JP2013520423A5 - - Google Patents
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- Publication number
- JP2013520423A5 JP2013520423A5 JP2012553956A JP2012553956A JP2013520423A5 JP 2013520423 A5 JP2013520423 A5 JP 2013520423A5 JP 2012553956 A JP2012553956 A JP 2012553956A JP 2012553956 A JP2012553956 A JP 2012553956A JP 2013520423 A5 JP2013520423 A5 JP 2013520423A5
- Authority
- JP
- Japan
- Prior art keywords
- acetic acid
- phenylsulfonamido
- cyclobutyl
- difluoromethoxy
- dichlorobiphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003839 salts Chemical class 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000000335 thiazolyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- -1 N- (1- (3 ′, 5′-dichlorobiphenyl-3-yl) cyclopropyl) -4- (difluoromethoxy) phenylsulfonamido Chemical group 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- NMHWKDJFMUCPDP-UHFFFAOYSA-N 2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[1-(3-phenylphenyl)cyclobutyl]amino]acetic acid Chemical compound C=1C=C2OC(C)(C)CCC2=CC=1S(=O)(=O)N(CC(O)=O)C1(C=2C=C(C=CC=2)C=2C=CC=CC=2)CCC1 NMHWKDJFMUCPDP-UHFFFAOYSA-N 0.000 claims 1
- TZUXYHYAMUNMQE-UHFFFAOYSA-N 2-[(2-chlorophenyl)sulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=CC=C(Cl)C=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 TZUXYHYAMUNMQE-UHFFFAOYSA-N 0.000 claims 1
- VOFBRAMKHNPEGG-UHFFFAOYSA-N 2-[(2-cyanophenyl)sulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=CC=C(C#N)C=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 VOFBRAMKHNPEGG-UHFFFAOYSA-N 0.000 claims 1
- BCLHIAOLMYFQHM-UHFFFAOYSA-N 2-[(3,4-dichlorophenyl)sulfonyl-[1-[3-(2-methoxyphenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound COC1=CC=CC=C1C1=CC=CC(C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=C(Cl)C(Cl)=CC=2)=C1 BCLHIAOLMYFQHM-UHFFFAOYSA-N 0.000 claims 1
- PYWMNHDIZDUFLI-UHFFFAOYSA-N 2-[(3-chlorophenyl)sulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 PYWMNHDIZDUFLI-UHFFFAOYSA-N 0.000 claims 1
- ACZMIGOZKWPGIM-UHFFFAOYSA-N 2-[(3-cyanophenyl)sulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=CC(C#N)=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 ACZMIGOZKWPGIM-UHFFFAOYSA-N 0.000 claims 1
- LJASMNBCJZEIKW-UHFFFAOYSA-N 2-[(4-chlorophenyl)sulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=C(Cl)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 LJASMNBCJZEIKW-UHFFFAOYSA-N 0.000 claims 1
- QVQJFARLTWLXIJ-UHFFFAOYSA-N 2-[(4-cyanophenyl)sulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=C(C#N)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 QVQJFARLTWLXIJ-UHFFFAOYSA-N 0.000 claims 1
- GDSNTDHQEWIIJA-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)cyclobutyl]-(3,4-dichlorophenyl)sulfonylamino]acetic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(Br)C=CC=2)CCC1 GDSNTDHQEWIIJA-UHFFFAOYSA-N 0.000 claims 1
- ROHHGXQCJBZHIL-UHFFFAOYSA-N 2-[[1-(3-bromophenyl)cyclopropyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(Br)C=CC=2)CC1 ROHHGXQCJBZHIL-UHFFFAOYSA-N 0.000 claims 1
- QPJUIEPTLQMADJ-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(Br)=CC=2)CCC1 QPJUIEPTLQMADJ-UHFFFAOYSA-N 0.000 claims 1
- WFEKNMKEYNOBGZ-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)cyclopentyl]-(4-methylphenyl)sulfonylamino]acetic acid Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N(CC(O)=O)C1(C=2C=CC(Br)=CC=2)CCCC1 WFEKNMKEYNOBGZ-UHFFFAOYSA-N 0.000 claims 1
- DSVDYFFZKIOMMI-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)cyclopentyl]-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl]amino]acetic acid Chemical compound C=1C=C2OC(C)(C)CCC2=CC=1S(=O)(=O)N(CC(O)=O)C1(C=2C=CC(Br)=CC=2)CCCC1 DSVDYFFZKIOMMI-UHFFFAOYSA-N 0.000 claims 1
- QMZUVQXZKOHTPD-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)cyclopentyl]-naphthalen-1-ylsulfonylamino]acetic acid Chemical compound C=1C=CC2=CC=CC=C2C=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(Br)=CC=2)CCCC1 QMZUVQXZKOHTPD-UHFFFAOYSA-N 0.000 claims 1
- UQDIDTCVOZXDDI-UHFFFAOYSA-N 2-[[1-(4-bromophenyl)cyclopropyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(Br)=CC=2)CC1 UQDIDTCVOZXDDI-UHFFFAOYSA-N 0.000 claims 1
- VWOPXHSOJUXQRQ-UHFFFAOYSA-N 2-[[1-(4-chlorophenyl)cyclopropyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(Cl)=CC=2)CC1 VWOPXHSOJUXQRQ-UHFFFAOYSA-N 0.000 claims 1
- CPFGGRNVBDOVRS-UHFFFAOYSA-N 2-[[1-[3-(2,4-dichlorophenyl)phenyl]cyclobutyl]-(3,4-dichlorophenyl)sulfonylamino]acetic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCC1 CPFGGRNVBDOVRS-UHFFFAOYSA-N 0.000 claims 1
- UJYRIQWQCNGNNB-UHFFFAOYSA-N 2-[[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]-(2-methoxyphenyl)sulfonylamino]acetic acid Chemical compound COC1=CC=CC=C1S(=O)(=O)N(CC(O)=O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 UJYRIQWQCNGNNB-UHFFFAOYSA-N 0.000 claims 1
- RCPBEZOLAIOBOK-UHFFFAOYSA-N 2-[[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]-(3-methoxyphenyl)sulfonylamino]acetic acid Chemical compound COC1=CC=CC(S(=O)(=O)N(CC(O)=O)C2(CCC2)C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)=C1 RCPBEZOLAIOBOK-UHFFFAOYSA-N 0.000 claims 1
- LWYHAUSQQMAJRN-UHFFFAOYSA-N 2-[[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl]amino]acetic acid Chemical compound C=1C=C2OC(C)(C)CCC2=CC=1S(=O)(=O)N(CC(O)=O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 LWYHAUSQQMAJRN-UHFFFAOYSA-N 0.000 claims 1
- VHGKQLHJJUPOCF-UHFFFAOYSA-N 2-[[1-[4-(2,4-dichlorophenyl)phenyl]cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCC1 VHGKQLHJJUPOCF-UHFFFAOYSA-N 0.000 claims 1
- UKYHIDBVOSCOLH-UHFFFAOYSA-N 2-[[1-[4-(2,4-dichlorophenyl)phenyl]cyclopropyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CC1 UKYHIDBVOSCOLH-UHFFFAOYSA-N 0.000 claims 1
- DOVYGZDYHIEWNY-UHFFFAOYSA-N 2-[[1-[4-(2-chlorophenyl)phenyl]cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC=CC=2)Cl)CCC1 DOVYGZDYHIEWNY-UHFFFAOYSA-N 0.000 claims 1
- QPQFFEUUKKDGRI-UHFFFAOYSA-N 2-[[1-[4-(3,5-dichlorophenyl)phenyl]cyclopentyl]-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl]amino]acetic acid Chemical compound C=1C=C2OC(C)(C)CCC2=CC=1S(=O)(=O)N(CC(O)=O)C1(C=2C=CC(=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCCC1 QPQFFEUUKKDGRI-UHFFFAOYSA-N 0.000 claims 1
- LXXILVTXTSOHHS-UHFFFAOYSA-N 2-[[1-[4-(3-chlorophenyl)phenyl]cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C=C(Cl)C=CC=2)CCC1 LXXILVTXTSOHHS-UHFFFAOYSA-N 0.000 claims 1
- QGIOXHXTLPVUPC-UHFFFAOYSA-N 2-[[1-[4-(4-chlorophenyl)phenyl]cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C=CC(Cl)=CC=2)CCC1 QGIOXHXTLPVUPC-UHFFFAOYSA-N 0.000 claims 1
- MWHSVVUEYFHTTD-UHFFFAOYSA-N 2-[[1-[4-(5-chloro-2-methoxyphenyl)phenyl]cyclobutyl]-[4-(difluoromethoxy)phenyl]sulfonylamino]acetic acid Chemical compound COC1=CC=C(Cl)C=C1C1=CC=C(C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)C=C1 MWHSVVUEYFHTTD-UHFFFAOYSA-N 0.000 claims 1
- OLXMFKAKXAAVKQ-UHFFFAOYSA-N 2-[[3-[4-(3,5-dichlorophenyl)phenyl]oxolan-3-yl]-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl]amino]acetic acid Chemical compound C=1C=C2OC(C)(C)CCC2=CC=1S(=O)(=O)N(CC(O)=O)C1(C=2C=CC(=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCOC1 OLXMFKAKXAAVKQ-UHFFFAOYSA-N 0.000 claims 1
- GQPIUZSIAURVAM-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-(3-phenylphenyl)cyclopropyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=CC=CC=2)CC1 GQPIUZSIAURVAM-UHFFFAOYSA-N 0.000 claims 1
- FCMZFBALSOTSMD-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-(4-phenylphenyl)cyclobutyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C=CC=CC=2)CCC1 FCMZFBALSOTSMD-UHFFFAOYSA-N 0.000 claims 1
- PGBBWSDHYRRODP-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-(4-pyrimidin-5-ylphenyl)cyclobutyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C=NC=NC=2)CCC1 PGBBWSDHYRRODP-UHFFFAOYSA-N 0.000 claims 1
- TZITZJREMJBLNJ-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[3-(2-methoxyphenyl)phenyl]cyclopropyl]amino]acetic acid Chemical compound COC1=CC=CC=C1C1=CC=CC(C2(CC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)=C1 TZITZJREMJBLNJ-UHFFFAOYSA-N 0.000 claims 1
- HGFBBOJJORKXDT-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[3-[2-(trifluoromethoxy)phenyl]phenyl]cyclopropyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C(=CC=CC=2)OC(F)(F)F)CC1 HGFBBOJJORKXDT-UHFFFAOYSA-N 0.000 claims 1
- VRQBKOYUGDLBPD-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(2,4-dimethyl-1,3-thiazol-5-yl)phenyl]cyclobutyl]amino]acetic acid Chemical compound S1C(C)=NC(C)=C1C1=CC=C(C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)C=C1 VRQBKOYUGDLBPD-UHFFFAOYSA-N 0.000 claims 1
- SUNUIUIDQSKEOT-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(2-fluorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC=CC=2)F)CCC1 SUNUIUIDQSKEOT-UHFFFAOYSA-N 0.000 claims 1
- BTLFDBMBFPDZOQ-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(2-methoxyphenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound COC1=CC=CC=C1C1=CC=C(C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)C=C1 BTLFDBMBFPDZOQ-UHFFFAOYSA-N 0.000 claims 1
- YAKHIFSVQWWENN-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(2-methoxyphenyl)phenyl]cyclopropyl]amino]acetic acid Chemical compound COC1=CC=CC=C1C1=CC=C(C2(CC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)C=C1 YAKHIFSVQWWENN-UHFFFAOYSA-N 0.000 claims 1
- YWTBCPPOFYMYOI-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(2-methylphenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound CC1=CC=CC=C1C1=CC=C(C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)C=C1 YWTBCPPOFYMYOI-UHFFFAOYSA-N 0.000 claims 1
- CWVIYBDLCOWTFM-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(3-methoxyphenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound COC1=CC=CC(C=2C=CC(=CC=2)C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)=C1 CWVIYBDLCOWTFM-UHFFFAOYSA-N 0.000 claims 1
- UQCGTHXCMQLHDI-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-(4-methoxyphenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C2(CCC2)N(CC(O)=O)S(=O)(=O)C=2C=CC(OC(F)F)=CC=2)C=C1 UQCGTHXCMQLHDI-UHFFFAOYSA-N 0.000 claims 1
- YZMDTMVHQAUYGH-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-[2-(trifluoromethoxy)phenyl]phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC=CC=2)OC(F)(F)F)CCC1 YZMDTMVHQAUYGH-UHFFFAOYSA-N 0.000 claims 1
- RMWSZICCCCJSSV-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-[2-(trifluoromethoxy)phenyl]phenyl]cyclopropyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC=CC=2)OC(F)(F)F)CC1 RMWSZICCCCJSSV-UHFFFAOYSA-N 0.000 claims 1
- GNPJPHNOCFYLSK-UHFFFAOYSA-N 2-[[4-(difluoromethoxy)phenyl]sulfonyl-[1-[4-[2-(trifluoromethyl)phenyl]phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=C(OC(F)F)C=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=CC(=CC=2)C=2C(=CC=CC=2)C(F)(F)F)CCC1 GNPJPHNOCFYLSK-UHFFFAOYSA-N 0.000 claims 1
- VUCGWEGPHBNVFX-UHFFFAOYSA-N 2-[benzenesulfonyl-[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]amino]acetic acid Chemical compound C=1C=CC=CC=1S(=O)(=O)N(CC(=O)O)C1(C=2C=C(C=CC=2)C=2C=C(Cl)C=C(Cl)C=2)CCC1 VUCGWEGPHBNVFX-UHFFFAOYSA-N 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 101000950831 Mus musculus Diacylglycerol lipase-beta Proteins 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30599610P | 2010-02-19 | 2010-02-19 | |
| US61/305,996 | 2010-02-19 | ||
| PCT/US2011/024726 WO2011103055A1 (en) | 2010-02-19 | 2011-02-14 | Glycine sulfonamides for use as inhibitors of diacylglycerol lipase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520423A JP2013520423A (ja) | 2013-06-06 |
| JP2013520423A5 true JP2013520423A5 (enExample) | 2014-04-03 |
Family
ID=43755254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553956A Withdrawn JP2013520423A (ja) | 2010-02-19 | 2011-02-14 | ジアシルグリセロールリパーゼ阻害剤としての使用のためのグリシンスルホンアミド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8404741B2 (enExample) |
| EP (1) | EP2536694B1 (enExample) |
| JP (1) | JP2013520423A (enExample) |
| CN (1) | CN102858753A (enExample) |
| WO (1) | WO2011103055A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11236055B2 (en) * | 2016-07-01 | 2022-02-01 | Venenum Biodesign, LLC | Non-systemic TGR5 agonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2348847A1 (en) | 2000-05-31 | 2001-11-30 | Pfizer Inc. | New isoxazole-sulfonamide endothelin antagonists |
| AU2009235634B8 (en) | 2008-04-08 | 2013-05-23 | Grunenthal Gmbh | Substituted sulfonamide derivatives |
-
2011
- 2011-02-11 US US13/025,384 patent/US8404741B2/en active Active
- 2011-02-14 WO PCT/US2011/024726 patent/WO2011103055A1/en not_active Ceased
- 2011-02-14 JP JP2012553956A patent/JP2013520423A/ja not_active Withdrawn
- 2011-02-14 CN CN2011800198869A patent/CN102858753A/zh active Pending
- 2011-02-14 EP EP11705768.7A patent/EP2536694B1/en not_active Not-in-force
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