JP2013524856A5 - - Google Patents
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- Publication number
- JP2013524856A5 JP2013524856A5 JP2013509258A JP2013509258A JP2013524856A5 JP 2013524856 A5 JP2013524856 A5 JP 2013524856A5 JP 2013509258 A JP2013509258 A JP 2013509258A JP 2013509258 A JP2013509258 A JP 2013509258A JP 2013524856 A5 JP2013524856 A5 JP 2013524856A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- formulation
- treatment
- fibroblasts
- per
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 54
- 210000004027 cell Anatomy 0.000 claims description 53
- 238000009472 formulation Methods 0.000 claims description 40
- 238000011282 treatment Methods 0.000 claims description 33
- 210000002950 fibroblast Anatomy 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 14
- 239000002243 precursor Substances 0.000 claims description 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- 230000002500 effect on skin Effects 0.000 claims description 8
- 230000017423 tissue regeneration Effects 0.000 claims description 6
- 206010039580 Scar Diseases 0.000 claims description 5
- 206010040954 Skin wrinkling Diseases 0.000 claims description 4
- 239000012595 freezing medium Substances 0.000 claims description 4
- 239000002609 medium Substances 0.000 claims description 4
- 230000037303 wrinkles Effects 0.000 claims description 4
- 230000007547 defect Effects 0.000 claims description 3
- 238000011069 regeneration method Methods 0.000 claims description 3
- 230000037390 scarring Effects 0.000 claims description 3
- 230000007910 cell fusion Effects 0.000 claims description 2
- 230000032459 dedifferentiation Effects 0.000 claims description 2
- 210000004709 eyebrow Anatomy 0.000 claims description 2
- 230000001815 facial effect Effects 0.000 claims description 2
- 238000002559 palpation Methods 0.000 claims description 2
- 210000001082 somatic cell Anatomy 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 239000002458 cell surface marker Substances 0.000 claims 5
- 238000002347 injection Methods 0.000 claims 5
- 239000007924 injection Substances 0.000 claims 5
- 210000002510 keratinocyte Anatomy 0.000 claims 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 239000002344 surface layer Substances 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000005138 cryopreservation Methods 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/776,163 US8529883B2 (en) | 2010-05-07 | 2010-05-07 | Dosage unit formulations of autologous dermal fibroblasts |
| US12/776,163 | 2010-05-07 | ||
| PCT/US2011/035332 WO2011140323A1 (en) | 2010-05-07 | 2011-05-05 | Dosage unit formulations of autologous dermal fibroblasts |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524856A JP2013524856A (ja) | 2013-06-20 |
| JP2013524856A5 true JP2013524856A5 (https=) | 2014-06-19 |
| JP6309268B2 JP6309268B2 (ja) | 2018-04-11 |
Family
ID=44121161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509258A Active JP6309268B2 (ja) | 2010-05-07 | 2011-05-05 | 自己真皮線維芽細胞の投与単位処方物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8529883B2 (https=) |
| EP (1) | EP2566489B1 (https=) |
| JP (1) | JP6309268B2 (https=) |
| KR (1) | KR102001254B1 (https=) |
| CN (2) | CN102905711A (https=) |
| AU (1) | AU2011248067B2 (https=) |
| CA (1) | CA2800333C (https=) |
| WO (1) | WO2011140323A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027984A1 (en) | 2006-08-29 | 2008-03-06 | Isolagen Technologies, Inc. | Methods for culturing minimally-passaged fibroblasts and uses thereof |
| US8512715B2 (en) * | 2008-08-14 | 2013-08-20 | The Cleveland Clinic Foundation | Apparatus and method for treating a neuromuscular defect |
| WO2011075676A2 (en) | 2009-12-18 | 2011-06-23 | Knowlton Edward W | A skin treatment and drug delivery device |
| US8529883B2 (en) * | 2010-05-07 | 2013-09-10 | Fibrocell Technologies, Inc. | Dosage unit formulations of autologous dermal fibroblasts |
| US8765121B2 (en) * | 2010-10-14 | 2014-07-01 | Fibrocell Technologies, Inc. | Treatment of vocal cords with autologous dermal fibroblast formulation |
| US11000310B2 (en) | 2010-12-17 | 2021-05-11 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| US10736653B2 (en) | 2013-12-06 | 2020-08-11 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| US10967162B2 (en) | 2010-12-17 | 2021-04-06 | Srgi Holdings, Llc | Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal |
| US10702684B2 (en) | 2010-12-17 | 2020-07-07 | Srgi Holdings, Llc | Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal |
| US11278309B2 (en) | 2010-12-17 | 2022-03-22 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| US11103275B2 (en) | 2010-12-17 | 2021-08-31 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| US11109887B2 (en) | 2013-12-06 | 2021-09-07 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| CA2866563A1 (en) * | 2012-03-07 | 2013-09-12 | Fibrocell Technologies, Inc. | Topical dermal formulations and methods of personalized treatment of skin |
| WO2013155109A1 (en) | 2012-04-09 | 2013-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for generation of pluripotent and multipotent cells |
| US20140072611A1 (en) * | 2012-09-07 | 2014-03-13 | Fibrocell Technologies, Inc. | Methods and Compositions for Treating Post-Cardial Infarction Damage |
| ITMI20131053A1 (it) * | 2013-06-25 | 2014-12-26 | Maria Oliva Salviati | Composizione che comprende ortica |
| BR112016007476A2 (pt) | 2013-10-02 | 2017-09-12 | Srgi Holdings Llc | métodos e dispositivos médicos de conjunto de pixel |
| ES2827049T3 (es) | 2013-10-02 | 2021-05-19 | Srgi Holdings Llc | Dispositivos médicos de conjunto de píxeles |
| US11229452B2 (en) | 2013-12-06 | 2022-01-25 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| US11937846B2 (en) | 2013-12-06 | 2024-03-26 | Srgi Holdings Llc | Pixel array medical systems, devices and methods |
| EP3579767B1 (en) | 2014-10-02 | 2025-10-08 | SRGI Holdings, LLC | Pixel array medical systems and devices |
| EP3253308A4 (en) | 2015-02-05 | 2018-10-24 | SRGI Holdings LLC | Pixel array medical systems, devices and methods |
| US11980389B2 (en) | 2015-08-31 | 2024-05-14 | Srgi Holdings Llc | Handed spiral slotted scalpet array |
| US11751903B2 (en) | 2015-08-31 | 2023-09-12 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| US11490952B2 (en) | 2015-08-31 | 2022-11-08 | Srgi Holdings, Llc | Pixel array medical devices and methods |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| WO2017100425A1 (en) * | 2015-12-10 | 2017-06-15 | Aesthetics Biomedical, Inc. | Topical formulation for skin care |
| US11564706B2 (en) | 2019-10-28 | 2023-01-31 | Srgi Holdings, Llc | Pixel array medical systems, devices and methods |
| WO2018217479A2 (en) | 2017-05-11 | 2018-11-29 | Srgi Holdings, Llc | Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal |
| GB201818243D0 (en) * | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| US20220211767A1 (en) * | 2019-04-27 | 2022-07-07 | Figene, Llc | Enhancement of fibroblast therapeutic activity by t cell modulation |
| US12544407B2 (en) | 2019-04-28 | 2026-02-10 | Fibrobiologics, Inc. | Fibroblast cell therapy for treatment of osteoporosis |
| CN110075125A (zh) * | 2019-05-10 | 2019-08-02 | 成都康景生物科技有限公司 | 一种用于治疗系统性硬化症伴随肢端硬化的脐带间充质干细胞注射液及其制备方法 |
| AU2020387177B2 (en) | 2019-11-22 | 2026-03-12 | Cutiss Ag | Methods and systems for producing skin grafts |
| AU2021245671A1 (en) * | 2020-03-31 | 2022-10-20 | Cell Exosome Therapeutics Inc. | Cell preservation method |
| KR20220074132A (ko) | 2020-11-27 | 2022-06-03 | 테고사이언스 (주) | 건 재생 효과를 나타내는 피부 유래 섬유아세포 및 이의 용도 |
| US20230293595A1 (en) * | 2022-03-16 | 2023-09-21 | Fibrobiologics, Inc. | Therapeutic use of fibroblasts for use in wound healing |
| JP2023150483A (ja) * | 2022-03-31 | 2023-10-16 | ポーラ化成工業株式会社 | コラーゲン代謝促進剤、及びコラーゲン代謝に関与する細胞群を特定する方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4524065A (en) | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
| US4772557A (en) | 1985-11-12 | 1988-09-20 | Washington University | DNA clone of human skin fibroblast collagenase enzyme |
| US5591444A (en) | 1995-07-28 | 1997-01-07 | Isolagen Technologies, Inc. | Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects |
| US20040229203A1 (en) * | 1996-06-14 | 2004-11-18 | Biostore New Zealand Ltd. | Compositions and methods for the preservation of living tissues |
| AU6662698A (en) | 1997-02-20 | 1998-09-09 | Gregory S. Keller | Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects |
| US7767452B2 (en) | 1997-02-20 | 2010-08-03 | Kleinsek Don A | Tissue treatments with adipocyte cells |
| US6110459A (en) | 1997-05-28 | 2000-08-29 | Mickle; Donald A. G. | Transplants for myocardial scars and methods and cellular preparations |
| US6150505A (en) * | 1997-09-19 | 2000-11-21 | Hadasit Medical Research Services & Development Ltd. | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII |
| US7115417B1 (en) * | 1998-05-01 | 2006-10-03 | Chancellor Michael B | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof |
| US6432710B1 (en) | 1998-05-22 | 2002-08-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions |
| US7846465B1 (en) | 1999-05-28 | 2010-12-07 | Fibrocell Science, Inc. | Method of using autologous fibroblasts to promote healing of wounds and fistulas |
| US6733530B1 (en) | 1999-08-02 | 2004-05-11 | Eric Sun-Yin Chan | Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin |
| US20080286242A2 (en) | 1999-11-05 | 2008-11-20 | Donald Kleinsek | Augmentation and repair of spincter defects with cells including mesenchymal cells |
| US7799325B2 (en) | 1999-11-05 | 2010-09-21 | Kleinsek Donald A | Removal of hypertrophic scars |
| US20040101959A1 (en) | 2002-11-21 | 2004-05-27 | Olga Marko | Treatment of tissue with undifferentiated mesenchymal cells |
| US7186557B2 (en) | 2003-06-13 | 2007-03-06 | Isolagen Technologies, Inc. | Methods of producing neurons |
| EP2399990B1 (en) | 2003-06-27 | 2015-07-22 | DePuy Synthes Products, Inc. | Cells derived from post-partum umbilical cord for use in treatment of disease of the heart and circulatory system |
| EP1689284A4 (en) * | 2003-11-10 | 2010-03-17 | Symphony Medical Inc | METHOD FOR REGULATING VENTRICULAR RHYTHM IN AURICULAR FIBRILLATION PATIENTS |
| EP1885280A1 (en) * | 2005-05-26 | 2008-02-13 | Intercytex Limited | Tissue repair using allogenic dermal fibroblasts |
| US20090029340A1 (en) * | 2006-01-04 | 2009-01-29 | Do-Coop Technologies Ltd. | Cryoprotective Compositions and Methods of Using Same |
| US20070264239A1 (en) * | 2006-05-10 | 2007-11-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Isolation of pericytes |
| GB2440908A (en) * | 2006-05-25 | 2008-02-20 | Intercytex Ltd | Tissue Repair and Augmentation |
| US20070298005A1 (en) * | 2006-06-22 | 2007-12-27 | Marie-Josee Thibault | Injectable composition for treatment of skin defects or deformations |
| KR20070122316A (ko) | 2006-06-26 | 2007-12-31 | (주) 에스바이오메딕스 | 주사용 인체 연조직 충전제 및 이의 제조 방법 |
| US20080015546A1 (en) * | 2006-07-13 | 2008-01-17 | Casas Jesus W | Methods and formulations for optimal local delivery of cell therapy via minimally invasive procedures |
| WO2008027984A1 (en) * | 2006-08-29 | 2008-03-06 | Isolagen Technologies, Inc. | Methods for culturing minimally-passaged fibroblasts and uses thereof |
| WO2008081818A1 (ja) * | 2006-12-28 | 2008-07-10 | National University Corporation Nagoya University | 皮膚組織改善材およびその製造方法 |
| WO2008083223A1 (en) | 2006-12-28 | 2008-07-10 | Isolagen Technologies, Inc. | Methods for culturing dermal cells for treatment of skin injuries such as burns |
| JP2008245583A (ja) * | 2007-03-30 | 2008-10-16 | Yamaguchi Univ | 哺乳動物の神経細胞の精製培養方法とその保存方法 |
| US7960098B2 (en) * | 2007-07-12 | 2011-06-14 | Warsaw Orthoperic, Inc. | Methods and compositions for the preservation of cells and tissues |
| US20090191160A1 (en) | 2007-08-10 | 2009-07-30 | University Of Dayton | Methods of producing pluripotent stem-like cells |
| JP2009148236A (ja) * | 2007-12-20 | 2009-07-09 | Glycoresearch Kk | 線維芽細胞の細胞識別方法 |
| US20090209456A1 (en) * | 2008-02-19 | 2009-08-20 | Iliana Sweis | Compositions and methods for improving facial and body aesthetics |
| WO2009142717A2 (en) * | 2008-05-19 | 2009-11-26 | President And Fellows Of Harvard College | Methods and products for dedifferentiation of cells |
| US8669048B2 (en) * | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| EP2297299A1 (en) * | 2008-06-25 | 2011-03-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for preparing human skin substitutes from human pluripotent stem cells |
| CA2752729A1 (en) * | 2009-02-20 | 2010-08-26 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| US8240314B2 (en) * | 2009-04-06 | 2012-08-14 | Eden Esthetics, A Professional Nursing Corporation | Method for injecting fillers into the dermis |
| JP5816416B2 (ja) * | 2010-04-23 | 2015-11-18 | 国立大学法人名古屋大学 | 細胞評価装置、インキュベータ、プログラム、および、培養方法 |
| US8529883B2 (en) * | 2010-05-07 | 2013-09-10 | Fibrocell Technologies, Inc. | Dosage unit formulations of autologous dermal fibroblasts |
-
2010
- 2010-05-07 US US12/776,163 patent/US8529883B2/en active Active
-
2011
- 2011-05-05 KR KR1020127030921A patent/KR102001254B1/ko active Active
- 2011-05-05 CN CN2011800230385A patent/CN102905711A/zh active Pending
- 2011-05-05 CN CN201710907274.2A patent/CN107812014B/zh active Active
- 2011-05-05 CA CA2800333A patent/CA2800333C/en active Active
- 2011-05-05 WO PCT/US2011/035332 patent/WO2011140323A1/en not_active Ceased
- 2011-05-05 AU AU2011248067A patent/AU2011248067B2/en active Active
- 2011-05-05 EP EP11720666.4A patent/EP2566489B1/en active Active
- 2011-05-05 JP JP2013509258A patent/JP6309268B2/ja active Active
-
2013
- 2013-07-12 US US13/941,265 patent/US11554142B2/en active Active
-
2022
- 2022-12-12 US US18/079,358 patent/US20230270793A1/en active Pending
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