JP2013523824A5 - - Google Patents
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- Publication number
- JP2013523824A5 JP2013523824A5 JP2013503875A JP2013503875A JP2013523824A5 JP 2013523824 A5 JP2013523824 A5 JP 2013523824A5 JP 2013503875 A JP2013503875 A JP 2013503875A JP 2013503875 A JP2013503875 A JP 2013503875A JP 2013523824 A5 JP2013523824 A5 JP 2013523824A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- composition
- dna
- exosomes
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 20
- 210000001808 exosome Anatomy 0.000 claims 14
- 241001465754 Metazoa Species 0.000 claims 10
- 210000004443 dendritic cell Anatomy 0.000 claims 7
- 239000006166 lysate Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 206010003445 Ascites Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000004080 punching Methods 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 102000003946 Prolactin Human genes 0.000 claims 1
- 108010057464 Prolactin Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 229940097325 prolactin Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32137010P | 2010-04-06 | 2010-04-06 | |
| US61/321,370 | 2010-04-06 | ||
| PCT/US2011/031359 WO2011127129A1 (en) | 2010-04-06 | 2011-04-06 | Methods of treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016129894A Division JP2017002054A (ja) | 2010-04-06 | 2016-06-30 | 癌を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523824A JP2013523824A (ja) | 2013-06-17 |
| JP2013523824A5 true JP2013523824A5 (enExample) | 2014-05-22 |
| JP6025707B2 JP6025707B2 (ja) | 2016-11-16 |
Family
ID=44763257
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013503875A Expired - Fee Related JP6025707B2 (ja) | 2010-04-06 | 2011-04-06 | 癌を治療する方法 |
| JP2016129894A Pending JP2017002054A (ja) | 2010-04-06 | 2016-06-30 | 癌を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016129894A Pending JP2017002054A (ja) | 2010-04-06 | 2016-06-30 | 癌を治療する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9107878B2 (enExample) |
| EP (2) | EP2555627A4 (enExample) |
| JP (2) | JP6025707B2 (enExample) |
| CN (1) | CN102905534B (enExample) |
| WO (1) | WO2011127129A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6025707B2 (ja) | 2010-04-06 | 2016-11-16 | エクソサイト セラピューティクス ピーティイー リミテッド | 癌を治療する方法 |
| JP6272765B2 (ja) * | 2012-10-01 | 2018-01-31 | 国立大学法人京都大学 | ナノゲル/エキソソーム複合体とdds |
| WO2017112919A1 (en) * | 2015-12-23 | 2017-06-29 | The Trustees Of Columbia University In The City Of New York | Tissue-engineered three-dimensional model for tumor analysis |
| US10883083B2 (en) | 2013-08-02 | 2021-01-05 | The Trustees Of Columbia University In The City Of New York | Tissue-engineered three-dimensional model for tumor analysis |
| CN104726410B (zh) * | 2013-12-23 | 2019-09-17 | 浙江大学 | 一种具有免疫抑制功能的外排体及其应用 |
| CN105505772B (zh) * | 2015-12-07 | 2018-07-10 | 中国科学院苏州生物医学工程技术研究所 | 对单个外泌体进行裂解的装置 |
| US20190125848A1 (en) * | 2016-03-30 | 2019-05-02 | Dana-Farber Cancer Institute, Inc. | Dendritic cell-extracellular vesicle fusions and methods of using same |
| JP2018070572A (ja) * | 2016-10-24 | 2018-05-10 | 義之 小山 | 免疫治療システム |
| JP6613499B2 (ja) * | 2017-08-24 | 2019-12-04 | 学校法人藤田学園 | 細胞殺傷剤 |
| US12241091B2 (en) * | 2018-08-20 | 2025-03-04 | Institute Of Process Engineering, Chinese Academy Of Sciences | Method of making exosomes from tumor cell/antigen presenting cell hybrid cells |
| JP6635637B1 (ja) | 2018-11-22 | 2020-01-29 | 株式会社細胞治療技術研究所 | 免疫療法ワクチンの製造方法 |
| CN110036976B (zh) * | 2019-05-08 | 2021-12-07 | 华南农业大学 | 一种阻断鸡禽白血病病毒垂直传播的方法及其应用 |
| CN111759862A (zh) * | 2020-06-04 | 2020-10-13 | 江苏大学 | 干细胞外泌体在制备抗结肠炎恶化药物中的应用 |
| JP7160963B2 (ja) * | 2021-01-15 | 2022-10-25 | Vaxosome合同会社 | 細胞外粒子の製造方法 |
| JP7079901B1 (ja) * | 2021-08-24 | 2022-06-02 | Vaxosome合同会社 | 細胞外粒子の産生方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605885A (en) * | 1988-05-05 | 1997-02-25 | Entremed, Inc. | Method for stimulating the immune system |
| EP0690671B1 (en) | 1993-03-23 | 2004-08-04 | Cbr Laboratories, Inc. | Method and apparatus for encapsulation of biologically-active substances in cells |
| DE4410136A1 (de) * | 1993-03-31 | 1994-10-06 | Boehringer Mannheim Gmbh | Tumorizide T-Lymphozyten |
| EP0698087A1 (en) * | 1993-05-14 | 1996-02-28 | Dr. L. Willems Instituut | Human t cell monoclone, process for its production and its use, diagnostic of infectious diseases, autoimmune diseases, t-cell mediated allergies and cancer |
| US5610013A (en) * | 1993-07-22 | 1997-03-11 | Ludwig Institute For Cancer Research | Method for diagnosing a disorder by determining expression of gage tumor rejection antigen precursors |
| US6773669B1 (en) | 1995-03-10 | 2004-08-10 | Maxcyte, Inc. | Flow electroporation chamber and method |
| US6074605A (en) | 1995-03-10 | 2000-06-13 | Entremed, Inc. | Flow electroporation chamber and method |
| US5720921A (en) | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
| US6090617A (en) | 1996-12-05 | 2000-07-18 | Entremed, Inc. | Flow electroporation chamber with electrodes having a crystalline metal nitride coating |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| US20020022036A1 (en) * | 2000-08-21 | 2002-02-21 | Riordan Neil H. | Method for inducing an anti-tumor and anti-cachexia immune response in mammals |
| US7029916B2 (en) | 2001-02-21 | 2006-04-18 | Maxcyte, Inc. | Apparatus and method for flow electroporation of biological samples |
| FR2827872A1 (fr) * | 2001-07-30 | 2003-01-31 | Roussy Inst Gustave | Vesicules membranaires de fluide biologique preleve in vivo, leur preparation et utilisation dans la stimulation d'une reponse immunitaire |
| EP1456345B1 (en) | 2001-08-22 | 2016-07-20 | Maxcyte, Inc. | Apparatus and method for electroporation of biological samples |
| AU2003277109A1 (en) | 2002-09-30 | 2004-04-23 | Maxcyte, Inc. | Apparatus and method for streaming electroporation |
| CN1446583A (zh) * | 2002-11-29 | 2003-10-08 | 帕弗瑞生物技术(北京)有限公司 | 一种肿瘤免疫治疗及预防性疫苗的组成、制备、应用方案 |
| WO2004053095A2 (en) * | 2002-12-10 | 2004-06-24 | Merix Bioscience, Inc. | In situ maturation of dendritic cells |
| MXPA05008687A (es) * | 2003-02-17 | 2005-10-05 | Mebiopharm Co Ltd | Remedio para cancer. |
| JP2006518219A (ja) * | 2003-02-18 | 2006-08-10 | マックスサイト インコーポレーティッド | 電気穿孔法による細胞への抗原の負荷方法 |
| US20060134067A1 (en) * | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
| US8247231B2 (en) * | 2003-07-31 | 2012-08-21 | Wilson Constance N | Methods and compositions for producing antigenic responses |
| KR101131727B1 (ko) * | 2004-06-11 | 2012-03-28 | 가톨릭대학교 산학협력단 | CEA-특이적인 세포독성 T세포를 생성하는 재조합 아데노바이러스 AdVCEA로 트랜스덕션된 수지상세포, 이를 포함하는 백신 및 약제학적 조성물 |
| US8338173B2 (en) * | 2005-08-11 | 2012-12-25 | University College Cardiff Consultants Limited | Preparation of antigen-presenting human γδ T cells and use in immunotherapy |
| JP4824389B2 (ja) * | 2005-10-28 | 2011-11-30 | 株式会社医学生物学研究所 | エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途 |
| CN101085349B (zh) * | 2006-06-09 | 2011-05-25 | 项雯华 | 囊泡导向的免疫细胞及其在制备抗肿瘤药物上的应用 |
| CN101883845B (zh) * | 2007-10-08 | 2015-06-10 | 英特瑞克斯顿股份有限公司 | 工程树突细胞及其在癌症治疗中的应用 |
| KR20090047290A (ko) * | 2007-11-07 | 2009-05-12 | 주식회사 바이오인프라 | 엑소좀 및 이를 함유한 암 백신 조성물 |
| KR101076879B1 (ko) | 2008-04-11 | 2011-10-25 | 주식회사 하이닉스반도체 | 셀프 부스팅을 이용한 플래시 메모리소자의 프로그램 방법 |
| EP2303319B1 (en) * | 2008-06-20 | 2016-10-05 | Duke University | Compositions, methods and kits for eliciting an immune response |
| JP6025707B2 (ja) | 2010-04-06 | 2016-11-16 | エクソサイト セラピューティクス ピーティイー リミテッド | 癌を治療する方法 |
-
2011
- 2011-04-06 JP JP2013503875A patent/JP6025707B2/ja not_active Expired - Fee Related
- 2011-04-06 WO PCT/US2011/031359 patent/WO2011127129A1/en not_active Ceased
- 2011-04-06 EP EP11766628.9A patent/EP2555627A4/en not_active Withdrawn
- 2011-04-06 EP EP17166666.2A patent/EP3238782A3/en not_active Withdrawn
- 2011-04-06 US US13/639,112 patent/US9107878B2/en not_active Expired - Fee Related
- 2011-04-06 CN CN201180019660.9A patent/CN102905534B/zh not_active Expired - Fee Related
-
2016
- 2016-06-30 JP JP2016129894A patent/JP2017002054A/ja active Pending
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