NC2=CC(OCC3CC3)=CC=C2O1 AFSPJJIONSZSCB-AWEZNQCLSA-N 0.000 claims 1
- NQFDYRVHKCXJQP-HNNXBMFYSA-N n-[(2s)-1-[1-[6-(2-cyclopropylethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCCC1CC1 NQFDYRVHKCXJQP-HNNXBMFYSA-N 0.000 claims 1
- ZTQJADDEMCINFS-AWEZNQCLSA-N n-[(2s)-1-[1-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCC1CC1 ZTQJADDEMCINFS-AWEZNQCLSA-N 0.000 claims 1
- MFVUXRRTNVGQNW-HNNXBMFYSA-N n-[(2s)-4-[1-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]butan-2-yl]acetamide Chemical compound C1CC(CC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCC1CC1 MFVUXRRTNVGQNW-HNNXBMFYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012547392A JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010102718 | 2010-04-27 | ||
| JP2010102718 | 2010-04-27 | ||
| JP2012547392A JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
| PCT/JP2011/060616 WO2011136385A1 (en) | 2010-04-27 | 2011-04-26 | Bicyclic compound derivatives and their use as acc inhibitors. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525262A JP2013525262A (ja) | 2013-06-20 |
| JP2013525262A5 true JP2013525262A5 (enExample) | 2014-04-17 |
| JP5693611B2 JP5693611B2 (ja) | 2015-04-01 |
Family
ID=44120718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547392A Expired - Fee Related JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8703758B2 (enExample) |
| EP (1) | EP2563765B1 (enExample) |
| JP (1) | JP5693611B2 (enExample) |
| KR (1) | KR20130094211A (enExample) |
| CN (1) | CN103025716B (enExample) |
| AR (1) | AR080969A1 (enExample) |
| AU (1) | AU2011246004A1 (enExample) |
| BR (1) | BR112012027648A2 (enExample) |
| CA (1) | CA2797767A1 (enExample) |
| CO (1) | CO6640253A2 (enExample) |
| CR (1) | CR20120598A (enExample) |
| EA (1) | EA021698B1 (enExample) |
| EC (1) | ECSP12012311A (enExample) |
| ES (1) | ES2546130T3 (enExample) |
| GE (1) | GEP20146178B (enExample) |
| MA (1) | MA34245B1 (enExample) |
| NZ (1) | NZ603777A (enExample) |
| PH (1) | PH12012502347A1 (enExample) |
| SG (1) | SG185759A1 (enExample) |
| TW (1) | TW201206911A (enExample) |
| UA (1) | UA108102C2 (enExample) |
| UY (1) | UY33354A (enExample) |
| WO (1) | WO2011136385A1 (enExample) |
| ZA (1) | ZA201208895B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2649062B1 (en) | 2010-11-30 | 2015-04-08 | Takeda Pharmaceutical Company Limited | Bicyclic compounds as inhibitors of acetyl-coa carboxylase (acc) |
| US9133129B2 (en) | 2011-10-24 | 2015-09-15 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| US8530460B2 (en) * | 2011-12-19 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| US8530461B2 (en) | 2011-12-29 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| US8623860B2 (en) * | 2011-12-30 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Azetidine derivatives, pharmaceutical compositions and uses thereof |
| BR112016004118A2 (pt) | 2013-09-12 | 2017-10-17 | Pfizer | uso de inibidores da acetil-coa carboxilase para tratamento de acne vulgar |
| JP6050291B2 (ja) * | 2014-08-07 | 2016-12-21 | 長谷川香料株式会社 | ソラノンの製造方法およびその合成中間体 |
| JP2016079168A (ja) * | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | ９員縮合環誘導体 |
| CN106636402B (zh) * | 2016-12-22 | 2020-09-15 | 中南大学湘雅医院 | 一种判断鼻咽癌放疗敏感性的分子标志物及应用 |
| JP7361584B2 (ja) * | 2018-12-19 | 2023-10-16 | 高砂香料工業株式会社 | アミドの還元によるアミンの製造方法 |
| JPWO2023090411A1 (enExample) * | 2021-11-19 | 2023-05-25 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010224A1 (en) | 1995-09-13 | 1997-03-20 | Takeda Chemical Industries, Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
| CA2372840C (en) | 1999-05-05 | 2008-07-22 | Aventis Pharma Limited | Substituted bicyclic compounds |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| CA2407149C (en) | 2000-04-28 | 2010-10-12 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| US20030187023A1 (en) | 2000-07-17 | 2003-10-02 | Keiji Kubo | Sulfone derivatives, process for their production and use thereof |
| EP1478437B1 (en) * | 2002-02-27 | 2005-08-31 | Pfizer Products Inc. | Acc inhibitors |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| PL376733A1 (pl) | 2002-11-01 | 2006-01-09 | Takeda Pharmaceutical Company Limited | Środek do zapobiegania lub leczenia neuropatii |
| AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| WO2004048363A1 (ja) | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | イミダゾール誘導体、その製造法および用途 |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| EP1669352A4 (en) | 2003-09-30 | 2008-12-17 | Takeda Pharmaceutical | THIAZOLINE DERIVATIVE AND ITS USE |
| EP1695961A4 (en) | 2003-12-17 | 2007-10-24 | Takeda Pharmaceutical | UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE |
| AU2004309271A1 (en) | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| US7585880B2 (en) | 2003-12-26 | 2009-09-08 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
| EP1726580A4 (en) | 2004-03-15 | 2008-02-13 | Takeda Pharmaceutical | AMINOPHNYLPROPANO ACID DERIVATIVE |
| EP1731505B1 (en) | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| WO2005108370A1 (ja) * | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | ベンゼン化合物 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| GB0511851D0 (en) * | 2005-06-11 | 2005-07-20 | Astrazeneca Ab | Chemical compounds |
| JPWO2007013694A1 (ja) | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | フェノキシアルカン酸化合物 |
| JP5084503B2 (ja) | 2005-07-29 | 2012-11-28 | 武田薬品工業株式会社 | シクロプロパンカルボン酸化合物 |
| CA2617969A1 (en) | 2005-08-10 | 2007-02-15 | Takeda Pharmaceutical Company Limited | Therapeutic agent for diabetes |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| AR058562A1 (es) * | 2005-12-22 | 2008-02-13 | Astrazeneca Ab | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 |
| EP1996567B1 (en) * | 2006-02-15 | 2013-09-18 | AbbVie Inc. | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| ES2379661T3 (es) | 2006-06-27 | 2012-04-30 | Takeda Pharmaceutical Company Limited | Compuestos cíclicos condensados |
| JP5306818B2 (ja) | 2006-10-18 | 2013-10-02 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| US8410087B2 (en) | 2006-10-19 | 2013-04-02 | Takeda Pharmaceutical Company Limited | Indole compound |
| JP2008179621A (ja) * | 2006-12-28 | 2008-08-07 | Taisho Pharmaceutical Co Ltd | 含窒素飽和複素環化合物 |
| WO2008090944A1 (ja) * | 2007-01-25 | 2008-07-31 | Takeda Pharmaceutical Company Limited | スピロ環化合物 |
| EP2128138A1 (en) | 2007-01-29 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
| CA2677736A1 (en) | 2007-02-09 | 2008-08-21 | Takeda Pharmaceutical Company Limited | Fused ring compounds as partial agonists of ppar-gamma |
| JPWO2008136428A1 (ja) | 2007-04-27 | 2010-07-29 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| WO2008156757A1 (en) | 2007-06-19 | 2008-12-24 | Takeda Pharmaceutical Company Limited | Indazole compounds for activating glucokinase |
| JP5613656B2 (ja) | 2008-03-26 | 2014-10-29 | グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント | 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール |
| EP2324036B1 (en) | 2008-07-16 | 2014-12-03 | Merck Sharp & Dohme Corp. | Bicyclic heterocycle derivatives and methods of use thereof |
| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| JP2010102718A (ja) | 2009-11-27 | 2010-05-06 | Toshiba Corp | 情報処理装置 |
| EP2649062B1 (en) | 2010-11-30 | 2015-04-08 | Takeda Pharmaceutical Company Limited | Bicyclic compounds as inhibitors of acetyl-coa carboxylase (acc) |
| WO2012108478A1 (ja) | 2011-02-09 | 2012-08-16 | 武田薬品工業株式会社 | 単環化合物 |
-
2011
- 2011-04-26 EA EA201291115A patent/EA021698B1/ru not_active IP Right Cessation
- 2011-04-26 SG SG2012086880A patent/SG185759A1/en unknown
- 2011-04-26 MA MA35387A patent/MA34245B1/fr unknown
- 2011-04-26 GE GEAP201112904A patent/GEP20146178B/en unknown
- 2011-04-26 WO PCT/JP2011/060616 patent/WO2011136385A1/en not_active Ceased
- 2011-04-26 NZ NZ603777A patent/NZ603777A/xx not_active IP Right Cessation
- 2011-04-26 US US13/094,015 patent/US8703758B2/en not_active Expired - Fee Related
- 2011-04-26 UA UAA201213528A patent/UA108102C2/ru unknown
- 2011-04-26 AU AU2011246004A patent/AU2011246004A1/en not_active Abandoned
- 2011-04-26 CN CN201180031899.8A patent/CN103025716B/zh not_active Expired - Fee Related
- 2011-04-26 UY UY0001033354A patent/UY33354A/es not_active Application Discontinuation
- 2011-04-26 KR KR1020127030925A patent/KR20130094211A/ko not_active Withdrawn
- 2011-04-26 ES ES11722184.6T patent/ES2546130T3/es active Active
- 2011-04-26 BR BR112012027648A patent/BR112012027648A2/pt not_active IP Right Cessation
- 2011-04-26 EP EP11722184.6A patent/EP2563765B1/en active Active
- 2011-04-26 AR ARP110101434A patent/AR080969A1/es unknown
- 2011-04-26 JP JP2012547392A patent/JP5693611B2/ja not_active Expired - Fee Related
- 2011-04-26 CA CA2797767A patent/CA2797767A1/en not_active Abandoned
- 2011-04-26 PH PH1/2012/502347A patent/PH12012502347A1/en unknown
- 2011-04-26 TW TW100114410A patent/TW201206911A/zh unknown
-
2012
- 2012-11-26 ZA ZA2012/08895A patent/ZA201208895B/en unknown
- 2012-11-26 CR CR20120598A patent/CR20120598A/es not_active Application Discontinuation
- 2012-11-27 CO CO12214563A patent/CO6640253A2/es active IP Right Grant
- 2012-11-27 EC ECSP12012311 patent/ECSP12012311A/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013525262A5 (enExample) | ||
| CA2797767A1 (en) | Bicyclic compound derivatives and their use as acc inhibitors | |
| JP2010506825A5 (enExample) | ||
| RU2009118602A (ru) | Производное индола | |
| JP2016516026A5 (enExample) | ||
| RU2017116196A (ru) | 2-амино-6-(дифторметил)-5,5-дифтор-6-фенил-3,4,5,6-тетрагидропиридины как ингибиторы васе1 | |
| RU2012116877A (ru) | Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы | |
| JP2013529210A5 (enExample) | ||
| JP2017526711A5 (enExample) | ||
| JP2016535772A5 (enExample) | ||
| JP2006517572A5 (enExample) | ||
| RU2008116581A (ru) | Сульфонамидные производные, как активаторы гликокиназы, применимые для лечения диабета типа 2 | |
| JP2013503167A5 (enExample) | ||
| JP2013535408A5 (enExample) | ||
| JP2011502958A5 (enExample) | ||
| RU2018104868A (ru) | 2-амино-3-фтор-3-(фторметил)-6-метил-6-фенил-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 | |
| RU2016133626A (ru) | 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 для лечения болезни альцгеймера | |
| JP2007520471A5 (enExample) | ||
| JP2020527175A5 (enExample) | ||
| JP2017505293A5 (enExample) | ||
| RU2010107169A (ru) | Фармацевтическая композиция, содержащая оптически активное соединение, обладающее активностью агониста рецептора тромбопоэтина, и промежуточное соединение для этого | |
| EA201071012A1 (ru) | Производные азетидинов, способ их получения и применение их в терапии | |
| RU2013130879A (ru) | Производные оксазолилметилового эфира в качестве агонистов рецептора alx | |
| JP2013537913A5 (enExample) | ||
| BR112013021848A2 (pt) | 5-(fenil/piridinil-etinil)-2-piridina/2-pirimidina-carboxamidas como moduladores de mglur5 |