JP2013523166A5 - - Google Patents
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- JP2013523166A5 JP2013523166A5 JP2013503998A JP2013503998A JP2013523166A5 JP 2013523166 A5 JP2013523166 A5 JP 2013523166A5 JP 2013503998 A JP2013503998 A JP 2013503998A JP 2013503998 A JP2013503998 A JP 2013503998A JP 2013523166 A5 JP2013523166 A5 JP 2013523166A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
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- chain variable
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32271210P | 2010-04-09 | 2010-04-09 | |
| US61/322,712 | 2010-04-09 | ||
| PCT/US2011/031829 WO2011136911A2 (en) | 2010-04-09 | 2011-04-08 | Anti-erbb3 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523166A JP2013523166A (ja) | 2013-06-17 |
| JP2013523166A5 true JP2013523166A5 (enExample) | 2014-05-22 |
| JP5906233B2 JP5906233B2 (ja) | 2016-04-20 |
Family
ID=44120965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013503998A Active JP5906233B2 (ja) | 2010-04-09 | 2011-04-08 | 抗ＥｒｂＢ３抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US8481687B2 (enExample) |
| EP (1) | EP2566895B1 (enExample) |
| JP (1) | JP5906233B2 (enExample) |
| KR (1) | KR101764453B1 (enExample) |
| CN (2) | CN102884085B (enExample) |
| AR (1) | AR080873A1 (enExample) |
| AU (1) | AU2011245636B2 (enExample) |
| BR (1) | BR112012025730B1 (enExample) |
| CA (1) | CA2795799C (enExample) |
| ES (1) | ES2566602T3 (enExample) |
| IL (1) | IL222272B (enExample) |
| MX (1) | MX343227B (enExample) |
| NZ (1) | NZ603271A (enExample) |
| PH (1) | PH12012502022B1 (enExample) |
| RU (1) | RU2568051C2 (enExample) |
| SG (1) | SG184452A1 (enExample) |
| WO (1) | WO2011136911A2 (enExample) |
| ZA (1) | ZA201208290B (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CA2638823A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| EP2132312B1 (en) | 2007-03-27 | 2016-01-27 | Sea Lane Biotechnologies,llc. | Constructs and libraries comprising antibody surrogate light chain sequences |
| CN102482345A (zh) | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| CA2782571C (en) | 2009-12-22 | 2018-01-23 | Roche Glycart Ag | Anti-her3 antibodies and uses thereof |
| BR112012025730B1 (pt) | 2010-04-09 | 2020-12-08 | Aveo Pharmaceuticals, Inc | anticorpo isolado que se liga ao erbb3 humano, seus usos, seu processo de produção e vetor de expressão |
| PL2606070T3 (pl) | 2010-08-20 | 2017-06-30 | Novartis Ag | Przeciwciała dla receptora epidermalnego czynnika wzrostu 3 (her3) |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| EP3156421B1 (en) | 2010-11-01 | 2018-06-06 | Symphogen A/S | Pan-her antibody composition |
| ITRM20100577A1 (it) | 2010-11-02 | 2012-05-03 | Takis Srl | Immunoterapia contro il recettore erbb-3 |
| AU2012229147B2 (en) | 2011-03-11 | 2015-12-24 | Merrimack Pharmaceuticals, Inc. | Use of inhibitors of EGFR-family receptors in the treatment of hormone refractory breast cancers |
| US20150231238A1 (en) | 2011-03-15 | 2015-08-20 | Merrimack Pharmaceuticals, Inc. | Overcoming resistance to erbb pathway inhibitors |
| KR20140138353A (ko) | 2011-04-19 | 2014-12-03 | 메리맥 파마슈티컬즈, 인크. | 단일특이적 및 이중특이적 항-igf-1r 및 항 erbb3 항체 |
| EP2736928B1 (en) * | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Sur-binding proteins against erbb3 |
| MX2014002289A (es) | 2011-08-26 | 2015-03-20 | Merrimack Pharmaceuticals Inc | Anticuerpos fc especificos en tandem. |
| US9273143B2 (en) | 2011-09-30 | 2016-03-01 | Regeneron Pharmaceuticals, Inc. | Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody |
| CA2849508C (en) * | 2011-09-30 | 2020-12-22 | Regeneron Pharmaceuticals, Inc. | Anti-erbb3 antibodies and uses thereof |
| AU2012318541B2 (en) * | 2011-10-06 | 2018-04-12 | Aveo Pharmaceuticals, Inc. | Predicting tumor response to anti-ERBB3 antibodies |
| AU2012340766B2 (en) * | 2011-11-23 | 2018-05-10 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| US20130273029A1 (en) * | 2011-12-05 | 2013-10-17 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) directed to domain ii of her3 |
| MX2014006731A (es) * | 2011-12-05 | 2015-06-04 | Novartis Ag | Anticuerpos para el receptor del factor de crecimiento epidermico 3 (her3) dirigidos al dominio iii y al dominio iv del her3. |
| AU2012349735B2 (en) * | 2011-12-05 | 2016-05-19 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (HER3) |
| EP2793940B1 (en) | 2011-12-22 | 2018-11-14 | i2 Pharmaceuticals, Inc. | Surrogate binding proteins |
| ES2723885T3 (es) | 2012-07-19 | 2019-09-03 | Daiichi Sankyo Co Ltd | Anticuerpos anti-Siglec-15 |
| US9180185B2 (en) | 2013-01-11 | 2015-11-10 | Hoffman-La Roche Inc. | Combination therapy of anti-HER3 antibodies |
| MX2015011712A (es) | 2013-03-06 | 2016-04-04 | Merrimack Pharmaceuticals Inc | Anticerpos biespecificos fc en fila anti-c-met. |
| EP2821071A1 (en) | 2013-07-04 | 2015-01-07 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Compounds for breast cancer treatment |
| US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| US10035847B2 (en) | 2013-10-02 | 2018-07-31 | The Rockefeller University | Amyloid protofibril antibodies and methods of use thereof |
| WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| WO2015138411A1 (en) * | 2014-03-10 | 2015-09-17 | The Brigham And Women's Hospital, Inc. | Anti-fibulin-3 antibodies and uses thereof |
| KR20170003912A (ko) | 2014-03-19 | 2017-01-10 | 매카이 메디컬 파운데이션 더 프레즈비티리언 처치 인 타이완 매카이 메모리얼 호스피탈 | 면역원성 당펩타이드에 대한 항체, 이를 포함하는 조성물 및 이의 용도 |
| EP3662928A1 (en) | 2014-04-10 | 2020-06-10 | OBI Pharma Inc. | Antibodies binding to tumour associated carbohydrate antigens, pharmaceutical compositions and uses thereof |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| US10526416B2 (en) | 2014-09-08 | 2020-01-07 | Yeda Research And Development Co. Ltd. | Anti-HER3 antibodies and uses of same |
| JP2017534574A (ja) | 2014-09-08 | 2017-11-24 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． | チロシンキナーゼ阻害薬（ｔｋｉ）に耐性のがんを処置するための組成物および方法 |
| KR102390359B1 (ko) * | 2014-09-29 | 2022-04-22 | 삼성전자주식회사 | 폴리펩타이드, 이를 포함하는 항 VEGF 항체 및 항 c-Met/항 VEGF 이중 특이 항체 |
| CN104861068B (zh) * | 2015-01-23 | 2020-11-17 | 中国人民解放军军事科学院军事医学研究院 | 一种全人源抗her3抗体及其治疗相关疾病的用途 |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| CN108472362B (zh) | 2015-10-07 | 2022-03-29 | 台湾浩鼎生技股份有限公司 | 新颖糖类抗体、医药组成物及其用途 |
| WO2017087547A1 (en) * | 2015-11-17 | 2017-05-26 | Oncomed Pharmaceuticals, Inc. | Pd-l1-binding agents and uses thereof |
| CA3004743A1 (en) * | 2015-11-24 | 2017-06-01 | Cellerant Therapeutics, Inc. | Humanized anti-cll-1 antibodies |
| KR101746152B1 (ko) * | 2015-12-07 | 2017-06-13 | 주식회사 이수앱지스 | ＥｒｂＢ3에 특이적으로 결합하는 항체 및 그의 용도 |
| MA43416A (fr) | 2015-12-11 | 2018-10-17 | Regeneron Pharma | Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3 |
| JP2019508428A (ja) | 2016-03-15 | 2019-03-28 | メリマック ファーマシューティカルズ インコーポレーティッド | 抗ｅｒｂｂ３抗体を含む組み合わせ療法を用いて、ｅｒ＋、ｈｅｒ２−、ｈｒｇ＋乳癌を治療するための方法 |
| AU2017282892B2 (en) | 2016-06-23 | 2023-10-26 | Jiangsu Hengrui Medicine Co., Ltd. | LAG-3 antibody, antigen-binding fragment thereof, and pharmaceutical application thereof |
| CN106692969B (zh) * | 2016-12-08 | 2021-08-10 | 北海康成（北京）医药科技有限公司 | 抗erbb3抗体及其用途 |
| JP2020511950A (ja) | 2016-12-22 | 2020-04-23 | アイカーン スクール オブ メディスン アット マウント シナイ | 抗ｌｉｌｒｂ３抗体およびその使用の方法 |
| BR112019015915A2 (pt) | 2017-02-28 | 2020-04-07 | Daiichi Sankyo Co Ltd | método para o tratamento de câncer de pulmão de células não pequenas resistentes a egfr-tki através da administração do conjugado de anticorpo anti-her3-fármaco |
| JOP20180021A1 (ar) * | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
| EP3600421A4 (en) * | 2017-03-23 | 2021-01-06 | The Trustees of The University of Pennsylvania | ANTI-C5A ANTIBODIES AND USES OF THEM |
| CN113621706B (zh) * | 2017-06-22 | 2024-05-10 | 北海康成（北京）医药科技有限公司 | 预测食管癌对抗erbb3抗体治疗的应答的方法和试剂盒 |
| US11161897B2 (en) * | 2017-07-17 | 2021-11-02 | Janssen Biotech, Inc. | Antigen binding regions against fibronectin type III domains and methods of using the same |
| US11021540B2 (en) * | 2017-09-07 | 2021-06-01 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
| WO2019076277A1 (zh) * | 2017-10-17 | 2019-04-25 | 江苏恒瑞医药股份有限公司 | 抗pd-1抗体和抗lag-3抗体联合在制备治疗肿瘤的药物中的用途 |
| AU2019232631A1 (en) | 2018-03-05 | 2020-09-24 | Janssen Pharmaceutica Nv | Anti-PHF-tau antibodies and uses thereof |
| GB201804094D0 (en) * | 2018-03-14 | 2018-04-25 | Ultrahuman Thirteen Ltd | ERBB3 Binding agents |
| EP3773658A4 (en) | 2018-04-06 | 2022-04-27 | Dana-Farber Cancer Institute, Inc. | KIR3DL3 AS HLA2 RECEPTOR, ANTI-HHLA2 ANTIBODY AND ITS USES |
| WO2020059772A1 (ja) | 2018-09-20 | 2020-03-26 | 第一三共株式会社 | 抗ｈｅｒ３抗体－薬物コンジュゲート投与によるｈｅｒ３変異がんの治療 |
| US20220106398A1 (en) * | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
| WO2020214957A1 (en) * | 2019-04-19 | 2020-10-22 | Tcrcure Biopharma Corp. | Anti-pd-1 antibodies and uses thereof |
| CN112898414B (zh) * | 2019-12-04 | 2024-05-10 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| US20230075244A1 (en) * | 2020-02-20 | 2023-03-09 | The Feinstein Institutes For Medical Research | Agonist antibodies against endoglin and uses thereof |
| MX2022011335A (es) * | 2020-03-18 | 2022-10-07 | Kindred Biosciences Inc | Anticuerpos del receptor anti-interleucina 4 para uso veterinario. |
| WO2022144025A1 (zh) * | 2021-01-04 | 2022-07-07 | 上海翰森生物医药科技有限公司 | 一种抗erbb3受体的抗体或其抗原结合片段及其医药用途 |
| WO2023147470A2 (en) | 2022-01-28 | 2023-08-03 | Georgiamune Inc. | Antibodies to programmed cell death protein 1 that are pd-1 agonists |
| CN114940714B (zh) * | 2022-05-20 | 2023-06-16 | 湖南师范大学 | 肝癌标志物soat1单克隆抗体制备及其应用 |
| CA3258344A1 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | CHELETARIANS AND BIFUNCTIONAL CONJUGATES |
| CN115109161B (zh) * | 2022-06-28 | 2023-08-11 | 广东赛尔生物科技有限公司 | 含有间充质干细胞的减肥药物组合物 |
| WO2024138019A1 (en) * | 2022-12-23 | 2024-06-27 | Actinium Pharmaceuticals, Inc. | Her3 radioimmunotherapy for the treatment of solid cancers |
| KR20260020406A (ko) | 2023-06-02 | 2026-02-11 | 다이이찌 산쿄 가부시키가이샤 | 항 her3 항체-약물 콘주게이트와 rasg12c 저해제의 조합 |
| CN118005795B (zh) * | 2024-04-09 | 2024-06-28 | 天津旷博同生生物技术有限公司 | 一种抗人cd64抗体及应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US6893625B1 (en) | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
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| US20070009972A1 (en) | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
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| AR056857A1 (es) * | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| PL2129396T3 (pl) | 2007-02-16 | 2014-02-28 | Merrimack Pharmaceuticals Inc | Przeciwciała przeciw ERBB3 i ich zastosowania |
| AU2010242914B2 (en) | 2009-04-29 | 2014-11-13 | Trellis Bioscience, Llc | Improved antibodies immunoreactive with heregulin-coupled HER3 |
| SG178509A1 (en) | 2009-08-21 | 2012-04-27 | Merrimack Pharmaceuticals Inc | Antibodies against the ectodomain of erbb3 and uses thereof |
| CA2775573A1 (en) | 2009-10-09 | 2011-04-14 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-her 3 antibodies |
| CA2782571C (en) | 2009-12-22 | 2018-01-23 | Roche Glycart Ag | Anti-her3 antibodies and uses thereof |
| BR112012025730B1 (pt) | 2010-04-09 | 2020-12-08 | Aveo Pharmaceuticals, Inc | anticorpo isolado que se liga ao erbb3 humano, seus usos, seu processo de produção e vetor de expressão |
| WO2012052230A1 (en) * | 2010-10-18 | 2012-04-26 | Mediapharma S.R.L. | Erbb3 binding antibody |
| AU2012318541B2 (en) * | 2011-10-06 | 2018-04-12 | Aveo Pharmaceuticals, Inc. | Predicting tumor response to anti-ERBB3 antibodies |
-
2011
- 2011-04-08 BR BR112012025730-7A patent/BR112012025730B1/pt active IP Right Grant
- 2011-04-08 CN CN201180018228.8A patent/CN102884085B/zh active Active
- 2011-04-08 WO PCT/US2011/031829 patent/WO2011136911A2/en not_active Ceased
- 2011-04-08 CA CA2795799A patent/CA2795799C/en active Active
- 2011-04-08 AR ARP110101193A patent/AR080873A1/es active IP Right Grant
- 2011-04-08 SG SG2012073961A patent/SG184452A1/en unknown
- 2011-04-08 NZ NZ603271A patent/NZ603271A/en unknown
- 2011-04-08 AU AU2011245636A patent/AU2011245636B2/en active Active
- 2011-04-08 EP EP11722942.7A patent/EP2566895B1/en active Active
- 2011-04-08 MX MX2012011718A patent/MX343227B/es active IP Right Grant
- 2011-04-08 CN CN201610416972.8A patent/CN105968206B/zh active Active
- 2011-04-08 PH PH1/2012/502022A patent/PH12012502022B1/en unknown
- 2011-04-08 ES ES11722942.7T patent/ES2566602T3/es active Active
- 2011-04-08 JP JP2013503998A patent/JP5906233B2/ja active Active
- 2011-04-08 US US13/082,852 patent/US8481687B2/en active Active
- 2011-04-08 KR KR1020127029296A patent/KR101764453B1/ko active Active
- 2011-04-08 RU RU2012147591/10A patent/RU2568051C2/ru active
-
2012
- 2012-10-09 IL IL222272A patent/IL222272B/en active IP Right Grant
- 2012-11-02 ZA ZA2012/08290A patent/ZA201208290B/en unknown
-
2013
- 2013-06-17 US US13/919,582 patent/US9228021B2/en active Active
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2016
- 2016-01-04 US US14/987,374 patent/US9598498B2/en active Active
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2017
- 2017-03-02 US US15/448,164 patent/US10494441B2/en active Active
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2019
- 2019-10-29 US US16/667,056 patent/US11680108B2/en active Active
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2023
- 2023-04-26 US US18/307,638 patent/US12486332B2/en active Active
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