CN107812014B - 自体真皮成纤维细胞的剂量单位调配物 - Google Patents

自体真皮成纤维细胞的剂量单位调配物 Download PDF

Info

Publication number
CN107812014B
CN107812014B CN201710907274.2A CN201710907274A CN107812014B CN 107812014 B CN107812014 B CN 107812014B CN 201710907274 A CN201710907274 A CN 201710907274A CN 107812014 B CN107812014 B CN 107812014B
Authority
CN
China
Prior art keywords
cells
fibroblasts
dosage formulation
treatment
dyes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201710907274.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN107812014A (zh
Inventor
约翰·马斯洛斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caserkrick bioscience Co.,Ltd.
Original Assignee
Caserkrick Bioscience Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caserkrick Bioscience Co ltd filed Critical Caserkrick Bioscience Co ltd
Publication of CN107812014A publication Critical patent/CN107812014A/zh
Application granted granted Critical
Publication of CN107812014B publication Critical patent/CN107812014B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33Fibroblasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
CN201710907274.2A 2010-05-07 2011-05-05 自体真皮成纤维细胞的剂量单位调配物 Active CN107812014B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/776,163 US8529883B2 (en) 2010-05-07 2010-05-07 Dosage unit formulations of autologous dermal fibroblasts
US12/776,163 2010-05-07
CN2011800230385A CN102905711A (zh) 2010-05-07 2011-05-05 自体真皮成纤维细胞的剂量单位调配物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2011800230385A Division CN102905711A (zh) 2010-05-07 2011-05-05 自体真皮成纤维细胞的剂量单位调配物

Publications (2)

Publication Number Publication Date
CN107812014A CN107812014A (zh) 2018-03-20
CN107812014B true CN107812014B (zh) 2021-11-16

Family

ID=44121161

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710907274.2A Active CN107812014B (zh) 2010-05-07 2011-05-05 自体真皮成纤维细胞的剂量单位调配物
CN2011800230385A Pending CN102905711A (zh) 2010-05-07 2011-05-05 自体真皮成纤维细胞的剂量单位调配物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800230385A Pending CN102905711A (zh) 2010-05-07 2011-05-05 自体真皮成纤维细胞的剂量单位调配物

Country Status (8)

Country Link
US (3) US8529883B2 (https=)
EP (1) EP2566489B1 (https=)
JP (1) JP6309268B2 (https=)
KR (1) KR102001254B1 (https=)
CN (2) CN107812014B (https=)
AU (1) AU2011248067B2 (https=)
CA (1) CA2800333C (https=)
WO (1) WO2011140323A1 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8728819B2 (en) 2006-08-29 2014-05-20 Fibrocell Technologies, Inc. Methods for culturing minimally-passaged fibroblasts and uses thereof
US8512715B2 (en) * 2008-08-14 2013-08-20 The Cleveland Clinic Foundation Apparatus and method for treating a neuromuscular defect
WO2011075676A2 (en) 2009-12-18 2011-06-23 Knowlton Edward W A skin treatment and drug delivery device
US8529883B2 (en) * 2010-05-07 2013-09-10 Fibrocell Technologies, Inc. Dosage unit formulations of autologous dermal fibroblasts
US8765121B2 (en) 2010-10-14 2014-07-01 Fibrocell Technologies, Inc. Treatment of vocal cords with autologous dermal fibroblast formulation
US11109887B2 (en) 2013-12-06 2021-09-07 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11278309B2 (en) 2010-12-17 2022-03-22 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10080581B2 (en) 2010-12-17 2018-09-25 Srgi Holding Llc Pixel array medical devices and methods
US10695546B2 (en) 2010-12-17 2020-06-30 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US10736653B2 (en) 2013-12-06 2020-08-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11000310B2 (en) 2010-12-17 2021-05-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10967162B2 (en) 2010-12-17 2021-04-06 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
US11103275B2 (en) 2010-12-17 2021-08-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US10702684B2 (en) 2010-12-17 2020-07-07 Srgi Holdings, Llc Systems, devices and methods for fractional resection, fractional skin grafting, fractional scar reduction and fractional tattoo removal
HK1205707A1 (en) * 2012-03-07 2015-12-24 Fibrocell Technologies, Inc. Topical dermal formulations and methods of personalized treatment of skin
EP2836591B1 (en) 2012-04-09 2018-06-06 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for generation of pluripotent and multipotent cells
WO2014039995A1 (en) * 2012-09-07 2014-03-13 Fibrocell Technologies, Inc. Fibroblast compositions for treating cardial damage after an infarct
ITMI20131053A1 (it) * 2013-06-25 2014-12-26 Maria Oliva Salviati Composizione che comprende ortica
ES2827049T3 (es) 2013-10-02 2021-05-19 Srgi Holdings Llc Dispositivos médicos de conjunto de píxeles
US11229452B2 (en) 2013-12-06 2022-01-25 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11937846B2 (en) 2013-12-06 2024-03-26 Srgi Holdings Llc Pixel array medical systems, devices and methods
EP3579767B1 (en) 2014-10-02 2025-10-08 SRGI Holdings, LLC Pixel array medical systems and devices
WO2016127091A1 (en) 2015-02-05 2016-08-11 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US11980389B2 (en) 2015-08-31 2024-05-14 Srgi Holdings Llc Handed spiral slotted scalpet array
US11490952B2 (en) 2015-08-31 2022-11-08 Srgi Holdings, Llc Pixel array medical devices and methods
US11751904B2 (en) 2015-08-31 2023-09-12 Srgi Holdings, Llc Pixel array medical systems, devices and methods
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
WO2017100425A1 (en) * 2015-12-10 2017-06-15 Aesthetics Biomedical, Inc. Topical formulation for skin care
US11564706B2 (en) 2019-10-28 2023-01-31 Srgi Holdings, Llc Pixel array medical systems, devices and methods
GB201818243D0 (en) * 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
WO2020223148A1 (en) * 2019-04-27 2020-11-05 Figene, Llc Enhancement of fibroblast therapeutic activity by t cell modulation
US12544407B2 (en) 2019-04-28 2026-02-10 Fibrobiologics, Inc. Fibroblast cell therapy for treatment of osteoporosis
CN110075125A (zh) * 2019-05-10 2019-08-02 成都康景生物科技有限公司 一种用于治疗系统性硬化症伴随肢端硬化的脐带间充质干细胞注射液及其制备方法
EP4061923A4 (en) * 2019-11-22 2024-01-03 Cutiss AG Methods and systems for producing skin grafts
AU2021245671A1 (en) * 2020-03-31 2022-10-20 Cell Exosome Therapeutics Inc. Cell preservation method
KR20220074132A (ko) 2020-11-27 2022-06-03 테고사이언스 (주) 건 재생 효과를 나타내는 피부 유래 섬유아세포 및 이의 용도
WO2023178219A1 (en) * 2022-03-16 2023-09-21 Fibrobiologics, Inc. Therapeutic use of fibroblasts for use in wound healing
JP2023150483A (ja) * 2022-03-31 2023-10-16 ポーラ化成工業株式会社 コラーゲン代謝促進剤、及びコラーゲン代謝に関与する細胞群を特定する方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524065A (en) 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
US4772557A (en) 1985-11-12 1988-09-20 Washington University DNA clone of human skin fibroblast collagenase enzyme
US5591444A (en) 1995-07-28 1997-01-07 Isolagen Technologies, Inc. Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects
US20040229203A1 (en) * 1996-06-14 2004-11-18 Biostore New Zealand Ltd. Compositions and methods for the preservation of living tissues
AU6662698A (en) 1997-02-20 1998-09-09 Gregory S. Keller Augmentation and repair of dermal, subcutaneous, and vocal cord tissue defects
US7767452B2 (en) 1997-02-20 2010-08-03 Kleinsek Don A Tissue treatments with adipocyte cells
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6150505A (en) * 1997-09-19 2000-11-21 Hadasit Medical Research Services & Development Ltd. Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII
US7115417B1 (en) * 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US6432710B1 (en) 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
WO2000073418A2 (en) 1999-05-28 2000-12-07 Pacgen Technologies Llc A method of using autologous fibroblasts to promote healing of wounds and fistulas
US6733530B1 (en) 1999-08-02 2004-05-11 Eric Sun-Yin Chan Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin
US20080286242A2 (en) 1999-11-05 2008-11-20 Donald Kleinsek Augmentation and repair of spincter defects with cells including mesenchymal cells
US7799325B2 (en) 1999-11-05 2010-09-21 Kleinsek Donald A Removal of hypertrophic scars
US20040101959A1 (en) 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
US7186557B2 (en) 2003-06-13 2007-03-06 Isolagen Technologies, Inc. Methods of producing neurons
WO2005001080A2 (en) 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
JP2007520259A (ja) * 2003-11-10 2007-07-26 シンフォニー メディカル, インコーポレイテッド 心房細動患者における心室速度を制御するための方法
AU2006251004C1 (en) * 2005-05-26 2013-05-23 Intercytex Limited Tissue repair using allogenic dermal fibroblasts
KR20080087148A (ko) * 2006-01-04 2008-09-30 두-쿱 테크놀로지스 리미티드 저온보호 조성물 및 그 이용방법
US20070264239A1 (en) * 2006-05-10 2007-11-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Isolation of pericytes
GB2440908A (en) * 2006-05-25 2008-02-20 Intercytex Ltd Tissue Repair and Augmentation
US20070298005A1 (en) * 2006-06-22 2007-12-27 Marie-Josee Thibault Injectable composition for treatment of skin defects or deformations
KR20070122316A (ko) 2006-06-26 2007-12-31 (주) 에스바이오메딕스 주사용 인체 연조직 충전제 및 이의 제조 방법
WO2008008827A2 (en) * 2006-07-13 2008-01-17 Medtronic, Inc. Methods and formulations for optimal local delivery of cell therapy via minimally invasive procedures
US8728819B2 (en) * 2006-08-29 2014-05-20 Fibrocell Technologies, Inc. Methods for culturing minimally-passaged fibroblasts and uses thereof
JP4247333B2 (ja) * 2006-12-28 2009-04-02 国立大学法人名古屋大学 皮膚組織改善材およびその製造方法
US20100303770A1 (en) 2006-12-28 2010-12-02 John Maslowski Methods for culturing dermal cells for treatment of skin injuries such as burns
JP2008245583A (ja) * 2007-03-30 2008-10-16 Yamaguchi Univ 哺乳動物の神経細胞の精製培養方法とその保存方法
US7960098B2 (en) * 2007-07-12 2011-06-14 Warsaw Orthoperic, Inc. Methods and compositions for the preservation of cells and tissues
EP2190976A4 (en) 2007-08-10 2010-10-20 Univ Dayton METHOD FOR PRODUCING PLURIPOTENTAL STEM CELL LENGTH CELLS
JP2009148236A (ja) * 2007-12-20 2009-07-09 Glycoresearch Kk 線維芽細胞の細胞識別方法
US20090209456A1 (en) * 2008-02-19 2009-08-20 Iliana Sweis Compositions and methods for improving facial and body aesthetics
WO2009142717A2 (en) * 2008-05-19 2009-11-26 President And Fellows Of Harvard College Methods and products for dedifferentiation of cells
US8669048B2 (en) * 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof
CN102186969A (zh) * 2008-06-25 2011-09-14 国家健康与医学研究院 由人多能干细胞制备人皮肤替代品的方法
JP2012518409A (ja) * 2009-02-20 2012-08-16 ベントリア・バイオサイエンス タンパク質の組み合わせを含有する細胞培養培地
US8240314B2 (en) * 2009-04-06 2012-08-14 Eden Esthetics, A Professional Nursing Corporation Method for injecting fillers into the dermis
JP5816416B2 (ja) * 2010-04-23 2015-11-18 国立大学法人名古屋大学 細胞評価装置、インキュベータ、プログラム、および、培養方法
US8529883B2 (en) * 2010-05-07 2013-09-10 Fibrocell Technologies, Inc. Dosage unit formulations of autologous dermal fibroblasts

Also Published As

Publication number Publication date
AU2011248067A1 (en) 2012-12-20
KR102001254B1 (ko) 2019-07-17
CA2800333A1 (en) 2011-11-10
US20110274665A1 (en) 2011-11-10
CA2800333C (en) 2018-10-30
JP6309268B2 (ja) 2018-04-11
KR20130060212A (ko) 2013-06-07
US20130295061A1 (en) 2013-11-07
EP2566489A1 (en) 2013-03-13
EP2566489B1 (en) 2019-04-24
US20230270793A1 (en) 2023-08-31
US11554142B2 (en) 2023-01-17
WO2011140323A1 (en) 2011-11-10
AU2011248067B2 (en) 2015-03-12
CN107812014A (zh) 2018-03-20
US8529883B2 (en) 2013-09-10
JP2013524856A (ja) 2013-06-20
CN102905711A (zh) 2013-01-30

Similar Documents

Publication Publication Date Title
CN107812014B (zh) 自体真皮成纤维细胞的剂量单位调配物
US10881695B2 (en) Treatment of vocal cords with autologous dermal fibroblast formulation
JP7386162B2 (ja) 線維芽細胞の再生活性の増強
Supp et al. Isolation and feeder-free primary culture of four cell types from a single human skin sample
CN102625689A (zh) 用于恢复面部或身体所选区域中年龄相关组织损失的方法和组合物
EP3579844A2 (en) Biological scaffolds, products containing biological scaffolds and methods of using the same
JP2022069524A (ja) 改良された細胞療法
CN108057116A (zh) 干细胞组合物在皮肤损伤治疗药物中的应用
JP4247333B2 (ja) 皮膚組織改善材およびその製造方法
CN108066750A (zh) 干细胞及其分泌物用于治疗皮肤烧烫伤的新用途
CN115404203A (zh) 毛囊间充质干细胞的制备方法以及应用
Tsimponis et al. The effect of host tissue and radiation on fat-graft survival: A comparative experimental study
HK1180968A (en) Dosage unit formulations of autologous dermal fibroblasts
CN108066824A (zh) 一种制备表皮缺损治疗药物的新方法
CN108057131A (zh) 一种含有干细胞的新型试剂盒
US20240293471A1 (en) Placental cell treatment for critical limb ischemia patient subpopulations
Martins et al. Adipose tissue mature stem cells in skin healing: a controlled randomized study
Manturova et al. Treatment of Skin Wounds in Old Animals Using Mesenzymal Progenitor Cells and Polymer Gel Compositions
Boon Expansion of Skin-Derived Precursor Cells (SKPs) in Stirred Suspension Bioreactors
大串始 Development of regenerative medical technology working toward practical application

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20210429

Address after: Pennsylvania, USA

Applicant after: Farbrossel science Inc.

Address before: Pennsylvania, USA

Applicant before: Fibrocell Technologies, Inc.

Effective date of registration: 20210429

Address after: Pennsylvania, USA

Applicant after: Caserkrick bioscience Co.,Ltd.

Address before: Pennsylvania, USA

Applicant before: Farbrossel science Inc.

GR01 Patent grant
GR01 Patent grant